Carcinogenicity of nitropyrenes in the newborn female rat.


:The carcinogenicities of 1-nitropyrene (1-NP), 4-nitropyrene (4-NP), 1,3-dinitropyrene (1,3-DNP), 1,6-dinitropyrene (1,6-DNP), 1,8-dinitropyrene (1,8-DNP), 3-hydroxy-1-nitropyrene (3-OH-1-NP) and a mixture of 6- and 8-hydroxy-1-nitropyrene (6/8-OH-1-NP) were investigated in newborn female rats. Newborn female CD rats were treated s.c. eight times at weekly intervals with a total dose of 6.3 mumol 1-NP,1,3-DNP,1,6-DNP or 1,8-DNP; control animals received only dimethylsulfoxide (DMSO). The experiment was terminated at 67 weeks. With the exception of 1,6-DNP- and 1,8-DNP-treated animals, which had average survival periods of 149 and 164 days respectively, the animals administered the other compounds did not show decreased survival. Malignant fibrous histiocytomas were observed in 12%, 100% and 100% of the rats treated with 1,3-, 1,6- and 1,8-DNP respectively. Leukemia was found in 20% and 22% of the animals treated with 1,6- and 1,8-DNP respectively. No control rats developed these tumors. Additionally, mammary tumors were induced in rats treated with 1-NP. Newborn female CD rats were similarly treated with 1-NP, 4-NP, 3-OH-1-NP, 6/8-OH-1-NP or DMSO and newborn female F344 rats were treated with 1-NP or DMSO. The experiment was terminated at 86 weeks, 1-NP and 4-NP produced mammary adenocarcinoma in CD rats. Although 1-NP did not produce mammary adenocarcinoma in F344 rats, it induced leukemia. 4-NP also induced malignant fibrous histiocytomas in CD rats. This study demonstrates that 4-NP is more carcinogenic than 1-NP and that CD rats are more susceptible than F344 rats to mammary carcinogenesis by 1-NP. Additionally, 1,6- and 1,8-DNP are more potent than 1-NP in inducing malignant fibrous histiocytomas and leukemia.






Imaida K,Lee MS,Land SJ,Wang CY,King CM




Has Abstract


1995-12-01 00:00:00












  • Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas.

    abstract::The hedgehog pathway plays a critical role in the development of the foregut. Recent studies indicate that the hedgehog pathway activation occurs in the stomach and other gastrointestinal cancers. However, the association of hedgehog pathway activation with tumor stage, differentiation and tumor subtype is not well do...


    pub_type: 杂志文章


    authors: Ma X,Chen K,Huang S,Zhang X,Adegboyega PA,Evers BM,Zhang H,Xie J

    更新日期:2005-10-01 00:00:00

  • Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells.

    abstract::Many chemoradiation therapies cause DNA damage through oxidative stress. An important cellular mechanism that protects cells against oxidative stress involves DNA repair. One of the primary DNA repair mechanisms for oxidative DNA damage is base excision repair (BER). BER involves the tightly coordinated function of fo...


    pub_type: 杂志文章


    authors: Zhang H,Mizumachi T,Carcel-Trullols J,Li L,Naito A,Spencer HJ,Spring PM,Smoller BR,Watson AJ,Margison GP,Higuchi M,Fan CY

    更新日期:2007-08-01 00:00:00

  • Far upstream element-binding protein 1 facilitates hepatocellular carcinoma invasion and metastasis.

    abstract::Previous research suggests that far upstream element-binding protein 1 (FUBP1) plays an important role in various tumors including epatocellular carcinoma (HCC). However, the role of FUBP1 in liver cancer remains controversial, and the regulatory pathway by FUBP1 awaits to be determined. This study aims to identify th...


    pub_type: 杂志文章


    authors: Fu PY,Hu B,Ma XL,Tang WG,Yang ZF,Sun HX,Yu MC,Huang A,Hu JW,Zhou CH,Fan J,Xu Y,Zhou J

    更新日期:2020-07-14 00:00:00

  • Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells.

