Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma.

abstract：:Arsenicals are epidemiologically significant chemicals in relation to induction of urinary bladder cancer in man. In the present study, we investigated the dose-dependent promotion potential of dimethylarsinic acid (DMA), a major metabolite of inorganic arsenicals in mammals, for rat urinary bladder carcinogenesis. In...

journal_title：Carcinogenesis

authors： Wanibuchi H,Yamamoto S,Chen H,Yoshida K,Endo G,Hori T,Fukushima S

更新日期：1996-11-01 00:00:00

abstract：:4-Oxo-4-(3-pyridyl)butanal (OPB) is an aldehyde formed during the activation of the tobacco-specific N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Using the DNA alkaline elution technique, the properties of DNA alkali-labile sites induced in the isolated rat hepatocytes by NNK and OPB were compar...

journal_title：Carcinogenesis

authors： Demkowicz-Dobrzanski K,Castonguay A

更新日期：1991-11-01 00:00:00

abstract：:Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disorder, and prophylactic colectomy has been shown to decrease the incidence of colorectal cancer (CRC). Duodenal cancer and desmoids are now the leading causes of death in FAP. We evaluate whether 3 months of oral supplementation with a patented...

journal_title：Carcinogenesis

authors： Calabrese C,Rizzello F,Gionchetti P,Calafiore A,Pagano N,De Fazio L,Valerii MC,Cavazza E,Strillacci A,Comelli MC,Poggioli G,Campieri M,Spisni E

更新日期：2016-06-01 00:00:00

abstract：:We have recently shown that a variety of human tumor cell lines are capable of preventing chloroethylnitrosourea (CNU)-induced DNA crosslinks, presumably by removing guanine O6-chloroethyl DNA monoadducts before crosslinks can form. Those cells capable of preventing crosslinking were of the Mer+ (Methylation repair) p...

journal_title：Carcinogenesis

authors： Zlotogorski C,Erickson LC

更新日期：1984-01-01 00:00:00

abstract：:The role of urinary pH and Na+ concentration on the bladder carcinogenesis of o-phenylphenol (OPP) was examined in male F344 rats. The rats were given powdered diet containing 2% sodium o-phenylphenate (OPP-Na, group 1), 1.25% OPP plus 0.64% NaHCO3 (group 2), 1.25% OPP plus 0.32% NaHCO3 (group 3), 1.25% OPP plus 0.16%...

journal_title：Carcinogenesis

authors： Fukushima S,Inoue T,Uwagawa S,Shibata MA,Ito N

更新日期：1989-09-01 00:00:00

abstract：:Resveratrol is a phytochemical that has been under consideration for use as a prostate cancer chemopreventive agent. However, the efficacy, as well as the mechanisms of action of resveratrol on prostate cancer prevention, remains largely unknown. This study seeks to address these questions and examine the cancer preve...

journal_title：Carcinogenesis

authors： Wang TT,Hudson TS,Wang TC,Remsberg CM,Davies NM,Takahashi Y,Kim YS,Seifried H,Vinyard BT,Perkins SN,Hursting SD

更新日期：2008-10-01 00:00:00

abstract：:Flow cytometric analysis of fibroblasts, normal breast epithelial cells and breast or other cancer cell lines identified variation in the abilities of cell lines to undergo cell cycle arrest as a response to hypoxia. Human mammary epithelial cells (HMEC), normal fibroblasts (Hs68 and WI38), HeLa cervical carcinoma and...

journal_title：Carcinogenesis

authors： Box AH,Demetrick DJ

更新日期：2004-12-01 00:00:00

abstract：:Heterocyclic aromatic amines (HAAs), formed during the cooking of foods, are known to induce tumours in rodent bioassays and may thus contribute to human cancer risk. We tested six HAAs in a morphological transformation assay and in three in vitro genotoxicity assays. The morphological transforming abilities of HAAs w...

journal_title：Carcinogenesis

authors： Pfau W,Martin FL,Cole KJ,Venitt S,Phillips DH,Grover PL,Marquardt H

更新日期：1999-04-01 00:00:00

abstract：:When exogenous [(3)H]retinol (vitamin A) was added to culture medium, normal human epithelial cells from the oral cavity, skin, lung and breast took up and esterified essentially all of the [(3)H]retinol within a few hours. As shown by [(3)H]retinol pulse-chase experiments, normal epithelial cells then slowly hydrolyz...

journal_title：Carcinogenesis

authors： Guo X,Ruiz A,Rando RR,Bok D,Gudas LJ

更新日期：2000-11-01 00:00:00

abstract：:Previously we have reported the development of a model in vitro system for the study of osteosarcoma. In this system, when chick periosteal explants are infected with Fujinami sarcoma virus (FSV), osteosarcoma-like tissue is formed. In the present study, a series of histopathologic parameters of neoplastic transformat...

