Expression of tumor-associated aldehyde dehydrogenase during rat hepatocarcinogenesis using the resistant hepatocyte model.

abstract：:Previous research suggests that far upstream element-binding protein 1 (FUBP1) plays an important role in various tumors including epatocellular carcinoma (HCC). However, the role of FUBP1 in liver cancer remains controversial, and the regulatory pathway by FUBP1 awaits to be determined. This study aims to identify th...

journal_title：Carcinogenesis

authors： Fu PY,Hu B,Ma XL,Tang WG,Yang ZF,Sun HX,Yu MC,Huang A,Hu JW,Zhou CH,Fan J,Xu Y,Zhou J

更新日期：2020-07-14 00:00:00

abstract：:The possible effect of oral 13 cis retinoic acid (13-cis-RA) on the carcinogenic process induced by 28 weekly s.c. injections of 1,2-dimethylhydrazine (DMH) in 34 Wistar rats was investigated. Using immunohistology, precancerous and cancerous stages were compared with the same stages induced by DMH without additional ...

journal_title：Carcinogenesis

authors： Decaëns C,Rosa B,Bara J,Daher N,Burtin P

更新日期：1983-09-01 00:00:00

abstract：:This study presents the physical characterization of mutants induced in mammalian cells by high linear energy transfer alpha-particle radiation that simulates exposure to radon daughters. Alpha-Particles from accelerated 4He at 150 keV/microns were used to induce 20 Chinese hamster ovary mutants that are deficient in ...

journal_title：Carcinogenesis

authors： Jin Y,Yie TA,Carothers AM

更新日期：1995-08-01 00:00:00

abstract：:The possibility that long-term exposure to relatively weak power frequency magnetic fields (MFs) emanating from the generation, transmission and use of electricity could increase the risk of breast cancer is a matter of ongoing debate. Laboratory studies using well-defined exposure conditions are useful to examine whe...

journal_title：Carcinogenesis

authors： Fedrowitz M,Löscher W

更新日期：2008-01-01 00:00:00

abstract：:Cell motility is partially dependent on interactions between the integrins and the extracellular matrix. Our previous studies have identified synthetic D-amino acid cell adhesion peptides using a combinatorial screening approach. In this study, we demonstrate that HYD1 (kikmviswkg) completely blocks random haptotactic...

journal_title：Carcinogenesis

authors： Sroka TC,Pennington ME,Cress AE

更新日期：2006-09-01 00:00:00

abstract：:A mismatch between metabolic demand and oxygen delivery leads to microenvironmental changes in solid tumors. The resulting tumor hypoxia is associated with malignant progression, therapy resistance and poor prognosis. However, the molecular mechanisms underlying therapy resistance in hypoxic tumors are not fully under...

journal_title：Carcinogenesis

authors： Wirthner R,Wrann S,Balamurugan K,Wenger RH,Stiehl DP

更新日期：2008-12-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been implicated in skin tumor promotion. Earlier, we showed that porphyrin-mediated cutaneous photosensitization results in the in situ generation of ROS. Recently, we have provided the first in situ evidence for the involvement of ROS in stage I tumor promotion. In this study we fur...

journal_title：Carcinogenesis

authors： Giri U,Iqbal M,Athar M

更新日期：1996-09-01 00:00:00

abstract：:In recent years, considerable emphasis has been placed on identifying new cancer chemopreventive agents which could be useful for human populations. Silymarin, an anti-oxidant flavonoid isolated from artichoke, has been shown to possess significant activity against hepatotoxicity and other pharmacological and physiolo...

journal_title：Carcinogenesis

authors： Agarwal R,Katiyar SK,Lundgren DW,Mukhtar H

更新日期：1994-06-01 00:00:00

abstract：:Macrophages and their immortalized cell lines can be activated to form nitrite and nitrate via oxidation of arginine and this is accompanied by the formation of N-nitroso compounds. The mechanism of nitrosamine formation has been investigated through the use of compounds which are known either to inhibit or enhance ac...

journal_title：Carcinogenesis

authors： Kosaka H,Wishnok JS,Miwa M,Leaf CD,Tannenbaum SR

更新日期：1989-03-01 00:00:00

abstract：:Skin is a major target of carcinogenic trivalent arsenic (arsenite, As3+). It has been thought that cell proliferation is one of the central events involved in the carcinogenic effect of arsenite. Cyclin D1, a nuclear protein playing a pivotal role in cell proliferation and cell cycle transition from G1 to S phases, h...

journal_title：Carcinogenesis

authors： Ouyang W,Li J,Ma Q,Huang C

更新日期：2006-04-01 00:00:00

abstract：:Here we report that colorectal cancer patients show a markedly higher frequency (3-fold) of wild-type NAT2*4 allele homozygotes than the control population. However, a marked difference in NAT2*4/NAT2*4 genotype frequency associated with the patients gender was observed pointing to a male-specific effect of this genot...

