Carcinogenicity of nitropyrenes in the newborn female rat.

abstract：:The hedgehog pathway plays a critical role in the development of the foregut. Recent studies indicate that the hedgehog pathway activation occurs in the stomach and other gastrointestinal cancers. However, the association of hedgehog pathway activation with tumor stage, differentiation and tumor subtype is not well do...

journal_title：Carcinogenesis

authors： Ma X,Chen K,Huang S,Zhang X,Adegboyega PA,Evers BM,Zhang H,Xie J

更新日期：2005-10-01 00:00:00

abstract：:Many chemoradiation therapies cause DNA damage through oxidative stress. An important cellular mechanism that protects cells against oxidative stress involves DNA repair. One of the primary DNA repair mechanisms for oxidative DNA damage is base excision repair (BER). BER involves the tightly coordinated function of fo...

journal_title：Carcinogenesis

authors： Zhang H,Mizumachi T,Carcel-Trullols J,Li L,Naito A,Spencer HJ,Spring PM,Smoller BR,Watson AJ,Margison GP,Higuchi M,Fan CY

更新日期：2007-08-01 00:00:00

abstract：:Previous research suggests that far upstream element-binding protein 1 (FUBP1) plays an important role in various tumors including epatocellular carcinoma (HCC). However, the role of FUBP1 in liver cancer remains controversial, and the regulatory pathway by FUBP1 awaits to be determined. This study aims to identify th...

journal_title：Carcinogenesis

authors： Fu PY,Hu B,Ma XL,Tang WG,Yang ZF,Sun HX,Yu MC,Huang A,Hu JW,Zhou CH,Fan J,Xu Y,Zhou J

更新日期：2020-07-14 00:00:00

abstract：:The anti-cancer efficacy of grape seed extract (GSE) against prostate cancer (PCA) via its anti-proliferative, pro-apoptotic and anti-angiogenic activities in both cell culture and animal models have recently been described by us. GSE is a complex mixture containing gallic acid (GA), catechin (C), epicatechin (EC) and...

journal_title：Carcinogenesis

authors： Veluri R,Singh RP,Liu Z,Thompson JA,Agarwal R,Agarwal C

更新日期：2006-07-01 00:00:00

abstract：:The mutational specificity of the monofunctional alkylating agent N-propyl-N'-nitro-N-nitrosoguanidine (PNNG) has been determined through the DNA sequence characterization of 109 LacI- mutations of Escherichia coli. The predominant mutation induced was the G:C----A:T transition (73%), presumably the result of O6-propy...

journal_title：Carcinogenesis

authors： van der Vliet GM,Zielenska M,Anderson MW,Glickman BW

更新日期：1989-05-01 00:00:00

abstract：:Cancer of the stomach is one of the most commonly diagnosed malignancies and remains an important cause of mortality world wide. This type of cancer is not uniformly distributed among populations but shows a marked variation in both incidence and mortality. Although gastric cancer is declining in many parts of the wor...

journal_title：Carcinogenesis

authors： Stadtländer CT,Waterbor JW

更新日期：1999-12-01 00:00:00

abstract：:This study was undertaken to investigate the hypothesis linking peroxisome proliferation with the production of reactive oxygen species and subsequent DNA damage. Hepatic peroxisomal proliferation was induced in male Wistar-derived rats by the administration of clofibrate, methyl clofenapate, di(2-ethylhexyl)phthalate...

journal_title：Carcinogenesis

authors： Elliott BM,Elcombe CR

更新日期：1987-09-01 00:00:00

abstract：:Reported habits of red meat consumption, particularly red meat that has been cooked to the degree termed 'well-done', is a positive risk factor for colorectal cancer. Under high, pyrolytic temperatures, heterocyclic amines (HCA) and benzo[a]pyrene (BP) molecules can form inside and on the surface of red meat, respecti...

journal_title：Carcinogenesis

authors： Gunter MJ,Probst-Hensch NM,Cortessis VK,Kulldorff M,Haile RW,Sinha R

更新日期：2005-03-01 00:00:00

abstract：:Genetically modified mice with overexpressed and/or deleted genes have been used extensively to model human cancer. However, it is uncertain as to what extent the mouse models reproduce the corresponding cancers in humans. We have compared the global gene expression patterns in human and mouse hepatocellular carcinoma...

journal_title：Carcinogenesis

authors： Lee JS,Grisham JW,Thorgeirsson SS

更新日期：2005-06-01 00:00:00

abstract：:Modification of 3,2'-dimethyl-4-aminobiphenyl (DMAB) multi-organ carcinogenesis by simultaneous treatment with butylated hydroxyanisole (BHA) or butylated hydroxytoluene (BHT) was studied using young and old male F344 rats. Animals, 4 or 54 weeks old, were given DMAB (s.c. injection of 50 mg/kg body wt once a week for...

