Reaction products of styrene oxide with guanosine in aqueous media.

abstract：:Earlier studies have shown that the profile of mutations induced by (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (+)-BPDE at the hypoxanthine (guanine) phosphoribosyltransferase (hprt) gene of Chinese hamster V79 cells was dependent on the concentration of (+)-BPDE. In the present study, we exami...

journal_title：Carcinogenesis

authors： Schiltz M,Cui XX,Lu YP,Yagi H,Jerina DM,Zdzienicka MZ,Chang RL,Conney AH,Wei SJ

更新日期：1999-12-01 00:00:00

abstract：:Rat hepatocytes maintained for up to 6 days in primary culture were used to test a variety of xenobiotics and steroids for effects on the activity of gamma-glutamyltranspeptidase (GGT) in normal cells. In control cultures GGT activity was low and increased slowly with time. When added to cultures for 5 days, a variety...

journal_title：Carcinogenesis

authors： Edwards AM,Lucas CM

更新日期：1985-05-01 00:00:00

abstract：:It is now unanimously accepted that neoplastic cells tend to become less susceptible to the growth regulatory effects of transforming growth factor-beta1 (TGF-beta1), mainly because of reduced expression and/or activity of TGF-beta1-specific receptors, as reported for many human cancers including colon cancer. Consequ...

journal_title：Carcinogenesis

authors： Biasi F,Mascia C,Poli G

更新日期：2008-05-01 00:00:00

abstract：:We have established a protocol that allows qualitative and quantitative determination of butadiene monoepoxide-DNA adducts formed as a result of inhalation exposure to 1,3-butadiene. We observed that in this particular case in vivo samples required extensive sample purification to facilitate a low background. Sample p...

journal_title：Carcinogenesis

authors： Koivisto P,Sorsa M,Pacchierotti F,Peltonen K

更新日期：1997-02-01 00:00:00

abstract：:The transcription factor Sp1 has been implicated in cell-type-specific activation of transforming growth factor-beta (TGFbeta) target genes in normal epithelial cells as well as in aberrant gene activation by TGFbeta in epithelial tumor cells. Here, we have examined the interaction of Sp1 with components of the Smad s...

journal_title：Carcinogenesis

authors： Jungert K,Buck A,Buchholz M,Wagner M,Adler G,Gress TM,Ellenrieder V

更新日期：2006-12-01 00:00:00

abstract：:Using conventional alkaline sucrose sedimentation analysis, we have compared the initial yield and subsequent enzymatic repair of DNA damage induced in cultured human [normal (GM38 and GM43) and xeroderma pigmentosum (XP12BE)] fibroblasts by the monofunctional alkylating agent methylmethanesulfonate (MMS). Exposure of...

journal_title：Carcinogenesis

authors： Mirzayans R,Liuzzi M,Paterson MC

更新日期：1988-12-01 00:00:00

abstract：:Untreated and Aroclor 1254-pretreated male Wistar rats were given a single dose of 1.0 mg/kg body weight of randomly tritium-labelled 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (3H-PhIP) by oral intubation. Urine and faeces were collected at 24, 48 and 72 hours after dosing, and total radioactivity determined. A...

journal_title：Carcinogenesis

authors： Dragsted LO,Frandsen H,Reistad R,Alexander J,Larsen JC

更新日期：1995-11-01 00:00:00

abstract：:The extracellular matrix (ECM) is known to play an active role in numerous biological processes such as differentiation, apoptosis and cancer. Extensive alterations of epithelial basement membranes and of interstitial ECM are known to occur during the progression of most invasive carcinomas. Collagen, which represents...

journal_title：Carcinogenesis

authors： Pucci-Minafra I,Andriolo M,Basiricò L,Alessandro R,Luparello C,Buccellato C,Garbelli R,Minafra S

更新日期：1998-04-01 00:00:00

abstract：:Epidemiological evidence suggests a link between meat consumption and prostate cancer. In this study, benign prostatic hyperplasia tissues, obtained by transurethral resection or radical retropubic prostatectomy from UK-resident individuals (n = 18), were examined for CYP1 expression and for their ability, in short-te...

journal_title：Carcinogenesis

authors： Williams JA,Martin FL,Muir GH,Hewer A,Grover PL,Phillips DH

更新日期：2000-09-01 00:00:00

abstract：:Integrins control the cell attachment to the extracellular matrix and play an important role in mediating cell proliferation, migration and survival. A number of important cancer-associated integrin genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3' untranslated regions. We examined...

journal_title：Carcinogenesis

authors： Brendle A,Lei H,Brandt A,Johansson R,Enquist K,Henriksson R,Hemminki K,Lenner P,Försti A

更新日期：2008-07-01 00:00:00

abstract：:Thioredoxin reductases (TrxRs) catalyse the NADPH-dependent reduction of thioredoxin and play an important role in multiple cellular events related to carcinogenesis including cell proliferation, apoptosis and cell signaling. We have used human hepatoma HepG2 cells to examine the regulation of TrxRs by isothiocyanate ...

