Carcinogenicity of nitropyrenes in the newborn female rat.


:The carcinogenicities of 1-nitropyrene (1-NP), 4-nitropyrene (4-NP), 1,3-dinitropyrene (1,3-DNP), 1,6-dinitropyrene (1,6-DNP), 1,8-dinitropyrene (1,8-DNP), 3-hydroxy-1-nitropyrene (3-OH-1-NP) and a mixture of 6- and 8-hydroxy-1-nitropyrene (6/8-OH-1-NP) were investigated in newborn female rats. Newborn female CD rats were treated s.c. eight times at weekly intervals with a total dose of 6.3 mumol 1-NP,1,3-DNP,1,6-DNP or 1,8-DNP; control animals received only dimethylsulfoxide (DMSO). The experiment was terminated at 67 weeks. With the exception of 1,6-DNP- and 1,8-DNP-treated animals, which had average survival periods of 149 and 164 days respectively, the animals administered the other compounds did not show decreased survival. Malignant fibrous histiocytomas were observed in 12%, 100% and 100% of the rats treated with 1,3-, 1,6- and 1,8-DNP respectively. Leukemia was found in 20% and 22% of the animals treated with 1,6- and 1,8-DNP respectively. No control rats developed these tumors. Additionally, mammary tumors were induced in rats treated with 1-NP. Newborn female CD rats were similarly treated with 1-NP, 4-NP, 3-OH-1-NP, 6/8-OH-1-NP or DMSO and newborn female F344 rats were treated with 1-NP or DMSO. The experiment was terminated at 86 weeks, 1-NP and 4-NP produced mammary adenocarcinoma in CD rats. Although 1-NP did not produce mammary adenocarcinoma in F344 rats, it induced leukemia. 4-NP also induced malignant fibrous histiocytomas in CD rats. This study demonstrates that 4-NP is more carcinogenic than 1-NP and that CD rats are more susceptible than F344 rats to mammary carcinogenesis by 1-NP. Additionally, 1,6- and 1,8-DNP are more potent than 1-NP in inducing malignant fibrous histiocytomas and leukemia.






Imaida K,Lee MS,Land SJ,Wang CY,King CM




Has Abstract


1995-12-01 00:00:00












  • TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways.

    abstract::TMPRSS4 is a novel type II transmembrane serine protease that is highly expressed on the cell surface in pancreatic, thyroid and other cancer tissues, although its oncogenic significance and molecular mechanisms are unknown. Previously, we have shown that TMPRSS4 promotes invasion, migration and metastasis of human tu...


    pub_type: 杂志文章


    authors: Kim S,Kang HY,Nam EH,Choi MS,Zhao XF,Hong CS,Lee JW,Lee JH,Park YK

    更新日期:2010-04-01 00:00:00

  • Synthesis of nitric oxide and nitrosamine by immortalized woodchuck hepatocytes.

    abstract::Woodchuck (Marmota monax) hepatic cells, which were immortalized by the simian virus 40 large T antigen (SV40 Tag) produced nitric oxide (NO; measured as nitrite) in vitro from L-arginine (L-Arg) after lipopolysaccharide (LPS) treatment. NO synthesis was related to L-Arg and LPS concentration and plateaued at 1.0 mM L...


    pub_type: 杂志文章


    authors: Liu RH,Jacob JR,Hotchkiss JH,Tennant BC

    更新日期:1993-08-01 00:00:00

  • Pre-natal factors in the origin of germ cell tumours of childhood.

    abstract::The Manchester (England) Children's Tumour Registry is population-based with a high level of ascertainment. Pathologic review ensured diagnostic accuracy. Routine monitoring of annual incidence revealed a significant increase in germ cell tumours from approximately 1 per million person years to approximately 4. Analys...


    pub_type: 杂志文章


    authors: Birch JM,Marsden HB,Swindell R

    更新日期:1982-01-01 00:00:00

  • Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis.

    abstract::Tamoxifen is a non-steroidal anti-estrogen used for the treatment of breast cancer and, more recently, as a chemopreventive agent in healthy women at high risk of developing breast cancer. On the other hand, tamoxifen is a potent hepatocarcinogen in rats, with both tumor-initiating and tumor-promoting properties. Ther...