journal_title：Carcinogenesis

authors： Shirai T,Fukushima S,Kawabe M,Shibata M,Iwasaki S,Tada M,Ito N

更新日期：1991-07-01 00:00:00

abstract：:Two complementary genetic parameters were followed in liver parenchymal cells during the first steps of rat hepatocarcinogenesis: the expression of nucleolar genes estimated from their silver stainability and the nuclear DNA content determined after Feulgen staining. Putative preneoplastic lesions as foci and nodules ...

journal_title：Carcinogenesis

authors： Deleener A,Castelain P,Preat V,de Gerlache J,Alexandre H,Kirsch-Volders M

更新日期：1987-02-01 00:00:00

abstract：:Specific methylated derivatives of anthracene are mutagenic in S. typhimurium and have tumor-initiating activity on mouse skin. In this study, the mutagenic activities of 1-, 2-, and 9-methylanthracene, 2,9- and 9,10-dimethylanthracene, 2,9,-10-trimethylanthracene, 2,3,9,10-tetramethylanthracene, and the photo-oxide o...

journal_title：Carcinogenesis

authors： La Voie EJ,Coleman DT,Rice JE,Geddie NG,Hoffmann D

更新日期：1985-10-01 00:00:00

abstract：:The purpose of this study was to determine if decreasing dietary protein from 24% (high protein) to 5% casein (low protein), substituting sucrose and cornstarch isocalorifically for casein, would modify the activity of protein kinase C (PKC) alpha and beta isoenzymes, as well as the expression of PKC alpha, beta, delt...

journal_title：Carcinogenesis

authors： La Porta CA,Comolli R

更新日期：1995-05-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants with high carcinogenic potencies that have been linked to the etiology of human cancers through their presence in cigarette smoke and environmental mixtures. They are metabolically activated in cells by cytochrome P450 enzymes and/or perox...

journal_title：Carcinogenesis

authors： Melendez-Colon VJ,Luch A,Seidel A,Baird WM

更新日期：1999-10-01 00:00:00

abstract：:The possibility that ascorbic acid, as a nucleophile, may inhibit mutagenicity induced by electrophilic metabolites of N-nitroso compounds was examined. In vitro data are presented to show that ascorbic acid does not decrease the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in a modified Ames bacterial ...

journal_title：Carcinogenesis

authors： Norkus EP,Kuenzig WA

更新日期：1985-11-01 00:00:00

abstract：:The karyopherin β proteins are involved in nuclear-cytoplasmic trafficking and are crucial for protein and RNA subcellular localization. We previously showed that Kpnβ1, a nuclear importin protein, is overexpressed in cervical cancer and is critical for cervical cancer cell survival and proliferation, whereas non-canc...

journal_title：Carcinogenesis

authors： Angus L,van der Watt PJ,Leaner VD

更新日期：2014-05-01 00:00:00

abstract：:Recent studies have demonstrated that K-ras mutations in lung epithelial cells elicit inflammation that promotes carcinogenesis in mice (intrinsic inflammation). The finding that patients with chronic obstructive pulmonary disease (COPD), an inflammatory disease of the lung, have an increased risk of lung cancer after...

journal_title：Carcinogenesis

authors： Moghaddam SJ,Barta P,Mirabolfathinejad SG,Ammar-Aouchiche Z,Garza NT,Vo TT,Newman RA,Aggarwal BB,Evans CM,Tuvim MJ,Lotan R,Dickey BF

更新日期：2009-11-01 00:00:00

abstract：:Groups of male Fischer-344 rats were fed two pairs of semi-purified choline-devoid and choline-supplemented diets, one set containing 5% corn oil and 10% partially hydrogenated fat, and the other only corn oil (15%). Analyses were performed on lipids extracted from whole liver, liver nuclei and adipose tissue of the r...

journal_title：Carcinogenesis

authors： Banni S,Salgo MG,Evans RW,Corongiu FP,Lombardi B

更新日期：1990-11-01 00:00:00

abstract：:Cancer is a leading cause of death worldwide and environmental factors, including chemicals, have been suggested as major etiological incitements. Cancer statistics indicates that men get more cancer than women. However, differences in the known risk factors including life style or occupational exposure only offer par...

journal_title：Carcinogenesis

authors： Ali I,Högberg J,Hsieh JH,Auerbach S,Korhonen A,Stenius U,Silins I

更新日期：2016-10-01 00:00:00

abstract：:Food-derived aminoimidazoazarenes have been shown to be mutagenic and carcinogenic and to form covalent DNA adducts. 32P-Post-labelling analysis of DNA modified with these heterocyclic amines (HA), including 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-...

