EDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer.

abstract：:A plant polysaccharide, Aloe gel extract, was reported to have an inhibitory effect on benzo[a]pyrene (B[a]P)-DNA adduct formation in vitro and in vivo. Hence, chemopreventive effects of plant polysaccharides [Aloe barbadensis Miller (APS), Lentinus edodes (LPS), Ganoderma lucidum (GPS) and Coriolus versicolor (CPS)] ...

journal_title：Carcinogenesis

authors： Kim HS,Kacew S,Lee BM

更新日期：1999-08-01 00:00:00

abstract：:An intrasanguineous host-mediated assay was used to establish the mutagenic potential of a series of dialkylnitrosamines to E. coli K12/343/113 in the liver and spleen of mice. For calibrating purposes, dose- and time-dependent kinetics of mutation induction by the model compound diethylnitrosamine in this assay was d...

journal_title：Carcinogenesis

authors： Kerklaan P,Mohn G,Bouter S

更新日期：1981-01-01 00:00:00

abstract：:A model of oral mucosal carcinogenesis using the water-soluble carcinogen 4-nitroquinoline-1-oxide (4NQO) was combined with a model of oral mucosal candidosis to examine the ability of Candida albicans to promote the development of neoplasia in suitably initiated epithelium. Sprague-Dawley rats were initiated by the a...

journal_title：Carcinogenesis

authors： O'Grady JF,Reade PC

更新日期：1992-05-01 00:00:00

abstract：:A number of distinct subtypes of neuroblastoma exist with different genetic abnormalities that are predicative of outcome. Whole chromosome gains are usually associated with low stage disease and favourable outcome, whereas loss of 1p, 3p and 11q, unbalanced gain of 17q and MYCN amplification (MNA) are indicative of h...

journal_title：Carcinogenesis

authors： McArdle L,McDermott M,Purcell R,Grehan D,O'Meara A,Breatnach F,Catchpoole D,Culhane AC,Jeffery I,Gallagher WM,Stallings RL

更新日期：2004-09-01 00:00:00

abstract：:Since its discovery, the E3 ubiquitin ligase E6-associated protein (E6AP) has been studied extensively in two pathological contexts: infection by the human papillomavirus (HPV), and the neurodevelopmental disorder, Angelman syndrome. Vital biological links between E6AP and other viruses, namely hepatitis C virus and e...

journal_title：Carcinogenesis

authors： Bandilovska I,Keam SP,Gamell C,Machicado C,Haupt S,Haupt Y

更新日期：2019-07-06 00:00:00

abstract：:We have shown that parathyroid hormone-related protein (PTHrP) is a survival factor for human renal cell carcinoma (RCC) and that its expression is negatively regulated by the von Hippel-Lindau (VHL) tumor suppressor gene at the level of messenger RNA (mRNA) stability, as observed for tumor growth factors (TGFs). Our ...

journal_title：Carcinogenesis

authors： Danilin S,Sourbier C,Thomas L,Rothhut S,Lindner V,Helwig JJ,Jacqmin D,Lang H,Massfelder T

更新日期：2009-03-01 00:00:00

abstract：:The effect of glucose on the formation of the food mutagen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) was studied in a model system. When a mixture of creatine (0.9 mmol), phenylalanine (0.9 mmol) and glucose (0.45 mmol) was heated in diethylene glycol and water (3 ml, 5:1) for 10 min at 180 or 225 degrees...

journal_title：Carcinogenesis

authors： Skog K,Jägerstad M

更新日期：1991-12-01 00:00:00

abstract：:The transcription factor Sp1 has been implicated in cell-type-specific activation of transforming growth factor-beta (TGFbeta) target genes in normal epithelial cells as well as in aberrant gene activation by TGFbeta in epithelial tumor cells. Here, we have examined the interaction of Sp1 with components of the Smad s...

journal_title：Carcinogenesis

authors： Jungert K,Buck A,Buchholz M,Wagner M,Adler G,Gress TM,Ellenrieder V

更新日期：2006-12-01 00:00:00

abstract：:The mutagenicity of N-nitroso-N-benzyl-methylamine (NBzMA), N-benzyl-N-nitrosourea (BzNU) and N-methyl-N-nitrosourea (MNU) in Salmonella typhimurium strains was investigated. BzNU selectively mutated TA100 strain as compared to TA1535, whereas MNU showed an inverse strain response, an effect probably related to the fa...

journal_title：Carcinogenesis

authors： Lin DX,Malaveille C,Park SS,Gelboin HV,Bartsch H

更新日期：1990-09-01 00:00:00

abstract：:The genes that are involved in estrogen biosynthesis, cellular binding and metabolism may contribute to breast cancer susceptibility. We examined the effect of the CYP17 promoter T --> C polymorphism and its interactions with the reproductive history, exogenous hormone use and selected lifestyle risk factors on breast...

journal_title：Carcinogenesis

authors： Chen Y,Gammon MD,Teitelbaum SL,Britton JA,Terry MB,Shantakumar S,Eng SM,Wang Q,Gurvich I,Neugut AI,Santella RM,Ahsan H

