Interactions among genes, tumor biology and the environment in cancer health disparities: examining the evidence on a national and global scale.

abstract：:The enzyme O6-methylguanine-DNA methyltransferase repairs alkylation-induced DNA damage, O6-methylguanine and O4-methylthymine, the former being formed more frequently. Previously, by means of gene targeting, we generated mice in which alleles for methyltransferase were disrupted. We now use these mouse lines, which a...

journal_title：Carcinogenesis

authors： Iwakuma T,Sakumi K,Nakatsuru Y,Kawate H,Igarashi H,Shiraishi A,Tsuzuki T,Ishikawa T,Sekiguchi M

更新日期：1997-08-01 00:00:00

abstract：:A monoclonal antibody specific for cyclobutane thymine dimers in DNA was used in immunofluorescence studies to detect these lesions in skin sections taken from hairless mice that had been irradiated with UV-B. The dimer-specific fluorescence in epidermal cell nuclei was quantified with fluorescence microscopy through ...

journal_title：Carcinogenesis

authors： Vink AA,Berg RJ,de Gruijl FR,Roza L,Baan RA

更新日期：1991-05-01 00:00:00

abstract：:Adducts produced by modification of DNA with benzo[a]pyrene diolepoxide (BPDE) are known to inhibit both DNA and RNA synthesis. This phenomenon has been used as a method for determining the distribution of carcinogen binding within defined DNA sequences. A critical comparison of different enzyme activities on adducted...

journal_title：Carcinogenesis

authors： Thrall BD,Mann DB,Smerdon MJ,Springer DL

更新日期：1992-09-01 00:00:00

abstract：:The NIH3T3 cell line undergoes transformation when the cells are maintained at high densities for extended periods. In an effort to define the physiological status of the cells before and during the transformation process, they were seeded in medium containing 2, 5 or 10% calf serum (CS) and growth was monitored by me...

journal_title：Carcinogenesis

authors： Rubin AL,Ellison BJ

更新日期：1991-10-01 00:00:00

abstract：:Covalent binding of [7-3H]styrene (S) to DNA in vivo was measured and evaluated in a quantitative manner in order to investigate whether DNA adduct formation could form a mechanistic basis for tumor induction in a carcinogenicity bioassay. [7-3H]S was administered by inhalation in a closed chamber to male and female C...

journal_title：Carcinogenesis

authors： Cantoreggi S,Lutz WK

更新日期：1993-03-01 00:00:00

abstract：:Microsatellite instability (MSI) is present in ulcerative colitis (UC) and colitis-associated colorectal cancers (CAC). Certain factors released by polymorphonuclear cells (PMNs) may drive mucosal frameshift mutations resulting in MSI and cancer. Here, we applied a co-culture system with PMNs and colon epithelial cell...

journal_title：Carcinogenesis

authors： Granofszky N,Lang M,Khare V,Schmid G,Scharl T,Ferk F,Jimenez K,Knasmüller S,Campregher C,Gasche C

更新日期：2018-02-09 00:00:00

abstract：:Here we report that colorectal cancer patients show a markedly higher frequency (3-fold) of wild-type NAT2*4 allele homozygotes than the control population. However, a marked difference in NAT2*4/NAT2*4 genotype frequency associated with the patients gender was observed pointing to a male-specific effect of this genot...

journal_title：Carcinogenesis

authors： Gil JP,Lechner MC

更新日期：1998-01-01 00:00:00

abstract：:Lung cancer continues to be the leading cause of cancer death in the USA and the best example of a cancer with undisputed evidence of environmental risk. However, a genetic contribution to lung cancer has also been demonstrated by studies of familial aggregation, family-based linkage, candidate gene studies and most r...

journal_title：Carcinogenesis

authors： Schwartz AG,Wenzlaff AS,Bock CH,Ruterbusch JJ,Chen W,Cote ML,Artis AS,Van Dyke AL,Land SJ,Harris CC,Pine SR,Spitz MR,Amos CI,Levin AM,McKeigue PM

更新日期：2011-03-01 00:00:00

abstract：:The rates of formation and disappearance of benzo[a]pyrene (B[a]P) DNA-adducts were analyzed in the epidermis of SENCAR mice over a 21-day time course. Mice were treated topically with 200 nmol/mouse of [3H]B[a]P at various times prior to sacrifice. The formation and disappearance of total adducts as well as individua...

journal_title：Carcinogenesis

authors： DiGiovanni J,Decina PC,Prichett WP,Fisher EP,Aalfs KK

更新日期：1985-05-01 00:00:00

abstract：:In order to investigate the modulatory effect of the immune response induced by recurrent carcinogen exposure, anti-2-acetylaminofluorene (anti-2-AAF) IgG were elicited in Swiss mice before subsequent carcinogen administration. The immunization schedule consisted of three weekly i.p. injections of 2-acetylaminofluoren...