    abstract::The anti-cancer efficacy of grape seed extract (GSE) against prostate cancer (PCA) via its anti-proliferative, pro-apoptotic and anti-angiogenic activities in both cell culture and animal models have recently been described by us. GSE is a complex mixture containing gallic acid (GA), catechin (C), epicatechin (EC) and...


    pub_type: 杂志文章


    authors: Veluri R,Singh RP,Liu Z,Thompson JA,Agarwal R,Agarwal C

    更新日期:2006-07-01 00:00:00

  • The complexity of nitrosoguanidine mutagenesis increases with size: observations of the mutational specificity of N-propyl-N'-nitro-N-nitrosoguanidine.

    abstract::The mutational specificity of the monofunctional alkylating agent N-propyl-N'-nitro-N-nitrosoguanidine (PNNG) has been determined through the DNA sequence characterization of 109 LacI- mutations of Escherichia coli. The predominant mutation induced was the G:C----A:T transition (73%), presumably the result of O6-propy...


    pub_type: 杂志文章


    authors: van der Vliet GM,Zielenska M,Anderson MW,Glickman BW

    更新日期:1989-05-01 00:00:00

  • Molecular epidemiology, pathogenesis and prevention of gastric cancer.

    abstract::Cancer of the stomach is one of the most commonly diagnosed malignancies and remains an important cause of mortality world wide. This type of cancer is not uniformly distributed among populations but shows a marked variation in both incidence and mortality. Although gastric cancer is declining in many parts of the wor...


    pub_type: 杂志文章,评审


    authors: Stadtländer CT,Waterbor JW

    更新日期:1999-12-01 00:00:00

  • Lack of DNA damage or lipid peroxidation measured in vivo in the rat liver following treatment with peroxisomal proliferators.

    abstract::This study was undertaken to investigate the hypothesis linking peroxisome proliferation with the production of reactive oxygen species and subsequent DNA damage. Hepatic peroxisomal proliferation was induced in male Wistar-derived rats by the administration of clofibrate, methyl clofenapate, di(2-ethylhexyl)phthalate...


    pub_type: 杂志文章


    authors: Elliott BM,Elcombe CR

    更新日期:1987-09-01 00:00:00

  • Meat intake, cooking-related mutagens and risk of colorectal adenoma in a sigmoidoscopy-based case-control study.

    abstract::Reported habits of red meat consumption, particularly red meat that has been cooked to the degree termed 'well-done', is a positive risk factor for colorectal cancer. Under high, pyrolytic temperatures, heterocyclic amines (HCA) and benzo[a]pyrene (BP) molecules can form inside and on the surface of red meat, respecti...


    pub_type: 杂志文章


    authors: Gunter MJ,Probst-Hensch NM,Cortessis VK,Kulldorff M,Haile RW,Sinha R

    更新日期:2005-03-01 00:00:00

  • Comparative functional genomics for identifying models of human cancer.

    abstract::Genetically modified mice with overexpressed and/or deleted genes have been used extensively to model human cancer. However, it is uncertain as to what extent the mouse models reproduce the corresponding cancers in humans. We have compared the global gene expression patterns in human and mouse hepatocellular carcinoma...


    pub_type: 杂志文章


    authors: Lee JS,Grisham JW,Thorgeirsson SS

    更新日期:2005-06-01 00:00:00

  • Selective induction of rat urinary bladder tumors by simultaneous administration of 3,2'-dimethyl-4-aminobiphenyl (DMAB) and butylated hydroxyanisole or butylated hydroxytoluene is associated with increased DMAB-DNA adduct formation.

    abstract::Modification of 3,2'-dimethyl-4-aminobiphenyl (DMAB) multi-organ carcinogenesis by simultaneous treatment with butylated hydroxyanisole (BHA) or butylated hydroxytoluene (BHT) was studied using young and old male F344 rats. Animals, 4 or 54 weeks old, were given DMAB (s.c. injection of 50 mg/kg body wt once a week for...


