Covalent binding of styrene to DNA in rat and mouse.

abstract：:Genetic variants in multiple cellular pathways have been associated with an altered risk of oesophageal cancer. In this study, eight genes previously associated with an altered risk of oesophageal squamous cell carcinoma (OSCC) in European or Asian populations were investigated in two South African populations. We gen...

journal_title：Carcinogenesis

authors： Bye H,Prescott NJ,Matejcic M,Rose E,Lewis CM,Parker MI,Mathew CG

更新日期：2011-12-01 00:00:00

abstract：:It is now unanimously accepted that neoplastic cells tend to become less susceptible to the growth regulatory effects of transforming growth factor-beta1 (TGF-beta1), mainly because of reduced expression and/or activity of TGF-beta1-specific receptors, as reported for many human cancers including colon cancer. Consequ...

journal_title：Carcinogenesis

authors： Biasi F,Mascia C,Poli G

更新日期：2008-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that are involved in different biological processes by suppressing target gene expression. Altered expression of miR-30a-5p has been reported in colon carcinoma. To elucidate its potential biological role in colon cancer, miR-30a-5p was overexpressed via a lentiviral vector...

journal_title：Carcinogenesis

authors： Baraniskin A,Birkenkamp-Demtroder K,Maghnouj A,Zöllner H,Munding J,Klein-Scory S,Reinacher-Schick A,Schwarte-Waldhoff I,Schmiegel W,Hahn SA

更新日期：2012-04-01 00:00:00

abstract：:The formation of thioether conjugates is an important pathway for inactivation of certain carcinogens. This study assessed the mechanism by which the bladder carcinogen 2-amino-4-(5-nitro-2-furyl)-thiazole (ANFT) forms a glutathione conjugate (ANFT-SG). Peroxidatic metabolism of ANFT, in the presence of glutathione, r...

journal_title：Carcinogenesis

authors： Lakshmi VM,Zenser TV,Sohani S,Davis BB

更新日期：1992-11-01 00:00:00

abstract：:Intratumor heterogeneity (ITH) plays an important role in tumor development, metastases, recurrence and has impact on clinical diagnosis, therapeutic responses. In this study, we used mutant-allele tumor heterogeneity (MATH) through whole-exome sequencing data to evaluate ITH in early stage diffuse large B-cell lympho...

journal_title：Carcinogenesis

authors： Wang Y,Feng W,Liu P

更新日期：2019-11-25 00:00:00

abstract：:Naturally occurring allyl isothiocyanate (AITC) was recently shown to be selectively delivered to bladder cancer tissue via urinary excretion and to inhibit bladder cancer growth and muscle invasion in an animal model. AITC is excreted in urine mainly as N-acetyl-S-(N-allylthiocarbamoyl)cysteine, more commonly known a...

journal_title：Carcinogenesis

authors： Bhattacharya A,Li Y,Geng F,Munday R,Zhang Y

更新日期：2012-02-01 00:00:00

abstract：:Exposure of rats to diesel emissions results in the development of lung tumors. The objective of this study was to determine whether the polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs or other polycyclic organic matter adsorbed to diesel particles induces the formation of DNA adducts in the lung when compared to ...

journal_title：Carcinogenesis

authors： Gallagher J,Heinrich U,George M,Hendee L,Phillips DH,Lewtas J

更新日期：1994-07-01 00:00:00

abstract：:We have established a protocol that allows qualitative and quantitative determination of butadiene monoepoxide-DNA adducts formed as a result of inhalation exposure to 1,3-butadiene. We observed that in this particular case in vivo samples required extensive sample purification to facilitate a low background. Sample p...

journal_title：Carcinogenesis

authors： Koivisto P,Sorsa M,Pacchierotti F,Peltonen K

更新日期：1997-02-01 00:00:00

abstract：:Docosahexaenoic acid (DHA), a 22:6 n-3 polyunsaturated fatty acid, is the longest and most highly unsaturated fatty acid found in most membranes and has been shown to inhibit cancer cell growth in part by modifying cell signaling. In the current study, alterations to epidermal growth factor receptor (EGFR) signaling u...

journal_title：Carcinogenesis

authors： Rogers KR,Kikawa KD,Mouradian M,Hernandez K,McKinnon KM,Ahwah SM,Pardini RS

更新日期：2010-09-01 00:00:00

abstract：:Both Snell dwarf mice (dw/dw) and their phenotypically normal heterozygotes (dw/+) were dosed with methylclofenapate (MCP) at daily intervals by gavage (25 mg/kg). Animals were killed at 12, 24, 36 and 72 h after the initial dose and the parameters of ploidy, nuclearity and DNA synthesis were measured in hepatocytes i...

