Abstract:
:Endocrine therapies, which inhibit estrogen receptor (ER)alpha signaling, are the most common and effective treatment for ERalpha-positive breast cancer. However, the use of these agents is limited by the frequent development of resistance. The cyclin-dependent kinase family member CRK7 (aka CRKRS) was identified from an RNA interference screen for modifiers of tamoxifen sensitivity. Here, we demonstrate that silencing of CRK7 not only causes resistance to tamoxifen but also leads to resistance to additional endocrine therapies including ICI 182780 and estrogen deprivation, a model of aromatase inhibition. We show that CRK7 silencing activates the mitogen-activated protein kinase (MAPK)-signaling pathway, which causes a loss of ER dependence, resulting in endocrine therapy resistance. This study identifies a novel role for CRK7 in MAPK regulation and resistance to estrogen signaling inhibitors.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Iorns E,Martens-de Kemp SR,Lord CJ,Ashworth Adoi
10.1093/carcin/bgp187subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1696-701issue
10eissn
0143-3334issn
1460-2180pii
bgp187journal_volume
30pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::Using an initiation--selection--promotion protocol for induction of liver tumors in Wistar rats, the modulating action of various peroxisome proliferators on neoplasia as well as on selected biochemical parameters was studied. After treatment with diethylnitrosamine (DEN), the animals were subsequently subjected to a ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.11.1899
更新日期:1990-11-01 00:00:00
abstract::The DNA damaging and mutagenic activities of procarbazine, a methylating drug employed in cancer chemotherapy and suspected of causing therapy-related leukaemia, were investigated in the liver and bone marrow of lambda lacZ transgenic mice (MutaMouse). The drug was administered using two different protocols, a 'high-d...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.11.2191
更新日期:1997-11-01 00:00:00
abstract::Weanling male F344 rats were fed either a semi-purified diet low in methionine and lacking in choline and folic acid (folate/methyl deficient) or a supplemented control diet for periods of 2, 5, 7 days, 3 weeks, and 9 weeks. Two days after initiating the folate/methyl deficient diet in weanling F344 rats, the incidenc...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.2.287
更新日期:1997-02-01 00:00:00
abstract::Conversion of the 2'-deoxyguanosine (dG) residues in calf thymus DNA to 8-hydroxy-2'-deoxyguanosine (8-OH-dG) was achieved at physiological pH by treating the DNA with hydrogen peroxide (H2O2) in the presence of nickel(II) chloride (NiCl2). The effectiveness of this reaction was enhanced by L-histidine (His) which for...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.2.283
更新日期:1992-02-01 00:00:00
abstract::MicroRNAs (miRNAs) are small non-coding RNA molecules that are often located in genomic breakpoint regions and can act as oncogenes or tumor suppressor genes in human cancer. Our previous study showed that microRNA-423 (miR-423), which localized to the frequently amplified region of chromosome 17q11, was upregulated i...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr199
更新日期:2011-11-01 00:00:00
abstract::Telomere dynamics are a critical component of both aging and cancer. Telomeres progressively shorten in almost all dividing cells and most human cells do not express or maintain sufficient telomerase activity to fully maintain telomeres. There is accumulating evidence that when only a few telomeres are short, they for...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgh296
更新日期:2005-05-01 00:00:00
abstract::Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in mice, resulting from a downregulation of p21, p27(kip1) and E-cadherin and an upregulation of β-caten...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr293
更新日期:2012-02-01 00:00:00
abstract::The variation in colorectal cancer (CRC) incidence worldwide strongly suggests a role for dietary influences. Based on epidemiological data, protective effects of vegetables and fruit intake on CRC are widely claimed, while other data indicate a possible increased CRC risk from (higher) dietary fat intake. Therefore, ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.9.1597
更新日期:1998-09-01 00:00:00
