Poly (ADP-ribose) is not involved in the rejoining of DNA breaks accumulated to high levels in u.v.-irradiated HeLa cells.

abstract：:This study was designed to investigate the role of the epidermal growth factor receptor (EGFR) and its ligands in chemically induced mouse bladder cancer. Bladder tumours were induced in C57Bl/6 and B6D2F1 mice by treatment with the carcinogen, N:-butyl-N:-(4-hydroxybutyl) nitrosamine (BBN). The levels of mRNA for EGF...

journal_title：Carcinogenesis

authors： el-Marjou A,Delouvée A,Thiery JP,Radvanyi F

更新日期：2000-12-01 00:00:00

abstract：:Oral squamous cell carcinoma (SCC) is among the most prevalent cancers in the world and is characterized by high morbidity and few therapeutic options. Like most cancers, oral SCC arises from a multistep process involving alterations of genes responsible for balancing proliferation and differentiation. Among these, Kr...

journal_title：Carcinogenesis

authors： Abrigo M,Alvarez R,Paparella ML,Calb DE,Bal de Kier Joffe E,Gutkind JS,Raimondi AR

更新日期：2014-03-01 00:00:00

abstract：:The effect of exposing mice to both a chemical carcinogen and leukemia virus with and without an inhibitor of DNA repair were compared. The data indicated that benzo[a]pyrene (BP) could exert a potentiating effect of Friend viral leukemogenesis in mice, which was dependent on the relative times of administration of th...

journal_title：Carcinogenesis

authors： Raikow RB,Okunewick JP,Buffo MJ,Jones DL,Brozovich BJ,Seeman PR,Koval TM

更新日期：1981-01-01 00:00:00

abstract：:To investigate the mechanistic basis for the biological properties of anthocyanins, two aglycone anthocyanins [delphinidin (DY) and cyanidin (CY)] were used to examine their effects on cell cycle progression and on induction of apoptosis in human cancer cells (uterine carcinoma and colon adenocarcinoma cells) and in n...

journal_title：Carcinogenesis

authors： Lazzè MC,Savio M,Pizzala R,Cazzalini O,Perucca P,Scovassi AI,Stivala LA,Bianchi L

更新日期：2004-08-01 00:00:00

abstract：:Precursor T-cell lymphoblastic neoplasms are aggressive malignancies in need for more effective and specific therapeutic treatments. A significant fraction of these neoplasms harbor deletions on the locus 9p21, targeting the tumor suppressor CDKN2A but also deleting the aconitase 1 (ACO1) gene, a neighboring housekeep...

journal_title：Carcinogenesis

authors： Gonzalez-Sanchez L,Cobos-Fernandez MA,Lopez-Nieva P,Villa-Morales M,Stamatakis K,Cuezva JM,Marin-Rubio JL,Vazquez-Dominguez I,Gonzalez-Vasconcellos I,Salido E,Llamas P,Lopez-Lorenzo JL,Santos J,Fernandez-Piqueras J

更新日期：2020-08-12 00:00:00

abstract：:Several members of the P450 family, including cytochrome P450 1B1 (CYP1B1), can convert tobacco smoke (TS) procarcinogens, including benzo[a]pyrene (B[a]P), to carcinogenic intermediates. In this study we investigated the effects of TS condensate and B[a]P on the expression of CYP1B1 in vitro and in vivo. CYP1B1 mRNA ...

journal_title：Carcinogenesis

authors： Port JL,Yamaguchi K,Du B,De Lorenzo M,Chang M,Heerdt PM,Kopelovich L,Marcus CB,Altorki NK,Subbaramaiah K,Dannenberg AJ

更新日期：2004-11-01 00:00:00

abstract：:Preparations of dietary fibre have an ability to bind potentially toxic compounds in vitro, but it is unclear how the measured binding properties are a reflection of either the relative affinity of such compounds for fibre or the saturation binding capacity of the fibre. Cooking and processing of foods and fermentatio...

journal_title：Carcinogenesis

authors： Ryden P,Robertson JA

更新日期：1995-02-01 00:00:00

abstract：:Cancer testis antigens (CTAs) are promising targets for T cell-based immunotherapy and studies have shown that certain CT genes are epigenetically depressed in cancer cells through DNA demethylation. Melanoma-associated antigen A11 (MAGE-A11) is a CTA that is frequently expressed in esophageal cancer and is correlated...

journal_title：Carcinogenesis

authors： Wu Y,Sang M,Liu F,Zhang J,Li W,Li Z,Gu L,Zheng Y,Li J,Shan B

更新日期：2020-07-14 00:00:00

abstract：:The carcinogenicity of two commonly used brown and black varieties of masheri, a pyrolysed tobacco product, was studied by feeding the masheri through the diet at a 10% level to three different animal species of both sexes. In Sprague-Dawley rats, only brown masheri was used, while in Swiss mice and Syrian golden hams...

journal_title：Carcinogenesis

authors： Kulkarni JR,Lalitha VS,Bhide SV

更新日期：1988-11-01 00:00:00

abstract：:In the era of precision oncology, bladder cancer (BlCa) is characterized by generic patient management and lack of personalized prognosis and surveillance. Herein, we have studied the clinical significance of urothelial cancer associated 1 (UCA1) lncRNA in improving patients' risk stratification and prognosis. A scree...

