Absence of DNA breaks during repair of DNA-protein cross-links induced by the mycotoxin botryodiplodin in mammalian cells.

abstract：:Epidemiologic studies have suggested that aromatic amines (and nitroaromatic hydrocarbons) may be carcinogenic for human pancreas. Pancreatic tissues from 29 organ donors (13 smokers, 16 non-smokers) were examined for their ability to metabolize aromatic amines and other carcinogens. Microsomes showed no activity for ...

journal_title：Carcinogenesis

authors： Anderson KE,Hammons GJ,Kadlubar FF,Potter JD,Kaderlik KR,Ilett KF,Minchin RF,Teitel CH,Chou HC,Martin MV,Guengerich FP,Barone GW,Lang NP,Peterson LA

更新日期：1997-05-01 00:00:00

abstract：:The catalytic activity of the nuclear enzyme poly(ADP-ribose) polymerase (NAD+ ADP-ribosyl transferase, EC 2,4,2,30) is totally dependent upon the presence of DNA strand breaks. Having isolated a full-length cDNA for the polymerase, we have now evaluated the effect of endogenously and exogenously induced DNA strand br...

journal_title：Carcinogenesis

authors： Bhatia K,Pommier Y,Giri C,Fornace AJ,Imaizumi M,Breitman TR,Cherney BW,Smulson ME

更新日期：1990-01-01 00:00:00

abstract：:Thyroid hormone (T(3)) regulates proliferation and differentiation of cells, via its nuclear receptors (TRs). These processes have been shown to be abnormally regulated during carcinogenesis. We have previously found aberrant expression of TRalpha and TRbeta mRNAs in renal clear cell carcinoma (RCCC), suggesting possi...

journal_title：Carcinogenesis

authors： Kamiya Y,Puzianowska-Kuznicka M,McPhie P,Nauman J,Cheng SY,Nauman A

更新日期：2002-01-01 00:00:00

abstract：:The association between prostate cancer risk and dietary fat consumption is well documented and explained partly by accelerated lipid peroxidation. We explored the possible effects of high dietary cholesterol on carcinogenesis and oxidative stress in the prostate of ACI/Seg rats. The rats develop prostate cancer spont...

journal_title：Carcinogenesis

authors： Homma Y,Kondo Y,Kaneko M,Kitamura T,Nyou WT,Yanagisawa M,Yamamoto Y,Kakizoe T

更新日期：2004-06-01 00:00:00

abstract：:The Notch pathway plays a key role in the development and is increasingly recognized for its importance in cancer. We demonstrated previously the overexpression of Notch-1 and its ligands in gliomas and showed that their knockdown inhibits glioma cell proliferation and survival. To elucidate the mechanisms downstream ...

journal_title：Carcinogenesis

authors： Purow BW,Sundaresan TK,Burdick MJ,Kefas BA,Comeau LD,Hawkinson MP,Su Q,Kotliarov Y,Lee J,Zhang W,Fine HA

更新日期：2008-05-01 00:00:00

abstract：:3-tert-Butyl-4-hydroxyanisole (3-BHA) and its metabolites, tert-butyl-1,4-benzoquinone (BQ) and 3-tert-butyl-5-methoxy-1,2-benzoquinone (BHAoQ), were tested for initiating activity in a two-stage transformation assay using BALB/3T3 cells. Cells were treated first with a test chemical and then with the tumor promoter 1...

journal_title：Carcinogenesis

authors： Sakai A,Miyata N,Takahashi A

更新日期：1990-11-01 00:00:00

abstract：:Angiogenesis, the formation of new blood vessels, is critical to tumor growth and metastasis. Vascular endothelial growth factor (VEGF), an important angiogenic activator, is essential for angiogenesis. Our laboratory has used a rodent model of human esophageal squamous cell carcinoma (ESCC) to identify putative chemo...

journal_title：Carcinogenesis

authors： Chen T,Rose ME,Hwang H,Nines RG,Stoner GD

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected becaus...

