Resistance of DRH strain rats to chemical carcinogenesis of liver: genetic analysis of later progression stage.

abstract：:It is now widely accepted that cancer is attributed to the accumulation of genetic alterations in cells. Thus, to understand the molecular mechanisms of cancer metastasis, it is indispensable to identify the genes whose alterations accumulate during cancer progression as well as the genes whose expression is responsib...

journal_title：Carcinogenesis

authors： Yokota J

更新日期：2000-03-01 00:00:00

abstract：:The anti-neoplastic agent procarbazine is genetically active in a variety of short term mutagenicity tests, and it also possesses carcinogenic and teratogenic potential. This compound has consistently yielded false negative results in in vitro microbial mutagenicity tests in the presence and absence of mammalian metab...

journal_title：Carcinogenesis

authors： Gatehouse DG,Paes DJ

更新日期：1983-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is the fourth leading cause of cancer mortality worldwide. Genome-wide association studies (GWAS) identified more than 50 CRC loci. However, most of the previous studies were conducted in European population, and host genetic factors among Japanese population are largely remained to be identifi...

journal_title：Carcinogenesis

authors： Tanikawa C,Kamatani Y,Takahashi A,Momozawa Y,Leveque K,Nagayama S,Mimori K,Mori M,Ishii H,Inazawa J,Yasuda J,Tsuboi A,Shimizu A,Sasaki M,Yamaji T,Sawada N,Iwasaki M,Tsugane S,Naito M,Wakai K,Koyama T,Takezaki T

更新日期：2018-05-03 00:00:00

abstract：:Apigenin is a plant flavonoid which has been shown to significantly inhibit UV-induced mouse skin tumorigenesis when applied topically, and may represent an alternative sunscreen agent in humans. We have investigated the molecular mechanism(s) by which apigenin inhibits skin tumorigenesis. Initial studies examined the...

journal_title：Carcinogenesis

authors： Lepley DM,Li B,Birt DF,Pelling JC

更新日期：1996-11-01 00:00:00

abstract：:Feeding male Wistar rats a choline-deficient diet containing 0.07% DL-ethionine (CDE diet) for up to 5 weeks results in the production of two distinct non-parenchymal cell populations, oval and duct-like cells. These cells can undergo replication and display different patterns of expression of glutathione S-transferas...

journal_title：Carcinogenesis

authors： Tee LB,Kirilak Y,Huang WH,Morgan RH,Yeoh GC

更新日期：1994-12-01 00:00:00

abstract：:Mice with non-phosphorylated serine 389 in p53 are susceptible for bladder tumors induced by 2-acetylaminofluorene (2-AAF). Since p53 is a transcription factor, this might well be preceded by differences in the regulation of gene expression. Microarray analysis was used to determine early transcriptional changes that ...

journal_title：Carcinogenesis

authors： Bruins W,Jonker MJ,Bruning O,Pennings JL,Schaap MM,Hoogervorst EM,van Steeg H,Breit TM,de Vries A

更新日期：2007-08-01 00:00:00

abstract：:3,4-Epoxy-1-butene (EB) is the major mutagenic metabolite of butadiene (BD), an important industrial chemical classified as a probable human carcinogen. Although the mechanism of carcinogenicity of EB is not known, its reactions with nucleophilic sites of DNA giving pro-mutagenic lesions are likely to constitute the e...

journal_title：Carcinogenesis

authors： Tretyakova N,Lin Y,Sangaiah R,Upton PB,Swenberg JA

更新日期：1997-01-01 00:00:00

abstract：:In vitro exposures of isolated DNA to one of the two carcinogenic and mutagenic chemicals, diethylsulfate or dimethylsulfate, induces several kinds of physicochemical and morphological alterations. These changes are detectable by a variety of independent techniques. A fraction of DNA treated briefly with either of the...

journal_title：Carcinogenesis

authors： Kubinski H,Kubinski ZO,Fiandt M,Konopa G

更新日期：1981-01-01 00:00:00

abstract：:It is widely believed that abnormal production of polypeptide growth factors, together with other molecular alterations, play an important role in neoplastic development. Transforming growth factor alpha (TGFalpha), hepatocyte growth factor (HGF) and acidic fibroblast growth factor (aFGF) are the three major growth fa...

journal_title：Carcinogenesis

authors： Hu Z,Evarts RP,Fujio K,Omori N,Omori M,Marsden ER,Thorgeirsson SS

更新日期：1996-05-01 00:00:00

abstract：:Plumbagin (PL) (5-hydroxy-2-methyl-1,4-napthoquinone), a medicinal plant-derived naphthoquinone, was isolated from the roots of the Plumbago zeylanica L. (also known as Chitrak). The roots of P. zeylanica L. have been used in Indian medicine for >2500 years as an anti-atherogenic, cardiotonic, hepatoprotective and neu...

