TIMP-2 suppresses tumor growth and metastasis in murine model of triple-negative breast cancer.

abstract：:Ulcerative colitis is a dynamic, chronic inflammatory condition of the colon associated with an increased colon cancer risk. Ginkgo biloba is a putative antioxidant and has been used for thousands of years to treat a variety of ailments. The aim of this study was to test whether the standardized G.biloba extract, EGb ...

journal_title：Carcinogenesis

authors： Kotakadi VS,Jin Y,Hofseth AB,Ying L,Cui X,Volate S,Chumanevich A,Wood PA,Price RL,McNeal A,Singh UP,Singh NP,Nagarkatti M,Nagarkatti PS,Matesic LE,Auclair K,Wargovich MJ,Hofseth LJ

更新日期：2008-09-01 00:00:00

abstract：:Oesophageal squamous cell carcinoma (OSCC) has a high incidence in southern Africa and a poor prognosis. Limited information is available on the contribution of genetic variants in susceptibility to OSCC in this region. However, recent genome-wide association studies have identified multiple susceptibility loci in Asi...

journal_title：Carcinogenesis

authors： Chen WC,Bye H,Matejcic M,Amar A,Govender D,Khew YW,Beynon V,Kerr R,Singh E,Prescott NJ,Lewis CM,Babb de Villiers C,Parker MI,Mathew CG

更新日期：2019-06-10 00:00:00

abstract：:The steroid hormone 1,25-dihydroxyvitamin D(3), [1,25(OH)(2)D(3), calcitriol], the active metabolite of vitamin D, exerts pleiotropic antitumor effects against several malignancies. However, the clinical use of this hormone is limited by hypercalcemia. 25-Hydroxyvitamin D(3), the prohormone of 1,25(OH)(2)D(3), is hydr...

journal_title：Carcinogenesis

authors： Schwartz GG,Eads D,Rao A,Cramer SD,Willingham MC,Chen TC,Jamieson DP,Wang L,Burnstein KL,Holick MF,Koumenis C

更新日期：2004-06-01 00:00:00

abstract：:We have previously shown that addition of short chain fructo-oligosaccharides (indigestible carbohydrates) to food prevented colon tumors in C57BL/6-Apc(Min/+) mice, a model for human colon cancer. As gut-associated lymphoid tissue was concomitantly developed, we suggested that the immune response generated by this fo...

journal_title：Carcinogenesis

authors： Pierre F,Perrin P,Bassonga E,Bornet F,Meflah K,Menanteau J

更新日期：1999-10-01 00:00:00

abstract：:The role of BRCA1 in sporadic breast and ovarian cancers remains elusive. Direct involvement of BRCA1 in the development of breast and ovarian cancer is suggested by the finding that the BRCA1 promoter region CpG island is methylated in a proportion of breast and ovarian cancers. The aim of this study was to compare t...

journal_title：Carcinogenesis

authors： Bianco T,Chenevix-Trench G,Walsh DC,Cooper JE,Dobrovic A

更新日期：2000-02-01 00:00:00

abstract：:Human fibroblasts repair DNA damaged by bleomycin through both short-patch and long-patch pathways, mediated by an aphidicolin-resistant (beta) and aphidicolin-sensitive (delta) DNA polymerase respectively (DiGiuseppe, J.A. and Dresler, S.L. (1989) Biochemistry, 28, 9515-9520). Despite certain similarities, aphidicoli...

journal_title：Carcinogenesis

authors： DiGiuseppe JA,Hunting DJ,Dresler SL

更新日期：1990-06-01 00:00:00

abstract：:This report shows that generation of hydrogen peroxide (H2O2) by human polymorphonuclear leukocytes (PMNs) activated with tumor promoters of varying potency as first and second stage promoters correlates well with activities of these promoters in vivo. Those tested were 12-O-tetradecanoylphorbol-13-acetate (TPA), a co...

