Dose and schedule of oral retinoic acid and indomethacin needed to effectively inhibit phorbol ester-induced epidermal ornithine decarboxylase activity.

abstract：:Previous studies have shown that in addition to serving as a target for covalent adduct formation, purified DNA catalyzes the detoxification of (+/-)-7r,8t-dihydroxy-9t,10t-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE). To begin to relate these in vitro findings with the processes important in carcinogenesis in vivo, w...

journal_title：Carcinogenesis

authors： Dock L,MacLeod MC

更新日期：1986-04-01 00:00:00

abstract：:To test the hypothesis that aberrations of DNA repair contribute to susceptibility for the progression of gastroesophageal reflux disease (GERD) into Barrett esophagus (BE) and esophageal adenocarcinoma (EADC), we studied the frequency of polymorphisms of selected DNA repair genes in patients with GERD (n = 126), BE (...

journal_title：Carcinogenesis

authors： Casson AG,Zheng Z,Evans SC,Veugelers PJ,Porter GA,Guernsey DL

更新日期：2005-09-01 00:00:00

abstract：:Multicellular tumor spheroids (MCTSs) constitute a three-dimensional culture system that recapitulates the in vivo tumor microenvironment. Tumor cells cultured as MCTSs present antineoplastic resistance due to the effect of microenvironmental signals acting upon them. In this work, we evaluated the biological function...

journal_title：Carcinogenesis

authors： García-Venzor A,Mandujano-Tinoco EA,Ruiz-Silvestre A,Sánchez JM,Lizarraga F,Zampedri C,Melendez-Zajgla J,Maldonado V

更新日期：2020-11-13 00:00:00

abstract：:Alterations in the Rb pathway have been described in many different tumors. In order to study this cell cycle regulatory mechanism in murine T cell lymphomas, we have analyzed the RNA and protein expression of the cyclin D1, cdk4 and retinoblastoma genes in primary tumor samples. We have detected overexpression of the...

journal_title：Carcinogenesis

authors： Pérez de Castro IP,Malumbres M,Santos J,Pellicer A,Fernández-Piqueras J

更新日期：1999-09-01 00:00:00

abstract：:5,9-Dimethyldibenzo[c,g]carbazole (DMDBC), a potent mouse hepatocarcinogen, has been shown to induce a non-linear increase in mutant frequency in the liver of the transgenic MutaMouse. To gain insight into the mechanisms underlying the mutagenicity of DMDBC in vivo, DNA damage formation and removal were monitored in m...

journal_title：Carcinogenesis

authors： Renault D,Brault D,Lossouarn Y,Périn-Roussel O,Taras-Valéro D,Périn F,Thybaud V

更新日期：2000-02-01 00:00:00

abstract：:Overexpression of ectopic mutant p53 represses wild-type p53-stimulated transcription, known as a dominant negative effect. On the other hand, overexpression of wild-type p53 can repress transcription stimulated by several transcription factors, including hypoxia-inducible factor-1 (HIF-1). Using a panel of well-chara...

journal_title：Carcinogenesis

authors： Blagosklonny MV,Giannakakou P,Romanova LY,Ryan KM,Vousden KH,Fojo T

更新日期：2001-06-01 00:00:00

abstract：:The carcinogenic effects of in utero exposure to 3-methylcholanthrene (MC) have been demonstrated in the tumor-resistant C57BL/6 (B6) and DBA (D2) strains of mice. In this study, we determined the effects of in utero exposure to MC in BALB/c mice, a strain which demonstrates greater susceptibility to lung tumor induct...

journal_title：Carcinogenesis

authors： Gressani KM,Leone-Kabler S,O'Sullivan MG,Case LD,Malkinson AM,Miller MS

更新日期：1999-11-01 00:00:00

abstract：:A dose-dependent and transiently elevated expression of a cytoplasmic 32 kDa protein was observed in Swiss albino 3T3 fibroblasts exposed to mainstream cigarette smoke (CS) trapped in phosphate-buffered saline solutions (smoke-bubbled PBS). The protein was identified as heme oxygenase (HO) (heme, hydrogen donor:oxygen...

journal_title：Carcinogenesis

authors： Müller T,Gebel S

更新日期：1994-01-01 00:00:00

abstract：:The spectrum of mutations induced by N-acetoxy-N-acetyl-2-aminofluorene (N-AcO-AAF) was examined by the pZipHprtNeo shuttle vector in mammalian cells. The vector carries a cDNA of the human hypoxanthine phosphoribosyl transferase (hprt) gene, which is stably integrated into chromosomal DNA of a mouse cell line, VH12. ...

journal_title：Carcinogenesis

authors： Ogawa HI,Kimura H,Koya M,Higuchi H,Kato T

更新日期：1993-11-01 00:00:00

abstract：:Several studies have shown that hexavalent chromium [Cr(VI)] induces apoptosis in a variety of in vitro test systems. We instilled intra-tracheally either saline or sodium dichromate (0.25 mg/kg body weight), for three consecutive days, to Sprague-Dawley rats. TUNEL analyses showed a marked increase of the apoptotic i...