journal_title：Carcinogenesis

authors： Sand JM,Bin Hafeez B,Jamal MS,Witkowsky O,Siebers EM,Fischer J,Verma AK

更新日期：2012-01-01 00:00:00

abstract：:The purpose of this study was to compare the metabolism and DNA binding of aflatoxicol (AFL) with that of aflatoxin B1 (AFB1) in vivo and in isolated hepatocytes from Mt Shasta strain rainbow trout (Salmo gairdneri). Maximum total binding of [3H]AFL to liver DNA from trout exposed by intraperitoneal injection was 38-4...

journal_title：Carcinogenesis

authors： Loveland PM,Wilcox JS,Pawlowski NE,Bailey GS

更新日期：1987-08-01 00:00:00

abstract：:The role of urinary pH and Na+ concentration on the bladder carcinogenesis of o-phenylphenol (OPP) was examined in male F344 rats. The rats were given powdered diet containing 2% sodium o-phenylphenate (OPP-Na, group 1), 1.25% OPP plus 0.64% NaHCO3 (group 2), 1.25% OPP plus 0.32% NaHCO3 (group 3), 1.25% OPP plus 0.16%...

journal_title：Carcinogenesis

authors： Fukushima S,Inoue T,Uwagawa S,Shibata MA,Ito N

更新日期：1989-09-01 00:00:00

abstract：:Human papillomavirus (HPV) type 16 infection is an etiologic factor in a subset of head and neck squamous cell carcinomas (HNSCC). It is unknown if host genetic susceptibility modifies the HPV16-HNSCC association. DNA samples collected as part of a Boston area case-control study of HNSCC were genotyped for single-nucl...

journal_title：Carcinogenesis

authors： Chen AA,Marsit CJ,Christensen BC,Houseman EA,McClean MD,Smith JF,Bryan JT,Posner MR,Nelson HH,Kelsey KT

更新日期：2009-06-01 00:00:00

abstract：:The influence of the smoking parameters (puff profile, puff duration, puff volume, puff frequency) on the delivery of tobacco-specific nitrosamines (TSNAs) in mainstream smoke was investigated for six different cigarette brands, including filter cigarettes with very low to medium smoke yields and non-filter cigarettes...

journal_title：Carcinogenesis

authors： Fischer S,Spiegelhalder B,Preussmann R

更新日期：1989-06-01 00:00:00

abstract：:Chemical carcinogenesis in mouse skin has been divided into the process of initiation, promotion and progression. Recently we have shown that ionizing radiation acts as an initiator in this model system. In this paper we describe a three-stage experiment using ionizing radiation in the third stage of mouse skin carcin...

journal_title：Carcinogenesis

authors： Jaffe DR,Williamson JF,Bowden GT

更新日期：1987-11-01 00:00:00

abstract：:Dehydroepiandrosterone sulfate (DHEAS) is the most abundant adrenal steroid with apparent anticarcinogenic properties. Given our recent observation of the dehydro-epiandrosterone-mediated inhibition of protein isoprenylation and the fact that 99% of the circulating dehydro-epiandrosterone is sulfated, with less than 1...

journal_title：Carcinogenesis

authors： Schulz S,Nyce JW

更新日期：1994-11-01 00:00:00

abstract：:Multiple myeloma (MM) cells accumulate in the bone marrow (BM) where their interactions impede disease therapy. We have shown that microvesicles (MVs) derived from BM mesenchymal stem cells (MSCs) of MM patients promote the malignant traits via modulation of translation initiation (TI), whereas MVs from normal donors ...

journal_title：Carcinogenesis

authors： Dabbah M,Jarchowsky-Dolberg O,Attar-Schneider O,Tartakover Matalon S,Pasmanik-Chor M,Drucker L,Lishner M

更新日期：2020-03-13 00:00:00

abstract：:Epidemiological studies have suggested that frequent olive oil consumption may be a protective factor against lung cancer formation. Squalene, a characteristic compound in olive oil, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and has been proposed to inhibit the farnesylation of ras on...

journal_title：Carcinogenesis

authors： Smith TJ,Yang GY,Seril DN,Liao J,Kim S

更新日期：1998-04-01 00:00:00

abstract：:We previously demonstrated that a single dose of gamma-radiation (350 rads) was able to induce thymic lymphomas in C57BL mice when followed by promoting treatment with oral cyclosporine (CsA), a non-genotoxic immunosuppressant. We have now tested the efficacy of various doses of gamma-radiation as an initiator of CsA ...

journal_title：Carcinogenesis

authors： Yabu K,Warty VS,Gorelik E,Shinozuka H

更新日期：1991-01-01 00:00:00

abstract：:Pulmonary adenocarcinoma (PAC) is the leading type of lung cancer in smokers and non-smokers that arises in most cases from small airway epithelial cells. PAC has a high mortality due to its aggressive behavior and resistance to cancer therapeutics. We have shown previously that the proliferation of human PAC cells NC...

