HGF induces CXCR4 and CXCL12-mediated tumor invasion through Ets1 and NF-kappaB.

abstract：:In a previous study a high first-pass metabolism of N-nitrosodi-[1-14C]amylamine (NDAA, 0.59-350 microM) has been shown in isolated perfused rat small intestinal segments. In the present work the identification of metabolites in samples of perfusate and absorbed fluid (absorbate) is reported. After HPLC enrichment and...

journal_title：Carcinogenesis

authors： Richter E,Lorck C,Wiessler M

更新日期：1988-03-01 00:00:00

abstract：:The H2-receptor antagonist, ranitidine, is among the most widely used pharmaceuticals to treat gastroesophageal reflux disease and peptic ulcers. While previous studies have demonstrated that amines can form N-nitrosamines when exposed to nitrite at stomach-relevant pH, N-nitrosamine formation from ranitidine, an amin...

journal_title：Carcinogenesis

authors： Zeng T,Mitch WA

更新日期：2016-06-01 00:00:00

abstract：:A diet that is deficient in methionine, choline, folic acid and vitamin B12 has been found to induce alterations rapidly in liver tRNA methylation in male Fischer rats. In vitro assays indicated that activity of N2-guanine tRNA methyltransferase II (NMG2) was increased to 150% of controls levels in 1 week and 300% of ...

journal_title：Carcinogenesis

authors： Wainfan E,Dizik M,Hluboky M,Balis ME

更新日期：1986-03-01 00:00:00

abstract：:A diet deficient in choline when fed to rats for as few as 3 days resulted in liver DNA damage. The damage could be monitored as alkali-labile lesions using alkaline-sucrose gradients as well as alkaline elution technique. The DNA damage disappeared when the choline-deficient diet was replaced by a choline-supplemente...

journal_title：Carcinogenesis

authors： Rushmore TH,Farber E,Ghoshal AK,Parodi S,Pala M,Taningher M

更新日期：1986-10-01 00:00:00

abstract：:The effects and mechanisms of action of diepoxybutane (DEB) and mitomycin C (MMC) were investigated on sea urchin embryogenesis, (Sphaerechinus granularis and Paracentrotus lividus). DEB- and MMC-induced toxicity was evaluated by means of selected end-points, including developmental defects, cytogenetic abnormalities ...

journal_title：Carcinogenesis

authors： Korkina LG,Deeva IB,De Biase A,Iaccarino M,Oral R,Warnau M,Pagano G

更新日期：2000-02-01 00:00:00

abstract：:The reaction of chloroacetaldehyde, a reactive metabolic of the carcinogen vinyl chloride, with DNA produces in addition to the hitherto known adducts, 1,N6-ethenoadenine and 3,N4-ethenocytosine, an ethenoguanine adduct, namely N2,3-ethenoguanine. This adduct is formed in the reaction of chloroacetaldehyde with the fr...

journal_title：Carcinogenesis

authors： Oesch F,Doerjer G

更新日期：1982-01-01 00:00:00

abstract：:Receptor tyrosine kinase EphB3 is expressed in cells in the bottom of intestinal crypts near stem cell niches. Loss of Ephb3 has recently been reported to produce invasive colorectal carcinoma in Apc(Min/+) mice and EphB-mediated compartmentalization was demonstrated to be a mechanism suppressing colorectal cancer pro...

journal_title：Carcinogenesis

authors： Chiu ST,Chang KJ,Ting CH,Shen HC,Li H,Hsieh FJ

更新日期：2009-09-01 00:00:00

abstract：:Monoclonal or affinity-purified antibodies specific to Novikoff hepatoma cytokeratin p39 were employed to study the origin and fate of p39-containing cell types during hepatocarcinogenesis induced with N,N-dimethyl-p(m-tolylazo)aniline. Frozen sections were obtained from the livers of animals autopsied temporally duri...

journal_title：Carcinogenesis

authors： Schmidt WN,Page DL,McKusick K,Hnilica LS

更新日期：1985-08-01 00:00:00

abstract：:In the era of precision oncology, bladder cancer (BlCa) is characterized by generic patient management and lack of personalized prognosis and surveillance. Herein, we have studied the clinical significance of urothelial cancer associated 1 (UCA1) lncRNA in improving patients' risk stratification and prognosis. A scree...

journal_title：Carcinogenesis

authors： Avgeris M,Tsilimantou A,Levis PK,Rampias T,Papadimitriou MA,Panoutsopoulou K,Stravodimos K,Scorilas A

更新日期：2019-08-22 00:00:00

abstract：:We have investigated the effect of the soybean isoflavone genistein on 8-hydroxy-2'-deoxyguanosine (8-OHdG) formation in calf thymus DNA exposed to either UV irradiation or the Fenton reaction system. Under the conditions used we observed that UV light and the Fenton reaction significantly increase 8-OHdG formation in...