journal_title：Carcinogenesis

authors： Frenkel K,Chrzan K

更新日期：1987-03-01 00:00:00

abstract：:Germline genetic variability might contribute, at least partially, to the survival of pancreatic ductal adenocarcinoma (PDAC) patients. Two recently performed genome-wide association studies (GWAS) on PDAC overall survival (OS) suggested (P < 10(-5)) the association between 30 genomic regions and PDAC OS. With the aim...

journal_title：Carcinogenesis

authors： Rizzato C,Campa D,Talar-Wojnarowska R,Halloran C,Kupcinskas J,Butturini G,Mohelníková-Duchoňová B,Sperti C,Tjaden C,Ghaneh P,Hackert T,Funel N,Giese N,Tavano F,Pezzilli R,Pedata M,Pasquali C,Gazouli M,Mambrini A,Sou

更新日期：2016-10-01 00:00:00

abstract：:Wnt signaling plays a central role in mammary stem cell (MaSC) homeostasis and in breast cancer. In particular, epigenetic alterations at different members of the Wnt pathway have been identified among triple-negative, basal-like breast cancers. Previously, we developed a mouse model for metaplastic breast adenocarcin...

journal_title：Carcinogenesis

authors： Monteiro J,Gaspar C,Richer W,Franken PF,Sacchetti A,Joosten R,Idali A,Brandao J,Decraene C,Fodde R

更新日期：2014-01-01 00:00:00

abstract：:Alcohol is a major risk factor for oesophageal squamous cell carcinoma (OSCC), the most prevalent histological subtype of oesophageal cancer (OC) worldwide. The metabolism of alcohol is regulated by specific enzymes whose activity and expression is influenced by genetic polymorphisms. We conducted a systematic review ...

journal_title：Carcinogenesis

authors： Matejcic M,Gunter MJ,Ferrari P

更新日期：2017-09-01 00:00:00

abstract：:This study is focused on chemical induction of lung tumors in xeroderma pigmentosum group A gene (XPA)-deficient mice to clarify the role of nucleotide excision repair (NER) in internal organs. Six-week-old female XPA-/-, XPA(+/-) and XPA(+/+) mice were instilled intratracheally with benzo[a] pyrene (B[a]P). A total o...

journal_title：Carcinogenesis

authors： Ide F,Iida N,Nakatsuru Y,Oda H,Tanaka K,Ishikawa T

更新日期：2000-06-01 00:00:00

abstract：:Comparative X-ray crystallographic structure analyses have been carried out on seven cyclopenta[a]phenanthrenes, namely 15,16-dihydocyclopenta[a]phenanthren-17-one and its 2-, 6- and 12-methyl homologues (non-carcinogens) and the 7-and 11-methyl and 1,11-methano derivatives (carcinogens). All-valence-electron molecula...

journal_title：Carcinogenesis

authors： Clayton AF,Coombs MM,Henrick K,McPartlin M,Trotter J

更新日期：1983-12-01 00:00:00

abstract：:Naturally occurring allyl isothiocyanate (AITC) was recently shown to be selectively delivered to bladder cancer tissue via urinary excretion and to inhibit bladder cancer growth and muscle invasion in an animal model. AITC is excreted in urine mainly as N-acetyl-S-(N-allylthiocarbamoyl)cysteine, more commonly known a...

journal_title：Carcinogenesis

authors： Bhattacharya A,Li Y,Geng F,Munday R,Zhang Y

更新日期：2012-02-01 00:00:00

abstract：:1,3-Butadiene (BD), a widely used monomer in the production of synthetic rubber and other resins, is one of the 189 hazardous air pollutants identified in the 1990 Clean Air Act Amendments. BD induces tumors at multiple organ sites in B6C3F1 mice and Sprague-Dawley rats; mice are much more susceptible to the carcinoge...