journal_title：Carcinogenesis

authors： Truong T,Sauter W,McKay JD,Hosgood HD 3rd,Gallagher C,Amos CI,Spitz M,Muscat J,Lazarus P,Illig T,Wichmann HE,Bickeböller H,Risch A,Dienemann H,Zhang ZF,Naeim BP,Yang P,Zienolddiny S,Haugen A,Le Marchand L,Hong YC

更新日期：2010-04-01 00:00:00

abstract：:Studies with experimental animals indicate that acetaldehyde, the first metabolite of ethanol that is microbially formed in the colonic lumen, may play a role in ethanol-associated colorectal co-carcinogenesis. Although intracoIonic acetaldehyde concentrations are highest during the metabolism of exogenous ethanol, so...

journal_title：Carcinogenesis

authors： Koivisto T,Salaspuro M

更新日期：1998-11-01 00:00:00

abstract：:Alternative pre-messenger RNA (mRNA) splicing is a key molecular event that allows for protein diversity and plays important roles in development and disease. Alternative pre-mRNA splicing regulations during spermatogenesis and alternative pre-mRNA splicing etiology in testicular tumorigenesis are yet to be characteri...

journal_title：Carcinogenesis

authors： He C,Zuo Z,Chen H,Zhang L,Zhou F,Cheng H,Zhou R

更新日期：2007-12-01 00:00:00

abstract：:This study evaluated the influence of genetic polymorphisms in the microsomal epoxide hydrolase (mEPHX) gene on lung cancer risk in a case-control study of two different ethnic groups, Mexican-Americans and African-Americans. There were 138 lung cancer cases (60 Mexican-American and 78 African-American) and 148 contro...

journal_title：Carcinogenesis

authors： Wu X,Gwyn K,Amos CI,Makan N,Hong WK,Spitz MR

更新日期：2001-06-01 00:00:00

abstract：:Our previous report demonstrated that RSK2 plays an important role in cell proliferation and transformation induced by tumor promoters such as epidermal growth factor mediated through the N-terminal kinase domain of RSK2 in JB6 Cl41 mouse skin epidermal cells in vitro. However, no direct evidence has been reported reg...

journal_title：Carcinogenesis

authors： Cho YY,Lee MH,Lee CJ,Yao K,Lee HS,Bode AM,Dong Z

更新日期：2012-12-01 00:00:00

abstract：:Basic in vitro systems can be used to model and assess complex diseases, such as cancer. Recent advances in this field include the incorporation of multiple cell types and extracellular matrix proteins into three-dimensional (3D) models to recapitulate the structure, organization and functionality of live tissue in si...

journal_title：Carcinogenesis

authors： Herrmann D,Conway JR,Vennin C,Magenau A,Hughes WE,Morton JP,Timpson P

更新日期：2014-08-01 00:00:00

abstract：:DNA damage induced by tetrachlorohydroquinone (Cl(4)HQ), the quinonoid metabolite of pentachlorophenol (PCP), was investigated in human HeLa S3 tumor cells. Formation of one major and two minor DNA adducts in cells treated with Cl(4)HQ (50-300 microM) was detected by (32)P-post-labeling assay and the adducts accumulat...

journal_title：Carcinogenesis

authors： Lin PH,Nakamura J,Yamaguchi S,La DK,Upton PB,Swenberg JA

更新日期：2001-04-01 00:00:00

abstract：:The coordinate regulation of DNA synthesis and suppression of apoptosis was investigated in a rat hepatocyte cell culture system which supports high level induction of DNA synthesis by the peroxisome proliferator, methylclofenapate (MCP) (Plant, N.J. et al., 1998, Carcinogenesis, 19, 925-931). The peroxisome prolifera...

