Genetic variations in the transforming growth factor-beta pathway as predictors of survival in advanced non-small cell lung cancer.

abstract：:Chemical carcinogens are generally activated enzymatically to electrophiles that form covalently bound carcinogen-DNA adducts. Detoxifying enzymes are competing with the activating enzymes for these procarcinogenic chemical substrates. Wide person-to-person variations in these two types of enzymatic activities are fou...

journal_title：Carcinogenesis

authors： Harris CC

更新日期：1989-09-01 00:00:00

abstract：:Benzene is a well-characterized human carcinogen and clastogen still present in both the occupational and general environment. However, the levels of benzene encountered today are, in most cases, relatively low and new methods, more specific and sensitive than classical cytogenetics, are probably needed to assess if c...

journal_title：Carcinogenesis

authors： Surrallés J,Autio K,Nylund L,Järventaus H,Norppa H,Veidebaum T,Sorsa M,Peltonen K

更新日期：1997-04-01 00:00:00

abstract：:The cyclooxygenase-2 (COX-2) inhibitor celecoxib and the ornithine decarboxylase (ODC) inhibitor difluoromethylornithine (DFMO) were each previously shown to prevent skin tumor development when administered throughout the course of UV irradiation. This raised the question of whether maintenance or continued growth of ...

journal_title：Carcinogenesis

authors： Fischer SM,Conti CJ,Viner J,Aldaz CM,Lubet RA

更新日期：2003-05-01 00:00:00

abstract：:The nasal passages are a common portal of entry and are a prime site for toxicant-induced pathology. Sustained increases in regenerative cell proliferation can be a significant driving force in chemical carcinogenesis. The atmosphere in Mexico City contains a complex mixture of air pollutants and its residents are exp...

journal_title：Carcinogenesis

authors： Calderón-Garcidueñas L,Rodriguez-Alcaraz A,Garcia R,Barragan G,Villarreal-Calderón A,Madden MC

更新日期：1999-03-01 00:00:00

abstract：:We present data showing that the major phenobarbital inducible cytochromes P-450 (cytochrome P-450IIB1 and cytochrome P-450IIB2) were phosphorylated in intact hepatocytes. This phosphorylation was greatly increased by the cAMP derivatives N6-dibutyryl-cAMP and 8-thiomethyl-cAMP mediated by a cAMP-dependent protein kin...

journal_title：Carcinogenesis

authors： Bartlomowicz B,Waxman DJ,Utesch D,Oesch F,Friedberg T

更新日期：1989-01-01 00:00:00

abstract：:Recent studies have shown opposing effects of n-6 and n-3 fatty acids on the development of cancer and suggest a role for the ratio of n-6 to n-3 fatty acids in the control of cancer. However, whether an alteration in the n-6/n-3 fatty acid ratio of cancer cells affects their invasive potential has not been well inves...

journal_title：Carcinogenesis

authors： Xia SH,Wang J,Kang JX

更新日期：2005-04-01 00:00:00

abstract：:Conversion of the 2'-deoxyguanosine (dG) residues in calf thymus DNA to 8-hydroxy-2'-deoxyguanosine (8-OH-dG) was achieved at physiological pH by treating the DNA with hydrogen peroxide (H2O2) in the presence of nickel(II) chloride (NiCl2). The effectiveness of this reaction was enhanced by L-histidine (His) which for...

journal_title：Carcinogenesis

authors： Dutta AK,Misra M,North SL,Kasprzak KS

更新日期：1992-02-01 00:00:00

abstract：:The effect of the protease inhibitor antipain (1.25 micrograms/ml) on the radiation-induced expression of a tumor-associated antigen in human cell hybrids has been investigated. A variety of treatment protocols have been studied where antipain was present before, during and at various times post-irradiation. It was fo...

journal_title：Carcinogenesis

authors： Sun C,Colman M,Redpath JL

更新日期：1988-12-01 00:00:00

abstract：:The expression of A and P forms of glutathione S-transferase (GST-A and P), two cytochrome P-450 isoenzymes (P-450 PB3a and P-450 MC2), microsomal epoxide hydrolase (mEHb), glucose-6-phosphate dehydrogenase (G6PD) and gamma-glutamyltranspeptidase (gamma-GT) was compared in preneoplastic liver lesions and background pa...

journal_title：Carcinogenesis

authors： Tsuda H,Moore MA,Asamoto M,Inoue T,Ito N,Satoh K,Ichihara A,Nakamura T,Amelizad Z,Oesch F

更新日期：1988-04-01 00:00:00

abstract：:Here we report that colorectal cancer patients show a markedly higher frequency (3-fold) of wild-type NAT2*4 allele homozygotes than the control population. However, a marked difference in NAT2*4/NAT2*4 genotype frequency associated with the patients gender was observed pointing to a male-specific effect of this genot...

