Diallyl disulfide (DADS) enhances gap-junctional intercellular communication by both direct and indirect mechanisms in rat liver cells.

abstract：:The kinetics of nuclear polyploidization in livers of CF-1 mice exposed to dieldrin were studied at concentrations of 0, 0.1, 1, 5 and 10 p.p.m. in the diet, in 'steady-state' situations (which are reached within a few weeks after initiation of treatment). Animals were killed at five time intervals (after 1.85, 3, 6, ...

journal_title：Carcinogenesis

authors： van Ravenzwaay B,Tennekes H,Stöhr M,Kunz W

更新日期：1987-02-01 00:00:00

abstract：:Autoradiography has been used to study the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), 4-O-methyl TPA, and phorbol on metabolic cooperation between human diploid fibroblasts. When the donors, hypoxanthine-guanine phosphoribosyl transferase+ (HGPRT+) cells, and recipients, HGPRT- cells, were plated together i...

journal_title：Carcinogenesis

authors： Mosser DD,Bols NC

更新日期：1982-01-01 00:00:00

abstract：:The mutagen sensitivity assay is an in vitro measure of DNA repair capacity used to evaluate intrinsic susceptibility for cancer. The high heritability of mutagen sensitivity to different mutagens validates the use of this phenotype to predict cancer susceptibility. However, genetic determinants of mutagen sensitivity...

journal_title：Carcinogenesis

authors： Leng S,Stidley CA,Bernauer AM,Picchi MA,Sheng X,Frasco MA,Van Den Berg D,Gilliland FD,Crowell RE,Belinsky SA

更新日期：2008-07-01 00:00:00

abstract：:Silicosis is an inflammatory lung disease induced by the inhalation of silica-containing dust particles. There is conflicting data on whether patients with silicosis are more susceptible to lung cancer induced by cigarette smoke. To examine this issue experimentally, a model was developed in which one of the most abun...

journal_title：Carcinogenesis

authors： Bode C,Kinjo T,Alvord WG,Klinman DM

更新日期：2014-05-01 00:00:00

abstract：:The fluorescent 12-O-tetradecanoylphorbol-13-acetate (TPA) analogue dansyl-TPA allowed the distribution of fluorescent molecules to be visualized in living mouse fibroblasts. The entry of dansyl-TPA into cells occurred within millisecond time scale and was found largely energy independent. Dansyl-TPA was shown to stai...

journal_title：Carcinogenesis

authors： Tran PL,Deugnier MA

更新日期：1985-03-01 00:00:00

abstract：:The caspase proteins are essential for the regulation of normal B cell development and regulation of apoptosis. We investigated five single nucleotide polymorphisms in four key caspase genes, CASP3 [Ex8-280C>A (rs6948) and Ex8+567T>C (rs1049216)], CASP8 Ex14-271A>T (rs13113), CASP9 Ex5+32G>A (rs1052576) and CASP10 Ex3...

journal_title：Carcinogenesis

authors： Lan Q,Zheng T,Chanock S,Zhang Y,Shen M,Wang SS,Berndt SI,Zahm SH,Holford TR,Leaderer B,Yeager M,Welch R,Hosgood D,Boyle P,Rothman N

更新日期：2007-04-01 00:00:00

abstract：:We have shown previously that the difference between C57BL/6J and C3H/HeJ male mice in their susceptibilities to chemically-induced liver tumors results predominantly from an allelic difference at the Hepatocarcinogen sensitivity (Hcs) locus. This locus modulates the rate of growth of preneoplastic liver lesions and m...

journal_title：Carcinogenesis

authors： Hanigan MH,Winkler ML,Drinkwater NR

更新日期：1990-04-01 00:00:00

abstract：:To study the relationship between epidermal DNA synthesis and carcinogenesis, hairless mice of both sexes were given a single topical application of 1 mg N-methyl-N-nitrosourea (MNU) in acetone. A control group received only MNU, whereas other groups were injected i.p. with 5 mg hydroxyurea (HU), 1 h, 45 min and 15 mi...

journal_title：Carcinogenesis

authors： Iversen OH

更新日期：1982-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that are often located in genomic breakpoint regions and can act as oncogenes or tumor suppressor genes in human cancer. Our previous study showed that microRNA-423 (miR-423), which localized to the frequently amplified region of chromosome 17q11, was upregulated i...

journal_title：Carcinogenesis

authors： Lin J,Huang S,Wu S,Ding J,Zhao Y,Liang L,Tian Q,Zha R,Zhan R,He X

更新日期：2011-11-01 00:00:00

abstract：:Groups of male Fischer-344 rats were fed two pairs of semi-purified choline-devoid and choline-supplemented diets, one set containing 5% corn oil and 10% partially hydrogenated fat, and the other only corn oil (15%). Analyses were performed on lipids extracted from whole liver, liver nuclei and adipose tissue of the r...

