Abstract:
:Bacterial formation of carcinogenic N-nitroso compounds may play a role in the etiology of human cancer. Biochemical and immunological studies in denitrifying bacteria (Pseudomonas aeruginosa) strongly support the identification of cytochrome cd(1)-nitrite reductase as the enzyme responsible for the catalysis of nitrosation through the production of nitric oxide or NO(+)-like species. Interestingly, electron paramagnetic resonance studies have shown that large quantities of nitric oxide or NO(+)-species were also produced by non-denitrifying enterobacteria (Escherichia coli, Proteus morganii).
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Calmels S,Ohshima H,Henry Y,Bartsch Hdoi
10.1093/carcin/17.3.533subject
Has Abstractpub_date
1996-03-01 00:00:00pages
533-6issue
3eissn
0143-3334issn
1460-2180journal_volume
17pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::The effect of a deoxycholic acid instillation on colonic epithelium was investigated and compared with the effect of an intervention scheme in which deoxycholic acid (DCA) treated mice received oral supplements of calcium lactate. The morphology of colonic tissue exposed to DCA was markedly affected when compared to t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.9.1205
更新日期:1983-09-01 00:00:00
abstract::It has recently been reported that the XPD (ERCC2) gene is an integral component of the basal transcription factor TFIIH. We have studied the direct role of this repair gene on the fine structure of DNA repair in hamster cells. The gene and strand specific DNA repair of UV induced pyrimidine dimers was determined in w...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.4.681
更新日期:1997-04-01 00:00:00
abstract::17beta-estradiol (E2), estrone and diethylstilbestrol (DES) had no effect on nuclear and nucleolar RNA synthesis in vitro. However, after reacting with dimethyldioxirane (DMDO), a versatile epoxide-forming oxidant, these estrogens were able to inhibit and in a dose-dependent manner nuclear and nucleolar RNA synthesis ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.9.1957
更新日期:1996-09-01 00:00:00
abstract::DNA repair after gamma radiation was studied in purified T lymphocytes from young and aged subjects. Two different assays were employed. In the first, T lymphocytes were stimulated with phytohemagglutinin (PHA) for 72 h and then treated with hydroxyurea, irradiated with 30 K rads and pulsed with [3H]thymidine (TdR) fo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.1.45
更新日期:1982-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptor (PPAR) gamma is a ligand-activated nuclear receptor that plays a key role in adipogenesis and adipocyte gene expression, and has recently been linked with possible antineoplastic effects in colonic carcinogenesis. PPARgamma2 and gamma3 are two transcripts arising from the PPA...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl001
更新日期:2006-09-01 00:00:00
abstract::The role of O-GlcNAc transferase (OGT) in gene regulation and tumor invasion is poorly understood. Here, we have identified several previously undiscovered OGT-interacting proteins, including the PRMT5/WDR77 complex, the PRC2 complex, the ten-eleven translocation (TET) family, the CRL4B complex and the nucleosome remo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy097
更新日期:2018-10-08 00:00:00
abstract::In this case-control study with 387 White esophageal patients and 462 White controls matched to cases by age and sex, we evaluated the associations between 13 potential functional polymorphisms in eight major nucleotide excision repair (NER) genes and esophageal cancer risk. In individual single nucleotide polymorphis...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp058
更新日期:2009-05-01 00:00:00
abstract::Mice with non-phosphorylated serine 389 in p53 are susceptible for bladder tumors induced by 2-acetylaminofluorene (2-AAF). Since p53 is a transcription factor, this might well be preceded by differences in the regulation of gene expression. Microarray analysis was used to determine early transcriptional changes that ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm041
更新日期:2007-08-01 00:00:00
abstract::The genotoxic effects of intragastrically administered benzo[a]pyrene (BaP) were studied in isolated rat liver and intestinal cells. We found that BaP was unable to induce unscheduled DNA synthesis in rat parenchymal liver cells in vivo. In contrast, alkaline elution showed that at 5 h after administration of BaP a co...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.2.393
