Abstract:
:There is no unique mechanism to explain the activity in animals of 'non-genotoxic' carcinogens. In this they differ from 'genotoxic' carcinogens that are DNA reactive. In the present study it is reported that non-mutagenic carcinogens, as a group, have significantly higher computed octanol/water partition coefficients than mutagenic ones. This property of non-mutagenic carcinogens may suggest that their ability to induce tumors is associated with membraneous receptor sites and/or a longer residence time in the animal.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
McCoy GD,Rosenkranz HS,Klopman Gdoi
10.1093/carcin/11.7.1111subject
Has Abstractpub_date
1990-07-01 00:00:00pages
1111-7issue
7eissn
0143-3334issn
1460-2180journal_volume
11pub_type
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