journal_title：Carcinogenesis

authors： Wei H,Cai Q,Rahn RO

更新日期：1996-01-01 00:00:00

abstract：:In order to study the mechanism of cancer production by aflatoxin B1 (AFB1) in extrahepatic tissues which have relatively low cytochrome P450 monooxygenase (P450) activity, we have examined prostaglandin H synthase (PHS)-mediated AFB1 activation [( 3H]AFB1-DNA binding). [3H]AFB1 was activated by both purified PHS and ...

journal_title：Carcinogenesis

authors： Liu L,Daniels JM,Stewart RK,Massey TE

更新日期：1990-11-01 00:00:00

abstract：:p53 is a tumor suppressor that responds to a variety of stresses such as oncogenes and DNA damage by activating its transcriptional targets to allow repair or elimination of damaged cells. In the absence of stress signals, p53 needs to be kept in check and this is achieved by the E3 ligase MDM2. For tumors that retain...

journal_title：Carcinogenesis

authors： Roxburgh P,Hock AK,Dickens MP,Mezna M,Fischer PM,Vousden KH

更新日期：2012-04-01 00:00:00

abstract：:Prostate cancer (PCa) is the second cause of cancer deaths in men in the USA. When the cancer recurs, early stages can be controlled with hormone ablation therapy to delay the rate of cancer progression but, over time, the cancer overcomes its hormone dependence, becomes highly aggressive and metastasizes. Clinical tr...

journal_title：Carcinogenesis

authors： Wang L,Li W,Lin M,Garcia M,Mulholland D,Lilly M,Martins-Green M

更新日期：2014-10-01 00:00:00

abstract：:Currently there is no well-defined biological parameter or marker to help define agents, doses, and dose schedules for human cancer chemoprevention trials. Induction of ornithine decarboxylase, the rate limiting enzyme in the polyamine biosynthetic pathway, has been shown to be an essential aspect of mouse skin tumor ...

journal_title：Carcinogenesis

authors： Loprinzi CL,Verma AK

更新日期：1985-11-01 00:00:00

abstract：:The effects of consumption of glucosinolate-containing Brussels sprouts on plasma and urinary glutathione S-transferase (GST) class-alpha and -pi were investigated. Five male and five female non-smoking volunteers were randomly assigned to two groups in a crossover design. Five persons started on a glucosinolate-free ...

journal_title：Carcinogenesis

authors： Nijhoff WA,Mulder TP,Verhagen H,van Poppel G,Peters WH

更新日期：1995-04-01 00:00:00

abstract：:The variation in colorectal cancer (CRC) incidence worldwide strongly suggests a role for dietary influences. Based on epidemiological data, protective effects of vegetables and fruit intake on CRC are widely claimed, while other data indicate a possible increased CRC risk from (higher) dietary fat intake. Therefore, ...

journal_title：Carcinogenesis

authors： van Kranen HJ,van Iersel PW,Rijnkels JM,Beems DB,Alink GM,van Kreijl CF

更新日期：1998-09-01 00:00:00

abstract：:The accumulation of O6-methylguanine (O6-meG) in the DNA of blood leukocytes of 21 Hodgkin's lymphoma patients (followed for up to 12 cycles of treatment) treated in the context of MOPP combination chemotherapy with 150 mg procarbazine daily for 10 days was examined and compared to that observed in rats treated with d...

journal_title：Carcinogenesis

authors： Souliotis VL,Valavanis C,Boussiotis VA,Pangalis GA,Kyrtopoulos SA

更新日期：1994-08-01 00:00:00

abstract：:The breast cancer gene BRCA1 has previously been cloned from both human and mouse. We cloned a fragment of the rat Brca1 homologue in order to map it and explore its biological function. Partial cDNA fragments of the rat Brca1 homologue were isolated by RT-PCR. Sequence analysis revealed that the RING-finger domain is...

journal_title：Carcinogenesis

authors： Chen KS,Shepel LA,Haag JD,Heil GM,Gould MN

更新日期：1996-08-01 00:00:00

abstract：:Cigarette smoke (CS) contains hundreds of carcinogens and is a potent inducer of oxidative and bulky DNA damage, which when insufficiently repaired leads to activation of DNA damage response and possibly mutations. The DNA repair protein xeroderma pigmentosum group C (XPC) is primed to play an important role in CS-ind...

journal_title：Carcinogenesis

authors： Zhou H,Saliba J,Sandusky GE,Sears CR

更新日期：2019-05-14 00:00:00

abstract：:Whole-body autoradiography of [3H]aflatoxin B1 ([3H]AFB1) in lamb showed a localization of bound labelling, in addition to the liver, in the nasal olfactory and respiratory mucosa, in the mucosa of the nasopharynx, pharynx, oesophagus, larynx, trachea, bronchi and bronchioles and in the palpebral and bulbar conjunctiv...