journal_title：Carcinogenesis

authors： Plant NJ,Horley NJ,Dickins M,Hasmall S,Elcombe CR,Bell DR

更新日期：1998-09-01 00:00:00

abstract：:The polysubstituted benzamide derivative metoclopramide (MCA) has previously been shown to enhance the effect of cisplatin and ionizing radiation treatment of xenografted human squamous cell carcinomas from the head and neck region. In the present work we show that MCA decreases the nucleoid sedimentation rate, indica...

journal_title：Carcinogenesis

authors： Lybak S,Pero RW

更新日期：1991-09-01 00:00:00

abstract：:Excess consumption of trans-fatty acid (TFA), an unsaturated fatty acid containing trans double bonds, is a major risk factor for cardiovascular disease and metabolic syndrome. However, little is known about the link between TFA and hepatocellular carcinoma (HCC) despite it being a frequent form of cancer in humans. I...

journal_title：Carcinogenesis

authors： Hu X,Wang X,Jia F,Tanaka N,Kimura T,Nakajima T,Sato Y,Moriya K,Koike K,Gonzalez FJ,Nakayama J,Aoyama T

更新日期：2020-04-22 00:00:00

abstract：:The aim of this work was to optimize the ionic strength (tau) in the liver microsomal assay (LMA) in performing short-term genotoxicity tests. tau optimization would increase the sensitivity (i.e. decrease false negatives) and at the same time increase the specificity (decrease false positives). Such optimization depe...

journal_title：Carcinogenesis

authors： Paolini M,Mesirca R,Pozzetti L,Silingardi P,Grilli S,Cantelli-Forti G

更新日期：1992-08-01 00:00:00

abstract：:Insulin-like growth factor-binding protein (IGFBP)-3 is overexpressed frequently in esophageal squamous cell carcinoma. Yet, the role of IGFBP3 in esophageal tumor biology remains to be elucidated. We find that IGFBP3 facilitates transforming growth factor (TGF)-beta1-mediated epithelial-to-mesenchymal transition (EMT...

journal_title：Carcinogenesis

authors： Natsuizaka M,Ohashi S,Wong GS,Ahmadi A,Kalman RA,Budo D,Klein-Szanto AJ,Herlyn M,Diehl JA,Nakagawa H

更新日期：2010-08-01 00:00:00

abstract：:Gene-environment interactions play an important role in folate metabolism, with a potential impact on human health. Deficiencies in the uptake of key micronutrients and variant genotypes can affect the folic acid cycle, modulating methyl group transfer in key processes and leading to increased cancer risk and Down syn...

journal_title：Carcinogenesis

authors： Zijno A,Andreoli C,Leopardi P,Marcon F,Rossi S,Caiola S,Verdina A,Galati R,Cafolla A,Crebelli R

更新日期：2003-06-01 00:00:00

abstract：:The enzyme O6-methylguanine-DNA methyltransferase repairs alkylation-induced DNA damage, O6-methylguanine and O4-methylthymine, the former being formed more frequently. Previously, by means of gene targeting, we generated mice in which alleles for methyltransferase were disrupted. We now use these mouse lines, which a...

journal_title：Carcinogenesis

authors： Iwakuma T,Sakumi K,Nakatsuru Y,Kawate H,Igarashi H,Shiraishi A,Tsuzuki T,Ishikawa T,Sekiguchi M

更新日期：1997-08-01 00:00:00

abstract：:The addition of supplementary cytosolic fraction greatly enhances the activation of 2-acetylaminofluorene (AAF) by uninduced 9,000 x g supernatant fractions (S9) in the Ames test. Uninduced S9 is poor at activating AAF in the Ames test (although it is effective in the liquid based fluctuation test) probably because cy...

journal_title：Carcinogenesis

authors： Forster R,Green MH,Priestley A

更新日期：1981-01-01 00:00:00

abstract：:Previous studies have shown that 1- and 3-nitrobenzo[a]pyrene (NBaP) were mutagenic in the Salmonella reversion assay without exogenous activation and that 1-, 3- and 6-NBaP were mutagenic in the presence of hepatocytes or liver homogenate (S9). In the present study, 1-, 3- and 6-NBaP were tested for mutagenicity in C...