    pub_type: 杂志文章


    authors: Tryndyak VP,Muskhelishvili L,Kovalchuk O,Rodriguez-Juarez R,Montgomery B,Churchwell MI,Ross SA,Beland FA,Pogribny IP

    更新日期:2006-08-01 00:00:00

  • Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis.

    abstract::Patients with inflammatory bowel diseases are at increased risk for colorectal cancer. Pharmacological inhibition of cyclooxygenase (COX) function exacerbates symptoms in colitis patients. Animal models of colitis using Cox-2-knockout mice and COX inhibitors also indicate that COX-2 has a protective role against colon...


    pub_type: 杂志文章


    authors: Ishikawa TO,Oshima M,Herschman HR

    更新日期:2011-03-01 00:00:00

  • Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress.

    abstract::The use of naturally occurring botanicals with substantial antioxidant activity to afford protection to human skin against UV damage is receiving increasing attention. The green tea constituent (-)-epigallocatechin-3-gallate (EGCG) is a potent antioxidant and has shown remarkable preventive effects against photocarcin...


    pub_type: 杂志文章


    authors: Katiyar SK,Afaq F,Perez A,Mukhtar H

    更新日期:2001-02-01 00:00:00

  • Interactions of DNA repair gene variants modulate chromosomal aberrations in healthy subjects.

    abstract::Human cancers are often associated with numerical and structural chromosomal instability. Structural chromosomal aberrations (CAs) in peripheral blood lymphocytes (PBL) arise as consequences of direct DNA damage or due to replication on a damaged DNA template. In both cases, DNA repair is critical and inter-individual...


    pub_type: 杂志文章


    authors: Vodicka P,Musak L,Frank C,Kazimirova A,Vymetalkova V,Barancokova M,Smolkova B,Dzupinkova Z,Jiraskova K,Vodenkova S,Kroupa M,Osina O,Naccarati A,Palitti F,Försti A,Dusinska M,Vodickova L,Hemminki K

    更新日期:2015-11-01 00:00:00

  • Mutations in the C-terminus of the X protein of hepatitis B virus regulate Wnt-5a expression in hepatoma Huh7 cells: cDNA microarray and proteomic analyses.

    abstract:BACKGROUND:The hepatitis B virus x gene (HBx) is a promiscuous transactivator implicated in the development of hepatocellular carcinoma (HCC). The present study was designed to investigate the molecular events regulated by HBx. METHODS:Genomic and proteomic expression profiling was performed in Huh7 HCC cells transfec...


    pub_type: 杂志文章


    authors: Liu X,Wang L,Zhang S,Lin J,Zhang S,Feitelson MA,Gao H,Zhu M

    更新日期:2008-06-01 00:00:00

  • Synthetic D-amino acid peptide inhibits tumor cell motility on laminin-5.

    abstract::Cell motility is partially dependent on interactions between the integrins and the extracellular matrix. Our previous studies have identified synthetic D-amino acid cell adhesion peptides using a combinatorial screening approach. In this study, we demonstrate that HYD1 (kikmviswkg) completely blocks random haptotactic...


    pub_type: 杂志文章


    authors: Sroka TC,Pennington ME,Cress AE

    更新日期:2006-09-01 00:00:00

  • Reactions of 'bay-region' and non-'bay-region' diol-epoxides of benz(a)anthracene with DNA: evidence indicating that the major products are hydrocarbon-N2-guanine adducts.

    abstract::The rates of reaction and the products formed when two vicinal diol-epoxides derived from benz(a)anthracene, anti-BA-3,4-diol 1,2-oxide (t-3,r-4-dihydroxy-t-1,2-oxy-1,2,3,4-tetrahydrobenz(a) anthracene)* and anti-BA-8,9-diol 10,11-oxide (r-8,t-9-dihydroxy-t-10,11-oxy-8,9,10,11-tetrahydrobenz(a)anthracene) reacted with...


