Abstract:
:The role of O-GlcNAc transferase (OGT) in gene regulation and tumor invasion is poorly understood. Here, we have identified several previously undiscovered OGT-interacting proteins, including the PRMT5/WDR77 complex, the PRC2 complex, the ten-eleven translocation (TET) family, the CRL4B complex and the nucleosome remodeling and deacetylase (NuRD) complex. Genome-wide analysis of target genes responsive to OGT resulted in identification of a cohort of genes including SNAI1 and ING4 that are critically involved in cell epithelial-mesenchymal transition and invasion/metastasis. We have demonstrated that OGT promotes carcinogenesis and metastasis of cervical cancer cells. OGT's expression is significantly upregulated in cervical cancer, and low OGT level is correlated with improved prognosis. Our study has thus revealed a mechanistic link between OGT and tumor progression, providing potential prognostic indicators and targets for cancer therapy.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Gao J,Yang Y,Qiu R,Zhang K,Teng X,Liu R,Wang Ydoi
10.1093/carcin/bgy097subject
Has Abstractpub_date
2018-10-08 00:00:00pages
1222-1234issue
10eissn
0143-3334issn
1460-2180pii
5057053journal_volume
39pub_type
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