Abstract:
:A quantitative relationship was established for 26 nitrosamines between their carcinogenic effectiveness in experimental animals and their mutagenic activity in a mammalian cell-mediated assay. Mutagenesis was measured in Chinese hamster V79 cells co-cultivated with primary rat hepatocytes, which are capable of activating nitrosamines. Resistance to ouabain and to 6-thioguanine served as the genetic markers.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Jones CA,Marlino PJ,Lijinsky W,Huberman Edoi
10.1093/carcin/2.10.1075subject
Has Abstractpub_date
1981-01-01 00:00:00pages
1075-7issue
10eissn
0143-3334issn
1460-2180journal_volume
2pub_type
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