journal_title：Carcinogenesis

authors： Gil JP,Lechner MC

更新日期：1998-01-01 00:00:00

abstract：:Skin is a major target of carcinogenic trivalent arsenic (arsenite, As3+). It has been thought that cell proliferation is one of the central events involved in the carcinogenic effect of arsenite. Cyclin D1, a nuclear protein playing a pivotal role in cell proliferation and cell cycle transition from G1 to S phases, h...

journal_title：Carcinogenesis

authors： Ouyang W,Li J,Ma Q,Huang C

更新日期：2006-04-01 00:00:00

abstract：:Previous studies have shown that 1- and 3-nitrobenzo[a]pyrene (NBaP) were mutagenic in the Salmonella reversion assay without exogenous activation and that 1-, 3- and 6-NBaP were mutagenic in the presence of hepatocytes or liver homogenate (S9). In the present study, 1-, 3- and 6-NBaP were tested for mutagenicity in C...

journal_title：Carcinogenesis

authors： Hass BS,Heflich RH,Schol HM,Chou MW,Fu PP,Casciano DA

更新日期：1986-04-01 00:00:00

abstract：:Incubation of 3-[3H]fluoranthene with a rat liver microsomal activation system in the presence of calf thymus DNA resulted in radioactivity bound to the DNA. The fluoranthene-modified DNA was enzymatically digested and a DNA adduct elution profile developed using h.p.l.c. The fraction containing the major fluoranthene...

journal_title：Carcinogenesis

authors： Babson JR,Russo-Rodriguez SE,Rastetter WH,Wogan GN

更新日期：1986-06-01 00:00:00

abstract：:Alternative pre-messenger RNA (mRNA) splicing is a key molecular event that allows for protein diversity and plays important roles in development and disease. Alternative pre-mRNA splicing regulations during spermatogenesis and alternative pre-mRNA splicing etiology in testicular tumorigenesis are yet to be characteri...

journal_title：Carcinogenesis

authors： He C,Zuo Z,Chen H,Zhang L,Zhou F,Cheng H,Zhou R

更新日期：2007-12-01 00:00:00

abstract：:Animal studies demonstrated that females are more susceptible than males to benzo[a]pyrene (BaP)-induced toxicities, including lung carcinogenesis. Elevation of cyclooxygenase-2 (COX-2) expression has been shown to increase the risk of cancer development. BaP induces COX-2 expression, and an interaction between BaP an...

journal_title：Carcinogenesis

authors： Chang LW,Chang YC,Ho CC,Tsai MH,Lin P

更新日期：2007-07-01 00:00:00

abstract：:To test the hypothesis that aberrations of DNA repair contribute to susceptibility for the progression of gastroesophageal reflux disease (GERD) into Barrett esophagus (BE) and esophageal adenocarcinoma (EADC), we studied the frequency of polymorphisms of selected DNA repair genes in patients with GERD (n = 126), BE (...

journal_title：Carcinogenesis

authors： Casson AG,Zheng Z,Evans SC,Veugelers PJ,Porter GA,Guernsey DL

更新日期：2005-09-01 00:00:00

abstract：:The modifying effects of 4,4'-diaminodiphenylmethane (DDPM) (0.1% in diet) administration on liver carcinogenesis induced by 2-acetylaminofluorene (2-AAF) (0.02% in diet), 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) ( 0.06% in diet), diethylnitrosamine (DEN) (0.001% in drinking water) and N-ethyl-N-hydroxyethylnit...

journal_title：Carcinogenesis

authors： Tsuda H,Ogiso T,Hasegawa R,Imaida K,Masui T,Ito N

更新日期：1987-05-01 00:00:00

abstract：:A culture method to grow two morphologically distinguishable normal human breast epithelial cell types derived from reduction mammoplasty has been developed. Type I cells were characterized by a more variable cell shape, smooth cell colony boundaries, the expression of epithelial membrane antigen (EMA) and keratin 18 ...

journal_title：Carcinogenesis

authors： Kao CY,Nomata K,Oakley CS,Welsch CW,Chang CC

更新日期：1995-03-01 00:00:00

abstract：:7-Methylguanine (7-meG) could be a useful marker of recent past exposure to environmental methylating agents for use in epidemiological studies. A method is described that is appropriate for such an application. 7-meG was released from DNA by thermal hydrolysis under conditions (pH 9, 70 degrees C, 8 h) that preferent...

journal_title：Carcinogenesis

authors： Bianchini F,Montesano R,Shuker DE,Cuzick J,Wild CP

更新日期：1993-08-01 00:00:00

abstract：:The effects of exposure to benzo[a]pyrene (BAP) and formaldehyde (HCHO), alone and combined, on the induction of carcinogenesis in rat tracheal implants was determined as the number of growth-altered cell populations (tumor-initiation sites, TIS) per trachea. While exposure twice-weekly for 4.5 months to 0.2% HCHO sol...

