Compensatory mammary growth following protein restriction during pregnancy and lactation increases early-onset mammary tumor incidence in rats.

abstract：:1,3-Butadiene (BD), a widely used monomer in the production of synthetic rubber and other resins, is one of the 189 hazardous air pollutants identified in the 1990 Clean Air Act Amendments. BD induces tumors at multiple organ sites in B6C3F1 mice and Sprague-Dawley rats; mice are much more susceptible to the carcinoge...

journal_title：Carcinogenesis

authors： Csanády GA,Guengerich FP,Bond JA

更新日期：1992-07-01 00:00:00

abstract：:The three human leukocyte antigen (HLA) class I antigens, HLA-A, HLA-B and HLA-C, play important roles in the elimination of transformed cells by cytotoxic T cells. Frequent loss of expression of these antigens at the cell surface has been observed in many human cancers. Various mechanisms for post-transcriptional reg...

journal_title：Carcinogenesis

authors： Nie Y,Yang G,Song Y,Zhao X,So C,Liao J,Wang LD,Yang CS

更新日期：2001-10-01 00:00:00

abstract：:In order to explore a possibility that the custom of drinking green tea infusion is efficacious for reducing the carcinogenic risk of environmental exposure to pentachlorophenol (PCP), we examined the effects in a hepato- and cholangiocarcinogenesis model in mice exposed to diethylnitrosamine (DEN). In the first exper...

journal_title：Carcinogenesis

authors： Umemura T,Kai S,Hasegawa R,Kanki K,Kitamura Y,Nishikawa A,Hirose M

更新日期：2003-06-01 00:00:00

abstract：:Chemopreventive agents are compounds that inhibit carcinogenesis when administered prior or subsequent to a course of carcinogen administration. The effects of dietary administration of crocin dyes on the hepatic damage induced by aflatoxin B1 (AFB1) and dimethylnitrosamine (DMN) in rats were investigated. Female Spra...

journal_title：Carcinogenesis

authors： Lin JK,Wang CJ

更新日期：1986-04-01 00:00:00

abstract：:Staurosporine (stsp) is a kinase inhibitor which induces cornified envelope assembly and terminal differentiation in normal and neoplastic mouse keratinocytes. In the tumorigenic cell lines 308 and SP-1 experiments were performed to determine if this effect was due only to activation of transglutaminases (TGases) alre...

journal_title：Carcinogenesis

authors： Stanwell C,Dlugosz AA,Yuspa SH

更新日期：1996-06-01 00:00:00

abstract：:Sphingadienes (SDs) derived from soy and other natural sphingolipids are cytotoxic to colon cancer cells via an Akt-dependent mechanism and reduce adenoma formation in Apc(Min/+) mice. Wnt signaling is fundamental to colon carcinogenesis and is the basis for spontaneous tumorigenesis in Apc(Min/+) mice and patients wi...

journal_title：Carcinogenesis

authors： Kumar A,Pandurangan AK,Lu F,Fyrst H,Zhang M,Byun HS,Bittman R,Saba JD

更新日期：2012-09-01 00:00:00

abstract：:Overall rates of tissue protein degradation in vivo during chemical hepatocarcinogenesis were estimated by a double-isotope method as well as from the accumulation of peptide intermediates in protein degradation induced by bestatin. Several parameters estimating rates of cell proliferation and cell loss have been meas...

journal_title：Carcinogenesis

authors： Canuto RA,Tessitore L,Muzio G,Autelli R,Baccino FM

更新日期：1993-12-01 00:00:00

abstract：:The organochlorine pesticides chlordane and heptachlor were demonstrated to be liver neoplasm promoters in mice. Male B6C3F1 mice exposed to diethylnitrosamine (DEN) for 14 weeks followed by 25 weeks on control diet developed a 40% incidence of liver neoplasms whereas those given chlordane or heptachlor afterwards had...

journal_title：Carcinogenesis

authors： Williams GM,Numoto S

更新日期：1984-12-01 00:00:00

abstract：:The role of sulfation in the metabolic activation of the liver carcinogen N-hydroxy-4'-fluoro-4-acetylaminobiphenyl (N-OH-FAABP) in male rat liver was investigated. N-OH-FAABP was a substrate for sulfotransferases in vitro and sulfation was inhibited by the sulfotransferase inhibitors pentachlorophenol (PCP) and 2,6-d...

journal_title：Carcinogenesis

authors： van de Poll ML,Tijdens RB,Vondrácek P,Bruins AP,Meijer DK,Meerman JH

更新日期：1989-12-01 00:00:00

abstract：:Multiple myeloma (MM) cells accumulate in the bone marrow (BM) where their interactions impede disease therapy. We have shown that microvesicles (MVs) derived from BM mesenchymal stem cells (MSCs) of MM patients promote the malignant traits via modulation of translation initiation (TI), whereas MVs from normal donors ...

journal_title：Carcinogenesis

authors： Dabbah M,Jarchowsky-Dolberg O,Attar-Schneider O,Tartakover Matalon S,Pasmanik-Chor M,Drucker L,Lishner M