    pub_type: 杂志文章


    authors: Hemminki K,Cooper CS,Ribeiro O,Grover PL,Sims P

    更新日期:1980-03-01 00:00:00

  • Epidermal growth factor, like tumor promoters, enhances viral and radiation-induced cell transformation.

    abstract::The polypeptide hormone epidermal growth factor (EGF) has been shown to enhance adenovirus type 5 transformation of a cloned culture of rat embryo cells (CREF) and X-ray or u.v.-light induced transformation of 10T1/2 mouse embryo cells. In both systems, the degree of enhancement was quantitatively similar to that obse...


    pub_type: 杂志文章


    authors: Fisher PB,Mufson RA,Weinstein IB,Little JB

    更新日期:1981-01-01 00:00:00

  • Transgenic mice containing hepatitis B virus sequences are more susceptible to carcinogen-induced hepatocarcinogenesis.

    abstract::Transgenic mice containing one copy of hepatitis B virus (HBV) genome without the core gene and expressing hepatitis B surface antigen (HBsAg) were crossed with C3H/He mice. The F1 hybrids (approximately 50% HBV positive and approximately 50% HBV negative) were treated with a single dose of diethylnitrosamine (NDEA) o...


    pub_type: 杂志文章


    authors: Dragani TA,Manenti G,Farza H,Della Porta G,Tiollais P,Pourcel C

    更新日期:1990-06-01 00:00:00

  • Conjugated linoleic acids (CLAs) decrease prostate cancer cell proliferation: different molecular mechanisms for cis-9, trans-11 and trans-10, cis-12 isomers.

    abstract::The aims of this study were to examine the anti-proliferative effects of different concentrations of a commercial preparation of conjugated linoleic acids (CLA) mixture of isomers [cis-9, trans-11 CLA (c9,t11 CLA): trans-10, cis-12 CLA (50:50)] and their constituent isomers on PC-3, a human prostatic carcinoma cell li...


    pub_type: 杂志文章


    authors: Ochoa JJ,Farquharson AJ,Grant I,Moffat LE,Heys SD,Wahle KW

    更新日期:2004-07-01 00:00:00

  • Alkenyl group is responsible for the disruption of microtubule network formation in human colon cancer cell line HT-29 cells.

    abstract::Alk(en)yl trisulfides (R-SSS-R') are organosulfur compounds produced by crushed garlic and other Allium vegetables. We found that these compounds exhibit potent anticancer effects through the reaction with microtubules, causing cell cycle arrest. Nine alk(en)yl trisulfides including dimethyl trisulfide, diethyl trisul...


    pub_type: 杂志文章


    authors: Hosono T,Hosono-Fukao T,Inada K,Tanaka R,Yamada H,Iitsuka Y,Seki T,Hasegawa I,Ariga T

    更新日期:2008-07-01 00:00:00

  • The R438W polymorphism of human DNA polymerase lambda triggers cellular sensitivity to camptothecin by compromising the homologous recombination repair pathway.

    abstract::The human DNA polymerase lambda (Polλ) is a DNA repair polymerase, which is believed not only to play a role in base excision repair but also to contribute to DNA double-strand break repair by non-homologous end joining. We described here that cellular expression of the recently described natural polymorphic variant o...


    pub_type: 杂志文章


    authors: Capp JP,Boudsocq F,Bergoglio V,Trouche D,Cazaux C,Blanco L,Hoffmann JS,Canitrot Y

    更新日期:2010-10-01 00:00:00

  • YAP is a candidate oncogene for esophageal squamous cell carcinoma.

    abstract::Yes-associated protein (YAP), the nuclear effector of the Hippo pathway, is a key regulator of organ size and a candidate human oncogene located at chromosome 11q22. Since we previously reported amplification of 11q22 region in esophageal squamous cell carcinoma (ESCC), in this study we focused on the clinical signifi...


    pub_type: 杂志文章


    authors: Muramatsu T,Imoto I,Matsui T,Kozaki K,Haruki S,Sudol M,Shimada Y,Tsuda H,Kawano T,Inazawa J

    更新日期:2011-03-01 00:00:00

  • Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment.

