Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer.

abstract：:Non-classical class Ib (class Ib) genes are found in all jawed vertebrates, including the amphibian Xenopus, which possesses at least 20 distinct Xenopus non-classical class Ib genes (XNCs). As an immune evasion strategy, tumors often downregulate surface expression of classical major histocompatibility complex class ...

journal_title：Carcinogenesis

authors： Haynes-Gilmore N,Banach M,Edholm ES,Lord E,Robert J

更新日期：2014-08-01 00:00:00

abstract：:A quantitative relationship was established for 26 nitrosamines between their carcinogenic effectiveness in experimental animals and their mutagenic activity in a mammalian cell-mediated assay. Mutagenesis was measured in Chinese hamster V79 cells co-cultivated with primary rat hepatocytes, which are capable of activa...

journal_title：Carcinogenesis

authors： Jones CA,Marlino PJ,Lijinsky W,Huberman E

更新日期：1981-01-01 00:00:00

abstract：:The antihistamine methapyrilene (hydrochloride) and four close structural analogs, methaphenilene, methafurylene, thenyldiamine and clorothen, were given to rats at a concentration of 0.1% in drinking water for 34 weeks. Only methapyrilene produced notable histopathological changes in the liver, bile duct hyperplasia ...

journal_title：Carcinogenesis

authors： Hernandez L,Allen PT,Poirier LA,Lijinsky W

更新日期：1989-03-01 00:00:00

abstract：:The development of a variety of odontogenic lesions was elicited by a single i.p. injection of N-nitroso-N-methylurea (NMU) at a dose of 150 mg/kg body weight. A total of 190 male Wistar/Furth rats were used in this study. The odontogenic lesions appeared macroscopically, mainly as supernumerary lower incisors, 88 +/-...

journal_title：Carcinogenesis

authors： Smulow JB,Konstantinidis A,Sonnenschein C

更新日期：1983-09-01 00:00:00

abstract：BACKGROUND:The hepatitis B virus x gene (HBx) is a promiscuous transactivator implicated in the development of hepatocellular carcinoma (HCC). The present study was designed to investigate the molecular events regulated by HBx. METHODS:Genomic and proteomic expression profiling was performed in Huh7 HCC cells transfec...

journal_title：Carcinogenesis

authors： Liu X,Wang L,Zhang S,Lin J,Zhang S,Feitelson MA,Gao H,Zhu M

更新日期：2008-06-01 00:00:00

abstract：:Carcinogenic tobacco-specific nitrosamines are present in tobacco products and are believed to play a significant role in human cancers associated with tobacco use. Additional amounts of tobacco-specific nitrosamines could be formed endogenously. We tested this hypothesis by treating rats with nicotine and sodium nitr...

journal_title：Carcinogenesis

authors： Carmella SG,Borukhova A,Desai D,Hecht SS

更新日期：1997-03-01 00:00:00

abstract：:Estrogen plays an important role in breast cancer development. While the mechanism of the estrogen effects is not fully elucidated, one possible route is by increasing the stem cell-like properties in the tumors. Tocopherols are known to reduce breast cancer development and progression. The aim of the present study is...

journal_title：Carcinogenesis

authors： Bak MJ,Furmanski P,Shan NL,Lee HJ,Bao C,Lin Y,Shih WJ,Yang CS,Suh N

更新日期：2018-07-30 00:00:00

abstract：:Skin is a major target of carcinogenic trivalent arsenic (arsenite, As3+). It has been thought that cell proliferation is one of the central events involved in the carcinogenic effect of arsenite. Cyclin D1, a nuclear protein playing a pivotal role in cell proliferation and cell cycle transition from G1 to S phases, h...

journal_title：Carcinogenesis

authors： Ouyang W,Li J,Ma Q,Huang C

更新日期：2006-04-01 00:00:00

abstract：:A 25mer oligonucleotide containing a single N-(deoxyguanosin-8-yl-)-1-aminopyrene (dGAP), the major DNA adduct formed by reductively activated 1-nitropyrene, was synthesized. The adduct was located at nucleotide 21 from the 3' end. DNA synthesis on this template by human DNA polymerases alpha and beta, HIV reverse tra...

journal_title：Carcinogenesis

authors： Vyas RR,Basu AK

更新日期：1995-04-01 00:00:00

abstract：:Expression of blood group-related antigens (BGRAs) A, B, H, Le(b), Le(x) and Le(y) was examined immunohistochemically in neoplastic and hyperplastic lesions induced by N-nitrosobis(2-oxopropyl)amine in Syrian hamsters to determine a relationship between histological and biological patterns of the lesion and expression...