journal_title：Carcinogenesis

authors： Pfau W,Brockstedt U,Söhren KD,Marquardt H

更新日期：1994-05-01 00:00:00

abstract：:A quantitative relationship was established for 26 nitrosamines between their carcinogenic effectiveness in experimental animals and their mutagenic activity in a mammalian cell-mediated assay. Mutagenesis was measured in Chinese hamster V79 cells co-cultivated with primary rat hepatocytes, which are capable of activa...

journal_title：Carcinogenesis

authors： Jones CA,Marlino PJ,Lijinsky W,Huberman E

更新日期：1981-01-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a type of head and neck cancer with significantly high prevalence in Southern China. Unlike other head and neck cancers, mutations or deletions of tumor suppressor genes in NPC are not common. Recently, downregulation of tumor suppressor genes expression by microRNA (miRNA) is increas...

journal_title：Carcinogenesis

authors： Zhang LY,Ho-Fun Lee V,Wong AM,Kwong DL,Zhu YH,Dong SS,Kong KL,Chen J,Tsao SW,Guan XY,Fu L

更新日期：2013-02-01 00:00:00

abstract：:Following intraperitoneal administration of [3H] aflatoxin B1 (AFB1) to young adult male rats, there is rapid uptake of the carcinogen by the liver, the target organ for carcinogenesis, leading to DNA covalent binding. Acid hydrolysis of this DNA shows that after 2h, the major DNA adduct is trans 8,9-dihydro-8-(7-guan...

journal_title：Carcinogenesis

authors： Hertzog PJ,Lindsay Smith JR,Garner RC

更新日期：1980-09-01 00:00:00

abstract：:Male Ah-responsive C57BL/10ScSn mice received a single dose of iron-dextran (600 mg Fe/kg) and were fed a diet containing 0.01% of the PCBs mixture Aroclor 1254 for up to 12 months. Iron caused a marked synergistic increase in liver size from 2 months with greatly elevated mitotic rates, numbers of basophilic foci and...

journal_title：Carcinogenesis

authors： Smith AG,Francis JE,Carthew P

更新日期：1990-03-01 00:00:00

abstract：:A growing body of evidence from human and animal cancer cytogenetics studies indicates that aneuploidy is an important chromosome change in carcinogenesis. To understand the role of this genetic phenomenon during the first steps of an experimental cancer model, molecular and cellular techniques were combined. A sequen...

journal_title：Carcinogenesis

authors： Van Goethem F,de Stoppelaar J,Hoebee B,Kirsch-Volders M

更新日期：1995-08-01 00:00:00

abstract：:Cell motility is partially dependent on interactions between the integrins and the extracellular matrix. Our previous studies have identified synthetic D-amino acid cell adhesion peptides using a combinatorial screening approach. In this study, we demonstrate that HYD1 (kikmviswkg) completely blocks random haptotactic...

journal_title：Carcinogenesis

authors： Sroka TC,Pennington ME,Cress AE

更新日期：2006-09-01 00:00:00

abstract：:5-Aminolevulinic acid (ALA), a heme precursor accumulated in chemical and inborn porphyrias, may behave as an endogenous pro-oxidant. In chronically treated rats (40 mg ALA/kg body wt every 2 days for 15 days) the steady-state level of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in liver DNA (94.5 +/- 23.3 residues/10(6) dG)...

journal_title：Carcinogenesis

authors： Fraga CG,Onuki J,Lucesoli F,Bechara EJ,Di Mascio P

更新日期：1994-10-01 00:00:00

abstract：:The induction of aberrant crypt foci (ACF) by irradiation of gamma-rays (60Co), and the effect of dietary sugar beet fiber (SBF) on irradiation-induced ACF were examined. We found that abdominal irradiation of gamma-rays could induce ACF in the rat colon. The irradiation was performed once a week at a dose rate of 2 o...

journal_title：Carcinogenesis

authors： Ishizuka S,Ito S,Onuma M,Kasai T,Aoyama Y,Hara H

更新日期：1999-06-01 00:00:00

abstract：:The effect of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was studied using an immortalized human bronchial epithelial cell line, BEAS-2B, both in vivo and in vitro. The in vivo model consisted of tracheas reconstituted with an epithelium of BEAS-2B cells xenotransplanted into athymic nude mice. Int...

journal_title：Carcinogenesis

authors： Bonfil RD,Momiki S,Fridman R,Reich R,Reddel R,Harris CC,Klein-Szanto A

更新日期：1989-12-01 00:00:00

abstract：:The spectrum of mutations induced by N-acetoxy-N-acetyl-2-aminofluorene (N-AcO-AAF) was examined by the pZipHprtNeo shuttle vector in mammalian cells. The vector carries a cDNA of the human hypoxanthine phosphoribosyl transferase (hprt) gene, which is stably integrated into chromosomal DNA of a mouse cell line, VH12. ...

journal_title：Carcinogenesis

authors： Ogawa HI,Kimura H,Koya M,Higuchi H,Kato T

更新日期：1993-11-01 00:00:00