更新日期:1989-02-01 00:00:00
abstract::Genistein is a major isoflavone with known hormonal and tyrosine kinase-modulating activities. Genistein has been shown to promote the growth of estrogen receptor positive (ER+) MCF-7 cells. In ER-negative (ER-)/erbB-2-overexpressing (erbB-2+) cells, genistein has been shown to inhibit cell growth through its tyrosine...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq007
更新日期:2010-04-01 00:00:00
abstract::Despite recent additions to the armory of chemotherapeutic agents for colorectal cancer (CRC) treatment, the results of chemotherapy remain unsatisfactory. 5-Fluorouracil (5-FU) still represents the cornerstone of treatment and resistance to its actions is a major obstacle to successful chemotherapy. Therefore, new ac...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi307
更新日期:2006-03-01 00:00:00
abstract::Isolated trout liver cells were treated with lysolecithin to produce an in situ system for characterizing DNA repair in teleosts. In this preparation, the integrity of the plasma membrane is altered, nuclei remain intact, and the concentrations of dNTPs and nucleotide analogs, which normally do not penetrate intact pl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.6.995
更新日期:1989-06-01 00:00:00
abstract::Base excision repair pathway may play an important role in repairing DNA damage related to Helicobacter pylori-induced inflammatory process. To evaluate the association between genetic polymorphisms of X-ray repair cross-complementing group 1 (XRCC1, Arg194Trp and Arg399Gln), adenosine diphosphate ribosyl transferase ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp018
更新日期:2009-03-01 00:00:00
abstract::Hepatic microsomes of female F344 rats were capable of N,O-acyltransfer of N-hydroxy-N-acetyl-2-aminofluorene (N-OH-AAF) and N-hydroxy-N-formyl-2-aminofluorene (N-OH-FAF), N-deacetylation of N-OH-AAF and N-acetyl-2-aminofluorene (2-AAF), and O-deacetylation of 4-nitrophenyl acetate (NPA). The activity for N,O-acyltran...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.11.2017
更新日期:1992-11-01 00:00:00
abstract::Heat treatment of foods containing reducing sugars and amino acids during cooking or sterilization triggers a sequence of non-enzymatic reactions collectively known as the Maillard reaction. 5-Hydroxymethylfurfural (HMF), one of the major intermediate products in the Maillard reaction, has been found to possess cytoto...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.10.2375
更新日期:1994-10-01 00:00:00
abstract::Multiple myeloma (MM) is characterized by a wide spectrum of genetic changes. Global hypomethylation of repetitive genomic sequences such as long interspersed nuclear element 1 (LINE-1), Alu and satellite alpha (SAT-alpha) sequences has been associated with chromosomal instability in cancer. Methylation status of repe...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp149
更新日期:2009-08-01 00:00:00
abstract::Vinyl carbamate epoxide (VCO) was found to possess strong electrophilic, mutagenic and carcinogenic activities. It reacted with water at 37 degrees C and pH 7.4 (phosphate buffer) to form glycolaldehyde and several related reducing compounds; none of these products were mutagenic for Salmonella typhimurium TA1535. Und...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.3.441
更新日期:1993-03-01 00:00:00
abstract::The association between prostate cancer risk and dietary fat consumption is well documented and explained partly by accelerated lipid peroxidation. We explored the possible effects of high dietary cholesterol on carcinogenesis and oxidative stress in the prostate of ACI/Seg rats. The rats develop prostate cancer spont...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh105
更新日期:2004-06-01 00:00:00
abstract::The role of parity before and after N-methyl-N-nitrosourea (MNU) treatment in protection against mammary carcinogenesis was investigated. The effect of lactation on reduction in the incidence of mammary carcinoma was also examined. Parous rats were compared with respective age-matched virgins (AMVs). Pregnancy and lac...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.4.623
更新日期:1999-04-01 00:00:00