abstract::Intratumor heterogeneity (ITH) plays an important role in tumor development, metastases, recurrence and has impact on clinical diagnosis, therapeutic responses. In this study, we used mutant-allele tumor heterogeneity (MATH) through whole-exome sequencing data to evaluate ITH in early stage diffuse large B-cell lympho...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz068
更新日期:2019-11-25 00:00:00
abstract::Carcinogenicity of catechol, a naturally occurring and industrial chemical which has been shown to have strong cell proliferating potential on rat glandular stomach epithelium, was investigated in male and female F344 rats and B6C3F1 mice. Groups of 30 male and female F344 rats and B6C3F1 mice were treated with 0.8% c...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.3.525
更新日期:1993-03-01 00:00:00
abstract::The modifying effects of the phenolic antioxidant catechol (CC) and its analogs hydroquinone (HQ) and resorcinol (RN) on pancreatic carcinogenesis were evaluated in 146 female Syrian golden hamsters. Groups of animals received either saline or 70 mg/kg body wt N-nitrosobis(2-oxopropyl)amine (BOP) s.c. injections, twic...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.7.1331
更新日期:1991-07-01 00:00:00
abstract::The fluorescent 12-O-tetradecanoylphorbol-13-acetate (TPA) analogue dansyl-TPA allowed the distribution of fluorescent molecules to be visualized in living mouse fibroblasts. The entry of dansyl-TPA into cells occurred within millisecond time scale and was found largely energy independent. Dansyl-TPA was shown to stai...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.3.433
更新日期:1985-03-01 00:00:00
abstract::Liver metastases develop in more than half of the patients with colorectal cancer (CRC) and are associated with a poor prognosis. The factors influencing liver metastasis of CRC are poorly characterized, but this information is urgently needed. We have now discovered that small extracellular vesicles (sEVs; exosomes) ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy115
更新日期:2018-12-13 00:00:00
abstract::Monoclonal antibodies were produced that recognized alkali-stabilized modifications of DNA formed by the anticancer drug melphalan in order to permit measurement of melphalan-DNA adducts in individual cells by immunofluorescent staining. Antibody Amp4/42 did not bind to alkali-treated control DNA or to DNA that had be...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.8.1895
更新日期:1995-08-01 00:00:00
abstract::Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disorder, and prophylactic colectomy has been shown to decrease the incidence of colorectal cancer (CRC). Duodenal cancer and desmoids are now the leading causes of death in FAP. We evaluate whether 3 months of oral supplementation with a patented...
journal_title:Carcinogenesis
pub_type: 临床试验,杂志文章
doi:10.1093/carcin/bgw041
更新日期:2016-06-01 00:00:00
abstract::Targeting tumor-initiating, drug-resistant populations of cancer stem cells (CSC) with phytochemicals is a novel paradigm for cancer prevention and treatment. We herein employed a phenotypic drug discovery approach coupled to mechanism-of-action profiling and target deconvolution to identify phenolic components of ext...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy023
更新日期:2018-04-05 00:00:00
abstract::DNA-methyltransferase-3B (DNMT3B) plays an important role in the generation of aberrant methylation in carcinogenesis. Polymorphisms and haplotypes of the DNMT3B gene may influence DNMT3B activity on DNA methylation, thereby modulating the susceptibility to lung cancer. To test this hypothesis, we investigated the ass...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh307
更新日期:2005-02-01 00:00:00
abstract::Oxidized DNA base lesions, such as thymine glycol (Tg) and 8-hydroxyguanine, are often toxic and mutagenic and have been implicated in carcinogenesis. To clarify whether NEIL1 protein, which exhibits excision repair activity towards such base lesions, is involved in gastric carcinogenesis, we examined 71 primary gastr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh267
更新日期:2004-12-01 00:00:00
abstract::Cancer incidence and mortality rates show great variations across nations and between population groups. These variations are largely explained by differences in age distribution, diet and lifestyle, access to health care, cultural barriers and exposure to carcinogens and pathogens. Cancers caused by infections are si...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgr066
更新日期:2011-08-01 00:00:00
