Monoclonal antibodies to 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) and their use in the analysis of well-done fried beef.

abstract：:We previously reported that quinacrine (QC) has anticancer activity against breast cancer cells. Here, we examine the mechanism of action of QC and its ability to inhibit Wnt-TCF signaling in two independent breast cancer cell lines. QC altered Wnt-TCF signaling components by increasing the levels of adenomatous polyp...

journal_title：Carcinogenesis

authors： Preet R,Mohapatra P,Das D,Satapathy SR,Choudhuri T,Wyatt MD,Kundu CN

更新日期：2013-02-01 00:00:00

abstract：:To investigate the sensitivity of heterozygous p53-deficient CBA mice to carcinogens, 20 female mice [p53(+/-)] and 20 wild-type littermates [p53(+/+)] were given an intraperitoneal injection of 120 mg/kg body wt of N-ethyl-N-nitrosourea (ENU) and were maintained without any other treatment for a further 26 weeks. His...

journal_title：Carcinogenesis

authors： Mitsumori K,Onodera H,Shimo T,Yasuhara K,Takagi H,Koujitani T,Hirose M,Maruyama C,Wakana S

更新日期：2000-05-01 00:00:00

abstract：:Animal studies demonstrated that females are more susceptible than males to benzo[a]pyrene (BaP)-induced toxicities, including lung carcinogenesis. Elevation of cyclooxygenase-2 (COX-2) expression has been shown to increase the risk of cancer development. BaP induces COX-2 expression, and an interaction between BaP an...

journal_title：Carcinogenesis

authors： Chang LW,Chang YC,Ho CC,Tsai MH,Lin P

更新日期：2007-07-01 00:00:00

abstract：:Cancer is a genetic disease in which the interplay between alterations in protein-coding genes and non-coding RNAs (ncRNAs) plays a fundamental role. In recent years, the full coding component of the human genome was sequenced in various cancers, whereas such attempts related to ncRNAs are still fragmentary. We screen...

journal_title：Carcinogenesis

authors： Wojcik SE,Rossi S,Shimizu M,Nicoloso MS,Cimmino A,Alder H,Herlea V,Rassenti LZ,Rai KR,Kipps TJ,Keating MJ,Croce CM,Calin GA

更新日期：2010-02-01 00:00:00

abstract：:Mouse ovarian surface epithelial cells (MOSEC) were obtained from virgin, mature mice by mild trypsinization and were repeatedly passaged in vitro. Early passage cells (<20 passages) exhibited a cobblestone morphology and contact inhibition of growth. After approximately 20 passages in vitro, cobblestone morphology an...

journal_title：Carcinogenesis

authors： Roby KF,Taylor CC,Sweetwood JP,Cheng Y,Pace JL,Tawfik O,Persons DL,Smith PG,Terranova PF

更新日期：2000-04-01 00:00:00

abstract：:The effect of the aromatic amines 2-acetylaminofluorene (AAF), 2-acetylaminophenanthrene (AAP) and trans-4-acetylaminostilbene (AAS) on the rat hepatic aromatic hydrocarbon (Ah) receptor level was studied. 3-Methylcholanthrene (MC), as a known receptor ligand, was used as a control. The complete liver carcinogen AAF a...

journal_title：Carcinogenesis

authors： Göttlicher M,Cikryt P

更新日期：1987-07-01 00:00:00

abstract：:To test the hypothesis that nucleotide excision repair (NER) plays a protective role in chemical carcinogenesis in internal organs, xeroderma pigmentosum group A gene-deficient (XPA(-/-)) mice, heterozygous (XPA(+/-)) and wild-type (XPA(+/+)) mice were orally administered 0.001% 4-nitroquinoline 1-oxide (4NQO) in thei...

journal_title：Carcinogenesis

authors： Ide F,Oda H,Nakatsuru Y,Kusama K,Sakashita H,Tanaka K,Ishikawa T

更新日期：2001-04-01 00:00:00

abstract：:FEZ1/LZTS1 is a tumor suppressor gene that is frequently altered in human cancers of different histotypes. We have reported previously that LZTS1 is downregulated in high-grade bladder cancer and that its restoration suppresses tumorigenicity in urothelial carcinoma cells. To further investigate the role of LZTS1 in t...

journal_title：Carcinogenesis

authors： Baffa R,Fassan M,Sevignani C,Vecchione A,Ishii H,Giarnieri E,Iozzo RV,Gomella LG,Croce CM

更新日期：2008-04-01 00:00:00

abstract：:The modifying effects of 4,4'-diaminodiphenylmethane (DDPM) (0.1% in diet) administration on liver carcinogenesis induced by 2-acetylaminofluorene (2-AAF) (0.02% in diet), 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) ( 0.06% in diet), diethylnitrosamine (DEN) (0.001% in drinking water) and N-ethyl-N-hydroxyethylnit...

