Cancer stemness in Wnt-driven mammary tumorigenesis.

abstract：:Aspirin- and non-steroidal anti-inflammatory drug (NSAID)-induced apoptosis is one of the important mechanisms for their anti-tumour effect in gastric cancer. We aimed at determining the role of bcl-2 family proteins and caspases in the apoptotic process. Gastric cancer cell lines AGS (wild-type p53) and MKN-28 (mutan...

journal_title：Carcinogenesis

authors： Zhou XM,Wong BC,Fan XM,Zhang HB,Lin MC,Kung HF,Fan DM,Lam SK

更新日期：2001-09-01 00:00:00

abstract：:Liver microsomes from male Syrian golden hamsters and Sprague Dawley rats metabolize the cis and trans isomers of N-nitroso-2,6-dimethylmorpholine (NNDM) to N-nitroso-(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) as the major product detectable by h.p.l.c. The rates of total metabolism are similar for both the cis and tr...

journal_title：Carcinogenesis

authors： Kokkinakis D,Hollenberg PF,Scarpelli DG

更新日期：1984-08-01 00:00:00

abstract：:A plant polysaccharide, Aloe gel extract, was reported to have an inhibitory effect on benzo[a]pyrene (B[a]P)-DNA adduct formation in vitro and in vivo. Hence, chemopreventive effects of plant polysaccharides [Aloe barbadensis Miller (APS), Lentinus edodes (LPS), Ganoderma lucidum (GPS) and Coriolus versicolor (CPS)] ...

journal_title：Carcinogenesis

authors： Kim HS,Kacew S,Lee BM

更新日期：1999-08-01 00:00:00

abstract：:The role of haplotypes and the interaction of haplotypes and smoking in lung cancer risk have not been well characterized. We analyzed data from an Italian population-based, case-control study with 1815 lung cancer patients and 1959 healthy controls in discovery, and performed a validation using a case-control study w...

journal_title：Carcinogenesis

authors： Ji X,Gui J,Han Y,Brennan P,Li Y,McKay J,Caporaso NE,Bertazzi PA,Landi MT,Amos CI

更新日期：2015-11-01 00:00:00

abstract：:Treatment of SV40-infected CV-1 cells with the ultimate carcinogen anti-benzo[a]pyrene diol epoxide (BPDE) at 1 X 10(-4) mg/ml or higher reduced the rate of viral DNA synthesis to an extent dependent on the BPDE concentration; similar reductions in cellular DNA synthesis were produced in infected and uninfected cells....

journal_title：Carcinogenesis

authors： Lockhart ML,Rosenberg BH

更新日期：1983-01-01 00:00:00

abstract：:Alternative splicing regulators have emerged as new players in cancer development, modulating the activities of many tumor suppressors and oncogenes and regulating the signaling pathways. However, little is known about the mechanisms by which these oncogenic splicing factors lead to cellular transformation. We have sh...

journal_title：Carcinogenesis

authors： Shimoni-Sebag A,Lebenthal-Loinger I,Zender L,Karni R

更新日期：2013-11-01 00:00:00

abstract：:TMPRSS4 is a novel type II transmembrane serine protease that is highly expressed on the cell surface in pancreatic, thyroid and other cancer tissues, although its oncogenic significance and molecular mechanisms are unknown. Previously, we have shown that TMPRSS4 promotes invasion, migration and metastasis of human tu...

journal_title：Carcinogenesis

authors： Kim S,Kang HY,Nam EH,Choi MS,Zhao XF,Hong CS,Lee JW,Lee JH,Park YK

更新日期：2010-04-01 00:00:00

abstract：:The relationship between striatal dopamine-stimulated adenylate cyclase (DAC) and 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors was studied. An inverse correlation between activity of this enzyme and the number and growth of tumors was observed in several strains and substrains of rats. Chronic, but not...

journal_title：Carcinogenesis

authors： Goldman PR,Vogel WH

更新日期：1984-07-01 00:00:00

abstract：:In order to develop more efficient in vitro systems for the study of pro-mutagenic or pro-carcinogenic chemicals, we have produced transgenic C3H/10T1/2 cell lines expressing human cytochrome P450 (CYP) 2A6. A retroviral vector containing the cDNA was packaged in psi-2 cells, and used to infect C3H/10T1/2 cells. From ...

journal_title：Carcinogenesis

authors： Tiano HF,Hosokawa M,Chulada PC,Smith PB,Wang RL,Gonzalez FJ,Crespi CL,Langenbach R

更新日期：1993-07-01 00:00:00

abstract：:Hypoxia-inducible factors (HIFs), in particular HIF-1alpha, have been implicated in tumor biology. However, HIF target genes in the esophageal tumor microenvironment remain elusive. Gene expression profiling was performed upon hypoxia-exposed non-transformed immortalized human esophageal epithelial cells, EPC2-hTERT, ...

journal_title：Carcinogenesis

authors： Lee JJ,Natsuizaka M,Ohashi S,Wong GS,Takaoka M,Michaylira CZ,Budo D,Tobias JW,Kanai M,Shirakawa Y,Naomoto Y,Klein-Szanto AJ,Haase VH,Nakagawa H