journal_title：Carcinogenesis

authors： Banni S,Salgo MG,Evans RW,Corongiu FP,Lombardi B

更新日期：1990-11-01 00:00:00

abstract：:Aromatic DNA adducts in total white blood cells, cytochrome P450 (CYP) class 1A1 and glutathione transferase (GST1) class mu genotypes and micronuclei in T- and B-lymphocytes were studied in 69 full-time chimney sweeps and 35 controls, all male subjects. The sweeps had a higher (22%) but statistically non-significant ...

journal_title：Carcinogenesis

authors： Ichiba M,Hagmar L,Rannug A,Högstedt B,Alexandrie AK,Carstensen U,Hemminki K

更新日期：1994-07-01 00:00:00

abstract：:Although microRNAs (miRNA) have extensively been investigated in cancer research, less attention has been paid to their regulation by carcinogens and/or protective factors in early stages of the carcinogenesis process. The present study was designed to evaluate the modulation of mRNA expression as related to exposure ...

journal_title：Carcinogenesis

authors： Izzotti A,Larghero P,Cartiglia C,Longobardi M,Pfeffer U,Steele VE,De Flora S

更新日期：2010-05-01 00:00:00

abstract：:Despite decreases in the cancer death rates in high-resource countries, such as the USA, the number of cancer cases and deaths is projected to more than double worldwide over the next 20-40 years. Cancer is now the third leading cause of death, with >12 million new cases and 7.6 million cancer deaths estimated to have...

journal_title：Carcinogenesis

authors： Thun MJ,DeLancey JO,Center MM,Jemal A,Ward EM

更新日期：2010-01-01 00:00:00

abstract：:The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate H...

journal_title：Carcinogenesis

authors： Ragin C,Liu JC,Jones G,Shoyele O,Sowunmi B,Kennett R,Groen HJ,Gibbs D,Blackman E,Esan M,Brandwein MS,Devarajan K,Bussu F,Chernock R,Chien CY,Cohen MA,Samir EM,Mikio S,D'Souza G,Funchain P,Eng C,Gollin SM,Hong

更新日期：2017-02-01 00:00:00

abstract：:The activation of 2-nitrofluorene (2-NF) to reactive intermediates that bind covalently to DNA, RNA and protein has been investigated both in vitro and in the rat in vivo. In vitro, such binding was catalyzed by the hepatic microsomal fraction, was NADPH dependent and could be inhibited by SKF 525A, an inhibitor of cy...

journal_title：Carcinogenesis

authors： Wierckx FC,Wedzinga R,Meerman JH,Mulder GJ

更新日期：1990-01-01 00:00:00

abstract：:Female inbred C3H/St mice infected with the Bittner Milk Particle, develop mammary adenocarcinoma with 27% incidence if maintained on a Torula Yeast diet supplemented with 1 ppm of selenium (organically bound, in yeast). Animals switched from the 1 ppm Se diet to a diet containing only 0.15 ppm Se after reaching the a...

journal_title：Carcinogenesis

authors： Schrauzer GN,McGinness JE,Kuehn K

更新日期：1980-02-01 00:00:00

abstract：:The resistant hepatocyte model was used to study expression of tumor-associated aldehyde dehydrogenase (ALDH) activity during the course of rat hepatocarcinogenesis. The hepatic ALDH phenotype was determined at intervals over 280 days by histochemical analysis, total ALDH activity assays and gel electrophoresis, using...

journal_title：Carcinogenesis

authors： Jones DE Jr,Evces S,Lindahl R

更新日期：1984-12-01 00:00:00

abstract：:The present study was conducted to clarify the cooperative significance of epigenomic and genomic abnormalities during gastric carcinogenesis. Using 21 samples of normal control gastric mucosa (C), 109 samples of non-cancerous gastric mucosa (N) and 105 samples of cancerous tissue (T) from 109 patients with primary ga...

journal_title：Carcinogenesis

authors： Yang M,Arai E,Takahashi Y,Totsuka H,Chiku S,Taniguchi H,Katai H,Sakamoto H,Yoshida T,Kanai Y

更新日期：2020-11-13 00:00:00

abstract：:Previous studies have shown that 1- and 3-nitrobenzo[a]pyrene (NBaP) were mutagenic in the Salmonella reversion assay without exogenous activation and that 1-, 3- and 6-NBaP were mutagenic in the presence of hepatocytes or liver homogenate (S9). In the present study, 1-, 3- and 6-NBaP were tested for mutagenicity in C...

journal_title：Carcinogenesis

authors： Hass BS,Heflich RH,Schol HM,Chou MW,Fu PP,Casciano DA

更新日期：1986-04-01 00:00:00

abstract：:The mutational specificity of the monofunctional alkylating agent N-propyl-N'-nitro-N-nitrosoguanidine (PNNG) has been determined through the DNA sequence characterization of 109 LacI- mutations of Escherichia coli. The predominant mutation induced was the G:C----A:T transition (73%), presumably the result of O6-propy...

journal_title：Carcinogenesis

authors： van der Vliet GM,Zielenska M,Anderson MW,Glickman BW

更新日期：1989-05-01 00:00:00

abstract：:Although the human O6-alkylguanine-DNA alkyltransferase (AGT) is very sensitive to inactivation by O6-benzylguanine (BG) or 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine (5-nitroso-BP), the equivalent protein formed by the carboxyl terminal domain of the product of the Escherichia coli ada gene (Ada-C) is unaffected by ...

