Abstract:
:The genotoxic effects of intragastrically administered benzo[a]pyrene (BaP) were studied in isolated rat liver and intestinal cells. We found that BaP was unable to induce unscheduled DNA synthesis in rat parenchymal liver cells in vivo. In contrast, alkaline elution showed that at 5 h after administration of BaP a considerable number of alkali-labile sites was present in the DNA of both intestinal cells and parenchymal liver cells, but not in that of non-parenchymal liver cells. The possibility is discussed that these sites were induced by radical intermediates, generated during the metabolization of BaP.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Mullaart E,Buytenhek M,Brouwer A,Lohman PH,Vijg Jdoi
10.1093/carcin/10.2.393subject
Has Abstractpub_date
1989-02-01 00:00:00pages
393-5issue
2eissn
0143-3334issn
1460-2180journal_volume
10pub_type
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