HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2.

abstract：:Strains of laboratory mice vary markedly in their susceptibility to two-stage skin carcinogenesis using 7,12-dimethylbenz[a]anthracene (DMBA) as the initiating carcinogen and croton oil as promoter. This study has been undertaken in order to clarify the basis of the strain differences. LACA mice were used as the susce...

journal_title：Carcinogenesis

authors： Ashman LK,Murray AW,Cook MG,Kotlarski I

更新日期：1982-01-01 00:00:00

abstract：:A large number of chemical carcinogens require metabolic activation before they are biologically active. The metabolism of a few of these compounds has been investigated in cultured human tissues and cells and the metabolism has been compared with the metabolism in organs from experimental animals in which the compoun...

journal_title：Carcinogenesis

authors： Autrup H

更新日期：1990-05-01 00:00:00

abstract：:Colorectal cancer (CRC) displays a predilection for metastasis to liver. Although stromal cell-derived factor-1 (SDF-1)/CXCR4 plays an important role in the liver metastasis, the molecular mechanism still remains obscure. We previously reported that integrin αvβ6 was implicated in the progression of CRC. However, no d...

journal_title：Carcinogenesis

authors： Wang B,Wang W,Niu W,Liu E,Liu X,Wang J,Peng C,Liu S,Xu L,Wang L,Niu J

更新日期：2014-02-01 00:00:00

abstract：:A remodeling of calcium homeostasis has been identified as a characterizing feature of some cancers. Possible consequences of this include alterations in many pivotal physiological responses including apoptosis, proliferation and gene transcription. An alteration in calcium homeostasis can occur via changes in the exp...

journal_title：Carcinogenesis

authors： Aung CS,Ye W,Plowman G,Peters AA,Monteith GR,Roberts-Thomson SJ

更新日期：2009-11-01 00:00:00

abstract：:U.v. damage to the DNA of HeLa cells induces the polymerisation of ADP-ribose, but only if repair synthesis is inhibited so that incomplete repair sites (i.e., DNA breaks) accumulate to abnormally high levels. 3-Aminobenzamide greatly reduces the ADP-ribose polymerisation response. However, 3-aminobenzamide does not r...

journal_title：Carcinogenesis

authors： Collins A

更新日期：1985-07-01 00:00:00

abstract：:Dietary resistant starch (RS), as a high amylose maize starch (HAMS), prevents dietary protein-induced colonocyte genetic damage in rats, possibly through the short-chain fatty acid (SCFA) butyrate produced by large bowel bacterial RS fermentation. Increasing butyrate availability may improve colonic health and dietar...

journal_title：Carcinogenesis

authors： Bajka BH,Clarke JM,Cobiac L,Topping DL

更新日期：2008-11-01 00:00:00

abstract：:Liver DNA, obtained at various time intervals from rats chronically fed a choline-devoid diet, was analysed for the presence of aromatic or alkyl adducts by the 32P-postlabeling assay. Alkyl adducts were not detected. Aromatic DNA adduct lesions were revealed, but only at levels (1 adduct per 0.5-3 X 10(9) nucleotides...

journal_title：Carcinogenesis

authors： Gupta RC,Earley K,Locker J,Lombardi B

更新日期：1987-01-01 00:00:00

abstract：:Using an 18 week two-stage protocol we have compared the tumour-promoting properties of a range of phorbol and daphnane esters on female CD-1 mice. The induction of epidermal hyperplasia in this mouse strain by these compounds has also been assessed by comparison with the standard phorbol ester, 12-O-tetradecanoylphor...

journal_title：Carcinogenesis

authors： Brooks G,Evans AT,Aitken A,Evans FJ

更新日期：1989-02-01 00:00:00

abstract：:Orotic acid, a precursor of pyrimidine nucleotide biosynthesis and a promoter for liver carcinogenesis, when fed at 1% level in a diet for 5 weeks resulted in liver DNA damage. The damage can be monitored as alkali-labile lesions using alkaline sucrose gradients as well as alkaline elution technique. Furthermore, the ...

journal_title：Carcinogenesis

authors： Rao PM,Rajalakshmi S,Alam A,Sarma DS,Pala M,Parodi S

更新日期：1985-05-01 00:00:00

abstract：:1,3-Butadiene (BD) is a more potent tumor inducer in mice than in rats. BD also shows striking differences in metabolic activation, with substantially higher blood concentrations of 1,2:3,4-diepoxybutane (butadiene diepoxide; BDE) in BD-exposed mice than in similarly exposed rats. The objective of this study was to de...

journal_title：Carcinogenesis

authors： Sweeney LM,Schlosser PM,Medinsky MA,Bond JA

更新日期：1997-04-01 00:00:00

abstract：:The Notch signaling pathway is evolutionarily conserved and responsible for cell fate determination in the developing embryo and mature tissue. At the molecular level, ligand binding activates Notch signaling by liberating the Notch intracellular domain, which then translocates into the nucleus and activates gene tran...