journal_title：Carcinogenesis

authors： Verdina A,Zito R,Cortese G,Leopardi P,Marcon F,Zijno A,Crebelli R

更新日期：1996-08-01 00:00:00

abstract：:Liposarcoma (LS) is the most common soft-tissue sarcoma. Dedifferentiated liposarcoma (DDLS) shows more aggressive biological behavior than that of well-differentiated liposarcoma (WDLS), so advanced therapeutic agents based on molecular mechanism are urgently needed. Here we show that tissue inhibitors of metalloprot...

journal_title：Carcinogenesis

authors： Shrestha M,Ando T,Chea C,Sakamoto S,Nishisaka T,Ogawa I,Miyauchi M,Takata T

更新日期：2019-10-16 00:00:00

abstract：:Reactive oxygen species (ROS) are a major cause of cellular injury in an increasing number of diseases, including cancer. Most ROS are created in the cell through normal cellular metabolism. They can be produced by environmental insults such as ultraviolet light and toxic chemicals, as well as by the inflammatory proc...

journal_title：Carcinogenesis

authors： Stoner GD,Wang LS,Casto BC

更新日期：2008-09-01 00:00:00

abstract：:1,3-Butadiene (BD), a widely used monomer in the production of synthetic rubber and other resins, is one of the 189 hazardous air pollutants identified in the 1990 Clean Air Act Amendments. BD induces tumors at multiple organ sites in B6C3F1 mice and Sprague-Dawley rats; mice are much more susceptible to the carcinoge...

journal_title：Carcinogenesis

authors： Csanády GA,Guengerich FP,Bond JA

更新日期：1992-07-01 00:00:00

abstract：:Isothiocyanates are anticarcinogenic phytochemicals found in cruciferous vegetables that both induce and are substrates for the gluthatione S-transferases (GSTs). The GSTs are phase II metabolizing enzymes involved in metabolism of various bioactive compounds. Functional polymorphisms in GST genes have been identified...

journal_title：Carcinogenesis

authors： Steck SE,Gaudet MM,Britton JA,Teitelbaum SL,Terry MB,Neugut AI,Santella RM,Gammon MD

更新日期：2007-09-01 00:00:00

abstract：:To better understand drug and carcinogen metabolism pathways in head and neck squamous cell carcinoma we assayed the principal drug- and carcinogen-metabolizing enzyme systems in both tumors and their corresponding adjacent non-tumoral tissues. Cytochromes P450 (1A1/A2, 2B1/B2, 2C8-10, 2E1, 3A4), epoxide hydrolase and...

journal_title：Carcinogenesis

authors： Janot F,Massaad L,Ribrag V,de Waziers I,Beaune PH,Luboinski B,Parise O Jr,Gouyette A,Chabot GG

更新日期：1993-07-01 00:00:00

abstract：:Iscador, an extract from the semi-parasitic plant Viscum album, was found to inhibit 20-methylcholanthrene-induced carcinogenesis in mice. Intraperitoneal administration of Iscador (1 mg/dose) twice weekly for 15 weeks could completely inhibit 20-methylcholanthrene-induced sarcoma in mice and protect these animals fro...

journal_title：Carcinogenesis

authors： Kuttan G,Menon LG,Kuttan R

更新日期：1996-05-01 00:00:00

abstract：:Mutant RAS (RAS(V12)) is known to transform most immortal cells but to induce premature senescence in primary cells. RAS(V12)-induced senescence in murine cells depends on the induction of the ARF/p53 and the retinoblastoma (Rb) family tumor suppressor pathways. We and others have shown previously that oncogene-induce...

journal_title：Carcinogenesis

authors： Vredeveld LC,Rowland BD,Douma S,Bernards R,Peeper DS

更新日期：2010-02-01 00:00:00

abstract：:Male and female strain A/J mice were exposed to a mixture of cigarette sidestream and mainstream smoke at a chamber concentration of total suspended particulates of 82.5 mg/m3. Exposure time was 6 h/day, 5 days/week for 5 months. The animals were allowed to recover for another 4 months in filtered air before sacrifice...

journal_title：Carcinogenesis

authors： Witschi H,Espiritu I,Yu M,Willits NH

更新日期：1998-10-01 00:00:00

abstract：:Inhalation of diesel exhaust (DE), which contains soot particles with adsorbed mutagenic organic compounds, and its virtually mutagen-free soot particle analog, carbon black (CB), produce similar types and prevalences of pulmonary neoplasms in chronically exposed F344 rats. This result suggests that DE-induced neoplas...

journal_title：Carcinogenesis

authors： Swafford DS,Nikula KJ,Mitchell CE,Belinsky SA

更新日期：1995-05-01 00:00:00

abstract：:We have shown previously that (NOHA) an intermediate in the nitric oxide (NO) synthetic pathway and an inhibitor of arginase significantly reduced intracellular polyamines, activated caspase-3 and induced apoptosis in the human breast cancer cell line MDA-MB-468. These actions of NOHA were abolished in the presence of...

journal_title：Carcinogenesis

authors： Singh R,Pervin S,Wu G,Chaudhuri G

更新日期：2001-11-01 00:00:00

abstract：:To evaluate the significance of C-C chemokine receptor type 5 (CCR5) in lung tumor development, we compared carcinogen-induced tumor growth in CCR5 knockout (CCR5(-/-)) mice and wild-type (CCR5(+/+)) mice. CCR5(-/-) mice showed reduced urethane (1g/kg)-induced tumor incidence when compared with those of CCR5(+/+) mice...