journal_title：Carcinogenesis

authors： Hass BS,Heflich RH,Schol HM,Chou MW,Fu PP,Casciano DA

更新日期：1986-04-01 00:00:00

abstract：:Although Epstein-Barr virus (EBV) infection is widely distributed, certain EBV-driven malignancies are geographically restricted. EBV-associated Burkitt's lymphoma (eBL) is endemic in children living in sub-Saharan Africa. This population is heavily exposed to food contaminated with the mycotoxin aflatoxin B1 (AFB1). ...

journal_title：Carcinogenesis

authors： Accardi R,Gruffat H,Sirand C,Fusil F,Gheit T,Hernandez-Vargas H,Le Calvez-Kelm F,Traverse-Glehen A,Cosset FL,Manet E,Wild CP,Tommasino M

更新日期：2015-11-01 00:00:00

abstract：:We have tested the hypothesis that the inhibition by hydroxyurea of repair patch ligation and chromatin rearrangement during u.v.-induced DNA excision repair results from a reduction in cellular deoxyribonucleotide concentrations and not from a direct effect of hydroxyurea on the repair process. Using permeable human ...

journal_title：Carcinogenesis

authors： Hunting DJ,Dresler SL

更新日期：1985-10-01 00:00:00

abstract：:Currently there is no well-defined biological parameter or marker to help define agents, doses, and dose schedules for human cancer chemoprevention trials. Induction of ornithine decarboxylase, the rate limiting enzyme in the polyamine biosynthetic pathway, has been shown to be an essential aspect of mouse skin tumor ...

journal_title：Carcinogenesis

authors： Loprinzi CL,Verma AK

更新日期：1985-11-01 00:00:00

abstract：:Interleukin 6 (IL6) is a key cytokine involved in the development and progression of inflammation-associated hepatocellular carcinoma (HCC). However, the mechanisms of IL6 action on HCC remain largely unknown. Proton and Ca(2+) are two intracellular messenger ions, which are believed to play a central role in tumorige...

journal_title：Carcinogenesis

authors： Xu J,Ji B,Wen G,Yang Y,Jin H,Liu X,Xie R,Song W,Song P,Dong H,Tuo B

更新日期：2016-03-01 00:00:00

abstract：:We hypothesized that superoxide from Kupffer cells (KC) contributes to hepatocarcinogenesis. p47phox(-/-) mice, deficient in phagocyte NADPH oxidase and superoxide generation, received a single dose of the hepatocarcinogen diethylnitrosamine (DEN). The following hepatic effects were observed at time points between 30 ...

journal_title：Carcinogenesis

authors： Teufelhofer O,Parzefall W,Kainzbauer E,Ferk F,Freiler C,Knasmüller S,Elbling L,Thurman R,Schulte-Hermann R

更新日期：2005-02-01 00:00:00

abstract：:Conversion of the 2'-deoxyguanosine (dG) residues in calf thymus DNA to 8-hydroxy-2'-deoxyguanosine (8-OH-dG) was achieved at physiological pH by treating the DNA with hydrogen peroxide (H2O2) in the presence of nickel(II) chloride (NiCl2). The effectiveness of this reaction was enhanced by L-histidine (His) which for...

journal_title：Carcinogenesis

authors： Dutta AK,Misra M,North SL,Kasprzak KS

更新日期：1992-02-01 00:00:00

abstract：:4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a major metabolite of the tobacco-specific pulmonary carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), has a chiral center but the tumorigenicity of the NNAL enantiomers has not been previously examined. In this study, we assessed the relative tumori...

journal_title：Carcinogenesis

authors： Upadhyaya P,Kenney PM,Hochalter JB,Wang M,Hecht SS

更新日期：1999-08-01 00:00:00