journal_title：Carcinogenesis

authors： Birek C,Pawson T,McCulloch CA,Tenenbaum HC

更新日期：1988-10-01 00:00:00

abstract：:Antimutagenic effects of a novel lipophilic antioxidant, 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), and other known antioxidants against heterocyclic amine- or other mutagen-induced mutagenesis were examined in the Ames assay using Salmonella strain TA 98 to access the chemo-preventive effects of antioxidants on he...

journal_title：Carcinogenesis

authors： Hirose M,Iwata S,Ito E,Nihro Y,Takahashi S,Mizoguchi Y,Miki T,Satoh T,Ito N,Shirai T

更新日期：1995-09-01 00:00:00

abstract：:The major mammalian apurinic/apyrimidinic (AP) endonuclease (APE1) plays a central role in the DNA base excision repair pathway (BER) in two distinct ways. As an AP endonuclease, it initiates repair of AP sites in DNA produced either spontaneously or after removal of uracil and alkylated bases in DNA by monofunctional...

journal_title：Carcinogenesis

authors： Izumi T,Hazra TK,Boldogh I,Tomkinson AE,Park MS,Ikeda S,Mitra S

更新日期：2000-07-01 00:00:00

abstract：:Human papillomavirus (HPV) type 16 infection is an etiologic factor in a subset of head and neck squamous cell carcinomas (HNSCC). It is unknown if host genetic susceptibility modifies the HPV16-HNSCC association. DNA samples collected as part of a Boston area case-control study of HNSCC were genotyped for single-nucl...

journal_title：Carcinogenesis

authors： Chen AA,Marsit CJ,Christensen BC,Houseman EA,McClean MD,Smith JF,Bryan JT,Posner MR,Nelson HH,Kelsey KT

更新日期：2009-06-01 00:00:00

abstract：:Mutations of the tumor suppressor gene p53 have been found in hepatocellular carcinomas (HCCs) from many countries where HCC is common, but p53 mutations detected by direct sequencing in HCCs from the United States (where HCC is uncommon) have been reported only rarely. p53 Exons 1 to 11 were analyzed by polymerase ch...

journal_title：Carcinogenesis

authors： Kazachkov Y,Khaoustov V,Yoffe B,Solomon H,Klintmalm GB,Tabor E

更新日期：1996-10-01 00:00:00

abstract：:The aim of this study was to investigate selected proteomic markers of the metabolic phenotype of breast carcinomas as prognostic markers of cancer progression. For this purpose, a series of 101 breast carcinomas and 13 uninvolved breast samples were examined for quantitative differences in protein expression of mitoc...

journal_title：Carcinogenesis

authors： Isidoro A,Casado E,Redondo A,Acebo P,Espinosa E,Alonso AM,Cejas P,Hardisson D,Fresno Vara JA,Belda-Iniesta C,González-Barón M,Cuezva JM

更新日期：2005-12-01 00:00:00

abstract：:The mapping near Kras2 of pulmonary adenoma susceptibility 1 (Pas1), a major locus affecting inherited predisposition to lung cancer in mice prompted us to test the homologous human region (12p12) for association with lung adenocarcinoma, by a population-based study. We genotyped 213 lung adenocarcinoma patients and 2...

journal_title：Carcinogenesis

authors： Manenti G,De Gregorio L,Pilotti S,Falvella FS,Incarbone M,Ravagnani F,Pierotti MA,Dragani TA

更新日期：1997-10-01 00:00:00

abstract：:In this report, we describe the isolation and characterization of six murine squamous cell carcinoma cell lines (BPCC) derived from carcinomas produced by a complete carcinogenesis protocol with benzo[a]pyrene (B[a]P). All six cell lines were tumorigenic to varying degrees in nude mice, and several were spontaneously ...

journal_title：Carcinogenesis

authors： Ruggeri BA,Bauer B,Zhang SY,Klein-Szanto AJ

更新日期：1994-08-01 00:00:00

abstract：:Base excision repair (BER) corrects DNA damage caused by oxidative stress and chronic inflammation, putative risk factors for cancer. To understand the relationship between genetic variation in BER genes and risk of biliary tract cancer and biliary stones, we examined non-synonymous polymorphisms in three key BER gene...

journal_title：Carcinogenesis

authors： Huang WY,Gao YT,Rashid A,Sakoda LC,Deng J,Shen MC,Wang BS,Han TQ,Zhang BH,Chen BE,Rosenberg PS,Chanock SJ,Hsing AW

更新日期：2008-01-01 00:00:00

abstract：:4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a major metabolite of the tobacco-specific pulmonary carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), has a chiral center but the tumorigenicity of the NNAL enantiomers has not been previously examined. In this study, we assessed the relative tumori...

journal_title：Carcinogenesis

authors： Upadhyaya P,Kenney PM,Hochalter JB,Wang M,Hecht SS

更新日期：1999-08-01 00:00:00

abstract：:The apoptotic response to DNA damage appears to be an innate biological mechanism for protection against tumourigenesis. It is possible that agents that protect against colorectal cancer act by enhancing the apoptotic deletion of cells suffering DNA damage, with consequent removal of those with tumourigenic mutations....

