Porphyrin-mediated photosensitization has a weak tumor promoting activity in mouse skin: possible role of in situ-generated reactive oxygen species.

abstract：:Glucoraphanin in Brassica vegetables breaks down to either sulforaphane or sulforaphane nitrile depending on the conditions, and sulforaphane can be further conjugated with glutathione. Using a high-throughput microtitre plate assay and TaqMan real time quantitative RT-PCR to measure mRNA, we show that sulforaphane an...

journal_title：Carcinogenesis

authors： Basten GP,Bao Y,Williamson G

更新日期：2002-08-01 00:00:00

abstract：:Apurinic/apyrimidinic endonuclease/redox effector factor-1 (APE/Ref-1) is a multifunctional protein involved both in DNA base excision repair and redox regulation. Studies have suggested that abnormal Ref-1 levels and/or activities are associated with tumor progression and sensitivities to treatment, but no direct evi...

journal_title：Carcinogenesis

authors： Yang S,Misner BJ,Chiu RJ,Meyskens FL Jr

更新日期：2007-11-01 00:00:00

abstract：:Sprague-Dawley rats were treated with N-nitrosomorpholine (NNM) alone (7 weeks, 120 mg/l in drinking water), with NNM followed by phenobarbital (PB) (750 mg/l for 6 weeks) or PB alone. The livers from these animals were investigated for glycogen content and activities of glucose-6-phosphatase, glucose-6-phosphate dehy...

journal_title：Carcinogenesis

authors： Mayer D,Moore MA,Bannasch P

更新日期：1983-01-01 00:00:00

abstract：:Benzene is a well-characterized human carcinogen and clastogen still present in both the occupational and general environment. However, the levels of benzene encountered today are, in most cases, relatively low and new methods, more specific and sensitive than classical cytogenetics, are probably needed to assess if c...

journal_title：Carcinogenesis

authors： Surrallés J,Autio K,Nylund L,Järventaus H,Norppa H,Veidebaum T,Sorsa M,Peltonen K

更新日期：1997-04-01 00:00:00

abstract：:A defect in DNA repair coupled to anomalous DNA synthesis after induction of certain radiogenic DNA damage is suspected to underlie the radiosensitivity of cells from patients with ataxia-telangiectasia (A-T). The response of cultured skin fibroblasts from A-T patients and A-T heterozygotes to six agents inducing vari...

journal_title：Carcinogenesis

authors： Shiloh Y,Tabor E,Becker Y

更新日期：1983-10-01 00:00:00

abstract：:Nutritional deficiencies or imbalances are suspected contributory factors to several types of human cancers, and perhaps other human diseases related to long-term metabolic derangements. In order to study these more effectively in laboratory animals, it is suggested that the laboratory diets more closely mimic the nut...

journal_title：Carcinogenesis

authors： Newmark HL

更新日期：1987-07-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related mortality, with most cases attributed to tobacco smoking, in which nicotine-derived nitrosamine ketone (NNK) is the most potent lung carcinogen. The ADAM17 protease is responsible for the ectodomain shedding of many pro-tumorigenic cytokines, growth factors and recept...

journal_title：Carcinogenesis

authors： Saad MI,McLeod L,Yu L,Ebi H,Ruwanpura S,Sagi I,Rose-John S,Jenkins BJ

更新日期：2020-06-17 00:00:00

abstract：:Patients with inflammatory bowel diseases are at increased risk for colorectal cancer. Pharmacological inhibition of cyclooxygenase (COX) function exacerbates symptoms in colitis patients. Animal models of colitis using Cox-2-knockout mice and COX inhibitors also indicate that COX-2 has a protective role against colon...

journal_title：Carcinogenesis

authors： Ishikawa TO,Oshima M,Herschman HR

更新日期：2011-03-01 00:00:00

abstract：:Inhalation of diesel exhaust (DE), which contains soot particles with adsorbed mutagenic organic compounds, and its virtually mutagen-free soot particle analog, carbon black (CB), produce similar types and prevalences of pulmonary neoplasms in chronically exposed F344 rats. This result suggests that DE-induced neoplas...

journal_title：Carcinogenesis

authors： Swafford DS,Nikula KJ,Mitchell CE,Belinsky SA

更新日期：1995-05-01 00:00:00

abstract：:Previous studies have shown that TIPE1 inhibits tumor proliferation and metastasis in certain cancers; however, increased expression of TIPE1 is observed in cervical cancer cell lines and tissues, indicating it might exert a distinctive role in cervical cancer. Cell and xenograft tumorigenicity assays showed that TIPE...

journal_title：Carcinogenesis

authors： Zhao P,Pang X,Jiang J,Wang L,Zhu X,Yin Y,Zhai Q,Xiang X,Feng F,Xu W

更新日期：2019-06-10 00:00:00

abstract：:Progress in prostate cancer research has been hindered by the lack of well characterized, immortalized, human prostatic epithelial cell lines that express markers of normal prostatic epithelial cells and mimic normal growth and differentiation responses to androgens. The objectives of this study were to: (i) establish...

