Increased activities of thymidine kinase isozymes in human colon polyp and carcinoma.

abstract：:Sulindac, a widely used non-steroidal anti-inflammatory drug (NSAID), has been shown to inhibit chemically induced carcinogenesis in animal models. In the present study, we have investigated the molecular mechanism by which sulindac affects the activity and expression of the enzymes that mediate the initial detoxifica...

journal_title：Carcinogenesis

authors： Ciolino HP,MacDonald CJ,Memon OS,Bass SE,Yeh GC

更新日期：2006-08-01 00:00:00

abstract：:Wnt signaling plays a central role in mammary stem cell (MaSC) homeostasis and in breast cancer. In particular, epigenetic alterations at different members of the Wnt pathway have been identified among triple-negative, basal-like breast cancers. Previously, we developed a mouse model for metaplastic breast adenocarcin...

journal_title：Carcinogenesis

authors： Monteiro J,Gaspar C,Richer W,Franken PF,Sacchetti A,Joosten R,Idali A,Brandao J,Decraene C,Fodde R

更新日期：2014-01-01 00:00:00

abstract：:In the present study the modulating effects of dietary fish oil (MaxEPA) on unsaturated fat-promoted pancreatic carcinogenesis in azaserine-treated rats were investigated. Three groups of 20 rats (each group comprised five saline-treated and 15 azaserine-treated animals) were fed an AIN76-based purified diet containin...

journal_title：Carcinogenesis

authors： Appel MJ,Woutersen RA

更新日期：1994-10-01 00:00:00

abstract：:The high incidence of oesophageal cancer in Northern Iran has been associated with opium. N-Nitrosamines are the only carcinogens known to induce oesophageal cancer in animals. Ethanol, which is the major influence on oesophageal cancer incidence in the West, inhibits the first pass clearance of N-nitrosodimethylamine...

journal_title：Carcinogenesis

authors： Ribeiro Pinto LF,Swann PF

更新日期：1997-02-01 00:00:00

abstract：:Metabolomic analysis of feces may provide insights on colorectal cancer (CRC) if assay performance is satisfactory. In lyophilized feces from 48 CRC cases, 102 matched controls, and 48 masked quality control specimens, 1043 small molecules were detected with a commercial platform. Assay reproducibility was good for 52...

journal_title：Carcinogenesis

authors： Goedert JJ,Sampson JN,Moore SC,Xiao Q,Xiong X,Hayes RB,Ahn J,Shi J,Sinha R

更新日期：2014-09-01 00:00:00

abstract：:Previous studies have demonstrated that O6-methylguanine-DNA methyltransferase (MGMT) is a major contributor to tumor cellular resistance toward chloroethylnitrosoureas. To further clarify the effect of MGMT gene expression on cellular chemosensitivity to 1-(4-amino-2-methyl-5-pyrimidinyl)-3-(2-chloroethyl)-3-nitrosou...

journal_title：Carcinogenesis

authors： Yang J,Chen JM,Zhang YP

更新日期：1995-09-01 00:00:00

abstract：:The potential carcinogenic activity of 5,6-dimethoxysterigmatocystin (DMSC) was examined by oral administration in rats. In Experiment I, all of eight effective ACI/N rats given DMSC in the diet at a concentration of 50 p.p.m. developed neoplastic nodules of the liver. Five rats developed hepatocellular carcinomas and...

journal_title：Carcinogenesis

authors： Mori H,Sugie S,Yoshimi N,Kuniyasu T,Iwata H,Kawai K,Hamasaki T

更新日期：1988-06-01 00:00:00

abstract：:Ultraconserved elements (UCEs) are segments of >200 bp length showing absolute sequence identity between orthologous regions of human, rat and mouse genomes. The selection factors acting on these UCEs are still unknown. Recent studies have shown that UCEs function as long-range enhancers of flanking genes or are invol...

journal_title：Carcinogenesis

authors： Yang R,Frank B,Hemminki K,Bartram CR,Wappenschmidt B,Sutter C,Kiechle M,Bugert P,Schmutzler RK,Arnold N,Weber BH,Niederacher D,Meindl A,Burwinkel B

更新日期：2008-02-01 00:00:00

abstract：:Although the alternative splicing of various genes is a common event in human tumors, the mechanisms behind it have not been characterized. We hypothesized that the expression of splicing regulatory factors would be changed during cellular transformation. Gene expression of three splicing regulatory factors, alternati...

journal_title：Carcinogenesis

authors： Maeda T,Hiranuma H,Jikko A

更新日期：1999-12-01 00:00:00

abstract：:The natural flavonoid quercetin has been suggested by epidemiological studies to have preventive activity against lung cancer; however, the mechanism of which has not been well elucidated. In this report, we demonstrate that quercetin significantly enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAI...