更新日期：2008-04-01 00:00:00

abstract：:CXCR4 is a chemokine receptor probably involved in the homing of metastatic breast cancer, and its expression is modulated by tumor environmental stimuli such as hepatocyte growth factor (HGF) and hypoxia. Here, we demonstrate that, depending on the stimulus, different transcription factors can cooperate in enhancing ...

journal_title：Carcinogenesis

authors： Maroni P,Bendinelli P,Matteucci E,Desiderio MA

更新日期：2007-02-01 00:00:00

abstract：:Alterations in the pattern of epidermal cell differentiation and proliferation in mouse skin and benign skin tumors were studied by two-color immunofluorescence using monospecific antibodies. Replicating cells were identified by 5-bromo-deoxyuridine (BrdU) pulse-labeling and differentiating cells by keratins K1 and K1...

journal_title：Carcinogenesis

authors： Huitfeldt HS,Heyden A,Clausen OP,Thrane EV,Roop D,Yuspa SH

更新日期：1991-11-01 00:00:00

abstract：:The broccoli constituent sulforaphane (1-isothiocyanate-4-methylsulfinylbutane) has previously been shown to protect rats against 9,10-dimethyl-1,2-benz[a]anthracene tumorigenesis, thought to be due, at least in part, to induction of phase II detoxification. We investigated the ability of sulforaphane to also inhibit ...

journal_title：Carcinogenesis

authors： Barcelo S,Gardiner JM,Gescher A,Chipman JK

更新日期：1996-02-01 00:00:00

abstract：:Functional inactivation of BRCA1 is an important mechanism involved in breast cancer pathogenesis. Mutation is often responsible for BRCA1 inactivation in familial breast cancer, but is not responsible for the decreased levels of BRCA1 seen in a subset of sporadic breast cancer patients. To determine if aberrant cytos...

journal_title：Carcinogenesis

authors： Rice JC,Ozcelik H,Maxeiner P,Andrulis I,Futscher BW

更新日期：2000-09-01 00:00:00

abstract：:The carcinogenic heterocyclic amine 2-amino-3,8-dimethyl-imidazo[4,5-f]quinoxaline (MeIQx) is widely distributed in cooked foods. The nuclease P1 method increased the sensitivity of the standard 32P-postlabeling analysis about 1000-fold for detection of MeIQx-DNA adducts. The recovery of MeIQx-DNA adducts by the nucle...

journal_title：Carcinogenesis

authors： Ochiai M,Nagaoka H,Wakabayashi K,Tanaka Y,Kim SB,Tada A,Nukaya H,Sugimura T,Nagao M

更新日期：1993-10-01 00:00:00

abstract：:High intake of red meat is associated with an increased risk of colon cancer. It has been suggested that fat from red meat is responsible, because high fat intake increases the concentration of cytotoxic lipids in the colon. Experimental studies have not unequivocally supported such a role for fat, however. Recently, ...

journal_title：Carcinogenesis

authors： Sesink AL,Termont DS,Kleibeuker JH,Van Der Meer R

更新日期：2000-10-01 00:00:00

abstract：:The most potent carcinogen of the cyclopenta[a]phenanthrene series, 15, 16-dihydro-11-methylcyclopenta[a]phenanthren-17-one and its non-carcinogenic, unmethylated parent compound, were compared for their abilities to induce micronuclei in epidermal keratinocytes after application onto the dorsal skin of Skh/HR-1 hairl...

journal_title：Carcinogenesis

authors： Baker RS,Bonin AM,Arlauskas A,He S,Coombs MM

更新日期：1992-03-01 00:00:00

abstract：:The aim of this study was to investigate selected proteomic markers of the metabolic phenotype of breast carcinomas as prognostic markers of cancer progression. For this purpose, a series of 101 breast carcinomas and 13 uninvolved breast samples were examined for quantitative differences in protein expression of mitoc...

journal_title：Carcinogenesis

authors： Isidoro A,Casado E,Redondo A,Acebo P,Espinosa E,Alonso AM,Cejas P,Hardisson D,Fresno Vara JA,Belda-Iniesta C,González-Barón M,Cuezva JM

更新日期：2005-12-01 00:00:00

abstract：:3-tert-Butyl-4-hydroxyanisole (3-BHA) and its metabolites, tert-butyl-1,4-benzoquinone (BQ) and 3-tert-butyl-5-methoxy-1,2-benzoquinone (BHAoQ), were tested for initiating activity in a two-stage transformation assay using BALB/3T3 cells. Cells were treated first with a test chemical and then with the tumor promoter 1...

journal_title：Carcinogenesis

authors： Sakai A,Miyata N,Takahashi A

更新日期：1990-11-01 00:00:00

abstract：:Remodeling or deregulation of the calcium signaling pathway is a relevant hallmark of cancer including cutaneous melanoma (CM). In this study, using data from a published genome-wide association study (GWAS) from The University of Texas M.D. Anderson Cancer Center, we assessed the role of 41,377 common single-nucleoti...

journal_title：Carcinogenesis

authors： Wang X,Liu H,Xu Y,Xie J,Zhu D,Amos CI,Fang S,Lee JE,Li X,Nan H,Song Y,Wei Q