更新日期：2010-03-01 00:00:00

abstract：:The present study was conducted to clarify the cooperative significance of epigenomic and genomic abnormalities during gastric carcinogenesis. Using 21 samples of normal control gastric mucosa (C), 109 samples of non-cancerous gastric mucosa (N) and 105 samples of cancerous tissue (T) from 109 patients with primary ga...

journal_title：Carcinogenesis

authors： Yang M,Arai E,Takahashi Y,Totsuka H,Chiku S,Taniguchi H,Katai H,Sakamoto H,Yoshida T,Kanai Y

更新日期：2020-11-13 00:00:00

abstract：:The adaptor protein regulator for ubiquitous kinase/c-Cbl-interacting protein of 85kDa (Ruk/CIN85) was found to modulate HER1/EGFR signaling and processes like cell adhesion and apoptosis. Although these features imply a role in carcinogenesis, it is so far unknown how and by which molecular mechanisms Ruk/CIN85 could...

journal_title：Carcinogenesis

authors： Samoylenko A,Vynnytska-Myronovska B,Byts N,Kozlova N,Basaraba O,Pasichnyk G,Palyvoda K,Bobak Y,Barska M,Mayevska O,Rzhepetsky Y,Shuvayeva H,Lyzogubov V,Usenko V,Savran V,Volodko N,Buchman V,Kietzmann T,Drobot L

更新日期：2012-10-01 00:00:00

abstract：:The inhibitory effects of three phenolic compounds (ferulic, chlorogenic and ellagic acids) on benzo[a]pyrene- and 7,12-dimethylbenz[a]anthracene-induced neoplasia have been investigated in mice. Ellagic acid was the most potent antagonist of tumorigenesis since this compound is active, by i.p. administration or added...

journal_title：Carcinogenesis

authors： Lesca P

更新日期：1983-12-01 00:00:00

abstract：:Carcinogen treatment of cultured mammalian cells prior to infection with u.v.-irradiated virus results in enhanced virus survival and mutagenesis suggesting the induction of SOS-type processes. In this paper, we report the development of a primary rat hepatocyte culture system to investigate cellular responses to DNA ...

journal_title：Carcinogenesis

authors： Zurlo J,Yager JD

更新日期：1984-04-01 00:00:00

abstract：:Inhalation of diesel exhaust (DE), which contains soot particles with adsorbed mutagenic organic compounds, and its virtually mutagen-free soot particle analog, carbon black (CB), produce similar types and prevalences of pulmonary neoplasms in chronically exposed F344 rats. This result suggests that DE-induced neoplas...

journal_title：Carcinogenesis

authors： Swafford DS,Nikula KJ,Mitchell CE,Belinsky SA

更新日期：1995-05-01 00:00:00

abstract：:Skin is a major target of carcinogenic trivalent arsenic (arsenite, As3+). It has been thought that cell proliferation is one of the central events involved in the carcinogenic effect of arsenite. Cyclin D1, a nuclear protein playing a pivotal role in cell proliferation and cell cycle transition from G1 to S phases, h...

journal_title：Carcinogenesis

authors： Ouyang W,Li J,Ma Q,Huang C

更新日期：2006-04-01 00:00:00

abstract：UNLABELLED:Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2) is recognized as oncogenic and simulative role on tumorigenesis by virtue of abnormal expression in cancer including nasopharyngeal carcinoma (NPC). We hypothesized that the copy number variation (CNV)-30450, which duplicates the MAPKAPK2...

journal_title：Carcinogenesis

authors： Yang L,Liu B,Qiu F,Huang B,Li Y,Huang D,Yang R,Yang X,Deng J,Jiang Q,Zhou Y,Lu J

更新日期：2014-01-01 00:00:00

abstract：:To test the hypothesis that nucleotide excision repair (NER) plays a protective role in chemical carcinogenesis in internal organs, xeroderma pigmentosum group A gene-deficient (XPA(-/-)) mice, heterozygous (XPA(+/-)) and wild-type (XPA(+/+)) mice were orally administered 0.001% 4-nitroquinoline 1-oxide (4NQO) in thei...

journal_title：Carcinogenesis

authors： Ide F,Oda H,Nakatsuru Y,Kusama K,Sakashita H,Tanaka K,Ishikawa T

更新日期：2001-04-01 00:00:00

abstract：:Understanding the molecular pathways that contribute to the development of tamoxifen resistance is a critical research priority as acquired tamoxifen resistance is the principal cause of poor prognosis and death of patients with originally good prognosis hormone-responsive breast tumors. In this report, we provide evi...

journal_title：Carcinogenesis

authors： Nagalingam A,Tighiouart M,Ryden L,Joseph L,Landberg G,Saxena NK,Sharma D

更新日期：2012-04-01 00:00:00

abstract：:A hallmark of cancer is aberrant DNA methylation, consisting of global hypomethylation and regional hypermethylation of tumor suppressor genes. DNA methyltransferase inhibitors have been recognized as promising candidate anticancer drugs. Drug development has focused on DNA methylation inhibitors with the goal of acti...