更新日期：2020-03-13 00:00:00

abstract：:Cancer is a genetic disease in which the interplay between alterations in protein-coding genes and non-coding RNAs (ncRNAs) plays a fundamental role. In recent years, the full coding component of the human genome was sequenced in various cancers, whereas such attempts related to ncRNAs are still fragmentary. We screen...

journal_title：Carcinogenesis

authors： Wojcik SE,Rossi S,Shimizu M,Nicoloso MS,Cimmino A,Alder H,Herlea V,Rassenti LZ,Rai KR,Kipps TJ,Keating MJ,Croce CM,Calin GA

更新日期：2010-02-01 00:00:00

abstract：:Salvia miltiorrhiza (SM) has been used clinically in Asian countries to improve the microcirculation in the human body. Salvianolic acid B (Sal B), a pure compound extracted from SM, has been reported to be effective against fibrosis and ischemia-reperfusion injury, possibly through its anti-lipid peroxidation action....

journal_title：Carcinogenesis

authors： Zhou ZT,Yang Y,Ge JP

更新日期：2006-04-01 00:00:00

abstract：:We describe studies to determine if susceptibility to pituitary tumours is associated with the putatively high risk GSTM1 null and CYP2D6 EM genotypes. Frequency distributions of these genotypes were similar in cases and controls though the frequency of CYP2D6 PM and GSTM1 B tended to be lower (P = 0.072 and P = 0.095...

journal_title：Carcinogenesis

authors： Perrett CW,Clayton RN,Pistorello M,Boscaro M,Scanarini M,Bates AS,Buckley N,Jones P,Fryer AA,Gilford J

更新日期：1995-07-01 00:00:00

abstract：:Neuroblastic tumors (NTs) include the neuroblastomas, ganglioneuroblastomas and ganglioneuromas. We have reported previously that the calcium-sensing receptor is expressed in differentiated, favorable NTs but almost undetectable in unfavorable neuroblastomas. We have now detected hypermethylation of a particular regio...

journal_title：Carcinogenesis

authors： Casalà C,Gil-Guiñón E,Ordóñez JL,Miguel-Queralt S,Rodríguez E,Galván P,Lavarino C,Munell F,de Alava E,Mora J,de Torres C

更新日期：2013-02-01 00:00:00

abstract：:Capsaicin, a pungent ingredient of red chili peppers, has been reported to possess antitumor activities. Here, we show that subtoxic doses of capsaicin effectively sensitize multiple malignant glioma cell lines to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Although TRAIL alone m...

journal_title：Carcinogenesis

authors： Kim JY,Kim EH,Kim SU,Kwon TK,Choi KS

更新日期：2010-03-01 00:00:00

abstract：:N-Hydroxy-2-acetylaminofluorene (N-OH-AAF), N-hydroxy-4'-fluoro-4-acetylaminobiphenyl (N-OH-FAABP) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) were compared for their initiation and promotion activity in the rat liver using a modified Solt-Farber system. N-OH-AAF, N-OH-FAABP and N-OH-AABP showed comparable initiat...

journal_title：Carcinogenesis

authors： van de Poll ML,van der Hulst DA,Tates AD,Meerman JH

更新日期：1990-02-01 00:00:00

abstract：:Benzidine diimine (BZDI), a reactive intermediate in the metabolic peroxidation of the carcinogen benzidine, has been reported to bind covalently to cellular proteins and nucleic acids. We have examined the nature of this interaction with DNA and have identified a major carcinogen-nucleoside adduct. BZDI (20-50 microM...

journal_title：Carcinogenesis

authors： Yamazoe Y,Roth RW,Kadlubar FF

更新日期：1986-01-01 00:00:00

abstract：:Recent studies have shown opposing effects of n-6 and n-3 fatty acids on the development of cancer and suggest a role for the ratio of n-6 to n-3 fatty acids in the control of cancer. However, whether an alteration in the n-6/n-3 fatty acid ratio of cancer cells affects their invasive potential has not been well inves...

journal_title：Carcinogenesis

authors： Xia SH,Wang J,Kang JX

更新日期：2005-04-01 00:00:00

abstract：:The role of rat O6-alkylguanine-DNA alkyltransferase (AGT) in modulating mutagenesis by O6-substituted guanines in the rat H-ras gene was examined. Rat4 cells were transfected with vectors carrying O6-methyl-, O6-ethyl- or O6-benzylguanine residues in place of the normal guanines at either the first, second, or both t...

journal_title：Carcinogenesis

authors： Bishop RE,Dunn LL,Pauly GT,Dolan ME,Moschel RC

更新日期：1993-04-01 00:00:00

abstract：:3-Methyladenine is one of the major products formed by reaction of a large number of environmental methylating agents with DNA in vivo and in vitro. In spite of the rapid spontaneous depurination of this base an enzyme, 3-methyladenine DNA glycosylase, has been shown to catalyse its excision. The relevance of this enz...