journal_title：Carcinogenesis

authors： Lee NJ,Choi DY,Song JK,Jung YY,Kim DH,Kim TM,Kim DJ,Kwon SM,Kim KB,Choi KE,Moon DC,Kim Y,Han SB,Hong JT

更新日期：2012-12-01 00:00:00

abstract：:Several studies have shown that hexavalent chromium [Cr(VI)] induces apoptosis in a variety of in vitro test systems. We instilled intra-tracheally either saline or sodium dichromate (0.25 mg/kg body weight), for three consecutive days, to Sprague-Dawley rats. TUNEL analyses showed a marked increase of the apoptotic i...

journal_title：Carcinogenesis

authors： D'Agostini F,Izzotti A,Bennicelli C,Camoirano A,Tampa E,De Flora S

更新日期：2002-04-01 00:00:00

abstract：:In the present study the modulating effects of dietary fish oil (MaxEPA) on unsaturated fat-promoted pancreatic carcinogenesis in azaserine-treated rats were investigated. Three groups of 20 rats (each group comprised five saline-treated and 15 azaserine-treated animals) were fed an AIN76-based purified diet containin...

journal_title：Carcinogenesis

authors： Appel MJ,Woutersen RA

更新日期：1994-10-01 00:00:00

abstract：:Recent studies have revealed that 1,2,3,4,6-penta-O-galloyl-beta-d-glucose (PGG) has anti-tumorigenic activity in vitro. In the present work, we evaluated the in vitro and in vivo antiangiogenic and antitumor activities of PGG and examined its molecular mechanisms. PGG significantly inhibited the proliferation and tub...

journal_title：Carcinogenesis

authors： Huh JE,Lee EO,Kim MS,Kang KS,Kim CH,Cha BC,Surh YJ,Kim SH

更新日期：2005-08-01 00:00:00

abstract：:Weanling male F344 rats were fed either a semi-purified diet low in methionine and lacking in choline and folic acid (folate/methyl deficient) or a supplemented control diet for periods of 2, 5, 7 days, 3 weeks, and 9 weeks. Two days after initiating the folate/methyl deficient diet in weanling F344 rats, the incidenc...

journal_title：Carcinogenesis

authors： James SJ,Miller BJ,Basnakian AG,Pogribny IP,Pogribna M,Muskhelishvili L

更新日期：1997-02-01 00:00:00

abstract：:Breast cancer is the most common cancer and the second most frequent cause of cancer death in women. Despite extensive research, the precise mechanisms of breast carcinogenesis remain unclear. One of the reasons for this is due, at least in part, to a lack of a suitable animal model which can closely mimic the breast ...

journal_title：Carcinogenesis

authors： Xie B,Tsao SW,Wong YC

更新日期：1999-06-01 00:00:00

abstract：:There is no unique mechanism to explain the activity in animals of 'non-genotoxic' carcinogens. In this they differ from 'genotoxic' carcinogens that are DNA reactive. In the present study it is reported that non-mutagenic carcinogens, as a group, have significantly higher computed octanol/water partition coefficients...

journal_title：Carcinogenesis

authors： McCoy GD,Rosenkranz HS,Klopman G

更新日期：1990-07-01 00:00:00

abstract：:Co-exposure to cadmium, cobalt, lead and other heavy metals occurs in many occupational settings, such as pigment and batteries production, galvanization and recycling of electric tools. However, little is known about interactions between several heavy metals. In the present study we determined DNA single strand break...

journal_title：Carcinogenesis

authors： Hengstler JG,Bolm-Audorff U,Faldum A,Janssen K,Reifenrath M,Götte W,Jung D,Mayer-Popken O,Fuchs J,Gebhard S,Bienfait HG,Schlink K,Dietrich C,Faust D,Epe B,Oesch F

更新日期：2003-01-01 00:00:00

abstract：:In this study, our goal was to identify genes whose expression in liver is altered in female F-344 rats during mitosuppression induced by 42 days of ethinyl estradiol (EE) treatment (Yager et al., Carcinogenesis, 15, 2117-2123, 1994). Northern analysis demonstrated that the mRNA levels for transforming growth factor-b...

journal_title：Carcinogenesis

authors： Chen J,Schwartz DA,Young TA,Norris JS,Yager JD

更新日期：1996-12-01 00:00:00

abstract：:Thioredoxin reductases (TrxRs) catalyse the NADPH-dependent reduction of thioredoxin and play an important role in multiple cellular events related to carcinogenesis including cell proliferation, apoptosis and cell signaling. We have used human hepatoma HepG2 cells to examine the regulation of TrxRs by isothiocyanate ...

journal_title：Carcinogenesis

authors： Zhang J,Svehlíková V,Bao Y,Howie AF,Beckett GJ,Williamson G

更新日期：2003-03-01 00:00:00