journal_title：Carcinogenesis

authors： Chik F,Szyf M

更新日期：2011-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that are involved in different biological processes by suppressing target gene expression. Altered expression of miR-30a-5p has been reported in colon carcinoma. To elucidate its potential biological role in colon cancer, miR-30a-5p was overexpressed via a lentiviral vector...

journal_title：Carcinogenesis

authors： Baraniskin A,Birkenkamp-Demtroder K,Maghnouj A,Zöllner H,Munding J,Klein-Scory S,Reinacher-Schick A,Schwarte-Waldhoff I,Schmiegel W,Hahn SA

更新日期：2012-04-01 00:00:00

abstract：:The purpose of this study was to determine whether the level of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) (8-oxo-dG), a major mutagenic DNA oxidation product, is enhanced in newborn rat liver DNA as a consequence of oxidative stress incurred during the early postnatal period. 32P-postlabeling s...

journal_title：Carcinogenesis

authors： Randerath K,Zhou GD,Monk SA,Randerath E

更新日期：1997-07-01 00:00:00

abstract：:The role of nitric oxide (NO) in colon cancer remains controversial. Inducible nitric oxide synthase (iNOS) has been reported to be up regulated and down regulated in colorectal cancer in both animal models and patient tissue samples. Cyclooxygenase-2 (COX-2) is important in colorectal carcinogenesis but its relations...

journal_title：Carcinogenesis

authors： Liu Q,Chan ST,Mahendran R

更新日期：2003-04-01 00:00:00

abstract：:Iron exclusion has been used to identify foci of hepatocellular alteration (FHA) in rats exposed to known carcinogens. This study investigates whether basophilic FHA occurring spontaneously in aged female Fischer 344 rats also exclude iron. Female rats 514-544 days of age were given supplemental iron by injection for ...

journal_title：Carcinogenesis

authors： Stitzel KA,Horn PA,Ezra MF

更新日期：1990-12-01 00:00:00

abstract：:The ability of cytosolic 3-methylcholanthrene binding proteins from rat liver to interact with DNA was studied using DNA-cellulose chromatography. Two DNA binding fractions, eluting in 0.15 M KCl (peak 1) and 0.33 M KCl (peak 2), were observed on salt elution from a denatured DNA-cellulose column which had been incuba...

journal_title：Carcinogenesis

authors： Weaver D,Amos A,Tierney B,Bresnick E

更新日期：1980-06-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been implicated in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance of many cancers. We evaluated the role of peroxiredoxin (Prx) I in TRAIL resistance governed by coupling of nicotinamide adenosine dinucleotide phosphate oxidase (Nox)-derived ROS signaling ...

journal_title：Carcinogenesis

authors： Song IS,Kim SU,Oh NS,Kim J,Yu DY,Huang SM,Kim JM,Lee DS,Kim NS

更新日期：2009-07-01 00:00:00

abstract：:Epidemiological studies have linked consumption of broccoli to a reduced risk of colon cancer in individuals with the glutathione S-transferase M1 (GSTM1) null genotype. GSTs are involved in excretion and elimination of isothiocyanates (ITCs), which are major constituents of broccoli and other cruciferous vegetables a...

journal_title：Carcinogenesis

authors： Chung FL,Conaway CC,Rao CV,Reddy BS

更新日期：2000-12-01 00:00:00

abstract：:Studies have shown that fisetin, a small phytochemical molecule, has antitumor activity; however, its antiangiogenic activity has not yet been examined. Accordingly, herein, we investigated the antiangiogenic efficacy and associated mechanisms of fisetin in human umbilical vein endothelial cells (HUVECs). Fisetin (10-...

journal_title：Carcinogenesis

authors： Bhat TA,Nambiar D,Pal A,Agarwal R,Singh RP

更新日期：2012-02-01 00:00:00

abstract：:In order to test the controversially discussed hypothesis that oval cells are part of a liver stem cell compartment and can give rise to cholangiocellular as well as hepatocellular carcinomas in the course of liver carcinogenesis, we transfected an oval cell line established in our laboratory with an oncogenically act...

journal_title：Carcinogenesis

authors： Becker R,Lüthgens B,Oesch F,Dienes HP,Steinberg P

更新日期：1996-12-01 00:00:00

abstract：:The expression of proteinase-activated receptor (PAR)(2) in human hepatocellular carcinoma (HCC) was established by reverse transcription-polymerase chain reaction, confocal immunofluorescence and electron microscopy in permanent cell lines, primary HCC cell cultures and HCC tumor tissue. Stimulation of HCC cells with...

journal_title：Carcinogenesis

authors： Kaufmann R,Oettel C,Horn A,Halbhuber KJ,Eitner A,Krieg R,Katenkamp K,Henklein P,Westermann M,Böhmer FD,Ramachandran R,Saifeddine M,Hollenberg MD,Settmacher U

更新日期：2009-09-01 00:00:00