    abstract::Basic in vitro systems can be used to model and assess complex diseases, such as cancer. Recent advances in this field include the incorporation of multiple cell types and extracellular matrix proteins into three-dimensional (3D) models to recapitulate the structure, organization and functionality of live tissue in si...


    pub_type: 杂志文章,评审


    authors: Herrmann D,Conway JR,Vennin C,Magenau A,Hughes WE,Morton JP,Timpson P

    更新日期:2014-08-01 00:00:00

  • Butyrylated starch protects colonocyte DNA against dietary protein-induced damage in rats.

    abstract::Dietary resistant starch (RS), as a high amylose maize starch (HAMS), prevents dietary protein-induced colonocyte genetic damage in rats, possibly through the short-chain fatty acid (SCFA) butyrate produced by large bowel bacterial RS fermentation. Increasing butyrate availability may improve colonic health and dietar...


    pub_type: 杂志文章


    authors: Bajka BH,Clarke JM,Cobiac L,Topping DL

    更新日期:2008-11-01 00:00:00

  • Effects of docosahexaenoic acid and eicosapentaenoic acid on androgen-mediated cell growth and gene expression in LNCaP prostate cancer cells.

    abstract::There is some epidemiological support for a protective influence of omega-3 fatty acids against prostate cancer. We wanted to explore whether omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) can affect androgen receptor function in prostate cancer cells. Our study ...


    pub_type: 杂志文章


    authors: Chung BH,Mitchell SH,Zhang JS,Young CY

    更新日期:2001-08-01 00:00:00

  • Studies on glutathione transferases belonging to class pi in cell lines with different capacities for conjugating (+)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

    abstract::The glutathione transferases (GST) belonging to class pi are primarily responsible for the intracellular detoxification of the highly mutagenic and carcinogenic compound (+)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE). The aim of the present investigation was to study the n...


    pub_type: 杂志文章


    authors: Swedmark S,Romert L,Morgenstern R,Jenssen D

    更新日期:1992-10-01 00:00:00

  • A microRNA-135a/b binding polymorphism in CD133 confers decreased risk and favorable prognosis of lung cancer in Chinese by reducing CD133 expression.

    abstract::CD133 is a pivotal marker of cancer stem cells (CSCs), which is involved in tumorigenesis and cancer progression. Recent studies have identified CD133 to be a prognostic factor for cancer rested with its expression and genetic variants. Here, we hypothesized that the single nuclear polymorphisms (SNPs) in CD133 may be...


    pub_type: 杂志文章


    authors: Cheng M,Yang L,Yang R,Yang X,Deng J,Yu B,Huang D,Zhang S,Wang H,Qiu F,Zhou Y,Lu J

    更新日期:2013-10-01 00:00:00

  • Inhibitory effect of alpha-tocopherol on the formation of nitrosomorpholine in mice treated with morpholine and exposed to nitrogen dioxide.

    abstract::The possibility that alpha-tocopherol (vitamin E) inhibits the formation of nitrosomorpholine (NMOR) in vivo was investigated in mice orally pretreated with alpha-tocopherol (2.5-100 mg/kg body wt) once daily for 6 days. Twenty-four hours later, the animals were injected i.p. with 2 mg of morpholine (MOR) per animal f...


    pub_type: 杂志文章


    authors: Norkus EP,Kuenzig WA,Chau J,Mergens WJ,Conney AH

    更新日期:1986-03-01 00:00:00

  • Comparison of hydrocarbon-DNA adducts formed in mouse skin in vivo and in organ culture in vitro following treatment with benzo[a]pyrene.

    abstract::Species differences in the metabolism of toxic chemicals can confound the extrapolation of experimentally determined risk data to man. However, it is often difficult to obtain reliable information on human metabolism, particularly of genotoxic agents. In this study, comparisons of chromatographic profiles of DNA adduc...


    pub_type: 杂志文章


    authors: Huckle KR,Smith RJ,Watson WP,Wright AS

    更新日期:1986-06-01 00:00:00

  • Oral microbial dysbiosis and its performance in predicting oral cancer.

    abstract::Dysbiosis of oral microbiome may dictate the progression of oral squamous cell carcinoma (OSCC). Yet, the composition of oral microbiome fluctuates by saliva and distinct sites of oral cavity and is affected by risky behaviors (smoking, drinking, and betel quid chewing) and individuals' oral health condition. To chara...