journal_title：Carcinogenesis

authors： Craddock VM,Henderson AR

更新日期：1982-01-01 00:00:00

abstract：:A mismatch between metabolic demand and oxygen delivery leads to microenvironmental changes in solid tumors. The resulting tumor hypoxia is associated with malignant progression, therapy resistance and poor prognosis. However, the molecular mechanisms underlying therapy resistance in hypoxic tumors are not fully under...

journal_title：Carcinogenesis

authors： Wirthner R,Wrann S,Balamurugan K,Wenger RH,Stiehl DP

更新日期：2008-12-01 00:00:00

abstract：:The effects of consumption of glucosinolate-containing Brussels sprouts on plasma and urinary glutathione S-transferase (GST) class-alpha and -pi were investigated. Five male and five female non-smoking volunteers were randomly assigned to two groups in a crossover design. Five persons started on a glucosinolate-free ...

journal_title：Carcinogenesis

authors： Nijhoff WA,Mulder TP,Verhagen H,van Poppel G,Peters WH

更新日期：1995-04-01 00:00:00

abstract：:In Thailand, smoking of commercial cigarettes and of handmade cigarettes has drastically increased in recent decades. Cancer of the lung and of the upper aero-digestive tract have also increased in Thailand as they have in many other countries. It is our working hypothesis that the increase of primary cancer of the li...

journal_title：Carcinogenesis

authors： Mitacek EJ,Brunnemann KD,Hoffmann D,Limsila T,Suttajit M,Martin N,Caplan LS

更新日期：1999-01-01 00:00:00

abstract：:MicroRNAs (miRNAs or miR) have been integrated into tumorigenic programs as either oncogenes or tumor suppressor genes. The miR-124 was reported to be attenuated in several tumors, such as glioma, medulloblastoma and hepatocellular carcinoma. However, its role in cancer remains greatly elusive. In this study, we show ...

journal_title：Carcinogenesis

authors： Liang YJ,Wang QY,Zhou CX,Yin QQ,He M,Yu XT,Cao DX,Chen GQ,He JR,Zhao Q

更新日期：2013-03-01 00:00:00

abstract：:Aloe-emodin (AE), one of the main bioactive anthraquinones of Rheum palmatum, possesses potent antitumor properties. Our previous proteomic study revealed that AE-induced apoptosis was associated with oxidative stress and oxidation of many redox-sensitive proteins. In this study, we aimed to further dissect the cell d...

journal_title：Carcinogenesis

authors： Lu GD,Shen HM,Chung MC,Ong CN

更新日期：2007-09-01 00:00:00

abstract：:Glucoraphanin in Brassica vegetables breaks down to either sulforaphane or sulforaphane nitrile depending on the conditions, and sulforaphane can be further conjugated with glutathione. Using a high-throughput microtitre plate assay and TaqMan real time quantitative RT-PCR to measure mRNA, we show that sulforaphane an...

journal_title：Carcinogenesis

authors： Basten GP,Bao Y,Williamson G

更新日期：2002-08-01 00:00:00

abstract：:The role of haplotypes and the interaction of haplotypes and smoking in lung cancer risk have not been well characterized. We analyzed data from an Italian population-based, case-control study with 1815 lung cancer patients and 1959 healthy controls in discovery, and performed a validation using a case-control study w...

journal_title：Carcinogenesis

authors： Ji X,Gui J,Han Y,Brennan P,Li Y,McKay J,Caporaso NE,Bertazzi PA,Landi MT,Amos CI

更新日期：2015-11-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have identified 58 susceptibility alleles across 37 regions associated with the risk of colorectal cancer (CRC) with P < 5×10(-8) Most studies have been conducted in non-Hispanic whites and East Asians; however, the generalizability of these findings and the potential for ethnic-...

journal_title：Carcinogenesis

authors： Schmit SL,Schumacher FR,Edlund CK,Conti DV,Ihenacho U,Wan P,Van Den Berg D,Casey G,Fortini BK,Lenz HJ,Tusié-Luna T,Aguilar-Salinas CA,Moreno-Macías H,Huerta-Chagoya A,Ordóñez-Sánchez ML,Rodríguez-Guillén R,Cruz-Bautista I

更新日期：2016-06-01 00:00:00

abstract：:In order to address the hypothesis that 6-aminochrysene (6-AC) is converted to genotoxic products by cytochrome P450 enzymes via two activation pathways (N-hydroxylation and epoxidation), the activation of 6-AC and trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene (6-AC-diol) to genotoxic metabolites was examined in rat...

journal_title：Carcinogenesis

authors： Yamazaki H,Mimura M,Oda Y,Gonzalez FJ,el-Bayoumy K,Chae YH,Guengerich FP,Shimada T

更新日期：1994-03-01 00:00:00

abstract：:It has previously been proposed that redox cycling between catechol estrogens and their quinones, mediated by cytochrome P450, could lead to the generation of free radicals that would subsequently cause oxidative damage to DNA and proteins that might have a role in hormonal carcinogenesis. Alternative, non-enzymatic m...

journal_title：Carcinogenesis

authors： Li Y,Trush MA,Yager JD

更新日期：1994-07-01 00:00:00