journal_title：Carcinogenesis

authors： Gil JP,Lechner MC

更新日期：1998-01-01 00:00:00

abstract：:Animal studies demonstrated that females are more susceptible than males to benzo[a]pyrene (BaP)-induced toxicities, including lung carcinogenesis. Elevation of cyclooxygenase-2 (COX-2) expression has been shown to increase the risk of cancer development. BaP induces COX-2 expression, and an interaction between BaP an...

journal_title：Carcinogenesis

authors： Chang LW,Chang YC,Ho CC,Tsai MH,Lin P

更新日期：2007-07-01 00:00:00

abstract：:Although Epstein-Barr virus (EBV) infection is widely distributed, certain EBV-driven malignancies are geographically restricted. EBV-associated Burkitt's lymphoma (eBL) is endemic in children living in sub-Saharan Africa. This population is heavily exposed to food contaminated with the mycotoxin aflatoxin B1 (AFB1). ...

journal_title：Carcinogenesis

authors： Accardi R,Gruffat H,Sirand C,Fusil F,Gheit T,Hernandez-Vargas H,Le Calvez-Kelm F,Traverse-Glehen A,Cosset FL,Manet E,Wild CP,Tommasino M

更新日期：2015-11-01 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors have the potential to derepress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. In the present study, we screened several garlic-derived small organosulfur compounds for their ability to inhibit HDAC activity in vitro. Among the organosul...

journal_title：Carcinogenesis

authors： Nian H,Delage B,Pinto JT,Dashwood RH

更新日期：2008-09-01 00:00:00

abstract：:Reactive oxygen species (ROS) are a major cause of cellular injury in an increasing number of diseases, including cancer. Most ROS are created in the cell through normal cellular metabolism. They can be produced by environmental insults such as ultraviolet light and toxic chemicals, as well as by the inflammatory proc...

journal_title：Carcinogenesis

authors： Stoner GD,Wang LS,Casto BC

更新日期：2008-09-01 00:00:00

abstract：:Maternal nutrition during pregnancy influences the development and metabolism of the fetus. Recent studies suggest that the cancer risk of offspring later in life is associated with maternal diet, but little is known about the effect of a maternal diet high in methyl nutrients on breast cancer risk. Lipotropes are met...

journal_title：Carcinogenesis

authors： Cho K,Mabasa L,Bae S,Walters MW,Park CS

更新日期：2012-05-01 00:00:00

abstract：:The reactive metabolites of the carcinogenic N-acetyl-2-aminofluorene (AAF) form adducts with the guanine base of DNA. The fluorescence emission characteristics of N-(deoxy-guanosin-8-yl)-N-acetyl-2-aminofluorene (dGuo-C8-AAF), N-(deoxyguanosin-8-yl)-2-aminofluorene (dGuo-C8-AF) and the two N7 = C8 imidazole ring-open...

journal_title：Carcinogenesis

authors： van Houte LP,Retèl J,Westra JG,van Grondelle R

更新日期：1990-04-01 00:00:00

abstract：:Metastatic disease is the leading cause of cancer mortality. Identifying biomarkers and regulatory mechanisms is important toward developing diagnostic and therapeutic tools against metastatic cancer. In this study, we demonstrated that podocalyxin-like 1 (PODXL) is overexpressed in breast tumor cells and increased in...

journal_title：Carcinogenesis

authors： Lin CW,Sun MS,Liao MY,Chung CH,Chi YH,Chiou LT,Yu J,Lou KL,Wu HC

更新日期：2014-11-01 00:00:00

abstract：:Liver microsomes from male Syrian golden hamsters and Sprague Dawley rats metabolize the cis and trans isomers of N-nitroso-2,6-dimethylmorpholine (NNDM) to N-nitroso-(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) as the major product detectable by h.p.l.c. The rates of total metabolism are similar for both the cis and tr...

journal_title：Carcinogenesis

authors： Kokkinakis D,Hollenberg PF,Scarpelli DG

更新日期：1984-08-01 00:00:00

abstract：:Since its discovery, the E3 ubiquitin ligase E6-associated protein (E6AP) has been studied extensively in two pathological contexts: infection by the human papillomavirus (HPV), and the neurodevelopmental disorder, Angelman syndrome. Vital biological links between E6AP and other viruses, namely hepatitis C virus and e...

journal_title：Carcinogenesis

authors： Bandilovska I,Keam SP,Gamell C,Machicado C,Haupt S,Haupt Y

更新日期：2019-07-06 00:00:00

abstract：:O(6)-alkylguanine-DNA alkyltransferase (AGT) is a suicide protein that corrects DNA damage by alkylating agents and may also serve to activate environmental carcinogens. We expressed human wild-type and two active mutant AGTs in bacteria that lack endogenous AGT and are also defective in nucleotide excision repair, to...