journal_title：Carcinogenesis

authors： Zhang J,Svehlíková V,Bao Y,Howie AF,Beckett GJ,Williamson G

更新日期：2003-03-01 00:00:00

abstract：:Cancer is a leading cause of death worldwide and environmental factors, including chemicals, have been suggested as major etiological incitements. Cancer statistics indicates that men get more cancer than women. However, differences in the known risk factors including life style or occupational exposure only offer par...

journal_title：Carcinogenesis

authors： Ali I,Högberg J,Hsieh JH,Auerbach S,Korhonen A,Stenius U,Silins I

更新日期：2016-10-01 00:00:00

abstract：:Oxidized DNA base lesions, such as thymine glycol (Tg) and 8-hydroxyguanine, are often toxic and mutagenic and have been implicated in carcinogenesis. To clarify whether NEIL1 protein, which exhibits excision repair activity towards such base lesions, is involved in gastric carcinogenesis, we examined 71 primary gastr...

journal_title：Carcinogenesis

authors： Shinmura K,Tao H,Goto M,Igarashi H,Taniguchi T,Maekawa M,Takezaki T,Sugimura H

更新日期：2004-12-01 00:00:00

abstract：:Benzene, a ubiquitous environmental pollutant, is known to cause leukemia and aplastic anemia in humans and hematotoxicity and myelotoxicity in rodents. Toxicity is thought to be exerted through oxidative metabolites formed in the liver, primarily via pathways mediated by cytochrome P450 2E1 (CYP2E1). Phenol, hydroqui...

journal_title：Carcinogenesis

authors： Lovern MR,Maris ME,Schlosser PM

更新日期：1999-08-01 00:00:00

abstract：:To investigate the sensitivity of heterozygous p53-deficient CBA mice to carcinogens, 20 female mice [p53(+/-)] and 20 wild-type littermates [p53(+/+)] were given an intraperitoneal injection of 120 mg/kg body wt of N-ethyl-N-nitrosourea (ENU) and were maintained without any other treatment for a further 26 weeks. His...

journal_title：Carcinogenesis

authors： Mitsumori K,Onodera H,Shimo T,Yasuhara K,Takagi H,Koujitani T,Hirose M,Maruyama C,Wakana S

更新日期：2000-05-01 00:00:00

abstract：:Glucosinolates are common components of cruciferous vegetables that can be hydrolyzed during food processing to yield isothiocyanates, some of which have been shown to inhibit the induction of mammary tumors in rats by 7,12-dimethyl-benz[a]anthracene. To determine how intact glucosinolates affect the metabolism of ben...

journal_title：Carcinogenesis

authors： Baird WM,Zennie TM,Ferin M,Chae YH,Hatchell J,Cassady JM

更新日期：1988-04-01 00:00:00

abstract：:BTG3/ANA/APRO4 has been reported to be a tumor suppressor gene in some malignancies. It constitutes important negative regulatory mechanism for Src-mediated signaling, a negative regulator of the cell cycle and inhibits transcription factor E2F1. We report that BTG3 is downregulated in renal cancer and that the mechan...

journal_title：Carcinogenesis

authors： Majid S,Dar AA,Ahmad AE,Hirata H,Kawakami K,Shahryari V,Saini S,Tanaka Y,Dahiya AV,Khatri G,Dahiya R

更新日期：2009-04-01 00:00:00

abstract：:Comparative X-ray crystallographic structure analyses have been carried out on seven cyclopenta[a]phenanthrenes, namely 15,16-dihydocyclopenta[a]phenanthren-17-one and its 2-, 6- and 12-methyl homologues (non-carcinogens) and the 7-and 11-methyl and 1,11-methano derivatives (carcinogens). All-valence-electron molecula...

journal_title：Carcinogenesis

authors： Clayton AF,Coombs MM,Henrick K,McPartlin M,Trotter J

更新日期：1983-12-01 00:00:00

abstract：:The ability of sodium bisulfite to induce morphological transformation and mutagenesis of cultured Syrian hamster embryo cells was examined. Treatment of the cells at neutral pH for 15 min with 5-20 mM sodium bisulfite resulted in a dose-dependent increase in cell transformation but no induction of gene mutations meas...

journal_title：Carcinogenesis

authors： Tsutsui T,Barrett JC

更新日期：1990-10-01 00:00:00

abstract：:Male F344 rats were administered phenobarbital, polychlorinated biphenyl (PCB), retinol acetate, indomethacin, 6-amino-caproic acid, dexamethasone (DEX) or diethylmaleate (DEM) for one week and then were treated with these chemicals plus butylated hydroxyanisole (BHA) for a further four weeks. Histopathologically, the...