journal_title：Carcinogenesis

authors： Chen W,Wang X,Zhuang J,Zhang L,Lin Y

更新日期：2007-10-01 00:00:00

abstract：:There is no unique mechanism to explain the activity in animals of 'non-genotoxic' carcinogens. In this they differ from 'genotoxic' carcinogens that are DNA reactive. In the present study it is reported that non-mutagenic carcinogens, as a group, have significantly higher computed octanol/water partition coefficients...

journal_title：Carcinogenesis

authors： McCoy GD,Rosenkranz HS,Klopman G

更新日期：1990-07-01 00:00:00

abstract：UNLABELLED:Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2) is recognized as oncogenic and simulative role on tumorigenesis by virtue of abnormal expression in cancer including nasopharyngeal carcinoma (NPC). We hypothesized that the copy number variation (CNV)-30450, which duplicates the MAPKAPK2...

journal_title：Carcinogenesis

authors： Yang L,Liu B,Qiu F,Huang B,Li Y,Huang D,Yang R,Yang X,Deng J,Jiang Q,Zhou Y,Lu J

更新日期：2014-01-01 00:00:00

abstract：:Tobacco-specific nitrosamines are a group of carcinogens that are present in tobacco and tobacco smoke. They are formed from nicotine and related tobacco alkaloids. Two of the nicotine-derived nitrosamines, NNK and NNN, are strong carcinogens in laboratory animals. They can induce tumors both locally and systemically....

journal_title：Carcinogenesis

authors： Hecht SS,Hoffmann D

更新日期：1988-06-01 00:00:00

abstract：:Thioredoxin-1 is a low molecular weight redox protein that protects cells against oxidant damage. Thioredoxin-1 levels are increased in the epidermal layer of sun-damaged human skin. Thioredoxin-1 levels are also increased in several human primary tumors where its expression is associated with increased tumor cell pro...

journal_title：Carcinogenesis

authors： Mustacich D,Wagner A,Williams R,Bair W,Barbercheck L,Stratton SP,Bhattacharyya AK,Powis G

更新日期：2004-10-01 00:00:00

abstract：:Mutant RAS (RAS(V12)) is known to transform most immortal cells but to induce premature senescence in primary cells. RAS(V12)-induced senescence in murine cells depends on the induction of the ARF/p53 and the retinoblastoma (Rb) family tumor suppressor pathways. We and others have shown previously that oncogene-induce...

journal_title：Carcinogenesis

authors： Vredeveld LC,Rowland BD,Douma S,Bernards R,Peeper DS

更新日期：2010-02-01 00:00:00

abstract：:The HSP70 family of heat shock proteins consists of molecular chaperones of approximately 70kDa in size that serve critical roles in protein homeostasis. These adenosine triphosphatases unfold misfolded or denatured proteins and can keep these proteins in an unfolded, folding-competent state. They also protect nascent...

journal_title：Carcinogenesis

authors： Murphy ME

更新日期：2013-06-01 00:00:00

abstract：:The reaction of chloroacetaldehyde, a reactive metabolic of the carcinogen vinyl chloride, with DNA produces in addition to the hitherto known adducts, 1,N6-ethenoadenine and 3,N4-ethenocytosine, an ethenoguanine adduct, namely N2,3-ethenoguanine. This adduct is formed in the reaction of chloroacetaldehyde with the fr...

journal_title：Carcinogenesis

authors： Oesch F,Doerjer G

更新日期：1982-01-01 00:00:00

abstract：:An intrasanguineous host-mediated assay was used to establish the mutagenic potential of a series of dialkylnitrosamines to E. coli K12/343/113 in the liver and spleen of mice. For calibrating purposes, dose- and time-dependent kinetics of mutation induction by the model compound diethylnitrosamine in this assay was d...

journal_title：Carcinogenesis

authors： Kerklaan P,Mohn G,Bouter S

更新日期：1981-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the leading causes for cancer related mortality worldwide. Poor prognosis of HCC patients is mainly due to frequent metastasis and recurrence. Deregulation of metastasis suppressors in malignant cells plays critical roles during cancer metastasis. Thus, novel metastasis suppres...

journal_title：Carcinogenesis

authors： Luo Q,Wang C,Jin G,Gu D,Wang N,Song J,Jin H,Hu F,Zhang Y,Ge T,Huo X,Chu W,Shu H,Fang J,Yao M,Gu J,Cong W,Qin W

更新日期：2015-10-01 00:00:00

abstract：:Previous studies have shown that in addition to serving as a target for covalent adduct formation, purified DNA catalyzes the detoxification of (+/-)-7r,8t-dihydroxy-9t,10t-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE). To begin to relate these in vitro findings with the processes important in carcinogenesis in vivo, w...