journal_title：Carcinogenesis

authors： Tsuda H,Ogiso T,Hasegawa R,Imaida K,Masui T,Ito N

更新日期：1987-05-01 00:00:00

abstract：:Ovarian surface epithelium (OSE) is considered to give rise to epithelial ovarian carcinomas (EOCs). To elucidate early processes contributing to the development of EOCs from the OSE, two batches of primary human OSE cells were transduced with non-viral human genes (mutant Cdk4, cyclinD1 and hTERT) so as to efficientl...

journal_title：Carcinogenesis

authors： Sasaki R,Narisawa-Saito M,Yugawa T,Fujita M,Tashiro H,Katabuchi H,Kiyono T

更新日期：2009-03-01 00:00:00

abstract：:The effects of retinol and retinoic acid on cytotoxicity and mutation expression at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in Chinese hamster ovary (CHO) cells with or without exogenous metabolic activation were studied in the presence and absence of known chemical mutagens. Neither retinol ...

journal_title：Carcinogenesis

authors： Budroe JD,Schol HM,Shaddock JG,Casciano DA

更新日期：1988-07-01 00:00:00

abstract：:Ultraconserved elements (UCEs) are segments of >200 bp length showing absolute sequence identity between orthologous regions of human, rat and mouse genomes. The selection factors acting on these UCEs are still unknown. Recent studies have shown that UCEs function as long-range enhancers of flanking genes or are invol...

journal_title：Carcinogenesis

authors： Yang R,Frank B,Hemminki K,Bartram CR,Wappenschmidt B,Sutter C,Kiechle M,Bugert P,Schmutzler RK,Arnold N,Weber BH,Niederacher D,Meindl A,Burwinkel B

更新日期：2008-02-01 00:00:00

abstract：:The physiological state of pregnancy confers significant resistance to polycyclic aromatic hydrocarbon (PAH)-induced mammary tumorigenesis. We have tested the abilities of primary mammary cells from pregnant and virgin rats cultured on collagen-coated plates to metabolize PAHs and convert these carcinogens to mutageni...

journal_title：Carcinogenesis

authors： Moore CJ,Gould MN

更新日期：1984-01-01 00:00:00

abstract：:We examined allelic loss in colon tumors induced by 1,2-dimethylhydrazine (DMH) in F1 hybrid mice, using sequence-tagged microsatellite site (STMS) primers derived from the chromosomal region closely linked to the p53 locus. Polymerase chain reaction--single-strand conformation polymorphism (PCR-SSCP) analysis of 155 ...

journal_title：Carcinogenesis

authors： Okamoto M,Ohtsu H,Miyaki M,Yonekawa H

更新日期：1993-07-01 00:00:00

abstract：:Mammalian DNA contains bulky endogenous DNA modifications (I-compounds), which increase with age in unexposed animals, as shown by 32P-postlabeling. We have examined the perinatal formation of a subclass (type II) of I-compounds in rat liver, kidney, skin and lung. These I-compounds represent bulky oxidative DNA lesio...

journal_title：Carcinogenesis

authors： Randerath E,Zhou GD,Randerath K

更新日期：1996-12-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of galacto-oligosaccharides (GOS, Elix'or) on the development of aberrant crypt foci (ACF) and colorectal tumours in rats treated with azoxymethane (AOM). Two groups of 102 male Fischer 344 rats were injected twice with AOM to induce colorectal tumours, and f...

journal_title：Carcinogenesis

authors： Wijnands MV,Schoterman HC,Bruijntjes JB,Hollanders VM,Woutersen RA

更新日期：2001-01-01 00:00:00

abstract：:Apigenin is a plant flavonoid which has been shown to significantly inhibit UV-induced mouse skin tumorigenesis when applied topically, and may represent an alternative sunscreen agent in humans. We have investigated the molecular mechanism(s) by which apigenin inhibits skin tumorigenesis. Initial studies examined the...

journal_title：Carcinogenesis

authors： Lepley DM,Li B,Birt DF,Pelling JC

更新日期：1996-11-01 00:00:00

abstract：:Aloe-emodin (AE), one of the main bioactive anthraquinones of Rheum palmatum, possesses potent antitumor properties. Our previous proteomic study revealed that AE-induced apoptosis was associated with oxidative stress and oxidation of many redox-sensitive proteins. In this study, we aimed to further dissect the cell d...

journal_title：Carcinogenesis

authors： Lu GD,Shen HM,Chung MC,Ong CN

更新日期：2007-09-01 00:00:00

abstract：:Male ICR Swiss mice, weighing 16-20 g, were fed ad libitum either a fat-free diet or a diet containing 10% corn oil. After three weeks on these diets, the rates of benzo[a]pyrene (B[a]P) metabolite formation and metabolism to products which covalently bind with macromolecules were compared using hepatic nuclei and mic...

journal_title：Carcinogenesis

authors： Baker MT,Karr SW,Wade AE

更新日期：1983-01-01 00:00:00

abstract：:p53 is a tumor suppressor that responds to a variety of stresses such as oncogenes and DNA damage by activating its transcriptional targets to allow repair or elimination of damaged cells. In the absence of stress signals, p53 needs to be kept in check and this is achieved by the E3 ligase MDM2. For tumors that retain...