journal_title：Carcinogenesis

authors： Avgeris M,Tsilimantou A,Levis PK,Rampias T,Papadimitriou MA,Panoutsopoulou K,Stravodimos K,Scorilas A

更新日期：2019-08-22 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) tend to have tumor-promoting capacity, and can provide therapeutic targets. Even without cancer cells, CAF phenotypes are stably maintained, and DNA methylation and H3K27me3 changes have been shown to be involved. Here, we searched for a potential therapeutic target in primary CAFs...

journal_title：Carcinogenesis

authors： Yasukawa Y,Hattori N,Iida N,Takeshima H,Maeda M,Kiyono T,Sekine S,Seto Y,Ushijima T

更新日期：2020-12-07 00:00:00

abstract：:Drug resistance is one of the main obstacles to the successful treatment of cancer. The availability of agents that are highly effective against drug-resistant cancer cells is therefore essential. The present study was performed to examine the anticancer effects of evodiamine, a major constituent of the Chinese herb E...

journal_title：Carcinogenesis

authors： Liao CH,Pan SL,Guh JH,Chang YL,Pai HC,Lin CH,Teng CM

更新日期：2005-05-01 00:00:00

abstract：:DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within Lynch syndrome. MSI-H is characterized by length alterations within simple repeated sequences, microsatellites. Lynch syndrome is primarily ...

journal_title：Carcinogenesis

authors： Imai K,Yamamoto H

更新日期：2008-04-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants with high carcinogenic potencies that have been linked to the etiology of human cancers through their presence in cigarette smoke and environmental mixtures. They are metabolically activated in cells by cytochrome P450 enzymes and/or perox...

journal_title：Carcinogenesis

authors： Melendez-Colon VJ,Luch A,Seidel A,Baird WM

更新日期：1999-10-01 00:00:00

abstract：:Effect of nicotine on PDGF AA and PDGF BB interaction with cervical cancer SiHa cells was tested. [125I]PDGF AA was internalized by cells and accumulated in the cytoplasm and nucleus (chromatin). In the absence of nicotine, maximal accumulation of [125I]PDGF AA inside the cells occurred after 1 day of incubation, whic...

journal_title：Carcinogenesis

authors： Rakowicz-Szulczynska EM,McIntosh DG,Perry M,Smith ML

更新日期：1996-09-01 00:00:00

abstract：:Observational studies suggest that fish consumption is associated with a decreased colorectal cancer (CRC) risk. A possible mechanism by which fish could reduce CRC risk is by decreasing colonic genotoxicity. However, concerns have also been raised over the levels of toxic compounds found in mainly oil-rich fish, whic...

journal_title：Carcinogenesis

authors： Pot GK,Habermann N,Majsak-Newman G,Harvey LJ,Geelen A,Przybylska-Philips K,Nagengast FM,Witteman BJ,van de Meeberg PC,Hart AR,Schaafsma G,Hooiveld G,Glei M,Lund EK,Pool-Zobel BL,Kampman E

更新日期：2010-06-01 00:00:00

abstract：:Four groups of six male Wistar rats (85 +/- 7 g) were fed a diet containing 0% (control) or 2% of the carcinogenic food antioxidant butylated hydroxyanisole (BHA) for 2 weeks. In this experiment, feeding 2% BHA is equivalent to a dose of 2.1 +/- 0.3 g BHA/kg/day. One 0% BHA and one 2% BHA-fed group of rats were daily ...

journal_title：Carcinogenesis

authors： Verhagen H,Furnée C,Schutte B,Hermans RJ,Bosman FT,Blijham GH,ten Hoor F,Henderson PT,Kleinjans JC

更新日期：1989-10-01 00:00:00

abstract：:Colonic epithelial cell migration is required for normal differentiated cell function. This migratory phenotype is dependent upon wild-type adenomatous polyposis coli (Apc) expression. Non-tumorigenic murine colon epithelial cell lines with distinct Apc genotypes, i.e. young adult mouse colon (YAMC; Apc(+/+)) and immo...

journal_title：Carcinogenesis

authors： Fenton JI,Wolff MS,Orth MW,Hord NG

更新日期：2002-06-01 00:00:00

abstract：:Lung cancer continues to be the leading cause of cancer death in the USA and the best example of a cancer with undisputed evidence of environmental risk. However, a genetic contribution to lung cancer has also been demonstrated by studies of familial aggregation, family-based linkage, candidate gene studies and most r...

journal_title：Carcinogenesis

authors： Schwartz AG,Wenzlaff AS,Bock CH,Ruterbusch JJ,Chen W,Cote ML,Artis AS,Van Dyke AL,Land SJ,Harris CC,Pine SR,Spitz MR,Amos CI,Levin AM,McKeigue PM

更新日期：2011-03-01 00:00:00

abstract：:The P53 tumor suppressor pathway plays an important role in cancer development. The auto-regulatory feedback mechanism of the P53 and MDM2 expression is critical in keeping proper tumor suppressor function of this pathway. This study examined the effect of P53 Arg72Pro variants on transactivation of polymorphic MDM2 p...