journal_title：Carcinogenesis

authors： Webber MM,Bello D,Kleinman HK,Wartinger DD,Williams DE,Rhim JS

更新日期：1996-08-01 00:00:00

abstract：:Metabolites of 15,16-dihydrocyclopenta[a]phenanthren-17-one and its 1- and 12-methyl homologues (all non-carcinogens) along with those from the 11-methyl and 11,12-dimethyl-17-ketones (carcinogens), produced in vitro by hepatic microsomes from methylcholanthrene induced rats, were separated by reverse phase h.p.l.c. I...

journal_title：Carcinogenesis

authors： Coombs MM,Russell JC,Jones JR,Ribeiro O

更新日期：1985-08-01 00:00:00

abstract：:The objective was to study the relationship between cyclin D1 gene (CCND1) polymorphism and lung cancer in the Chinese population. Blood samples of 182 cases and 185 controls were collected from a hospital based case-control study. PCR-SSCP was used to examine the G/A polymorphism in exon 4 of CCND1. The results showe...

journal_title：Carcinogenesis

authors： Qiuling S,Yuxin Z,Suhua Z,Cheng X,Shuguang L,Fengsheng H

更新日期：2003-09-01 00:00:00

abstract：:Liver microsomes from male Syrian golden hamsters and Sprague Dawley rats metabolize the cis and trans isomers of N-nitroso-2,6-dimethylmorpholine (NNDM) to N-nitroso-(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) as the major product detectable by h.p.l.c. The rates of total metabolism are similar for both the cis and tr...

journal_title：Carcinogenesis

authors： Kokkinakis D,Hollenberg PF,Scarpelli DG

更新日期：1984-08-01 00:00:00

abstract：:Spices and flavoring plants part rich in supposedly health-promoting phytochemicals are currently receiving much attention as a possible source of cancer chemopreventive compounds. Clove, the sun-dried unopened flower bud from the plant Syzygium aromaticum L. is a commonly used spice and food flavor. In the present wo...

journal_title：Carcinogenesis

authors： Banerjee S,Panda CK,Das S

更新日期：2006-08-01 00:00:00

abstract：:p90 Ribosomal S6 kinase (RSK) 4 is a serine-threonine kinase that belongs to the p90RSK family. RSK4 has been proposed as a tumor suppressor gene, related with anti-invasive activity, inhibition of the RAS-mitogen-activated protein kinase (MAPK) pathway and induction of senescence. Despite the related findings, little...

journal_title：Carcinogenesis

authors： López-Vicente L,Pons B,Coch L,Teixidó C,Hernández-Losa J,Armengol G,Ramon Y Cajal S

更新日期：2011-04-01 00:00:00

abstract：:Telomerase contributes to the infinite replicative potential of cancer cells by conferring proliferation and survival through the regulation of growth factors and apoptotic proteins. Although it is generally known that the phytoestrogen, genistein, has telomerase-repressing and anti-proliferative effects on various ca...

journal_title：Carcinogenesis

authors： Chau MN,El Touny LH,Jagadeesh S,Banerjee PP

更新日期：2007-11-01 00:00:00

abstract：:Glioblastoma (GBM) is amongst the most aggressive brain tumors with a dismal prognosis. Despite significant advances in the current multimodality therapy including surgery, postoperative radiotherapy (RT) and temozolomide (TMZ)-based concomitant and adjuvant chemotherapy (CT), tumor recurrence is nearly universal with...

journal_title：Carcinogenesis

authors： Vengoji R,Ponnusamy MP,Rachagani S,Mahapatra S,Batra SK,Shonka N,Macha MA

更新日期：2019-03-12 00:00:00

abstract：:The purpose of this study was to determine if decreasing dietary protein from 24% (high protein) to 5% casein (low protein), substituting sucrose and cornstarch isocalorifically for casein, would modify the activity of protein kinase C (PKC) alpha and beta isoenzymes, as well as the expression of PKC alpha, beta, delt...

journal_title：Carcinogenesis

authors： La Porta CA,Comolli R

更新日期：1995-05-01 00:00:00

abstract：:Glucosinolates are common components of cruciferous vegetables that can be hydrolyzed during food processing to yield isothiocyanates, some of which have been shown to inhibit the induction of mammary tumors in rats by 7,12-dimethyl-benz[a]anthracene. To determine how intact glucosinolates affect the metabolism of ben...

journal_title：Carcinogenesis

authors： Baird WM,Zennie TM,Ferin M,Chae YH,Hatchell J,Cassady JM

更新日期：1988-04-01 00:00:00

abstract：:Nitric oxide (NO) has been shown to induce double strand DNA breaks in Barrett's oesophagus (BO) and in other cancers has a role in invasion. The specific aims of this study were to investigate whether NO can induce invasion in cells representative of different stages of Barrett's progression and to determine possible...