journal_title：Carcinogenesis

authors： Styles JA,Kelly MD,Pritchard NR,Foster JR

更新日期：1990-03-01 00:00:00

abstract：:Effect of nicotine on PDGF AA and PDGF BB interaction with cervical cancer SiHa cells was tested. [125I]PDGF AA was internalized by cells and accumulated in the cytoplasm and nucleus (chromatin). In the absence of nicotine, maximal accumulation of [125I]PDGF AA inside the cells occurred after 1 day of incubation, whic...

journal_title：Carcinogenesis

authors： Rakowicz-Szulczynska EM,McIntosh DG,Perry M,Smith ML

更新日期：1996-09-01 00:00:00

abstract：:A series of cells representing normal, non-tumorigenic cell lines, as well as differentiating neoplastic and undifferentiated neoplastic rat tracheal epithelial cell populations were evaluated for their ability to establish homologous and/or heterologous cell-cell gap junction communication in culture. Gap junction co...

journal_title：Carcinogenesis

authors： Terzaghi-Howe M,Chang GW,Popp D

更新日期：1997-11-01 00:00:00

abstract：:The aim of this study was to investigate selected proteomic markers of the metabolic phenotype of breast carcinomas as prognostic markers of cancer progression. For this purpose, a series of 101 breast carcinomas and 13 uninvolved breast samples were examined for quantitative differences in protein expression of mitoc...

journal_title：Carcinogenesis

authors： Isidoro A,Casado E,Redondo A,Acebo P,Espinosa E,Alonso AM,Cejas P,Hardisson D,Fresno Vara JA,Belda-Iniesta C,González-Barón M,Cuezva JM

更新日期：2005-12-01 00:00:00

abstract：:Effects of estrogens on the cytoplasmic microtubule network were examined by the indirect immunofluorescence method using anti-beta-tubulin antibody. Estradiol, a naturally occurring estrogen, decreased the amount of cytoplasmic microtubule fibers during interphase in the human breast cancer cell lines MCF-7 and MDA-M...

journal_title：Carcinogenesis

authors： Aizu-Yokota E,Ichinoseki K,Sato Y

更新日期：1994-09-01 00:00:00

abstract：:Epidemiological evidence has been supporting a relationship between dietary aflatoxin B1 (AFB1) exposure, development of human primary hepatocellular carcinoma (HCC) and mutations in the p53 tumor suppressor gene. However, the correlation between the observed p53 mutations, the AFB1 DNA adducts and their activation pa...

journal_title：Carcinogenesis

authors： Macé K,Aguilar F,Wang JS,Vautravers P,Gómez-Lechón M,Gonzalez FJ,Groopman J,Harris CC,Pfeifer AM

更新日期：1997-07-01 00:00:00

abstract：:Phenobarbital and clofibrate, two non-genotoxic carcinogens, have been investigated regarding the relationship between reactive oxygen species, antioxidant enzyme expression and apoptosis in primary cultures of rat hepatocytes. Low toxicity concentrations, 200 and 100 microg/ml for phenobarbital and clofibrate respect...

journal_title：Carcinogenesis

authors： Díez-Fernández C,Sanz N,Alvarez AM,Wolf A,Cascales M

更新日期：1998-10-01 00:00:00

abstract：:Earlier studies have shown that the profile of mutations induced by (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (+)-BPDE at the hypoxanthine (guanine) phosphoribosyltransferase (hprt) gene of Chinese hamster V79 cells was dependent on the concentration of (+)-BPDE. In the present study, we exami...

journal_title：Carcinogenesis

authors： Schiltz M,Cui XX,Lu YP,Yagi H,Jerina DM,Zdzienicka MZ,Chang RL,Conney AH,Wei SJ

更新日期：1999-12-01 00:00:00

abstract：:Monoterpenes have been shown to both prevent and treat mammary cancer in animal models and are currently in clinical testing in advanced cancer patients. In this study, we investigated a biochemical modulation associated with the antitumor activity of monoterpenes, the inhibition of protein isoprenylation in monoterpe...

journal_title：Carcinogenesis

authors： Ren Z,Gould MN

更新日期：1998-05-01 00:00:00

abstract：:Retinoids have been shown to exert an anticarcinogenic effect through suppression of the cell cycle, induction of apoptosis and/or differentiation. In rat liver, in particular, retinoic acid has been shown to inhibit regeneration after partial hepatectomy, most probably through repression of the expression of c-fos an...

journal_title：Carcinogenesis

authors： Ledda-Columbano GM,Pibiri M,Molotzu F,Cossu C,Sanna L,Simbula G,Perra A,Columbano A

更新日期：2004-11-01 00:00:00

abstract：:Both trans-4-acetylaminostilbene (AAS) and 2-acetylaminofluorene (AAF) exert tumor-initiating activity in rat liver when administered in the initiation phase of an initiation-promotion experiment. The effects are more than additive when the compounds are sequentially combined in the initiation phase of such an experim...

