Abstract:
:4-Hydroxyphenylretinamide (4-HPR) is a synthetic retinoid with minimal toxicity and favorable pharmacokinetics during long-term administration to patients in clinical trials. Since 4-HPR binds poorly to the retinoic acid receptors, the issue of whether 4-HPR exerts its biological actions via classical retinoid receptor pathways remains to be resolved. We have previously reported that stable expression of a truncated retinoic acid receptor alpha, RARalpha403, transduced in NIH 3T3 cells by a retroviral vector, rendered the cells resistant to retinoic acid for growth inhibition and induction of tissue transglutaminase (TGase II). Here, we report that stable expression of the dominant negative construct RARalpha403 fails to blunt growth inhibition and TGase II induction by 4-HPR, a potent chemopreventive retinoid, in the same cells. These data show that retinoic acid receptors do not mediate either growth inhibition or induction of TGase II activity by 4-HPR in mouse fibroblast cells.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Giandomenico V,Andreola F,Rodriguez de la Concepcion ML,Collins SJ,De Luca LMdoi
10.1093/carcin/20.6.1133keywords:
subject
Has Abstractpub_date
1999-06-01 00:00:00pages
1133-5issue
6eissn
0143-3334issn
1460-2180journal_volume
20pub_type
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