journal_title：Carcinogenesis

authors： Clemons NJ,Shannon NB,Abeyratne LR,Walker CE,Saadi A,O'Donovan ML,Lao-Sirieix PP,Fitzgerald RC

更新日期：2010-09-01 00:00:00

abstract：:Transgenic mice containing one copy of hepatitis B virus (HBV) genome without the core gene and expressing hepatitis B surface antigen (HBsAg) were crossed with C3H/He mice. The F1 hybrids (approximately 50% HBV positive and approximately 50% HBV negative) were treated with a single dose of diethylnitrosamine (NDEA) o...

journal_title：Carcinogenesis

authors： Dragani TA,Manenti G,Farza H,Della Porta G,Tiollais P,Pourcel C

更新日期：1990-06-01 00:00:00

abstract：:Using conventional alkaline sucrose sedimentation analysis, we have compared the initial yield and subsequent enzymatic repair of DNA damage induced in cultured human [normal (GM38 and GM43) and xeroderma pigmentosum (XP12BE)] fibroblasts by the monofunctional alkylating agent methylmethanesulfonate (MMS). Exposure of...

journal_title：Carcinogenesis

authors： Mirzayans R,Liuzzi M,Paterson MC

更新日期：1988-12-01 00:00:00

abstract：:The rates of formation and disappearance of benzo[a]pyrene (B[a]P) DNA-adducts were analyzed in the epidermis of SENCAR mice over a 21-day time course. Mice were treated topically with 200 nmol/mouse of [3H]B[a]P at various times prior to sacrifice. The formation and disappearance of total adducts as well as individua...

journal_title：Carcinogenesis

authors： DiGiovanni J,Decina PC,Prichett WP,Fisher EP,Aalfs KK

更新日期：1985-05-01 00:00:00

abstract：:Currently there is no well-defined biological parameter or marker to help define agents, doses, and dose schedules for human cancer chemoprevention trials. Induction of ornithine decarboxylase, the rate limiting enzyme in the polyamine biosynthetic pathway, has been shown to be an essential aspect of mouse skin tumor ...

journal_title：Carcinogenesis

authors： Loprinzi CL,Verma AK

更新日期：1985-11-01 00:00:00

abstract：:Common genetic variation may play an important role in altering lung cancer risk. We conducted a pathway-based candidate gene evaluation to identify genetic variations that may be associated with lung cancer in a population-based case-control study in Xuan Wei, China (122 cases and 111 controls). A total of 1260 singl...

journal_title：Carcinogenesis

authors： Hosgood HD 3rd,Menashe I,Shen M,Yeager M,Yuenger J,Rajaraman P,He X,Chatterjee N,Caporaso NE,Zhu Y,Chanock SJ,Zheng T,Lan Q

更新日期：2008-10-01 00:00:00

abstract：:Whole-body autoradiography of [3H]aflatoxin B1 ([3H]AFB1) in lamb showed a localization of bound labelling, in addition to the liver, in the nasal olfactory and respiratory mucosa, in the mucosa of the nasopharynx, pharynx, oesophagus, larynx, trachea, bronchi and bronchioles and in the palpebral and bulbar conjunctiv...

journal_title：Carcinogenesis

authors： Larsson P,Busk L,Tjälve H

更新日期：1994-05-01 00:00:00

abstract：:Overexpressed DNA methyltransferase 1 (DNMT1) strongly contributes to tumor suppressor gene silencing in colorectal cancer (CRC). However, the underlying mechanism of DNMT1 overexpression is still unclear. MicroRNAs (miRNA) have been implicated as gene regulators controlling diverse biological processes, including car...

journal_title：Carcinogenesis

authors： Wang H,Wu J,Meng X,Ying X,Zuo Y,Liu R,Pan Z,Kang T,Huang W

更新日期：2011-07-01 00:00:00

abstract：:The possibility that long-term exposure to relatively weak power frequency magnetic fields (MFs) emanating from the generation, transmission and use of electricity could increase the risk of breast cancer is a matter of ongoing debate. Laboratory studies using well-defined exposure conditions are useful to examine whe...

journal_title：Carcinogenesis

authors： Fedrowitz M,Löscher W

更新日期：2008-01-01 00:00:00

abstract：:Dose-response relationships in the induction of urinary bladder cancer in male C57BL/6 x DBA/2-F1 (BDF) mice by intragastric instillation of N-butyl-N-(4-hydroxybutyl)nitrosamine (OH-BBN) were studied. Administration of a total dose of 0 to 80 mg OH-BBN in 10 weekly fractions to groups of 25 mice resulted in a linear ...

journal_title：Carcinogenesis

authors： McCormick DL,Ronan SS,Becci PJ,Moon RC

更新日期：1981-01-01 00:00:00