journal_title：Carcinogenesis

authors： Schuller HM,Al-Wadei HA,Majidi M

更新日期：2008-10-01 00:00:00

abstract：:Carcinogenesis develops in stages that have been operationally defined as initiation, promotion and progression. Although morphological end points have been described for detection and quantitation of these stages, to date initiation has been assessed only in the context of clonal growth in response to certain promoti...

journal_title：Carcinogenesis

authors： Dragan YP,Campbell HA,Baker K,Vaughan J,Mass M,Pitot HC

更新日期：1994-11-01 00:00:00

abstract：:To determine whether B or T lymphoid malignancies could be induced following the exposure of lymphoid cells within different lymphoid organs to a potential chemical carcinogen, 3-methylcholanthrene (3-MC) was directly injected into surgically exposed Peyer's patches (PP), mesenteric lymph nodes (MLN), axillary lymph n...

journal_title：Carcinogenesis

authors： Bost KL,Garrett LR,Cuchens MA

更新日期：1986-08-01 00:00:00

abstract：:In the previous 500 2-year chemical bioassays within the National Toxicology Program, large intestinal tumors (cecal carcinomas) related to chemical exposure have not been observed in B6C3F1 mice. The recently completed o-nitrotoluene study provided the first cecal tumor response and an opportunity to evaluate the mor...

journal_title：Carcinogenesis

authors： Sills RC,Hong HL,Flake G,Moomaw C,Clayton N,Boorman GA,Dunnick J,Devereux TR

更新日期：2004-04-01 00:00:00

abstract：:The human DNA polymerase lambda (Polλ) is a DNA repair polymerase, which is believed not only to play a role in base excision repair but also to contribute to DNA double-strand break repair by non-homologous end joining. We described here that cellular expression of the recently described natural polymorphic variant o...

journal_title：Carcinogenesis

authors： Capp JP,Boudsocq F,Bergoglio V,Trouche D,Cazaux C,Blanco L,Hoffmann JS,Canitrot Y

更新日期：2010-10-01 00:00:00

abstract：:Mutagenicity assays were carried out in the Salmonella/microsome test, using five S. typhimurium his(-) strains (TA1535, TA1537, TA1538, TA98 and TA100), both in the presence and absence of post-mitochondrial preparations from Aroclor-induced rat livers and suitable co-factors. Seven oil dispersants showed a wide rang...

journal_title：Carcinogenesis

authors： Petrilli FL,De Renzi GP,De Flora S

更新日期：1980-01-01 00:00:00

abstract：:Karyotype, mitochondrial ultrastructure and several enzymatic activities were studied in two clones, D22 and D27, from SV40-transformed rabbit chondrocytes. Similar chromosome alterations, with recurrent losses and gains were observed at the various passages. Mitochondria were rare, with increase in size and crest alt...

journal_title：Carcinogenesis

authors： Bravard A,Beaumatin J,Luccioni C,Fritsch P,Lefrançois D,Thenet S,Adolphe M,Dutrillaux B

更新日期：1992-05-01 00:00:00

abstract：:Although epidemiological evidence in humans and bile acid feeding studies in rodents implicate bile acids as tumor promoters, the role of endogenous bile acids in colon carcinogenesis remains unclear. In this study, we exploited mice deficient in the ileal apical sodium-dependent bile acid transporter (ASBT, encoded b...

journal_title：Carcinogenesis

authors： Raufman JP,Dawson PA,Rao A,Drachenberg CB,Heath J,Shang AC,Hu S,Zhan M,Polli JE,Cheng K

更新日期：2015-10-01 00:00:00

abstract：:A growing body of evidence from human and animal cancer cytogenetics studies indicates that aneuploidy is an important chromosome change in carcinogenesis. To understand the role of this genetic phenomenon during the first steps of an experimental cancer model, molecular and cellular techniques were combined. A sequen...

journal_title：Carcinogenesis

authors： Van Goethem F,de Stoppelaar J,Hoebee B,Kirsch-Volders M

更新日期：1995-08-01 00:00:00

abstract：:Alcohol is a major risk factor for oesophageal squamous cell carcinoma (OSCC), the most prevalent histological subtype of oesophageal cancer (OC) worldwide. The metabolism of alcohol is regulated by specific enzymes whose activity and expression is influenced by genetic polymorphisms. We conducted a systematic review ...

journal_title：Carcinogenesis

authors： Matejcic M,Gunter MJ,Ferrari P

更新日期：2017-09-01 00:00:00

abstract：:A number of drug-metabolizing systems were measured in hyperplastic noduli from the livers of rats receiving 2-acetyl-aminofluorene in their diet and compared with corresponding activities in control liver. The level of microsomal cytochrome P-450 is reduced 54% in the nodular tissue, while 5 activities catalyzed by t...

journal_title：Carcinogenesis

authors： Aström A,DePierre JW,Eriksson L

更新日期：1983-01-01 00:00:00