    pub_type: 杂志文章


    authors: Shirai T,Fukushima S,Kawabe M,Shibata M,Iwasaki S,Tada M,Ito N

    更新日期:1991-07-01 00:00:00

  • Changes in nucleolar transcriptional activity and nuclear DNA content during the first steps of rat hepatocarcinogenesis.

    abstract::Two complementary genetic parameters were followed in liver parenchymal cells during the first steps of rat hepatocarcinogenesis: the expression of nucleolar genes estimated from their silver stainability and the nuclear DNA content determined after Feulgen staining. Putative preneoplastic lesions as foci and nodules ...


    pub_type: 杂志文章


    authors: Deleener A,Castelain P,Preat V,de Gerlache J,Alexandre H,Kirsch-Volders M

    更新日期:1987-02-01 00:00:00

  • Tumor-initiating activity, mutagenicity, and metabolism of methylated anthracenes.

    abstract::Specific methylated derivatives of anthracene are mutagenic in S. typhimurium and have tumor-initiating activity on mouse skin. In this study, the mutagenic activities of 1-, 2-, and 9-methylanthracene, 2,9- and 9,10-dimethylanthracene, 2,9,-10-trimethylanthracene, 2,3,9,10-tetramethylanthracene, and the photo-oxide o...


    pub_type: 杂志文章


    authors: La Voie EJ,Coleman DT,Rice JE,Geddie NG,Hoffmann D

    更新日期:1985-10-01 00:00:00

  • Over-expression of protein kinase C delta is associated with a delay in preneoplastic lesion development in diethylnitrosamine-induced rat hepatocarcinogenesis.

    abstract::The purpose of this study was to determine if decreasing dietary protein from 24% (high protein) to 5% casein (low protein), substituting sucrose and cornstarch isocalorifically for casein, would modify the activity of protein kinase C (PKC) alpha and beta isoenzymes, as well as the expression of PKC alpha, beta, delt...


    pub_type: 杂志文章


    authors: La Porta CA,Comolli R

    更新日期:1995-05-01 00:00:00

  • Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites.

    abstract::Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants with high carcinogenic potencies that have been linked to the etiology of human cancers through their presence in cigarette smoke and environmental mixtures. They are metabolically activated in cells by cytochrome P450 enzymes and/or perox...


    pub_type: 杂志文章


    authors: Melendez-Colon VJ,Luch A,Seidel A,Baird WM

    更新日期:1999-10-01 00:00:00

  • Studies on the antimutagenic activity of ascorbic acid in vitro and in vivo.

    abstract::The possibility that ascorbic acid, as a nucleophile, may inhibit mutagenicity induced by electrophilic metabolites of N-nitroso compounds was examined. In vitro data are presented to show that ascorbic acid does not decrease the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in a modified Ames bacterial ...


    pub_type: 杂志文章


    authors: Norkus EP,Kuenzig WA

    更新日期:1985-11-01 00:00:00

  • Inhibition of the nuclear transporter, Kpnβ1, results in prolonged mitotic arrest and activation of the intrinsic apoptotic pathway in cervical cancer cells.

    abstract::The karyopherin β proteins are involved in nuclear-cytoplasmic trafficking and are crucial for protein and RNA subcellular localization. We previously showed that Kpnβ1, a nuclear importin protein, is overexpressed in cervical cancer and is critical for cervical cancer cell survival and proliferation, whereas non-canc...


    pub_type: 杂志文章


    authors: Angus L,van der Watt PJ,Leaner VD

    更新日期:2014-05-01 00:00:00

  • Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice.

    abstract::Recent studies have demonstrated that K-ras mutations in lung epithelial cells elicit inflammation that promotes carcinogenesis in mice (intrinsic inflammation). The finding that patients with chronic obstructive pulmonary disease (COPD), an inflammatory disease of the lung, have an increased risk of lung cancer after...


    pub_type: 杂志文章


    authors: Moghaddam SJ,Barta P,Mirabolfathinejad SG,Ammar-Aouchiche Z,Garza NT,Vo TT,Newman RA,Aggarwal BB,Evans CM,Tuvim MJ,Lotan R,Dickey BF