journal_title：Carcinogenesis

authors： Larsson P,Busk L,Tjälve H

更新日期：1994-05-01 00:00:00

abstract：:The role of O-GlcNAc transferase (OGT) in gene regulation and tumor invasion is poorly understood. Here, we have identified several previously undiscovered OGT-interacting proteins, including the PRMT5/WDR77 complex, the PRC2 complex, the ten-eleven translocation (TET) family, the CRL4B complex and the nucleosome remo...

journal_title：Carcinogenesis

authors： Gao J,Yang Y,Qiu R,Zhang K,Teng X,Liu R,Wang Y

更新日期：2018-10-08 00:00:00

abstract：:Karyotype, mitochondrial ultrastructure and several enzymatic activities were studied in two clones, D22 and D27, from SV40-transformed rabbit chondrocytes. Similar chromosome alterations, with recurrent losses and gains were observed at the various passages. Mitochondria were rare, with increase in size and crest alt...

journal_title：Carcinogenesis

authors： Bravard A,Beaumatin J,Luccioni C,Fritsch P,Lefrançois D,Thenet S,Adolphe M,Dutrillaux B

更新日期：1992-05-01 00:00:00

abstract：:A hallmark of cancer is aberrant DNA methylation, consisting of global hypomethylation and regional hypermethylation of tumor suppressor genes. DNA methyltransferase inhibitors have been recognized as promising candidate anticancer drugs. Drug development has focused on DNA methylation inhibitors with the goal of acti...

journal_title：Carcinogenesis

authors： Chik F,Szyf M

更新日期：2011-02-01 00:00:00

abstract：:Methylation of the non-carcinogen 15,16-dihydrocyclopenta[a]phenanthren-17-one (CPP-17-one) at the bay region to form 11-CH3-CPP-17-one confers carcinogenic potential. In the present study we have investigated the in vitro metabolism and mutagenicity of the methylated compound by hepatic microsomal preparations from r...

journal_title：Carcinogenesis

authors： Boyd GW,Young RJ,Harvey RG,Coombs MM,Ioannides C

更新日期：1993-09-01 00:00:00

abstract：:Colorectal cancer (CRC) is the fourth leading cause of cancer mortality worldwide. Genome-wide association studies (GWAS) identified more than 50 CRC loci. However, most of the previous studies were conducted in European population, and host genetic factors among Japanese population are largely remained to be identifi...

journal_title：Carcinogenesis

authors： Tanikawa C,Kamatani Y,Takahashi A,Momozawa Y,Leveque K,Nagayama S,Mimori K,Mori M,Ishii H,Inazawa J,Yasuda J,Tsuboi A,Shimizu A,Sasaki M,Yamaji T,Sawada N,Iwasaki M,Tsugane S,Naito M,Wakai K,Koyama T,Takezaki T

更新日期：2018-05-03 00:00:00

abstract：:There is increasing concern that compounds formed during the chemical or biological transformation of pollutants in the environment may be more detrimental to human and environmental health than the original pollutant. In this study, two bacterial transformation products of polycyclic aromatic hydrocarbons (PAHs), pyr...

journal_title：Carcinogenesis

authors： Zielinska-Park J,Nakamura J,Swenberg JA,Aitken MD

更新日期：2004-09-01 00:00:00

abstract：:Six N-nitroso compounds (N-nitrosodimethylamine, N-nitrosodiethylamine, N-nitrosodi-n-propylamine, N-nitroso-N-methylurea, N-nitrosopyrrolidine, and N-nitrosodi-n-butylamine) were tested in rats for liver DNA damaging activity by the alkaline elution technique. On molar basis their DNA damaging potency was found to de...

journal_title：Carcinogenesis

authors： Brambilla G,Cavanna M,Pino A,Robbiano L

更新日期：1981-01-01 00:00:00

abstract：:Breast cancer incidence is increased in women with both high and low birth weight. The latter is also associated with hyperglycaemia, insulin resistance and type-2 diabetes, each of which independently increases breast cancer risk. We showed previously in our model of poor early-growth that pregnancy estradiol levels ...

journal_title：Carcinogenesis

authors： Fernandez-Twinn DS,Ekizoglou S,Gusterson BA,Luan J,Ozanne SE

更新日期：2007-03-01 00:00:00

abstract：:In two separate in vivo studies, ethionine was evaluated for carcinogenic activity in mice. In the first study, DL-ethionine was fed in a chow diet at 0 (controls), 0.1 (low dose, LD) and 0.25% (high dose, HD) concentrations to the following groups of mice (30 animals/group): Swiss Webster CD-1 females, BALB/c males, ...

journal_title：Carcinogenesis

authors： Hoover KL,Hyde CL,Wenk ML,Poirier LA

更新日期：1986-07-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mammary gland carcinogen present in the human diet. Herein, the expression of estrogen receptor alpha (ERalpha), estrogen receptor beta (ER beta) and progesterone receptor (PR) was examined in mammary gland carcinomas induced by PhIP in female Sprague-Dawley ...

journal_title：Carcinogenesis

authors： Qiu C,Shan L,Yu M,Snyderwine EG

更新日期：2005-04-01 00:00:00