journal_title：Carcinogenesis

authors： D'Agostini F,Izzotti A,Bennicelli C,Camoirano A,Tampa E,De Flora S

更新日期：2002-04-01 00:00:00

abstract：:Recent evidence demonstrates the existence of diversified microbiota in the lung. However, the effect of lung carcinogenesis on the flora in lung microenvironment has yet not been well investigated. In this study, we surveyed the microbial composition and diversity in lung tumor and paired adjacent normal tissues obta...

journal_title：Carcinogenesis

authors： Mao Q,Ma W,Wang Z,Liang Y,Zhang T,Yang Y,Xia W,Jiang F,Hu J,Xu L

更新日期：2020-08-12 00:00:00

abstract：:The organochlorine pesticides chlordane and heptachlor were demonstrated to be liver neoplasm promoters in mice. Male B6C3F1 mice exposed to diethylnitrosamine (DEN) for 14 weeks followed by 25 weeks on control diet developed a 40% incidence of liver neoplasms whereas those given chlordane or heptachlor afterwards had...

journal_title：Carcinogenesis

authors： Williams GM,Numoto S

更新日期：1984-12-01 00:00:00

abstract：:Woodchuck (Marmota monax) hepatic cells, which were immortalized by the simian virus 40 large T antigen (SV40 Tag) produced nitric oxide (NO; measured as nitrite) in vitro from L-arginine (L-Arg) after lipopolysaccharide (LPS) treatment. NO synthesis was related to L-Arg and LPS concentration and plateaued at 1.0 mM L...

journal_title：Carcinogenesis

authors： Liu RH,Jacob JR,Hotchkiss JH,Tennant BC

更新日期：1993-08-01 00:00:00

abstract：:The hypolipidaemic drug nafenopin (NAF) has been shown to enhance the hepatocarcinogenic effect of N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine in rats. We have investigated whether the NAF-induced peroxisome proliferation in hepatocytes interferes with NDMA's metabolism and interaction with DNA. Adult male...

journal_title：Carcinogenesis

authors： Wiestler OD,Schmerold I,Fringes B,Volk B,Kleihues P

更新日期：1985-09-01 00:00:00

abstract：:The role of nitric oxide (NO) in colon cancer remains controversial. Inducible nitric oxide synthase (iNOS) has been reported to be up regulated and down regulated in colorectal cancer in both animal models and patient tissue samples. Cyclooxygenase-2 (COX-2) is important in colorectal carcinogenesis but its relations...

journal_title：Carcinogenesis

authors： Liu Q,Chan ST,Mahendran R

更新日期：2003-04-01 00:00:00

abstract：:Transgenic mice containing one copy of hepatitis B virus (HBV) genome without the core gene and expressing hepatitis B surface antigen (HBsAg) were crossed with C3H/He mice. The F1 hybrids (approximately 50% HBV positive and approximately 50% HBV negative) were treated with a single dose of diethylnitrosamine (NDEA) o...

journal_title：Carcinogenesis

authors： Dragani TA,Manenti G,Farza H,Della Porta G,Tiollais P,Pourcel C

更新日期：1990-06-01 00:00:00

abstract：:The role of haplotypes and the interaction of haplotypes and smoking in lung cancer risk have not been well characterized. We analyzed data from an Italian population-based, case-control study with 1815 lung cancer patients and 1959 healthy controls in discovery, and performed a validation using a case-control study w...

journal_title：Carcinogenesis

authors： Ji X,Gui J,Han Y,Brennan P,Li Y,McKay J,Caporaso NE,Bertazzi PA,Landi MT,Amos CI

更新日期：2015-11-01 00:00:00

abstract：:Reduced DNA repair capacity of carcinogen-induced DNA damage is now thought to significantly influence inherent susceptibility to lung cancer. DNA-dependent protein kinase (DNA-PK) is a serine-threonine kinase activated by the presence of double-strand breaks in DNA that appears to play a major role in non-homologous ...

journal_title：Carcinogenesis

authors： Auckley DH,Crowell RE,Heaphy ER,Stidley CA,Lechner JF,Gilliland FD,Belinsky SA

更新日期：2001-05-01 00:00:00

abstract：:The expression of CYP1B1 in human mammary fibroblasts (HMFs) was characterized as a potential modulator of their individual function as well as effects on adjacent mammary epithelia. We have used these characteristics to explore the diversity of fibroblast cells isolated from reduction mammoplasty patients and from di...

journal_title：Carcinogenesis

authors： Eltom SE,Larsen MC,Jefcoate CR

更新日期：1998-08-01 00:00:00

abstract：:Benzo[a]pyrene diol epoxide (BPDE)-DNA adducts are involved in the induction of p53 mutations and probably in the causation of human lung cancer associated with cigarette smoking. The ratio between CYP1A1 and GST enzyme activities is a critical determinant of the target dose of carcinogenic BPDE and other DNA-reactive...