journal_title：Carcinogenesis

authors： Roxburgh P,Hock AK,Dickens MP,Mezna M,Fischer PM,Vousden KH

更新日期：2012-04-01 00:00:00

abstract：:It is now unanimously accepted that neoplastic cells tend to become less susceptible to the growth regulatory effects of transforming growth factor-beta1 (TGF-beta1), mainly because of reduced expression and/or activity of TGF-beta1-specific receptors, as reported for many human cancers including colon cancer. Consequ...

journal_title：Carcinogenesis

authors： Biasi F,Mascia C,Poli G

更新日期：2008-05-01 00:00:00

abstract：:Sixty-three male cigarette smokers were entered into a cross-sectional study to determine whether inverse associations existed between polycyclic aromatic hydrocarbon (PAH)-DNA adduct levels and intake/serum levels of vitamin A, vitamin C and vitamin E. Associations between PAH-DNA adducts and intakes of carotene, as ...

journal_title：Carcinogenesis

authors： Grinberg-Funes RA,Singh VN,Perera FP,Bell DA,Young TL,Dickey C,Wang LW,Santella RM

更新日期：1994-11-01 00:00:00

abstract：:An electron microscope study was carried out on changes in the pancreatic acinar tissues of male Syrian hamsters during the course of induction of pancreatic neoplasia by lifetime weekly injections of N-nitroso-bis(2-hydroxypropyl)amine (BHP). The dominant process observed was a loss of differentiation of the acinar c...

journal_title：Carcinogenesis

authors： Flaks B,Moore MA,Flaks A

更新日期：1982-01-01 00:00:00

abstract：:Effects of estrogens on the cytoplasmic microtubule network were examined by the indirect immunofluorescence method using anti-beta-tubulin antibody. Estradiol, a naturally occurring estrogen, decreased the amount of cytoplasmic microtubule fibers during interphase in the human breast cancer cell lines MCF-7 and MDA-M...

journal_title：Carcinogenesis

authors： Aizu-Yokota E,Ichinoseki K,Sato Y

更新日期：1994-09-01 00:00:00

abstract：:The potential carcinogenic activity of 5,6-dimethoxysterigmatocystin (DMSC) was examined by oral administration in rats. In Experiment I, all of eight effective ACI/N rats given DMSC in the diet at a concentration of 50 p.p.m. developed neoplastic nodules of the liver. Five rats developed hepatocellular carcinomas and...

journal_title：Carcinogenesis

authors： Mori H,Sugie S,Yoshimi N,Kuniyasu T,Iwata H,Kawai K,Hamasaki T

更新日期：1988-06-01 00:00:00

abstract：:The HSP70 family of heat shock proteins consists of molecular chaperones of approximately 70kDa in size that serve critical roles in protein homeostasis. These adenosine triphosphatases unfold misfolded or denatured proteins and can keep these proteins in an unfolded, folding-competent state. They also protect nascent...

journal_title：Carcinogenesis

authors： Murphy ME

更新日期：2013-06-01 00:00:00

abstract：:58 MCA Cl 16 is an oncogenic methylcholanthrene-transformed variant of the non-transformed mouse embryo fibroblast cell line, C3H/10T1/2 Cl 8. Using two different protocols, we have isolated six temperature-sensitive mutants from N-methyl-N'-nitro-N-nitrosoguanidine treated cultures of 58 MCA Cl 16. C3H/10T1/2 Cl 8, 5...

journal_title：Carcinogenesis

authors： Boreiko C,Heidelberger C

更新日期：1980-01-01 00:00:00

abstract：:Metabolites of 15,16-dihydrocyclopenta[a]phenanthren-17-one and its 1- and 12-methyl homologues (all non-carcinogens) along with those from the 11-methyl and 11,12-dimethyl-17-ketones (carcinogens), produced in vitro by hepatic microsomes from methylcholanthrene induced rats, were separated by reverse phase h.p.l.c. I...

journal_title：Carcinogenesis

authors： Coombs MM,Russell JC,Jones JR,Ribeiro O

更新日期：1985-08-01 00:00:00

abstract：:Recent studies have suggested that the straightforward role of p53 as a transcription factor that functions by inducing apoptotic target genes to eliminate developing tumor cells is only part of a much more complicated story. There is now a firm body of evidence supporting a transcriptionally independent activity of p...

journal_title：Carcinogenesis

authors： Yee KS,Vousden KH

更新日期：2005-08-01 00:00:00

abstract：:Co-exposure to cadmium, cobalt, lead and other heavy metals occurs in many occupational settings, such as pigment and batteries production, galvanization and recycling of electric tools. However, little is known about interactions between several heavy metals. In the present study we determined DNA single strand break...

journal_title：Carcinogenesis

authors： Hengstler JG,Bolm-Audorff U,Faldum A,Janssen K,Reifenrath M,Götte W,Jung D,Mayer-Popken O,Fuchs J,Gebhard S,Bienfait HG,Schlink K,Dietrich C,Faust D,Epe B,Oesch F

更新日期：2003-01-01 00:00:00