abstract::Genomic alterations affecting components of the mechanistic target of rapamycin (mTOR) pathway are found rather frequently in cancers, suggesting that aberrant pathway activity is implicated in oncogenesis of different tumor types. mTOR functions as the core catalytic kinase of two distinct complexes, mTOR complex 1 (...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgy086
更新日期:2018-07-30 00:00:00
abstract::BALB/c 3T3 A31-1-13 cells are highly susceptible to chemical-induced cell transformation and their gap-junctional intercellular communication (GJIC) is decreased when these cells become confluent. On the other hand, A31-1-1 cells do not show such a change in GJIC and are more resistant to chemical induction of transfo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.10.1923
更新日期:1991-10-01 00:00:00
abstract::The expression of cytochrome (CYP) P450 enzymes in human oesophageal mucosa was investigated in a total of 25 histologically non-neoplastic surgical tissue specimens by using specific antibodies in immunoblots and by RT-PCR mRNA analysis. The presence of CYP1A, 2E1, 3A and 4A enzymes was demonstrated by both technique...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.2.243
更新日期:1999-02-01 00:00:00
abstract::The carcinogenic effects of in utero exposure to 3-methylcholanthrene (MC) have been demonstrated in the tumor-resistant C57BL/6 (B6) and DBA (D2) strains of mice. In this study, we determined the effects of in utero exposure to MC in BALB/c mice, a strain which demonstrates greater susceptibility to lung tumor induct...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.11.2159
更新日期:1999-11-01 00:00:00
abstract::The present study was designed to evaluate whether etodolac, a cyclooxgenase-2 (COX-2)-specific inhibitor, could prevent chemically induced biliary carcinogenesis in bilioenterostomized hamsters. Syrian golden hamsters were subjected to choledochojejunostomy and then received subcutaneous injections of N-nitrosobis(2-...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh311
更新日期:2005-02-01 00:00:00
abstract::The aim of this work was to optimize the ionic strength (tau) in the liver microsomal assay (LMA) in performing short-term genotoxicity tests. tau optimization would increase the sensitivity (i.e. decrease false negatives) and at the same time increase the specificity (decrease false positives). Such optimization depe...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.8.1403
更新日期:1992-08-01 00:00:00
abstract::The accumulation of O6-methylguanine (O6-meG) in the DNA of blood leukocytes of 21 Hodgkin's lymphoma patients (followed for up to 12 cycles of treatment) treated in the context of MOPP combination chemotherapy with 150 mg procarbazine daily for 10 days was examined and compared to that observed in rats treated with d...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.8.1675
更新日期:1994-08-01 00:00:00
abstract::Cryptic deletions at chromosome 6q are common cytogenetic abnormalities in T-cell lymphoblastic leukemia/lymphoma (T-LBL), but the target genes have not been formally identified. Our results build on detection of specific chromosomal losses in a mouse model of γ-radiation-induced T-LBLs and provide interesting clues f...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr271
更新日期:2012-02-01 00:00:00
abstract::The experiments reported in this study were designed to examine the question of whether a mammary epithelial cell's independence from hormonal requirements is established at the time of carcinogenic initiation, or whether the emergence of hormone independence is associated with the process of tumor progression. A newl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.3.383
更新日期:1998-03-01 00:00:00
abstract::Recent studies have shown opposing effects of n-6 and n-3 fatty acids on the development of cancer and suggest a role for the ratio of n-6 to n-3 fatty acids in the control of cancer. However, whether an alteration in the n-6/n-3 fatty acid ratio of cancer cells affects their invasive potential has not been well inves...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi019
更新日期:2005-04-01 00:00:00
abstract::The Notch pathway plays a key role in the development and is increasingly recognized for its importance in cancer. We demonstrated previously the overexpression of Notch-1 and its ligands in gliomas and showed that their knockdown inhibits glioma cell proliferation and survival. To elucidate the mechanisms downstream ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn079
更新日期:2008-05-01 00:00:00