Abstract:
:Prostate cancer (PCa) is one of the most common cancers in the world. Inflammation has been described as a risk factor for PCa and depends on the production of cytokines in response to tissue damage or the presence of stimuli that induces cellular stress. Interindividual variation in cytokine production is partially controlled by single-nucleotide polymorphisms (SNPs) that have been associated with differential production of cytokines. We have recently showed that SNP-SNP interactions of cytokine genes are associated with PCa risk. However, little is known about the association of cytokine SNPs and PCa aggressiveness. In this study, we evaluated the association of 15 SNPs in five cytokine genes and aggressiveness of PCa in African- and Caucasian-American individuals. Caucasian Americans with the genotypes IL10-1082GG or IL1B+3954TT had 2.31-fold [95% confidence interval (CI) = 1.13-4.72] and 3.11 (95% CI = 1.20-8.06)-fold risk, respectively, of developing aggressive PCa, as compared with individuals without those genotypes. We did not find any associations in the African-American group. Using Multivariate Adaptive Regression Splines modeling for exploratory SNP-SNP interactions, our results showed that more aggressive PCa in Caucasians Americans is associated with the CT genotype at IL8-47 [odds ratios (OR) = 3.50; 95% CI = 1.13-10.88] or combined genotypes of IL1B-511CC and IL10-1082GG (OR = 3.38; 95% CI = 1.70-6.71). Unfortunately, the same analysis could not be performed in the African-Americans due to limited number of individuals. With limited sample size, the results from this study suggest that SNPs in cytokine genes may be associated with PCa aggressiveness. More extensive studies are warranted to validate our findings.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Zabaleta J,Su LJ,Lin HY,Sierra RA,Hall MC,Sartor AO,Clark PE,Hu JJ,Ochoa ACdoi
10.1093/carcin/bgp124subject
Has Abstractpub_date
2009-08-01 00:00:00pages
1358-62issue
8eissn
0143-3334issn
1460-2180pii
bgp124journal_volume
30pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::Mevastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol synthesis. Butyrate, a short-chain fatty acid, reduces proliferation and induces differentiation of human colon cancer cells. The aim of our study was to determine the effect of mevastatin, ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/22.7.1061
更新日期:2001-07-01 00:00:00
abstract::A model of oral mucosal carcinogenesis using the water-soluble carcinogen 4-nitroquinoline-1-oxide (4NQO) was combined with a model of oral mucosal candidosis to examine the ability of Candida albicans to promote the development of neoplasia in suitably initiated epithelium. Sprague-Dawley rats were initiated by the a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.5.783
更新日期:1992-05-01 00:00:00
abstract::There is indirect evidence to suggest that the excision-repair mechanism responsible for the removal of UV-induced thymine dimers may also play a role in the repair of cis-diamminedichloroplatinum(II) (cis-DDP)-induced DNA adducts in both bacteria and mammalian cells. It was hypothesized that UV dimers and cis-DDP add...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.8.1465
更新日期:1989-08-01 00:00:00
abstract::Co-exposure to cadmium, cobalt, lead and other heavy metals occurs in many occupational settings, such as pigment and batteries production, galvanization and recycling of electric tools. However, little is known about interactions between several heavy metals. In the present study we determined DNA single strand break...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/24.1.63
更新日期:2003-01-01 00:00:00
abstract::Recent studies have examined and demonstrated the potential cancer chemopreventive activity of freeze-dried berries including strawberries and black raspberries. Although ellagic acid, an abundant component in these berries, has been shown to inhibit carcinogenesis both in vivo and in vitro, several studies have repor...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/22.2.351
更新日期:2001-02-01 00:00:00
abstract::Modulation of microsome mediated benzo[a]pyrene (BP) metabolism by oleic and linoleic acids was studied. Oleic and linoleic acids did not influence the apparent activity of aryl hydrocarbon hydroxylase or the relative ratios of BP-7,8-dihydrodiol to phenol metabolites on high performance liquid chromatography. The tot...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.10.1253
更新日期:1983-10-01 00:00:00
abstract::Dysbiosis of oral microbiome may dictate the progression of oral squamous cell carcinoma (OSCC). Yet, the composition of oral microbiome fluctuates by saliva and distinct sites of oral cavity and is affected by risky behaviors (smoking, drinking, and betel quid chewing) and individuals' oral health condition. To chara...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa062