    pub_type: 杂志文章


    authors: Su SC,Chang LC,Huang HD,Peng CY,Chuang CY,Chen YT,Lu MY,Chiu YW,Chen PY,Yang SF

    更新日期:2020-07-04 00:00:00

  • Evidence from 32P-postlabeling and the use of pentachlorophenol for a novel metabolic activation pathway of diethylstilbestrol and its dimethyl ether in mouse live: likely alpha-hydroxylation of ethyl group(s) followed by sulfate conjugation.

    abstract::Diethylstilbestrol (DES), a synthetic stilbene estrogen, is a potent development toxin and carcinogen in humans and rodents. A number of 32P-postlabeling studies suggest that genotoxic effects of DES substantially contribute to these biological effects. The mechanisms involved in DES-mediated genotoxicity are not comp...


    pub_type: 杂志文章


    authors: Moorthy B,Liehr J,Randerath E,Randerath K

    更新日期:1995-11-01 00:00:00

  • Opium and oesophageal cancer: effect of morphine and opium on the metabolism of N-nitrosodimethylamine and N-nitrosodiethylamine in the rat.

    abstract::The high incidence of oesophageal cancer in Northern Iran has been associated with opium. N-Nitrosamines are the only carcinogens known to induce oesophageal cancer in animals. Ethanol, which is the major influence on oesophageal cancer incidence in the West, inhibits the first pass clearance of N-nitrosodimethylamine...


    pub_type: 杂志文章


    authors: Ribeiro Pinto LF,Swann PF

    更新日期:1997-02-01 00:00:00

  • Carcinogenicity of catechol in F344 rats and B6C3F1 mice.

    abstract::Carcinogenicity of catechol, a naturally occurring and industrial chemical which has been shown to have strong cell proliferating potential on rat glandular stomach epithelium, was investigated in male and female F344 rats and B6C3F1 mice. Groups of 30 male and female F344 rats and B6C3F1 mice were treated with 0.8% c...


    pub_type: 杂志文章


    authors: Hirose M,Fukushima S,Tanaka H,Asakawa E,Takahashi S,Ito N

    更新日期:1993-03-01 00:00:00

  • Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual.

    abstract::The genetic factors that mediate the pathogenesis of multiple primary cutaneous basal cell carcinomas (BCC) are largely unclear. Thus, some patients suffer many BCC (>30) and/or rapid accrual (number of tumours/year from first presentation) of further lesions. We have studied, in 827 English Caucasians, the influence ...


    pub_type: 杂志文章


    authors: Lear JT,Heagerty AH,Smith A,Bowers B,Payne CR,Smith CA,Jones PW,Gilford J,Yengi L,Alldersea J,Fryer AA,Strange RC

    更新日期:1996-09-01 00:00:00

  • Osteopontin is a downstream effector of the PI3-kinase pathway in melanomas that is inversely correlated with functional PTEN.

    abstract::The tumor suppressor PTEN antagonizes phosphatidylinositol 3-kinase (PI3K), which contributes to tumorigenesis in many cancer types. While PTEN mutations occur in some melanomas, their precise mechanistic consequences have yet to be elucidated. We sought to identify novel downstream effectors of PI3K using a combinati...


    pub_type: 杂志文章


    authors: Packer L,Pavey S,Parker A,Stark M,Johansson P,Clarke B,Pollock P,Ringner M,Hayward N

    更新日期:2006-09-01 00:00:00

  • Genetic consequences of tolerance to methylation DNA damage in mammalian cells.

    abstract::We previously characterized a clone of CHO cells, clone B, that displayed tolerance to the cytotoxic effects of N-methylnitrosourea (MNU) and 6-thioguanine (6-TG). To determine whether this phenotype affected the mutagenic response of the cells, MNU-induced mutation to 8-azaadenine resistance (8-AAr) was measured in t...


    pub_type: 杂志文章


    authors: Aquilina G,Biondo R,Dogliotti E,Bignami M

    更新日期:1993-10-01 00:00:00