journal_title：Carcinogenesis

authors： Capaccione KM,Pine SR

更新日期：2013-07-01 00:00:00

abstract：:4-Aminobiphenyl (4-ABP), a potent carcinogen in rodents (liver cancer) and human (bladder cancer), is found as an environmental contaminant and in tobacco smoke. Hemoglobin adducts and lung DNA adducts of 4-ABP are found in tobacco smokers. In vitro metabolism studies with human and rat liver microsomes have shown tha...

journal_title：Carcinogenesis

authors： Kimura S,Kawabe M,Ward JM,Morishima H,Kadlubar FF,Hammons GJ,Fernandez-Salguero P,Gonzalez FJ

更新日期：1999-09-01 00:00:00

abstract：:Following intraperitoneal administration of [3H] aflatoxin B1 (AFB1) to young adult male rats, there is rapid uptake of the carcinogen by the liver, the target organ for carcinogenesis, leading to DNA covalent binding. Acid hydrolysis of this DNA shows that after 2h, the major DNA adduct is trans 8,9-dihydro-8-(7-guan...

journal_title：Carcinogenesis

authors： Hertzog PJ,Lindsay Smith JR,Garner RC

更新日期：1980-09-01 00:00:00

abstract：:Cancer incidence and mortality rates show great variations across nations and between population groups. These variations are largely explained by differences in age distribution, diet and lifestyle, access to health care, cultural barriers and exposure to carcinogens and pathogens. Cancers caused by infections are si...

journal_title：Carcinogenesis

authors： Wallace TA,Martin DN,Ambs S

更新日期：2011-08-01 00:00:00

abstract：:DNA mismatch repair defects in certain cell types confer resistance to the cytotoxic effects of alkylating agents, suggesting that a normally functioning DNA mismatch repair pathway can actually mediate alkylation-induced cell death. In eukaryotic cells this phenomenon is only observed in cells lacking adequate DNA me...

journal_title：Carcinogenesis

authors： Rasmussen LJ,Samson L

更新日期：1996-09-01 00:00:00

abstract：:Cyclin E is reported to be an important cell cycle regulator, and its dysregulation is implicated in tumorigenesis including esophageal squamous cell carcinoma (ESCC). MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level and play important roles in tumor initiation and progression. However, the...

journal_title：Carcinogenesis

authors： Ding DP,Chen ZL,Zhao XH,Wang JW,Sun J,Wang Z,Tan FW,Tan XG,Li BZ,Zhou F,Shao K,Li N,Qiu B,He J

更新日期：2011-07-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of galacto-oligosaccharides (GOS, Elix'or) on the development of aberrant crypt foci (ACF) and colorectal tumours in rats treated with azoxymethane (AOM). Two groups of 102 male Fischer 344 rats were injected twice with AOM to induce colorectal tumours, and f...

journal_title：Carcinogenesis

authors： Wijnands MV,Schoterman HC,Bruijntjes JB,Hollanders VM,Woutersen RA

更新日期：2001-01-01 00:00:00

abstract：:The bioactivation of cyclopenta[cd]pyrene (CPP) was investigated to determine the major DNA adduct-forming metabolite(s) of this widespread environmental contaminant and suspect carcinogen. DNA adducts were analyzed by 32P-postlabeling. Four major and at least seven minor adducts formed when CPP was incubated with cal...

journal_title：Carcinogenesis

authors： Beach AC,Gupta RC

更新日期：1994-05-01 00:00:00

abstract：:In the present study the modulating effects of dietary fish oil (MaxEPA) on unsaturated fat-promoted pancreatic carcinogenesis in azaserine-treated rats were investigated. Three groups of 20 rats (each group comprised five saline-treated and 15 azaserine-treated animals) were fed an AIN76-based purified diet containin...

journal_title：Carcinogenesis

authors： Appel MJ,Woutersen RA

更新日期：1994-10-01 00:00:00

abstract：:The carcinogen N-acetoxy-N-2-acetylaminofluorene reacts with dG and dG-containing nucleotides to give good yields of the C-8 adducts, but the analogous 4-aminobiphenyl derivative does not. Replacement of the N-acetoxy group by 2,6-dichlorobenzoyloxy circumvents this difficulty. This reaction is shown to be generally a...

journal_title：Carcinogenesis

authors： Underwood GR,Price MF,Shapiro R

更新日期：1988-10-01 00:00:00

abstract：:Chronic oral administration of the carcinogenic aminoazo dye N-methyl-4-aminoazobenzene (MAB) to rats is known to result in the induction of liver tumors. In order to assess the role of carcinogen-DNA adduct formation in MAB hepatocarcinogenesis, male rats were fed 0.06% [3'-3H]MAB in the diet for 1, 3 or 5 weeks. Gro...