更新日期:2020-07-04 00:00:00
abstract::58 MCA Cl 16 is an oncogenic methylcholanthrene-transformed variant of the non-transformed mouse embryo fibroblast cell line, C3H/10T1/2 Cl 8. Using two different protocols, we have isolated six temperature-sensitive mutants from N-methyl-N'-nitro-N-nitrosoguanidine treated cultures of 58 MCA Cl 16. C3H/10T1/2 Cl 8, 5...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.12.1059
更新日期:1980-01-01 00:00:00
abstract::Inbred strains of mice with differential response to known tumor promoters were compared with respect to their susceptibility to modulation of hepatic antioxidant enzymes by long-term treatment with high fat diet (HF) and phenobarbital (PB). Mice of the C57BL/6J (C57), C3H/HeOuJ (C3H) and DBA/2J (DBA) strains were fed...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.6.1225
更新日期:1993-06-01 00:00:00
abstract::Using conventional alkaline sucrose sedimentation analysis, we have compared the initial yield and subsequent enzymatic repair of DNA damage induced in cultured human [normal (GM38 and GM43) and xeroderma pigmentosum (XP12BE)] fibroblasts by the monofunctional alkylating agent methylmethanesulfonate (MMS). Exposure of...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.12.2257
更新日期:1988-12-01 00:00:00
abstract::Compounds of nickel(II) and cadmium(II) are carcinogenic to humans and to experimental animals. One frequently discussed mechanism involved in tumor formation is an increase in reactive oxygen species by both metals with the subsequent generation of oxidative DNA damage. In the present study we used human HeLa cells t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.5.1021
更新日期:1997-05-01 00:00:00
abstract::Dacarbazine (DTIC) is an antitumor agent, used for the treatment of metastatic melanoma. It is metabolized to an alkylating agent which reacts with DNA. A fast and simple method was developed in order to measure drug-induced DNA damage in lymphocytes isolated from frozen blood samples of treated patients. The level of...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.6.1153
更新日期:1991-06-01 00:00:00
abstract::Structural analogs of diethylstilbestrol (DES) with at least one phenolic hydroxyl group are metabolized by prostaglandin H synthase (PHS) from ram seminal vesicle microsomes (RSVM) in vitro in the presence of arachidonic acid (20:4). U.v. spectroscopy revealed the formation of p-quinoid intermediates in incubations o...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.1.137
更新日期:1986-01-01 00:00:00
abstract::The present study was aimed at verifying the occurrence, if any, of in vivo oxidative DNA damage in FA homozygotes, their parents and siblings. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) was measured, by HPLC/EC, in DNA from circulating blood leucocytes from FA homozygotes and their relatives and compared with a group of pa...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.4.735
更新日期:1995-04-01 00:00:00
abstract::To establish a cell culture model for lung carcinogenesis, independent populations of the human papillomavirus 18-immortalized human bronchial epithelial cell line BEP2D were treated with high linear energy transfer radon-simulated alpha-particles, expanded and xenotransplanted into Nu/Nu mice. Six independent cell li...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.6.1251
更新日期:1997-06-01 00:00:00
abstract::Epidemiological evidence has been supporting a relationship between dietary aflatoxin B1 (AFB1) exposure, development of human primary hepatocellular carcinoma (HCC) and mutations in the p53 tumor suppressor gene. However, the correlation between the observed p53 mutations, the AFB1 DNA adducts and their activation pa...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.7.1291
更新日期:1997-07-01 00:00:00
abstract::The pulmonary adenoma susceptibility 1 (Pas1) gene affects susceptibility to the development of lung adenomas in mice with a subset of the adenomas progressing to adenocarcinoma (ADC). In this study, genotype distributions for 10 polymorphisms in the human counterparts for three mouse candidate Pas1 genes, KRAS, CASC1...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn048
更新日期:2008-05-01 00:00:00
abstract::Telomeres are critical in maintaining chromosome and genomic stability. Arsenic, a human carcinogen as well as an anticancer agent, is known for its clastogenicity. To better understand molecular mechanisms of arsenic actions, we investigated arsenite effects on telomere and telomerase and determined cell growth and a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgg141
更新日期:2003-11-01 00:00:00