    更新日期:2009-11-01 00:00:00

  • Conjugated diene and trans fatty acids in tissue lipids of rats fed an hepatocarcinogenic choline-devoid diet.

    abstract::Groups of male Fischer-344 rats were fed two pairs of semi-purified choline-devoid and choline-supplemented diets, one set containing 5% corn oil and 10% partially hydrogenated fat, and the other only corn oil (15%). Analyses were performed on lipids extracted from whole liver, liver nuclei and adipose tissue of the r...


    pub_type: 杂志文章


    authors: Banni S,Salgo MG,Evans RW,Corongiu FP,Lombardi B

    更新日期:1990-11-01 00:00:00

  • Gender differences in cancer susceptibility: role of oxidative stress.

    abstract::Cancer is a leading cause of death worldwide and environmental factors, including chemicals, have been suggested as major etiological incitements. Cancer statistics indicates that men get more cancer than women. However, differences in the known risk factors including life style or occupational exposure only offer par...


    pub_type: 杂志文章,meta分析


    authors: Ali I,Högberg J,Hsieh JH,Auerbach S,Korhonen A,Stenius U,Silins I

    更新日期:2016-10-01 00:00:00

  • 32P-post-labelling analysis of DNA adducts formed by food-derived heterocyclic amines: evidence for incomplete hydrolysis and a procedure for adduct pattern simplification.

    abstract::Food-derived aminoimidazoazarenes have been shown to be mutagenic and carcinogenic and to form covalent DNA adducts. 32P-Post-labelling analysis of DNA modified with these heterocyclic amines (HA), including 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-...


    pub_type: 杂志文章


    authors: Pfau W,Brockstedt U,Söhren KD,Marquardt H

    更新日期:1994-05-01 00:00:00

  • The relationship between the carcinogenicity and mutagenicity of nitrosamines in a hepatocyte-mediated mutagenicity assay.

    abstract::A quantitative relationship was established for 26 nitrosamines between their carcinogenic effectiveness in experimental animals and their mutagenic activity in a mammalian cell-mediated assay. Mutagenesis was measured in Chinese hamster V79 cells co-cultivated with primary rat hepatocytes, which are capable of activa...


    pub_type: 杂志文章


    authors: Jones CA,Marlino PJ,Lijinsky W,Huberman E

    更新日期:1981-01-01 00:00:00

  • MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN.

    abstract::Nasopharyngeal carcinoma (NPC) is a type of head and neck cancer with significantly high prevalence in Southern China. Unlike other head and neck cancers, mutations or deletions of tumor suppressor genes in NPC are not common. Recently, downregulation of tumor suppressor genes expression by microRNA (miRNA) is increas...


    pub_type: 杂志文章


    authors: Zhang LY,Ho-Fun Lee V,Wong AM,Kwong DL,Zhu YH,Dong SS,Kong KL,Chen J,Tsao SW,Guan XY,Fu L

    更新日期:2013-02-01 00:00:00

  • A high pressure liquid chromatography study on the removal of DNA-bound aflatoxin B1 in rat liver and in vitro.

    abstract::Following intraperitoneal administration of [3H] aflatoxin B1 (AFB1) to young adult male rats, there is rapid uptake of the carcinogen by the liver, the target organ for carcinogenesis, leading to DNA covalent binding. Acid hydrolysis of this DNA shows that after 2h, the major DNA adduct is trans 8,9-dihydro-8-(7-guan...


    pub_type: 杂志文章


    authors: Hertzog PJ,Lindsay Smith JR,Garner RC

    更新日期:1980-09-01 00:00:00

  • Iron as a synergist for hepatocellular carcinoma induced by polychlorinated biphenyls in Ah-responsive C57BL/10ScSn mice.

    abstract::Male Ah-responsive C57BL/10ScSn mice received a single dose of iron-dextran (600 mg Fe/kg) and were fed a diet containing 0.01% of the PCBs mixture Aroclor 1254 for up to 12 months. Iron caused a marked synergistic increase in liver size from 2 months with greatly elevated mitotic rates, numbers of basophilic foci and...