journal_title：Carcinogenesis

authors： Ruthsatz M,Neumann HG

更新日期：1988-02-01 00:00:00

abstract：:Endocrine therapies, which inhibit estrogen receptor (ER)alpha signaling, are the most common and effective treatment for ERalpha-positive breast cancer. However, the use of these agents is limited by the frequent development of resistance. The cyclin-dependent kinase family member CRK7 (aka CRKRS) was identified from...

journal_title：Carcinogenesis

authors： Iorns E,Martens-de Kemp SR,Lord CJ,Ashworth A

更新日期：2009-10-01 00:00:00

abstract：:Iron participates in the generation of hydroxyl radicals by the iron-catalyzed Fenton reaction. Its role in estrogen-induced carcinogenesis has been examined in this study by investigating the effects of iron content of hamster diets on tumor induction by estradiol. The renal tumor incidence and number of tumor nodule...

journal_title：Carcinogenesis

authors： Wyllie S,Liehr JG

更新日期：1998-07-01 00:00:00

abstract：:Using the polymerase chain reaction (PCR), a human kidney glutathione S-transferase (GST) alpha cDNA clone (GST alpha 12 K) was synthesized; it is identical to a known liver GST alpha cDNA clone except for one base change (G----A), indicating that an alpha class gene expressed in human kidney is similar to one express...

journal_title：Carcinogenesis

authors： Klöne A,Weidner U,Hussnätter R,Harris J,Meyer D,Peter S,Ketterer B,Sies H

更新日期：1990-12-01 00:00:00

abstract：:The apoptotic response to DNA damage appears to be an innate biological mechanism for protection against tumourigenesis. It is possible that agents that protect against colorectal cancer act by enhancing the apoptotic deletion of cells suffering DNA damage, with consequent removal of those with tumourigenic mutations....

journal_title：Carcinogenesis

authors： Hu Y,Martin J,Le Leu R,Young GP

更新日期：2002-07-01 00:00:00

abstract：:The O6-methylguanine-DNA methyltransferase gene (MGMT) encodes the direct reversal DNA repair protein that removes alkyl adducts from the O6 position of guanine. Several single-nucleotide polymorphisms (SNPs) exist in the MGMT promoter/enhancer (P/E) region. However, the haplotype structure encompassing these SNPs and...

journal_title：Carcinogenesis

authors： Xu M,Nekhayeva I,Cross CE,Rondelli CM,Wickliffe JK,Abdel-Rahman SZ

更新日期：2014-03-01 00:00:00

abstract：:Epidemiological studies indicate that N-nitroso compounds (NOC) are causally linked to colorectal cancer (CRC). NOC induce DNA alkylations, including O (6)-methylguanine (O (6)-MeG) and N-methylated purines, which are repaired by O (6)-MeG-DNA methyltransferase (MGMT) and N-alkyladenine-DNA glycosylase (AAG)-initiated...

journal_title：Carcinogenesis

authors： Fahrer J,Frisch J,Nagel G,Kraus A,Dörsam B,Thomas AD,Reißig S,Waisman A,Kaina B

更新日期：2015-10-01 00:00:00

abstract：:The dose and time dependence of the cellular phenotype in preneoplastic and neoplastic liver lesions was evaluated quantitatively in groups of male Sprague-Dawley rats exposed for 7 weeks to 0, 12 and 24 mg/kg body wt of N-nitrosomorpholine (NNM) and studied at different time points up to 80 weeks after withdrawal of ...

journal_title：Carcinogenesis

authors： Weber E,Bannasch P

更新日期：1994-06-01 00:00:00

abstract：:Overexpression of the helix-loop-helix protein Id-1 has been reported in over 20 types of cancer. While a number of factors have been demonstrated to regulate Id-1 gene transcription, little is known about the mechanisms responsible for its degradation. In this study, we have demonstrated that Id-1 protein stability w...

journal_title：Carcinogenesis

authors： Ling MT,Kwok WK,Fung MK,Xianghong W,Wong YC

更新日期：2006-02-01 00:00:00

abstract：:A quantitative relationship was established for 26 nitrosamines between their carcinogenic effectiveness in experimental animals and their mutagenic activity in a mammalian cell-mediated assay. Mutagenesis was measured in Chinese hamster V79 cells co-cultivated with primary rat hepatocytes, which are capable of activa...

journal_title：Carcinogenesis

authors： Jones CA,Marlino PJ,Lijinsky W,Huberman E

更新日期：1981-01-01 00:00:00

abstract：:Dietary resistant starch (RS), as a high amylose maize starch (HAMS), prevents dietary protein-induced colonocyte genetic damage in rats, possibly through the short-chain fatty acid (SCFA) butyrate produced by large bowel bacterial RS fermentation. Increasing butyrate availability may improve colonic health and dietar...

journal_title：Carcinogenesis

authors： Bajka BH,Clarke JM,Cobiac L,Topping DL

更新日期：2008-11-01 00:00:00