journal_title：Carcinogenesis

authors： Crone TM,Kanugula S,Pegg AE

更新日期：1995-08-01 00:00:00

abstract：:The expression of A and P forms of glutathione S-transferase (GST-A and P), two cytochrome P-450 isoenzymes (P-450 PB3a and P-450 MC2), microsomal epoxide hydrolase (mEHb), glucose-6-phosphate dehydrogenase (G6PD) and gamma-glutamyltranspeptidase (gamma-GT) was compared in preneoplastic liver lesions and background pa...

journal_title：Carcinogenesis

authors： Tsuda H,Moore MA,Asamoto M,Inoue T,Ito N,Satoh K,Ichihara A,Nakamura T,Amelizad Z,Oesch F

更新日期：1988-04-01 00:00:00

abstract：:In efforts to determine common and consistent morphological parameters of transformation in C3H/10T1/2 cells, 15 cell lines transformed by different carcinogens were examined with the scanning electron microscope (SEM) and compared to non-transformed cells. Cell lines were studied at different passages, at different c...

journal_title：Carcinogenesis

authors： Narayan KS,Young R,Heidelberger C,Landolph JR

更新日期：1984-07-01 00:00:00

abstract：:The conformation of N-(deoxyguanosin-8-yl)-2-acetylaminofluorene and N-(deoxyguanosin-8-yl)-2-aminofluorene was investigated by 1H n.m.r. spectroscopy. There was rotation about the glycosyl bond and preference for either the anti or syn conformation depended on whether or not the 8-arylamino nitrogen was acetylated. T...

journal_title：Carcinogenesis

authors： Evans FE,Miller DW,Beland FA

更新日期：1980-01-01 00:00:00

abstract：:N-Hydroxy-2-acetylaminofluorene (N-OH-AAF) was administered i.p. to male Wistar rats 17 h after partial hepatectomy. Hepatocytes were analyzed for the presence of micronuclei 7 h, 1, 2, 3 and 4 days after injection. N-OH-AAF treatment resulted in a high frequency of micronucleated hepatocytes at days 3 and 4 (19.5% an...

journal_title：Carcinogenesis

authors： van de Poll ML,van der Hulst DA,Tates AD,Mulder GJ,Meerman JH

更新日期：1989-04-01 00:00:00

abstract：:Constituents in food and fluids, tobacco chemicals and many drugs are candidates for oral absorption and oxidative metabolism. On this basis, the expression of cytochrome P450 isozymes (CYPs) and the conversion of CYP substrates were analysed in reference to buccal mucosa. A RT-PCR based analysis of human buccal tissu...

journal_title：Carcinogenesis

authors： Vondracek M,Xi Z,Larsson P,Baker V,Mace K,Pfeifer A,Tjälve H,Donato MT,Gomez-Lechon MJ,Grafström RC

更新日期：2001-03-01 00:00:00

abstract：:Transforming growth factor beta1 (TGFbeta1) expression is elevated by tumor promoters in the mouse skin, but its role in tumor promotion has not been well defined. To investigate this, we have compared TGFbeta1+/+ and +/- mice in a two-stage skin chemical carcinogenesis protocol. Surprisingly, TGFbeta1+/- mice had few...

journal_title：Carcinogenesis

authors： Pérez-Lorenzo R,Markell LM,Hogan KA,Yuspa SH,Glick AB

更新日期：2010-06-01 00:00:00

abstract：:Human Papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (HPV+OPSCC) is increasing in prevalence in the United States, as are cases of patients with multiple HPV+OPSCCs (mHPV+OPSCC). mHPV+OPSCCs present a unique opportunity to examine HPV+OPSCC mutation acquisition and evolution. We performed sequenci...

journal_title：Carcinogenesis

authors： Faden DL,Langenbucher A,Kuhs K,Lewis JS,Mirabello L,Yeager M,Boland JF,Bass S,Steinberg M,Cullen M,Lawrence MS,Ferris RL

更新日期：2020-10-19 00:00:00

abstract：:Comparisons of aromatic amine activation were made by using intact cells or cell homogenates (S-9) from bovine bladder urothelium and liver. Since both liver and bladder are thought to contribute carcinogenic metabolites for bladder cancer initiation, comparisons of these two organs' relative ability to activate aroma...

journal_title：Carcinogenesis

authors： Hix C,Oglesby L,MacNair P,Sieg M,Langenbach R

更新日期：1983-11-01 00:00:00

abstract：:Basic in vitro systems can be used to model and assess complex diseases, such as cancer. Recent advances in this field include the incorporation of multiple cell types and extracellular matrix proteins into three-dimensional (3D) models to recapitulate the structure, organization and functionality of live tissue in si...

journal_title：Carcinogenesis

authors： Herrmann D,Conway JR,Vennin C,Magenau A,Hughes WE,Morton JP,Timpson P

更新日期：2014-08-01 00:00:00