journal_title：Carcinogenesis

authors： Csanády GA,Guengerich FP,Bond JA

更新日期：1992-07-01 00:00:00

abstract：:Telomeres are critical in maintaining chromosome and genomic stability. Arsenic, a human carcinogen as well as an anticancer agent, is known for its clastogenicity. To better understand molecular mechanisms of arsenic actions, we investigated arsenite effects on telomere and telomerase and determined cell growth and a...

journal_title：Carcinogenesis

authors： Zhang TC,Schmitt MT,Mumford JL

更新日期：2003-11-01 00:00:00

abstract：:The enzyme O6-methylguanine-DNA methyltransferase repairs alkylation-induced DNA damage, O6-methylguanine and O4-methylthymine, the former being formed more frequently. Previously, by means of gene targeting, we generated mice in which alleles for methyltransferase were disrupted. We now use these mouse lines, which a...

journal_title：Carcinogenesis

authors： Iwakuma T,Sakumi K,Nakatsuru Y,Kawate H,Igarashi H,Shiraishi A,Tsuzuki T,Ishikawa T,Sekiguchi M

更新日期：1997-08-01 00:00:00

abstract：:Constituents in food and fluids, tobacco chemicals and many drugs are candidates for oral absorption and oxidative metabolism. On this basis, the expression of cytochrome P450 isozymes (CYPs) and the conversion of CYP substrates were analysed in reference to buccal mucosa. A RT-PCR based analysis of human buccal tissu...

journal_title：Carcinogenesis

authors： Vondracek M,Xi Z,Larsson P,Baker V,Mace K,Pfeifer A,Tjälve H,Donato MT,Gomez-Lechon MJ,Grafström RC

更新日期：2001-03-01 00:00:00

abstract：:Benzene is a well-characterized human carcinogen and clastogen still present in both the occupational and general environment. However, the levels of benzene encountered today are, in most cases, relatively low and new methods, more specific and sensitive than classical cytogenetics, are probably needed to assess if c...

journal_title：Carcinogenesis

authors： Surrallés J,Autio K,Nylund L,Järventaus H,Norppa H,Veidebaum T,Sorsa M,Peltonen K

更新日期：1997-04-01 00:00:00

abstract：:Continuous dietary administration of the hepatocarcinogen 2-acetylaminofluorene (AAF) to rats produces a gradual increase in hepatic DNA adducts until a plateau is reached after approximately 2 weeks. The rate of DNA adduct formation remains constant through 1 month of AAF feeding, while adduct removal profiles are bi...

journal_title：Carcinogenesis

authors： Poirier MC,Fullerton NF,Patterson ED,Beland FA

更新日期：1990-08-01 00:00:00

abstract：:In this study, our goal was to identify genes whose expression in liver is altered in female F-344 rats during mitosuppression induced by 42 days of ethinyl estradiol (EE) treatment (Yager et al., Carcinogenesis, 15, 2117-2123, 1994). Northern analysis demonstrated that the mRNA levels for transforming growth factor-b...

journal_title：Carcinogenesis

authors： Chen J,Schwartz DA,Young TA,Norris JS,Yager JD

更新日期：1996-12-01 00:00:00

abstract：:Isoflavone genistein is a specific inhibitor of protein tyrosine kinase (PTK) and has been shown to have a variety of anticancer activities in cultured cells and animal models. We report here that genistein significantly inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoyl phorbol-13-acetate...

journal_title：Carcinogenesis

authors： Wei H,Bowen R,Zhang X,Lebwohl M

更新日期：1998-08-01 00:00:00

abstract：:A pilot study was conducted to determine whether any relationship exists between micronucleated cell rates of female uterine cervical epithelium and current smoking status. Cervical uterine cells obtained from 118 pre-menopausal females, seen between September 1994 and June 1995 at the Occupational Medecine Interprofe...

