Abstract:
:2-Nitrofluorene (NF) is a potent genotoxic substance found in environments where incomplete combustion takes place. NF is a mutagen and a carcinogen in animal models. NF or 7,12-dimethylbenz[a]anthracene (DMBA) was administered once topically to female SENCAR mice followed by promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) in two different studies. TPA (2-5 micrograms) was administered twice a week for 13 or 19 weeks after initiation of DMBA (5-10 micrograms) or NF (50-1500 micrograms). DMBA administration (positive control) resulted in the formation of many papillomas, which were seen from week 8-9 after initiation. The negative controls administered acetone only were free of tumours. NF administration did not result in papilloma formation, even at high initiating doses of NF combined with a dose of TPA causing a systemic toxic effect in terms of a significant reduced body weight. The mechanism behind the absence of papilloma formation after administration of genotoxic and carcinogenic NF remains to be investigated.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Möller L,Zeisig M,Toftgård Rdoi
10.1093/carcin/14.8.1723subject
Has Abstractpub_date
1993-08-01 00:00:00pages
1723-5issue
8eissn
0143-3334issn
1460-2180journal_volume
14pub_type
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