Abstract:
:Expression of blood group-related antigens (BGRAs) A, B, H, Le(b), Le(x) and Le(y) was examined immunohistochemically in neoplastic and hyperplastic lesions induced by N-nitrosobis(2-oxopropyl)amine in Syrian hamsters to determine a relationship between histological and biological patterns of the lesion and expression of BGRAs. With the exception of papillary ductal cell hyperplasia, A-antigen discriminated between the benign and malignant lesions far better than the other antigens, which showed heterogeneity in the expression of benign and malignant tumors. However, production of A-antigen decreased with the degree of tumor dedifferentiation and was absent in anaplastic regions of tumors. Marked differences were found in the expression of A- and B-antigen in tubular complexes, one of the earliest induced changes, in relation to the type of cells populating these lesions. Overall, B-antigen seemed to be associated more with benign cells than malignant cells. On the other hand, Le(x)-antigen was expressed primarily in the invasive portion of some cancers and seemed to reflect active proliferative processes.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Tomioka T,Fujii H,Egami H,Takiyama Y,Pour PMdoi
10.1093/carcin/12.3.441subject
Has Abstractpub_date
1991-03-01 00:00:00pages
441-7issue
3eissn
0143-3334issn
1460-2180journal_volume
12pub_type
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