journal_title：Carcinogenesis

authors： Tullis DL,Dooley KL,Miller DW,Baetcke KP,Kadlubar FF

更新日期：1987-04-01 00:00:00

abstract：:In order to establish an animal model for studying the cause and prevention of esophageal adenocarcinoma (EAC) and its frequent precursor, Barrett's esophagus (BE), factors affecting the pathogenic processes were investigated in an esophagoduodenal anastomosis model with rats. Experiments by us and others have shown t...

journal_title：Carcinogenesis

authors： Goldstein SR,Yang GY,Curtis SK,Reuhl KR,Liu BC,Mirvish SS,Newmark HL,Yang CS

更新日期：1997-11-01 00:00:00

abstract：:Tumor induction with chronic feeding of methyl-donor-deficient diets has been well established; however, the biochemical and molecular mechanisms which predipose to tumorigenesis in this model are still not well understood. The purpose of the present investigation was to assess DNA damage and altered nucleotide metabo...

journal_title：Carcinogenesis

authors： James SJ,Yin L

更新日期：1989-07-01 00:00:00

abstract：UNLABELLED:Neurotrophic factors possess an emerging role in the pathophysiology of several gastrointestinal disorders, regulating innervation, pain sensation and disease-associated neuroplasticity. Here, we aimed at characterizing the role of the neurotrophic factor neurturin (NRTN) and its receptor glial-cell-line-der...

journal_title：Carcinogenesis

authors： Wang K,Demir IE,D'Haese JG,Tieftrunk E,Kujundzic K,Schorn S,Xing B,Kehl T,Friess H,Ceyhan GO

更新日期：2014-01-01 00:00:00

abstract：:The Tsc-2 tumor suppressor gene encodes the protein tuberin, a multi-functional protein with sequence homology to the GTPase activating protein (GAP) for Rap1. Mutations in the Tsc-2 gene are associated with the development of renal tumors. The Eker rat (Tsc-2(EK/+)) bears a mutation in one allele of the Tsc-2 gene, w...

journal_title：Carcinogenesis

authors： Habib SL,Phan MN,Patel SK,Li D,Monks TJ,Lau SS

更新日期：2003-03-01 00:00:00

abstract：:The accumulation of O6-methylguanine (O6-meG) in the DNA of blood leukocytes of 21 Hodgkin's lymphoma patients (followed for up to 12 cycles of treatment) treated in the context of MOPP combination chemotherapy with 150 mg procarbazine daily for 10 days was examined and compared to that observed in rats treated with d...

journal_title：Carcinogenesis

authors： Souliotis VL,Valavanis C,Boussiotis VA,Pangalis GA,Kyrtopoulos SA

更新日期：1994-08-01 00:00:00

abstract：:Phenobarbital (PB) is a potent tumor promoter in rodent liver. In this study we investigated whether PB selectively promotes a population of initiated cells with reduced levels of transforming growth factor-beta (TGF beta) receptors types I, II and III. Liver tumors were induced in male Fischer F344 rats by diethylnit...

journal_title：Carcinogenesis

authors： Mansbach JM,Mills JJ,Boyer IJ,De Souza AT,Hankins GR,Jirtle RL

更新日期：1996-01-01 00:00:00

abstract：:Mammalian DNA contains bulky endogenous DNA modifications (I-compounds), which increase with age in unexposed animals, as shown by 32P-postlabeling. We have examined the perinatal formation of a subclass (type II) of I-compounds in rat liver, kidney, skin and lung. These I-compounds represent bulky oxidative DNA lesio...

journal_title：Carcinogenesis

authors： Randerath E,Zhou GD,Randerath K

更新日期：1996-12-01 00:00:00

abstract：:Specific repair endonucleases were used to quantify oxidative modifications in mitochondrial DNA (mtDNA) from rat liver and from porcine liver and kidney by means of a relaxation assay. In rat liver mitochondria the number of modifications sensitive to formamidopyrimidine--DNA glycosylase (FPG protein), which include ...

journal_title：Carcinogenesis

authors： Hegler J,Bittner D,Boiteux S,Epe B

更新日期：1993-11-01 00:00:00

abstract：:Mutagenicity assays were carried out in the Salmonella/microsome test, using five S. typhimurium his(-) strains (TA1535, TA1537, TA1538, TA98 and TA100), both in the presence and absence of post-mitochondrial preparations from Aroclor-induced rat livers and suitable co-factors. Seven oil dispersants showed a wide rang...

journal_title：Carcinogenesis

authors： Petrilli FL,De Renzi GP,De Flora S

更新日期：1980-01-01 00:00:00