journal_title：Carcinogenesis

authors： Abril N,Luque-Romero FL,Christians FC,Encell LP,Loeb LA,Pueyo C

更新日期：1999-11-01 00:00:00

abstract：:2-Hexenal is an alpha,beta-unsaturated carbonyl compound which is mutagenic, genotoxic and forms cyclic 1,N2-propanodeoxyguanosine adducts like similar propenals for which carcinogenicity was shown, e.g. acrolein or crotonaldehyde. Since humans have a permanent intake of 2-hexenal via vegetarian food this genotoxic co...

journal_title：Carcinogenesis

authors： Schuler D,Eder E

更新日期：1999-07-01 00:00:00

abstract：:Gastrointestinal tumours are among the most common malignancies in Western society, the majority of which are associated with dietary and lifestyle factors. Many dietary or lifestyle factors have been identified which may have toxic or carcinogenic properties. However, several dietary compounds also able to reduce gas...

journal_title：Carcinogenesis

authors： van der Logt EM,Roelofs HM,Nagengast FM,Peters WH

更新日期：2003-10-01 00:00:00

abstract：:Glioblastoma (GBM) is amongst the most aggressive brain tumors with a dismal prognosis. Despite significant advances in the current multimodality therapy including surgery, postoperative radiotherapy (RT) and temozolomide (TMZ)-based concomitant and adjuvant chemotherapy (CT), tumor recurrence is nearly universal with...

journal_title：Carcinogenesis

authors： Vengoji R,Ponnusamy MP,Rachagani S,Mahapatra S,Batra SK,Shonka N,Macha MA

更新日期：2019-03-12 00:00:00

abstract：:Results of previous serologic studies on the association of human papillomavirus (HPV) with esophageal squamous cell carcinoma (ESCC) have been inconsistent. From 2007 to 2010, the authors collected blood samples and relevant demographic data from 1435 patients with ESCC and 2071 age- and sex-matched normal controls f...

journal_title：Carcinogenesis

authors： He Z,Xu Z,Hang D,Guo F,Abliz A,Weiss NS,Xi L,Liu F,Ning T,Pan Y,Guo C,Liang Y,Lu C,Zhang L,Cai H,Ke Y

更新日期：2014-04-01 00:00:00

abstract：:The effects of exposure to benzo[a]pyrene (BAP) and formaldehyde (HCHO), alone and combined, on the induction of carcinogenesis in rat tracheal implants was determined as the number of growth-altered cell populations (tumor-initiation sites, TIS) per trachea. While exposure twice-weekly for 4.5 months to 0.2% HCHO sol...

journal_title：Carcinogenesis

authors： Cosma GN,Marchok AC

更新日期：1987-12-01 00:00:00

abstract：:The mechanism(s) of tumour promotion in liver by estrogens is not well understood although growth stimulation is known to be one important element of their action. As a basis for studying mechanisms of growth control by estrogens, effects of both natural and synthetic estrogens on DNA synthesis and protooncogene c-fos...

journal_title：Carcinogenesis

authors： Lee CH,Edwards AM

更新日期：2001-09-01 00:00:00

abstract：:Use of supercritical carbon dioxide extraction in the analysis of smokeless tobacco for tobacco-specific N-nitrosamines revealed the presence of higher levels of 4-(methylnitros-amino)-1-(3-pyridyl)-1-butanone (NNK) than had been determined with conventional methods. Whether human saliva may be similarly capable of re...

journal_title：Carcinogenesis

authors： Prokopczyk B,Wu M,Cox JE,Hoffmann D

更新日期：1992-05-01 00:00:00

abstract：:Carcinogen treatment of cultured mammalian cells prior to infection with u.v.-irradiated virus results in enhanced virus survival and mutagenesis suggesting the induction of SOS-type processes. In this paper, we report the development of a primary rat hepatocyte culture system to investigate cellular responses to DNA ...

journal_title：Carcinogenesis

authors： Zurlo J,Yager JD

更新日期：1984-04-01 00:00:00

abstract：:Gemcitabine has limited clinical benefits in pancreatic ductal adenocarcinoma. The solvent-based traditional taxanes docetaxel and paclitaxel have not shown clinical results superior to gemcitabine. Nab-paclitaxel, a water-soluble albumin-bound paclitaxel, may carry superior distribution properties into the tumor micr...

journal_title：Carcinogenesis

authors： Awasthi N,Zhang C,Schwarz AM,Hinz S,Wang C,Williams NS,Schwarz MA,Schwarz RE

更新日期：2013-10-01 00:00:00