journal_title：Carcinogenesis

authors： Hu Y,Martin J,Le Leu R,Young GP

更新日期：2002-07-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR) gamma is a ligand-activated nuclear receptor that plays a key role in adipogenesis and adipocyte gene expression, and has recently been linked with possible antineoplastic effects in colonic carcinogenesis. PPARgamma2 and gamma3 are two transcripts arising from the PPA...

journal_title：Carcinogenesis

authors： Koh WP,Yuan JM,Van Den Berg D,Ingles SA,Yu MC

更新日期：2006-09-01 00:00:00

abstract：:We reported the inhibitory effects of genistein, an inhibitor of tyrosine protein kinase (TPK), on ultraviolet B (UVB)-induced expression of c-fos and c-jun in SENCAR mouse skin. UVB irradiation substantially increased transcript levels of c-fos and c-jun mRNA in mouse skin. Topical application of genistein 60 min bef...

journal_title：Carcinogenesis

authors： Wang Y,Zhang X,Lebwohl M,DeLeo V,Wei H

更新日期：1998-04-01 00:00:00

abstract：:Adipocytokines are a group of adipocyte-secreted proteins that have significant effects on the metabolism of lipids and carbohydrates, as well as numerous other processes. A number of recent studies have indicated that some adipocytokines may significantly influence the proliferation of malignant cells in vitro, where...

journal_title：Carcinogenesis

authors： Miyamoto S,Yasui Y,Tanaka T,Ohigashi H,Murakami A

更新日期：2008-05-01 00:00:00

abstract：:Pulsed field gel electrophoresis showed that caffeic acid induced DNA strand breaks in cultured human cells in the presence of Mn(II). With alkali treatment, DNA single-strand breaks were observed. The strand breakage was increased by the treatment of buthionine sulphoximine (a GSH synthesis inhibitor) and 3-aminotria...

journal_title：Carcinogenesis

authors： Inoue S,Ito K,Yamamoto K,Kawanishi S

更新日期：1992-09-01 00:00:00

abstract：:Estrogen plays an important role in breast cancer development. While the mechanism of the estrogen effects is not fully elucidated, one possible route is by increasing the stem cell-like properties in the tumors. Tocopherols are known to reduce breast cancer development and progression. The aim of the present study is...

journal_title：Carcinogenesis

authors： Bak MJ,Furmanski P,Shan NL,Lee HJ,Bao C,Lin Y,Shih WJ,Yang CS,Suh N

更新日期：2018-07-30 00:00:00

abstract：:Cyclic 1,N2-propanodeoxyguanosine adducts are formed in vitro in DNA treated with alpha-acetoxy-N-nitrosopyrrolidine or its metabolite, crotonaldehyde. However, the in vivo formation of these cyclic adducts in DNA has not been demonstrated due to the lack of a sensitive detection method. In this study, a 32P-postlabel...

journal_title：Carcinogenesis

authors： Chung FL,Young R,Hecht SS

更新日期：1989-07-01 00:00:00

abstract：:The DNA double-strand breaks (DSBs) repair pathway has been implicated in maintaining genomic integrity via suppression of chromosomal rearrangements. DNA-dependent protein kinase (DNA-PK) has an important role with DNA DSBs repair. In this study, 93 of untreated cancer patients and 41 of cancer-free healthy volunteer...

journal_title：Carcinogenesis

authors： Someya M,Sakata K,Matsumoto Y,Yamamoto H,Monobe M,Ikeda H,Ando K,Hosoi Y,Suzuki N,Hareyama M

更新日期：2006-01-01 00:00:00

abstract：:DNA double-strand break (DSB) repair is an important mechanism underlying chemotherapy resistance in human cancers. Dicer participates in DSB repair by facilitating homologous recombination. However, whether Dicer is involved in non-homologous end joining (NHEJ) remains unknown. Here, we addressed whether Dicer regula...

journal_title：Carcinogenesis

authors： Chen X,Li WF,Wu X,Zhang HC,Chen L,Zhang PY,Liu LY,Ma D,Chen T,Zhou L,Xu Y,Zhou MT,Tang KF

更新日期：2017-09-01 00:00:00

abstract：:Dietary-related indoles, isothiocyanates, and the allyl isothiocyanate glucosinolate, sinigrin, were administered to F344 rats in the diet for 2 weeks (chronic protocol) or by gavage 2 h before sacrifice (acute protocol) and the effects of these pretreatments on the alpha-hydroxylation of two carcinogenic nitrosamines...

journal_title：Carcinogenesis

authors： Chung FL,Wang MY,Hecht SS

更新日期：1985-04-01 00:00:00

abstract：:To determine whether B or T lymphoid malignancies could be induced following the exposure of lymphoid cells within different lymphoid organs to a potential chemical carcinogen, 3-methylcholanthrene (3-MC) was directly injected into surgically exposed Peyer's patches (PP), mesenteric lymph nodes (MLN), axillary lymph n...

journal_title：Carcinogenesis

authors： Bost KL,Garrett LR,Cuchens MA

更新日期：1986-08-01 00:00:00