journal_title：Carcinogenesis

authors： Dock L,MacLeod MC

更新日期：1986-04-01 00:00:00

abstract：:The extracellular matrix (ECM) is known to play an active role in numerous biological processes such as differentiation, apoptosis and cancer. Extensive alterations of epithelial basement membranes and of interstitial ECM are known to occur during the progression of most invasive carcinomas. Collagen, which represents...

journal_title：Carcinogenesis

authors： Pucci-Minafra I,Andriolo M,Basiricò L,Alessandro R,Luparello C,Buccellato C,Garbelli R,Minafra S

更新日期：1998-04-01 00:00:00

abstract：:1,3-Butadiene (BD) is a more potent tumor inducer in mice than in rats. BD also shows striking differences in metabolic activation, with substantially higher blood concentrations of 1,2:3,4-diepoxybutane (butadiene diepoxide; BDE) in BD-exposed mice than in similarly exposed rats. The objective of this study was to de...

journal_title：Carcinogenesis

authors： Sweeney LM,Schlosser PM,Medinsky MA,Bond JA

更新日期：1997-04-01 00:00:00

abstract：:Arsenic is an established human carcinogen. Deficiencies in available animal models have inhibited a detailed analysis of the mechanism of arsenic induced cancer. This study sought to determine the role of a methyl-deficient diet in combination with sodium arsenite on the genomic methylation status and Ha-ras methylat...

journal_title：Carcinogenesis

authors： Okoji RS,Yu RC,Maronpot RR,Froines JR

更新日期：2002-05-01 00:00:00

abstract：:We investigated possible mechanisms associated with promotion of hepatocarcinogenesis by the synthetic estrogens mestranol (M) and ethinyl estradiol (EE). Our first objective was to determine whether chronic EE treatment was associated with hepatotoxicity accompanied by regenerative hyperplasia. Female Sprague-Dawley ...

journal_title：Carcinogenesis

authors： Yager JD,Roebuck BD,Paluszcyk TL,Memoli VA

更新日期：1986-12-01 00:00:00

abstract：:Cytochrome P4501A1 (CYP1A1) has been implicated in the conversion of numerous polycyclic aromatic hydrocarbons into electrophilic species capable of binding covalently to DNA and has therefore been postulated to be involved in the initiation of carcinogenesis. The expression of CYP1A1 protein appears not to be constit...

journal_title：Carcinogenesis

authors： Drahushuk AT,McGarrigle BP,Larsen KE,Stegeman JJ,Olson JR

更新日期：1998-08-01 00:00:00

abstract：:A number of drug-metabolizing systems were measured in hyperplastic noduli from the livers of rats receiving 2-acetyl-aminofluorene in their diet and compared with corresponding activities in control liver. The level of microsomal cytochrome P-450 is reduced 54% in the nodular tissue, while 5 activities catalyzed by t...

journal_title：Carcinogenesis

authors： Aström A,DePierre JW,Eriksson L

更新日期：1983-01-01 00:00:00

abstract：:As rat tracheal epithelial cells progress from a normal to a neoplastic phenotype there are systematic changes in their ability to produce and activate latent transforming growth factor type beta (TGF-beta) as well as systematic changes in their response to this growth factor. Using a TGF-beta radioreceptor binding co...

journal_title：Carcinogenesis

authors： Terzaghi-Howe M

更新日期：1989-06-01 00:00:00

abstract：:The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), is negatively correlated with tumor progression in multiple neoplasms, being a promising new target for cancer treatment. However, the precise molecular effects of NDRG1 remain unclear. Herein, we summarize recent advances in understanding the impac...

journal_title：Carcinogenesis

authors： Sun J,Zhang D,Bae DH,Sahni S,Jansson P,Zheng Y,Zhao Q,Yue F,Zheng M,Kovacevic Z,Richardson DR

更新日期：2013-09-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed in cooked meats and may be linked to dietary-associated colorectal, prostate and mammary cancers. Genotoxic N-oxidized metabolites of PhIP react with the Cys34 of albumin (Alb) to form a sulfinamide adduct, a biomarker of the biologically effective dose....

journal_title：Carcinogenesis

authors： Bellamri M,Wang Y,Yonemori K,White KK,Wilkens LR,Le Marchand L,Turesky RJ

更新日期：2018-12-31 00:00:00

abstract：:Cancer is a genetic disease in which the interplay between alterations in protein-coding genes and non-coding RNAs (ncRNAs) plays a fundamental role. In recent years, the full coding component of the human genome was sequenced in various cancers, whereas such attempts related to ncRNAs are still fragmentary. We screen...

journal_title：Carcinogenesis

authors： Wojcik SE,Rossi S,Shimizu M,Nicoloso MS,Cimmino A,Alder H,Herlea V,Rassenti LZ,Rai KR,Kipps TJ,Keating MJ,Croce CM,Calin GA

更新日期：2010-02-01 00:00:00