journal_title：Carcinogenesis

authors： Hirose M,Inoue T,Masuda A,Tsuda H,Ito N

更新日期：1987-10-01 00:00:00

abstract：:The complete tumour promoter phorbol, 12-myristate, 13-acetate (PMA) induces terminal differentiation in the majority of normal cultured human and mouse keratinocytes but a subpopulation exists which is resistant to this effect (PMAR). We have compared with PMA the effects of mezerein (Mez) and phorbol, 12-retinoate, ...

journal_title：Carcinogenesis

authors： Parkinson EK,Pera MF,Emmerson A,Gorman PA

更新日期：1984-08-01 00:00:00

abstract：:To determine the contribution of susceptibility loci in explaining the genetic basis of acute lymphoblastic leukemia (ALL), we genotyped 29 high-potential candidate genes with 672 tagged single-nucleotide polymorphisms (SNPs) in a sample (163 cases and 251 healthy controls) of Caucasian children. Fifty SNPs in 15 gene...

journal_title：Carcinogenesis

authors： Beuten J,Gelfond JA,Piwkham D,Pollock BH,Winick NJ,Collier AB 3rd,Tomlinson GE

更新日期：2011-09-01 00:00:00

abstract：:The genes that are involved in estrogen biosynthesis, cellular binding and metabolism may contribute to breast cancer susceptibility. We examined the effect of the CYP17 promoter T --> C polymorphism and its interactions with the reproductive history, exogenous hormone use and selected lifestyle risk factors on breast...

journal_title：Carcinogenesis

authors： Chen Y,Gammon MD,Teitelbaum SL,Britton JA,Terry MB,Shantakumar S,Eng SM,Wang Q,Gurvich I,Neugut AI,Santella RM,Ahsan H

更新日期：2008-04-01 00:00:00

abstract：:The denitrosation of a novel nitrosourea, 1-(2-chloroethyl)-3-[(2-dimethylaminosulfonyl)-ethyl]-1-nitrosoure a, tauromustine (TCNU), has been investigated in liver cytosol from various species and with a pool of cytosolic rat liver glutathione transferases (GSTs). In addition, the denitrosation of related nitrosoureas...

journal_title：Carcinogenesis

authors： Tuvesson H,Gunnarsson PO,Seidegård J

更新日期：1993-06-01 00:00:00

abstract：:The Notch signaling pathway is evolutionarily conserved and responsible for cell fate determination in the developing embryo and mature tissue. At the molecular level, ligand binding activates Notch signaling by liberating the Notch intracellular domain, which then translocates into the nucleus and activates gene tran...

journal_title：Carcinogenesis

authors： Capaccione KM,Pine SR

更新日期：2013-07-01 00:00:00

abstract：:When hepatocytes isolated from mouse liver are cultivated in vitro, a small fraction of cells can survive, forming colonies, while most cells die within a few weeks. We compared the colony forming capacity of hepatocytes in three mouse strains; two strains susceptible for hepatocarcinogenesis, C3H/HeJ (C3) and DBA/2J ...

journal_title：Carcinogenesis

authors： Yoshie M,Nishimori H,Lee GH,Ogawa K

更新日期：1998-06-01 00:00:00

abstract：:In the era of precision oncology, bladder cancer (BlCa) is characterized by generic patient management and lack of personalized prognosis and surveillance. Herein, we have studied the clinical significance of urothelial cancer associated 1 (UCA1) lncRNA in improving patients' risk stratification and prognosis. A scree...

journal_title：Carcinogenesis

authors： Avgeris M,Tsilimantou A,Levis PK,Rampias T,Papadimitriou MA,Panoutsopoulou K,Stravodimos K,Scorilas A

更新日期：2019-08-22 00:00:00

abstract：:Reactive oxygen species (ROS) have been implicated in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance of many cancers. We evaluated the role of peroxiredoxin (Prx) I in TRAIL resistance governed by coupling of nicotinamide adenosine dinucleotide phosphate oxidase (Nox)-derived ROS signaling ...

journal_title：Carcinogenesis

authors： Song IS,Kim SU,Oh NS,Kim J,Yu DY,Huang SM,Kim JM,Lee DS,Kim NS

更新日期：2009-07-01 00:00:00

abstract：:[14C]Benzo[a]pyrene (BP) was administered to male germfree rats. Urinary metabolites, constituting 9% of the administered radioactivity, were fractionated by lipophilic ion exchange chromatography. More than 80% of the urinary metabolites were conjugated, while neutral metabolites constituted 13-18%. The latter group ...

journal_title：Carcinogenesis

authors： Yang Y,Sjövall J,Rafter J,Gustafsson JA

更新日期：1994-04-01 00:00:00

abstract：:Breakdown of basement membrane (BM) is believed to be an essential step for tumor invasion and metastases. We have previously demonstrated that matrix metalloproteinase-9 (MMP-9), the 92 kDa collagenase expression correlates with metastases in human colorectal cancer (CRC). This study explores the relationship between...

journal_title：Carcinogenesis

authors： Zeng ZS,Cohen AM,Guillem JG

更新日期：1999-05-01 00:00:00