    pub_type: 杂志文章


    authors: Smith AG,Francis JE,Carthew P

    更新日期:1990-03-01 00:00:00

  • Identification of clastogenic and/or aneugenic events during the preneoplastic stages of experimental rat hepatocarcinogenesis by fluorescence in situ hybridization.

    abstract::A growing body of evidence from human and animal cancer cytogenetics studies indicates that aneuploidy is an important chromosome change in carcinogenesis. To understand the role of this genetic phenomenon during the first steps of an experimental cancer model, molecular and cellular techniques were combined. A sequen...


    pub_type: 杂志文章


    authors: Van Goethem F,de Stoppelaar J,Hoebee B,Kirsch-Volders M

    更新日期:1995-08-01 00:00:00

  • Synthetic D-amino acid peptide inhibits tumor cell motility on laminin-5.

    abstract::Cell motility is partially dependent on interactions between the integrins and the extracellular matrix. Our previous studies have identified synthetic D-amino acid cell adhesion peptides using a combinatorial screening approach. In this study, we demonstrate that HYD1 (kikmviswkg) completely blocks random haptotactic...


    pub_type: 杂志文章


    authors: Sroka TC,Pennington ME,Cress AE

    更新日期:2006-09-01 00:00:00

  • 5-Aminolevulinic acid mediates the in vivo and in vitro formation of 8-hydroxy-2'-deoxyguanosine in DNA.

    abstract::5-Aminolevulinic acid (ALA), a heme precursor accumulated in chemical and inborn porphyrias, may behave as an endogenous pro-oxidant. In chronically treated rats (40 mg ALA/kg body wt every 2 days for 15 days) the steady-state level of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in liver DNA (94.5 +/- 23.3 residues/10(6) dG)...


    pub_type: 杂志文章


    authors: Fraga CG,Onuki J,Lucesoli F,Bechara EJ,Di Mascio P

    更新日期:1994-10-01 00:00:00

  • Ingestion of sugar beet fiber enhances irradiation-induced aberrant crypt foci in the rat colon under an apoptosis-suppressed condition.

    abstract::The induction of aberrant crypt foci (ACF) by irradiation of gamma-rays (60Co), and the effect of dietary sugar beet fiber (SBF) on irradiation-induced ACF were examined. We found that abdominal irradiation of gamma-rays could induce ACF in the rat colon. The irradiation was performed once a week at a dose rate of 2 o...


    pub_type: 杂志文章


    authors: Ishizuka S,Ito S,Onuma M,Kasai T,Aoyama Y,Hara H

    更新日期:1999-06-01 00:00:00

  • Enhancement of the invasive ability of a transformed human bronchial epithelial cell line by 12-O-tetradecanoyl-phorbol-13-acetate and diacylglycerol.

    abstract::The effect of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was studied using an immortalized human bronchial epithelial cell line, BEAS-2B, both in vivo and in vitro. The in vivo model consisted of tracheas reconstituted with an epithelium of BEAS-2B cells xenotransplanted into athymic nude mice. Int...


    pub_type: 杂志文章


    authors: Bonfil RD,Momiki S,Fridman R,Reich R,Reddel R,Harris CC,Klein-Szanto A

    更新日期:1989-12-01 00:00:00

  • N-acetoxy-N-acetyl-2-aminofluorene-induced mutation spectrum in a human hprt cDNA shuttle vector integrated into mammalian cells.

    abstract::The spectrum of mutations induced by N-acetoxy-N-acetyl-2-aminofluorene (N-AcO-AAF) was examined by the pZipHprtNeo shuttle vector in mammalian cells. The vector carries a cDNA of the human hypoxanthine phosphoribosyl transferase (hprt) gene, which is stably integrated into chromosomal DNA of a mouse cell line, VH12. ...


    pub_type: 杂志文章


    authors: Ogawa HI,Kimura H,Koya M,Higuchi H,Kato T

    更新日期:1993-11-01 00:00:00