更新日期：2019-04-29 00:00:00

abstract：:Antibodies specific for u.v.-induced DNA damage were raised in rabbits, and used to study damage and repair of nuclear DNA in nude mouse and human skin in vivo by immuno-fluorescence and immunoperoxidase techniques. Purification of the antibodies by affinity chromatography strongly reduced unspecific background staini...

journal_title：Carcinogenesis

authors： Eggset G,Volden G,Krokan H

更新日期：1983-01-01 00:00:00

abstract：:Cells from patients with genomic instability syndromes have high predisposition to cancer. However, little is known about whether these mutant cells have high susceptibility to oncogenic transformation. We have tested the hypothesis that a defect in maintaining genome integrity is necessary but not sufficient alone fo...

journal_title：Carcinogenesis

authors： Li J,Sejas DP,Burma S,Chen DJ,Pang Q

更新日期：2007-06-01 00:00:00

abstract：:The O6-methylguanine-DNA methyltransferase gene (MGMT) encodes the direct reversal DNA repair protein that removes alkyl adducts from the O6 position of guanine. Several single-nucleotide polymorphisms (SNPs) exist in the MGMT promoter/enhancer (P/E) region. However, the haplotype structure encompassing these SNPs and...

journal_title：Carcinogenesis

authors： Xu M,Nekhayeva I,Cross CE,Rondelli CM,Wickliffe JK,Abdel-Rahman SZ

更新日期：2014-03-01 00:00:00

abstract：:Analysis of 24 h urine samples of rats administered N-nitrosodipropylamine (NDPA), N-nitroso-2-hydroxypropylpropylamine (NHPPA) or N-nitroso-2-oxopropylpropylamine (NOPPA) showed that the major excretion product in each case was the beta-glucuronide of NHPPA. This conjugate was shown to be present at levels of about 5...

journal_title：Carcinogenesis

authors： Leung KH,Archer MC

更新日期：1981-01-01 00:00:00

abstract：:In order to find potentially effective compounds that could prevent the covalent binding of the carcinogen N-hydroxy-2-acetylaminofluorene (N-OH-AAF) to rat liver macromolecules in vivo, the prevention of the covalent binding to RNA of the sulfate ester of the carcinogen N-OH-AAF by a series of thioethers was investig...

journal_title：Carcinogenesis

authors： van den Goorbergh JA,de Wit H,Tijdens RB,Mulder GJ,Meerman JH

更新日期：1987-02-01 00:00:00

abstract：:Dose-response relationships in the induction of urinary bladder cancer in male C57BL/6 x DBA/2-F1 (BDF) mice by intragastric instillation of N-butyl-N-(4-hydroxybutyl)nitrosamine (OH-BBN) were studied. Administration of a total dose of 0 to 80 mg OH-BBN in 10 weekly fractions to groups of 25 mice resulted in a linear ...

journal_title：Carcinogenesis

authors： McCormick DL,Ronan SS,Becci PJ,Moon RC

更新日期：1981-01-01 00:00:00

abstract：:Aberrant crypt foci (ACF) are microscopic surface abnormalities that are putative precursors to colorectal cancer (CRC). ACF exhibit similar histological and molecular abnormalities to adenomas and CRC and potentially represent useful biomarkers of cancer risk. Microsatellite instability (MSI) is one molecular abnorma...

journal_title：Carcinogenesis

authors： Greenspan EJ,Cyr JL,Pleau DC,Levine J,Rajan TV,Rosenberg DW,Heinen CD

更新日期：2007-04-01 00:00:00

abstract：:The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), is negatively correlated with tumor progression in multiple neoplasms, being a promising new target for cancer treatment. However, the precise molecular effects of NDRG1 remain unclear. Herein, we summarize recent advances in understanding the impac...

journal_title：Carcinogenesis

authors： Sun J,Zhang D,Bae DH,Sahni S,Jansson P,Zheng Y,Zhao Q,Yue F,Zheng M,Kovacevic Z,Richardson DR

更新日期：2013-09-01 00:00:00

abstract：:Retinoids have been shown to exert an anticarcinogenic effect through suppression of the cell cycle, induction of apoptosis and/or differentiation. In rat liver, in particular, retinoic acid has been shown to inhibit regeneration after partial hepatectomy, most probably through repression of the expression of c-fos an...

journal_title：Carcinogenesis

authors： Ledda-Columbano GM,Pibiri M,Molotzu F,Cossu C,Sanna L,Simbula G,Perra A,Columbano A

更新日期：2004-11-01 00:00:00

abstract：:Naturally occurring allyl isothiocyanate (AITC) was recently shown to be selectively delivered to bladder cancer tissue via urinary excretion and to inhibit bladder cancer growth and muscle invasion in an animal model. AITC is excreted in urine mainly as N-acetyl-S-(N-allylthiocarbamoyl)cysteine, more commonly known a...

journal_title：Carcinogenesis

authors： Bhattacharya A,Li Y,Geng F,Munday R,Zhang Y

更新日期：2012-02-01 00:00:00