journal_title：Carcinogenesis

authors： Tomioka T,Fujii H,Egami H,Takiyama Y,Pour PM

更新日期：1991-03-01 00:00:00

abstract：:Structural analogs of diethylstilbestrol (DES) with at least one phenolic hydroxyl group are metabolized by prostaglandin H synthase (PHS) from ram seminal vesicle microsomes (RSVM) in vitro in the presence of arachidonic acid (20:4). U.v. spectroscopy revealed the formation of p-quinoid intermediates in incubations o...

journal_title：Carcinogenesis

authors： Degen GH,Metzler M,Sivarajah KS

更新日期：1986-01-01 00:00:00

abstract：:Genotoxic carcinogens, including 2-acetylaminofluorene (2-AAF), in addition to exerting their genotoxic effects, often cause a variety of non-genotoxic alterations in cells. It is believed that these non-genotoxic effects may be indispensable events in tumorigenesis; however, there is insufficient knowledge to clarify...

journal_title：Carcinogenesis

authors： Bagnyukova TV,Tryndyak VP,Montgomery B,Churchwell MI,Karpf AR,James SR,Muskhelishvili L,Beland FA,Pogribny IP

更新日期：2008-03-01 00:00:00

abstract：:Diallyl disulfide (DADS), a sulfur compound from garlic has been shown to exert many biological effects: induction of carcinogen detoxication, inhibition of tumor cell proliferation, etc. These effects are consistent with its anticarcinogenic properties in animal models and could account for garlic protective effects ...

journal_title：Carcinogenesis

authors： Huard C,Druesne N,Guyonnet D,Thomas M,Pagniez A,Le Bon AM,Martel P,Chaumontet C

更新日期：2004-01-01 00:00:00

abstract：:Glucoraphanin in Brassica vegetables breaks down to either sulforaphane or sulforaphane nitrile depending on the conditions, and sulforaphane can be further conjugated with glutathione. Using a high-throughput microtitre plate assay and TaqMan real time quantitative RT-PCR to measure mRNA, we show that sulforaphane an...

journal_title：Carcinogenesis

authors： Basten GP,Bao Y,Williamson G

更新日期：2002-08-01 00:00:00

abstract：:Aphidicolin is a specific inhibitor of DNA polymerase alpha. Its influence of DNA repair has been studied in both normal and excision deficient xeroderma pigmentosum cells exposed to u.v. irradiation at 254 nm. Single strand DNA breaks accumulated in u.v. irradiated normal cells when the inhibitor was present. Such br...

journal_title：Carcinogenesis

authors： Waters R

更新日期：1981-01-01 00:00:00

abstract：:DNA mismatch repair defects in certain cell types confer resistance to the cytotoxic effects of alkylating agents, suggesting that a normally functioning DNA mismatch repair pathway can actually mediate alkylation-induced cell death. In eukaryotic cells this phenomenon is only observed in cells lacking adequate DNA me...

journal_title：Carcinogenesis

authors： Rasmussen LJ,Samson L

更新日期：1996-09-01 00:00:00

abstract：:Gene-environment interactions play an important role in folate metabolism, with a potential impact on human health. Deficiencies in the uptake of key micronutrients and variant genotypes can affect the folic acid cycle, modulating methyl group transfer in key processes and leading to increased cancer risk and Down syn...

journal_title：Carcinogenesis

authors： Zijno A,Andreoli C,Leopardi P,Marcon F,Rossi S,Caiola S,Verdina A,Galati R,Cafolla A,Crebelli R

更新日期：2003-06-01 00:00:00

abstract：:2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) is a heterocyclic amine mutagen found in cooked meats and is carcinogenic in mice and rats at high doses (mg/kg body wt). Humans, however, are exposed to low amounts (p.p.b.) in the diet, and the effects caused by exposure to human equivalent doses of MeIQx have be...

journal_title：Carcinogenesis

authors： Frantz CE,Bangerter C,Fultz E,Mayer KM,Vogel JS,Turteltaub KW

更新日期：1995-02-01 00:00:00

abstract：:The effects of D-limonene and citrus fruit oils, i.e. orange oil and lemon oil, on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced neoplasia of the lungs and forestomach of female A/J mice were investigated. D-Limonene and the citrus fruit oils given p.o. 1 h prior to NNK, also administered p.o., inhibite...

journal_title：Carcinogenesis

authors： Wattenberg LW,Coccia JB

更新日期：1991-01-01 00:00:00

abstract：:Acrylamide is an alkylating agent which reacts very slowly in direct reactions with DNA and is negative in the Ames test, but is carcinogenic in mice and rats. In order to explain the cancer-initiating properties of acrylamide we have studied DNA adduct formation in vitro with a metabolizing system and in vivo in mice...

journal_title：Carcinogenesis

authors： Segerbäck D,Calleman CJ,Schroeder JL,Costa LG,Faustman EM

更新日期：1995-05-01 00:00:00

abstract：:Common polymorphisms in genes encoding phase I and phase II enzymes are considered to modify lung cancer risk due to changes in enzyme activity. Candidates include genetic variants of glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and myeloperoxidase (MPO). We performed a large case-control study of these candida...