abstract::The experiments reported in this study were designed to examine the question of whether a mammary epithelial cell's independence from hormonal requirements is established at the time of carcinogenic initiation, or whether the emergence of hormone independence is associated with the process of tumor progression. A newl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.3.383
更新日期:1998-03-01 00:00:00
abstract::A monoclonal antibody specific for cyclobutane thymine dimers in DNA was used in immunofluorescence studies to detect these lesions in skin sections taken from hairless mice that had been irradiated with UV-B. The dimer-specific fluorescence in epidermal cell nuclei was quantified with fluorescence microscopy through ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.5.861
更新日期:1991-05-01 00:00:00
abstract::4,4'-Methylene-bis(2-chloroaniline) (MOCA) can produce tumors in rodents and dogs and an increased incidence of bladder tumors has been reported in exposed workers. It is therefore of interest to identify the human cytochrome P450 (P450) enzymes involved in MOCA N-oxidation, the primary reaction involved in the format...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.2.217
更新日期:1992-02-01 00:00:00
abstract::Monoterpenes have been shown to both prevent and treat mammary cancer in animal models and are currently in clinical testing in advanced cancer patients. In this study, we investigated a biochemical modulation associated with the antitumor activity of monoterpenes, the inhibition of protein isoprenylation in monoterpe...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.5.827
更新日期:1998-05-01 00:00:00
abstract::Optimal proliferation of cultured hepatocytes from normal rats occurs in response to epidermal growth factor (EGF) at an extracellular calcium concentration of 0.4 mM, whereas physiological concentrations of calcium have been shown to decrease hepatocyte proliferation. Exposure of hepatocytes in vivo to phenobarbital ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.3.479
更新日期:1988-03-01 00:00:00
abstract::Modulation of cellular thiols has been used to ameliorate the toxic side effects associated with cancer chemotherapy and is currently being investigated as a novel therapeutic strategy in cancer treatment. One of the most extensively studied modulators of thiol levels is N-acetylcysteine (NAC), a cytoprotective drug w...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.9.2099
更新日期:1995-09-01 00:00:00
abstract::3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, pravastatin (Pr) and simvastatin (Si), suppressed 1,2-dimethylhydrazine (DMH)-induced colon cancer development in female ICR mice. All mice received an i.p. injection of 10 mg DMH/kg body wt once weekly for 15 weeks. Pr was administered at 0.01, 0.0...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.9.2045
更新日期:1994-09-01 00:00:00
abstract::Mutations or transcriptional silencing of mismatch repair genes have been linked with tumour cell resistance to O(6)-guanine methylating agents, 6-thioguanine, cisplatin, doxorubicin and etoposide. Recently, it has been demonstrated that overexpression of the MSH3 protein is associated with depletion of the mismatch b...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/22.8.1131
更新日期:2001-08-01 00:00:00
abstract::Cancer-associated fibroblasts (CAFs) tend to have tumor-promoting capacity, and can provide therapeutic targets. Even without cancer cells, CAF phenotypes are stably maintained, and DNA methylation and H3K27me3 changes have been shown to be involved. Here, we searched for a potential therapeutic target in primary CAFs...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa131
更新日期:2020-12-07 00:00:00
abstract::The O6-alkylguanine-DNA alkyltransferase (ATase) is known to overcome the effects of promutagenic, precarcinogenic O6-alkylguanine induced in DNA by exposure to environmental, chemotherapeutic and dietary alkylating agents. Within an organ, the cell type-specific responses to these agents may be attributed, in part, t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.4.737
更新日期:1993-04-01 00:00:00
abstract::Aphidicolin is a specific inhibitor of DNA polymerase alpha. Its influence of DNA repair has been studied in both normal and excision deficient xeroderma pigmentosum cells exposed to u.v. irradiation at 254 nm. Single strand DNA breaks accumulated in u.v. irradiated normal cells when the inhibitor was present. Such br...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.8.795
更新日期:1981-01-01 00:00:00
abstract::This study analyzes the mechanism by which the tumor promoter 12-0-tetradecanoyl-phorbol 13-acetate (TPA) inhibits binding of epidermal growth factor (EGF) to its membrane receptors in HeLa cells. Kinetic studies indicate that inhibition of EGF binding occurs within a few minutes after exposure of cells to TPA; delaye...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.8.669
更新日期:1980-08-01 00:00:00