journal_title：Carcinogenesis

authors： Lehucher-Michel MP,Favre-Eloff G,Devictor B,Duffaud F,Botta A

更新日期：1997-04-01 00:00:00

abstract：:Woodchuck (Marmota monax) hepatic cells, which were immortalized by the simian virus 40 large T antigen (SV40 Tag) produced nitric oxide (NO; measured as nitrite) in vitro from L-arginine (L-Arg) after lipopolysaccharide (LPS) treatment. NO synthesis was related to L-Arg and LPS concentration and plateaued at 1.0 mM L...

journal_title：Carcinogenesis

authors： Liu RH,Jacob JR,Hotchkiss JH,Tennant BC

更新日期：1993-08-01 00:00:00

abstract：:The 80%-ethanol extract of lemon grass (Cymbopogon citratus Stapf), a medicinal plant in Thailand, has been reported to be antimutagenic against various known mutagens in the Salmonella mutation assay. To investigate chemoprevention in an animal carcinogenesis model, we examined inhibitory effects of the lemon grass e...

journal_title：Carcinogenesis

authors： Suaeyun R,Kinouchi T,Arimochi H,Vinitketkumnuen U,Ohnishi Y

更新日期：1997-05-01 00:00:00

abstract：:We have shown previously that the difference between C57BL/6J and C3H/HeJ male mice in their susceptibilities to chemically-induced liver tumors results predominantly from an allelic difference at the Hepatocarcinogen sensitivity (Hcs) locus. This locus modulates the rate of growth of preneoplastic liver lesions and m...

journal_title：Carcinogenesis

authors： Hanigan MH,Winkler ML,Drinkwater NR

更新日期：1990-04-01 00:00:00

abstract：:In this report we describe results showing that both arachidonic acid (20:4) release and prostaglandin (PG) synthesis in herpes simplex virus type 2 (HSV-2)-transformed tumor-derived rat fibrosarcoma (RFS) cells are inhibited by indomethacin (cyclooxygenase inhibitor). These data suggest that cyclooxygenase (prostagla...

journal_title：Carcinogenesis

authors： Heitman CR,Waite M,Kucera LS

更新日期：1989-11-01 00:00:00

abstract：:Syrian hamster embryo cells were treated with crocidolite asbestos at a dose (1 microgram/cm2) which was shown in previous studies to induce cell transformation and aneuploidy in these cells. Treatment of cells with asbestos induced a greater than 20-fold increase in the incidence of cells in anaphase with abnormaliti...

journal_title：Carcinogenesis

authors： Hesterberg TW,Barrett JC

更新日期：1985-03-01 00:00:00

abstract：:Carcinogenicity of catechol, a naturally occurring and industrial chemical which has been shown to have strong cell proliferating potential on rat glandular stomach epithelium, was investigated in male and female F344 rats and B6C3F1 mice. Groups of 30 male and female F344 rats and B6C3F1 mice were treated with 0.8% c...

journal_title：Carcinogenesis

authors： Hirose M,Fukushima S,Tanaka H,Asakawa E,Takahashi S,Ito N

更新日期：1993-03-01 00:00:00

abstract：:Sulfur-containing substances derived from garlic and onion have been shown to prevent experimental carcinogenesis. One of the hypotheses explaining the mechanisms of the chemopreventive activity of these substances is that they activate detoxification systems such as glutathione S-transferase (GST). In this study the ...

journal_title：Carcinogenesis

authors： Hatono S,Jimenez A,Wargovich MJ

更新日期：1996-05-01 00:00:00

abstract：:Cyclin E is reported to be an important cell cycle regulator, and its dysregulation is implicated in tumorigenesis including esophageal squamous cell carcinoma (ESCC). MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level and play important roles in tumor initiation and progression. However, the...

journal_title：Carcinogenesis

authors： Ding DP,Chen ZL,Zhao XH,Wang JW,Sun J,Wang Z,Tan FW,Tan XG,Li BZ,Zhou F,Shao K,Li N,Qiu B,He J

更新日期：2011-07-01 00:00:00