journal_title：Carcinogenesis

authors： Cosma GN,Marchok AC

更新日期：1987-12-01 00:00:00

abstract：:We have tested the hypothesis that the inhibition by hydroxyurea of repair patch ligation and chromatin rearrangement during u.v.-induced DNA excision repair results from a reduction in cellular deoxyribonucleotide concentrations and not from a direct effect of hydroxyurea on the repair process. Using permeable human ...

journal_title：Carcinogenesis

authors： Hunting DJ,Dresler SL

更新日期：1985-10-01 00:00:00

abstract：:Not all carcinogens are mutagens, and many mutagens are not carcinogens. Among related chemicals, small changes of structure can markedly influence carcinogenic potency. Many tumours are genetically unstable, but some, especially 'benign' types, rarely exhibit 'progression' or show other evidence of genetic instabilit...

journal_title：Carcinogenesis

authors： Bignold LP

更新日期：2004-03-01 00:00:00

abstract：:The influence of various dietary constituents--phenethylisothiocyanate (PEITC), oleic acid (OA), triolein (TO), and vitamin A (ROL)--on the genotoxic activity of nitrosamines (NDMA, NDELA, NPYR) was investigated. For this purpose differential DNA repair assays with Escherichia coli K-12 strains were performed in vitro...

journal_title：Carcinogenesis

authors： Knasmüller S,Huber WW,Kienzl H,Schulte-Hermann R

更新日期：1992-09-01 00:00:00

abstract：:The purpose of this study was to examine the activity and associated kinetic parameters of epidermal protein kinase C (PKC) following stimulation by sn-1,2-dioctanoylglycerol (DIC8) or 12-O-tetradecanoylphorbol-13-acetate (TPA) and to examine the relationship between levels of epidermal PKC activity and the induction ...

journal_title：Carcinogenesis

authors： Mills KJ,Smart RC

更新日期：1989-05-01 00:00:00

abstract：:Azido-PhIP (2-azido-1-methyl-6-phenylimidazo[4,5-b]pyridine) and nitro-PhIP (2-nitro-1-methyl-6-phenylimidazo[4,5-b]pyridine) have been synthesized and characterized chemically. The mutagenic potencies of azido-PhIP (with photoactivation by near UV irradiation), of nitro-PhIP (without exogenous activation) and of the ...

journal_title：Carcinogenesis

authors： Wild D,Watkins BE,Vanderlaan M

更新日期：1991-06-01 00:00:00

abstract：:Genetically based differences in metabolism, related to MspI restriction site and Ile-Val polymorphisms of the cytochrome P450 (CYP) 1A1 gene and the null genotype of glutathione transferase class mu (GSTM1), have been reported to be associated with lung cancer susceptibility. The present study was set up to establish...

journal_title：Carcinogenesis

authors： Alexandrie AK,Sundberg MI,Seidegård J,Tornling G,Rannug A

更新日期：1994-09-01 00:00:00

abstract：:Colorectal cancer (CRC) displays a predilection for metastasis to liver. Although stromal cell-derived factor-1 (SDF-1)/CXCR4 plays an important role in the liver metastasis, the molecular mechanism still remains obscure. We previously reported that integrin αvβ6 was implicated in the progression of CRC. However, no d...

journal_title：Carcinogenesis

authors： Wang B,Wang W,Niu W,Liu E,Liu X,Wang J,Peng C,Liu S,Xu L,Wang L,Niu J

更新日期：2014-02-01 00:00:00

abstract：:Dacarbazine (DTIC) is an antitumor agent, used for the treatment of metastatic melanoma. It is metabolized to an alkylating agent which reacts with DNA. A fast and simple method was developed in order to measure drug-induced DNA damage in lymphocytes isolated from frozen blood samples of treated patients. The level of...

journal_title：Carcinogenesis

authors： Walles SA,Ringborg U

更新日期：1991-06-01 00:00:00

abstract：:In the present study the role of two families of cytochrome P-450 proteins and the contribution of the cytosolic fraction in the activation of N-nitrosopiperidine to mutagens in the Ames test were investigated. The bioactivation of this nitrosamine was preferentially catalysed by the phenobarbitone-induced cytochromes...

journal_title：Carcinogenesis

authors： Ayrton AD,Smith JN,Ioannides C

更新日期：1987-11-01 00:00:00

abstract：:Cancer is a leading cause of death worldwide and environmental factors, including chemicals, have been suggested as major etiological incitements. Cancer statistics indicates that men get more cancer than women. However, differences in the known risk factors including life style or occupational exposure only offer par...

journal_title：Carcinogenesis

authors： Ali I,Högberg J,Hsieh JH,Auerbach S,Korhonen A,Stenius U,Silins I

更新日期：2016-10-01 00:00:00