journal_title：Carcinogenesis

authors： Alexandrov K,Cascorbi I,Rojas M,Bouvier G,Kriek E,Bartsch H

更新日期：2002-12-01 00:00:00

abstract：:Breast cancer is a leading cause of cancer-related mortality in women. Triple-negative breast cancer (TNBC; HER2-, ER-/PR-) is an aggressive subtype prone to drug resistance and metastasis, which is characterized by high intratumor microvascular density (iMVD) resulting from angiogenesis. However, the mechanisms contr...

journal_title：Carcinogenesis

authors： Kumar N,Prasad P,Jash E,Jayasundar S,Singh I,Alam N,Murmu N,Somashekhar SP,Goldman A,Sehrawat S

更新日期：2018-10-08 00:00:00

abstract：:5-Aminolevulinic acid (ALA), a heme precursor accumulated in chemical and inborn porphyrias, may behave as an endogenous pro-oxidant. In chronically treated rats (40 mg ALA/kg body wt every 2 days for 15 days) the steady-state level of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in liver DNA (94.5 +/- 23.3 residues/10(6) dG)...

journal_title：Carcinogenesis

authors： Fraga CG,Onuki J,Lucesoli F,Bechara EJ,Di Mascio P

更新日期：1994-10-01 00:00:00

abstract：:N-nitrosopiperidine (NPIP) is a potent esophageal carcinogen in rats whereas structurally similar N-nitrosopyrrolidine (NPYR) induces liver, but not esophageal tumors. NPIP is a possible causative agent for human esophageal cancer. Our goal is to explain mechanistically these differing carcinogenic activities in the e...

journal_title：Carcinogenesis

authors： Wong HL,Murphy SE,Wang M,Hecht SS

更新日期：2003-02-01 00:00:00

abstract：:Staurosporine (stsp) is a kinase inhibitor which induces cornified envelope assembly and terminal differentiation in normal and neoplastic mouse keratinocytes. In the tumorigenic cell lines 308 and SP-1 experiments were performed to determine if this effect was due only to activation of transglutaminases (TGases) alre...

journal_title：Carcinogenesis

authors： Stanwell C,Dlugosz AA,Yuspa SH

更新日期：1996-06-01 00:00:00

abstract：:Alcohol is a major risk factor for oesophageal squamous cell carcinoma (OSCC), the most prevalent histological subtype of oesophageal cancer (OC) worldwide. The metabolism of alcohol is regulated by specific enzymes whose activity and expression is influenced by genetic polymorphisms. We conducted a systematic review ...

journal_title：Carcinogenesis

authors： Matejcic M,Gunter MJ,Ferrari P

更新日期：2017-09-01 00:00:00

abstract：:The present study was designed to evaluate whether etodolac, a cyclooxgenase-2 (COX-2)-specific inhibitor, could prevent chemically induced biliary carcinogenesis in bilioenterostomized hamsters. Syrian golden hamsters were subjected to choledochojejunostomy and then received subcutaneous injections of N-nitrosobis(2-...

journal_title：Carcinogenesis

authors： Tsuneoka N,Tajima Y,Kitazato A,Fukuda K,Kitajima T,Kuroki T,Onizuka S,Kanematsu T

更新日期：2005-02-01 00:00:00

abstract：:Measurement of carcinogen DNA adducts in blood has been used as a surrogate for the target lung tissue. We aimed to examine whether genetic polymorphisms in several metabolic pathway genes modify the relation between DNA adducts in target lung and blood. One hundred and thirty-five early-stage lung cancer patients fro...

journal_title：Carcinogenesis

authors： Lee MS,Su L,Mark EJ,Wain JC,Christiani DC

更新日期：2010-12-01 00:00:00

abstract：:It is estimated that one-third of Americans use dietary herbal supplements on a regular basis. Diets rich in bioactive phytochemicals are associated with reduced risk of certain cancers, notably, colon cancer. Herbal supplements have not been directly tested as sources of bioactive cancer preventives. Hence, this stud...

journal_title：Carcinogenesis

authors： Volate SR,Davenport DM,Muga SJ,Wargovich MJ

更新日期：2005-08-01 00:00:00

abstract：:In recent years, considerable emphasis has been placed on identifying new cancer chemopreventive agents which could be useful for human populations. Silymarin, an anti-oxidant flavonoid isolated from artichoke, has been shown to possess significant activity against hepatotoxicity and other pharmacological and physiolo...

journal_title：Carcinogenesis

authors： Agarwal R,Katiyar SK,Lundgren DW,Mukhtar H

更新日期：1994-06-01 00:00:00

abstract：:Despite advances in detection and treatment for breast cancer (BC), recurrence and death rates remain unacceptably high. Therefore, more convenient diagnostic and prognostic methods still required to optimize treatments among the patients. Here, we report the clinical significance of the serum cathepsin E (CatE) activ...

journal_title：Carcinogenesis

authors： Kawakubo T,Yasukochi A,Toyama T,Takahashi S,Okamoto K,Tsukuba T,Nakamura S,Ozaki Y,Nishigaki K,Yamashita H,Yamamoto K

更新日期：2014-03-01 00:00:00