journal_title：Carcinogenesis

authors： Larsen JE,Colosimo ML,Yang IA,Bowman R,Zimmerman PV,Fong KM

更新日期：2006-03-01 00:00:00

abstract：:The O6-methylguanine-DNA methyltransferase gene (MGMT) encodes the direct reversal DNA repair protein that removes alkyl adducts from the O6 position of guanine. Several single-nucleotide polymorphisms (SNPs) exist in the MGMT promoter/enhancer (P/E) region. However, the haplotype structure encompassing these SNPs and...

journal_title：Carcinogenesis

authors： Xu M,Nekhayeva I,Cross CE,Rondelli CM,Wickliffe JK,Abdel-Rahman SZ

更新日期：2014-03-01 00:00:00

abstract：:Precursor T-cell lymphoblastic neoplasms are aggressive malignancies in need for more effective and specific therapeutic treatments. A significant fraction of these neoplasms harbor deletions on the locus 9p21, targeting the tumor suppressor CDKN2A but also deleting the aconitase 1 (ACO1) gene, a neighboring housekeep...

journal_title：Carcinogenesis

authors： Gonzalez-Sanchez L,Cobos-Fernandez MA,Lopez-Nieva P,Villa-Morales M,Stamatakis K,Cuezva JM,Marin-Rubio JL,Vazquez-Dominguez I,Gonzalez-Vasconcellos I,Salido E,Llamas P,Lopez-Lorenzo JL,Santos J,Fernandez-Piqueras J

更新日期：2020-08-12 00:00:00

abstract：:Bile acids have been implicated in the aetiology of colon cancer. We have previously found, using 32P-postlabelling, that bile from control patients and from patients with familial adenomatous polyposis (FAP) produces DNA adducts when incubated with salmon sperm DNA in vitro. In the present study we have incubated the...

journal_title：Carcinogenesis

authors： Scates DK,Spigelman AD,Venitt S

更新日期：1994-12-01 00:00:00

abstract：:Diethylstilbestrol (DES), a synthetic stilbene estrogen, is a potent development toxin and carcinogen in humans and rodents. A number of 32P-postlabeling studies suggest that genotoxic effects of DES substantially contribute to these biological effects. The mechanisms involved in DES-mediated genotoxicity are not comp...

journal_title：Carcinogenesis

authors： Moorthy B,Liehr J,Randerath E,Randerath K

更新日期：1995-11-01 00:00:00

abstract：:The activity of nuclear transcription factors is often regulated by specific kinase-signaling pathways. We have previously shown that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) stimulates activator protein-1 activity through the p38 mitogen-activated protein kinase (MAPK). Here, we show that DD...

journal_title：Carcinogenesis

authors： Bratton MR,Frigo DE,Vigh-Conrad KA,Fan D,Wadsworth S,McLachlan JA,Burow ME

更新日期：2009-01-01 00:00:00

abstract：:We demonstrated previously that growth factor receptor-bound protein 2 (Grb2) associates with the transforming growth factor-beta (TGF-beta) type II receptor [TbetaR-II] upon its phosphorylation on Tyr284 by Src. Although this phosphotransferase reaction is critical in mediating TGF-beta stimulation of epithelial-mese...

journal_title：Carcinogenesis

authors： Galliher-Beckley AJ,Schiemann WP

更新日期：2008-02-01 00:00:00

abstract：:Iron participates in the generation of hydroxyl radicals by the iron-catalyzed Fenton reaction. Its role in estrogen-induced carcinogenesis has been examined in this study by investigating the effects of iron content of hamster diets on tumor induction by estradiol. The renal tumor incidence and number of tumor nodule...

journal_title：Carcinogenesis

authors： Wyllie S,Liehr JG

更新日期：1998-07-01 00:00:00

abstract：:gamma-Glutamyl transpeptidase (gamma GT) positive hepatocytes were isolated from F344 male rats fed 2-acetylaminofluorene. The isolation procedure is rapid and highly selective for cells exhibiting gamma GT on their surface. Suspensions of liver cells obtained from perfusion in situ with a collagenase solution were in...

journal_title：Carcinogenesis

authors： Hanigan HM,Pitot HC

更新日期：1982-01-01 00:00:00

abstract：:Hepatic microsomes of female F344 rats were capable of N,O-acyltransfer of N-hydroxy-N-acetyl-2-aminofluorene (N-OH-AAF) and N-hydroxy-N-formyl-2-aminofluorene (N-OH-FAF), N-deacetylation of N-OH-AAF and N-acetyl-2-aminofluorene (2-AAF), and O-deacetylation of 4-nitrophenyl acetate (NPA). The activity for N,O-acyltran...

journal_title：Carcinogenesis

authors： Wang CY,Zukowski K,Lee MS,Sone T

更新日期：1992-11-01 00:00:00