journal_title：Carcinogenesis

authors： Yang M,Guo Y,Zhang X,Miao X,Tan W,Sun T,Zhao D,Yu D,Liu J,Lin D

更新日期：2007-09-01 00:00:00

abstract：:4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most abundant and carcinogenic tobacco-specific nitrosamine in tobacco and tobacco smoke. The major metabolic pathway for NNK is carbonyl reduction to form the (R) and (S) enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) which, like NNK, is...

journal_title：Carcinogenesis

authors： Ashmore JH,Luo S,Watson CJW,Lazarus P

更新日期：2018-07-30 00:00:00

abstract：:A mouse monoclonal antibody (Mab) was prepared which showed high specificity for a potential marker of exposure to methylating carcinogens such as 3-methyladenine (3-MeAde). In a low-temperature (4 degrees C) ELISA a linear calibration curve was obtained between 3 and 50 fmol/well. In combination with an immunoaffinit...

journal_title：Carcinogenesis

authors： Prevost V,Shuker DE,Bartsch H,Pastorelli R,Stillwell WG,Trudel LJ,Tannenbaum SR

更新日期：1990-10-01 00:00:00

abstract：:Endocrine therapies, which inhibit estrogen receptor (ER)alpha signaling, are the most common and effective treatment for ERalpha-positive breast cancer. However, the use of these agents is limited by the frequent development of resistance. The cyclin-dependent kinase family member CRK7 (aka CRKRS) was identified from...

journal_title：Carcinogenesis

authors： Iorns E,Martens-de Kemp SR,Lord CJ,Ashworth A

更新日期：2009-10-01 00:00:00

abstract：:Bacterial formation of carcinogenic N-nitroso compounds may play a role in the etiology of human cancer. Biochemical and immunological studies in denitrifying bacteria (Pseudomonas aeruginosa) strongly support the identification of cytochrome cd(1)-nitrite reductase as the enzyme responsible for the catalysis of nitro...

journal_title：Carcinogenesis

authors： Calmels S,Ohshima H,Henry Y,Bartsch H

更新日期：1996-03-01 00:00:00

abstract：:Modulation of cellular thiols has been used to ameliorate the toxic side effects associated with cancer chemotherapy and is currently being investigated as a novel therapeutic strategy in cancer treatment. One of the most extensively studied modulators of thiol levels is N-acetylcysteine (NAC), a cytoprotective drug w...

journal_title：Carcinogenesis

authors： McLellan LI,Lewis AD,Hall DJ,Ansell JD,Wolf CR

更新日期：1995-09-01 00:00:00

abstract：:Phenobarbital (PB) is a potent tumor promoter in rodent liver. In this study we investigated whether PB selectively promotes a population of initiated cells with reduced levels of transforming growth factor-beta (TGF beta) receptors types I, II and III. Liver tumors were induced in male Fischer F344 rats by diethylnit...

journal_title：Carcinogenesis

authors： Mansbach JM,Mills JJ,Boyer IJ,De Souza AT,Hankins GR,Jirtle RL

更新日期：1996-01-01 00:00:00

abstract：:p90 Ribosomal S6 kinase (RSK) 4 is a serine-threonine kinase that belongs to the p90RSK family. RSK4 has been proposed as a tumor suppressor gene, related with anti-invasive activity, inhibition of the RAS-mitogen-activated protein kinase (MAPK) pathway and induction of senescence. Despite the related findings, little...

journal_title：Carcinogenesis

authors： López-Vicente L,Pons B,Coch L,Teixidó C,Hernández-Losa J,Armengol G,Ramon Y Cajal S

更新日期：2011-04-01 00:00:00

abstract：:Several nitroarenes derived from benzo[a]pyrene and perylene and the parent hydrocarbons have been assayed for mutagenicity in the Salmonella microsome test and for affinity for the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-receptor protein in rat liver cytosol. 1- and 3-nitrobenzo[a]pyrene are mutagenic in the absen...

journal_title：Carcinogenesis

authors： Löfroth G,Toftgård R,Nilsson L,Agurell E,Gustafsson JA

更新日期：1984-07-01 00:00:00

abstract：:Functional activation of beta-catenin/Tcf signaling plays an important role in the early events in colorectal carcinogenesis. We examined the effect of ionomycin against beta-catenin/Tcf signaling in colon cancer cells. Reporter gene assay showed that ionomycin inhibited beta-catenin/Tcf signaling efficiently. In addi...

journal_title：Carcinogenesis

authors： Park CH,Hahm ER,Lee JH,Jung KC,Rhee HS,Yang CH

更新日期：2005-11-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most common cancers in the world. Inflammation has been described as a risk factor for PCa and depends on the production of cytokines in response to tissue damage or the presence of stimuli that induces cellular stress. Interindividual variation in cytokine production is partially c...

journal_title：Carcinogenesis

authors： Zabaleta J,Su LJ,Lin HY,Sierra RA,Hall MC,Sartor AO,Clark PE,Hu JJ,Ochoa AC

更新日期：2009-08-01 00:00:00