Abstract:
:The carcinogen N-acetoxy-N-2-acetylaminofluorene reacts with dG and dG-containing nucleotides to give good yields of the C-8 adducts, but the analogous 4-aminobiphenyl derivative does not. Replacement of the N-acetoxy group by 2,6-dichlorobenzoyloxy circumvents this difficulty. This reaction is shown to be generally applicable, and biphenylamido adducts with dG, d(CpG), d(GpC) and d(ApG) have been prepared. A new, useful deacetylation procedure employing the heterogeneous system sodium carbonate/methanol which leads to the corresponding biphenylamino derivative without appreciable imidazole ring opening is also reported.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Underwood GR,Price MF,Shapiro Rdoi
10.1093/carcin/9.10.1817subject
Has Abstractpub_date
1988-10-01 00:00:00pages
1817-21issue
10eissn
0143-3334issn
1460-2180journal_volume
9pub_type
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