abstract::Soy-based products consumed in Asian countries are minimally processed whereas in the USA many of the soy foods and soy ingredients are highly processed. Soy foods contain complex mixtures of bioactive compounds, which may interact with one another. The objective of this study was to evaluate the ability of various so...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh178
更新日期:2004-09-01 00:00:00
abstract::Nitric oxide (NO) has been shown to induce double strand DNA breaks in Barrett's oesophagus (BO) and in other cancers has a role in invasion. The specific aims of this study were to investigate whether NO can induce invasion in cells representative of different stages of Barrett's progression and to determine possible...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq130
更新日期:2010-09-01 00:00:00
abstract::1,3-Dimethyl-3-phenyl-1-nitrosourea (DMPNU) shows no spontaneous decomposition in aqueous buffered solution (pH 7.0) at 37 degrees C over a measuring period of 10 days, but it is directly genotoxic in all assays applied. This compound induces base substitutions in Salmonella typhimurium (especially in the plasmid harb...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.4.409
更新日期:1983-01-01 00:00:00
abstract::To evaluate the significance of C-C chemokine receptor type 5 (CCR5) in lung tumor development, we compared carcinogen-induced tumor growth in CCR5 knockout (CCR5(-/-)) mice and wild-type (CCR5(+/+)) mice. CCR5(-/-) mice showed reduced urethane (1g/kg)-induced tumor incidence when compared with those of CCR5(+/+) mice...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs265
更新日期:2012-12-01 00:00:00
abstract::Woodchuck (Marmota monax) hepatic cells, which were immortalized by the simian virus 40 large T antigen (SV40 Tag) produced nitric oxide (NO; measured as nitrite) in vitro from L-arginine (L-Arg) after lipopolysaccharide (LPS) treatment. NO synthesis was related to L-Arg and LPS concentration and plateaued at 1.0 mM L...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.8.1609
更新日期:1993-08-01 00:00:00
abstract::A series of cells representing normal, non-tumorigenic cell lines, as well as differentiating neoplastic and undifferentiated neoplastic rat tracheal epithelial cell populations were evaluated for their ability to establish homologous and/or heterologous cell-cell gap junction communication in culture. Gap junction co...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.11.2043
更新日期:1997-11-01 00:00:00
abstract::MicroRNAs (miRNAs) are small non-coding RNA molecules that are often located in genomic breakpoint regions and can act as oncogenes or tumor suppressor genes in human cancer. Our previous study showed that microRNA-423 (miR-423), which localized to the frequently amplified region of chromosome 17q11, was upregulated i...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr199
更新日期:2011-11-01 00:00:00
abstract::DNA polymerase beta (polbeta) is a major contributor to mammalian DNA damage repair through its gap-filling DNA synthesis and 5'-deoxyribose phosphate lyase activities. In this way, polbeta plays pivotal roles in the repair of oxidative DNA damage, replication, embryonic survival, neuronal development, meiosis, apopto...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl239
更新日期:2007-06-01 00:00:00
abstract::Iscador, an extract from the semi-parasitic plant Viscum album, was found to inhibit 20-methylcholanthrene-induced carcinogenesis in mice. Intraperitoneal administration of Iscador (1 mg/dose) twice weekly for 15 weeks could completely inhibit 20-methylcholanthrene-induced sarcoma in mice and protect these animals fro...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.5.1107
更新日期:1996-05-01 00:00:00
abstract::Inactivation of the adenomatous polyposis coli (Apc) gene by loss of the wild-type Apc allele (LOH) is a prerequisite for the development of intestinal adenomas in Msh2 proficient Min (Apc+/-Msh2+/+) mice. In contrast, adenomas from Msh2 deficient Min (Apc+/-Msh2-/-) mice are not usually associated with LOH. Given the...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/24.2.217
更新日期:2003-02-01 00:00:00
abstract::Alterations of epigenetic modifications are promising targets for cancer therapy, and several epigenetic drugs are now being clinically utilized. At the same time, individual epigenetic modifications have physiological functions in normal cells, and cancer cell specificity is considered difficult to achieve using a dr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgu238
更新日期:2015-02-01 00:00:00