Colorectal cancer-derived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis.

abstract：:Diabetes mellitus has been suggested as a possible risk factor for the development of pancreatic cancer in humans. Previous studies in our laboratory have shown, however, that streptozotocin (STZ) diabetes inhibits the development of cancer of the exocrine pancreas in hamsters when STZ is administered prior to treatme...

journal_title：Carcinogenesis

authors： Povoski SP,Fenoglio-Preiser CM,Sayers HJ,McCullough PJ,Zhou W,Bell RH Jr

更新日期：1993-05-01 00:00:00

abstract：:The role of nitric oxide (NO) in colon cancer remains controversial. Inducible nitric oxide synthase (iNOS) has been reported to be up regulated and down regulated in colorectal cancer in both animal models and patient tissue samples. Cyclooxygenase-2 (COX-2) is important in colorectal carcinogenesis but its relations...

journal_title：Carcinogenesis

authors： Liu Q,Chan ST,Mahendran R

更新日期：2003-04-01 00:00:00

abstract：:The pyrene-like fluorescence of adducts derived from the covalent binding of (+/-)-trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9, 10-tetrahydrobenzo[a]pyrene [+/-]-anti-BPDE] to DNA increases in intensity by factors of 20 or more as the temperature is lowered from ambient to approximately 100 K. This effect is primarily a...

journal_title：Carcinogenesis

authors： Zhao R,Liu TM,Kim SK,MacLeod MC,Geacintov NE

更新日期：1992-10-01 00:00:00

abstract：:Circulating microRNAs (miRNAs) are potential biomarkers for cancer diagnosis, screening and prognosis. This study aimed to identify serum miRNAs as predictors of survival in patients with advanced non-small cell lung cancer (NSCLC). We profiled serum miRNAs in a pilot set of four patients with good survival (>24 month...

journal_title：Carcinogenesis

authors： Zhang Y,Roth JA,Yu H,Ye Y,Xie K,Zhao H,Chang DW,Huang M,Li H,Qu J,Wu X

更新日期：2019-07-04 00:00:00

abstract：:3,3-[3H]Dimethyl-1-phenyltriazene, 1-(4-chlorophenyl)-3,3-[3H]dimethyltriazene and 3,3-[3H]dimethyl-1-(2,4,6-trichlorophenyl)-triazene methylate initiator tRNA in vitro only after pre-incubation with microsomal enzymes and NADPH. The finding confirms that procarcinogenic dialkyl aryltriazenes must be enzymatically con...

journal_title：Carcinogenesis

authors： Hradec J,Kolar GF

更新日期：1985-07-01 00:00:00

abstract：:Using an initiation--selection--promotion protocol for induction of liver tumors in Wistar rats, the modulating action of various peroxisome proliferators on neoplasia as well as on selected biochemical parameters was studied. After treatment with diethylnitrosamine (DEN), the animals were subsequently subjected to a ...

journal_title：Carcinogenesis

authors： Abdellatif AG,Préat V,Vamecq J,Nilsson R,Roberfroid M

更新日期：1990-11-01 00:00:00

abstract：:Germline genetic variability might contribute, at least partially, to the survival of pancreatic ductal adenocarcinoma (PDAC) patients. Two recently performed genome-wide association studies (GWAS) on PDAC overall survival (OS) suggested (P < 10(-5)) the association between 30 genomic regions and PDAC OS. With the aim...

journal_title：Carcinogenesis

authors： Rizzato C,Campa D,Talar-Wojnarowska R,Halloran C,Kupcinskas J,Butturini G,Mohelníková-Duchoňová B,Sperti C,Tjaden C,Ghaneh P,Hackert T,Funel N,Giese N,Tavano F,Pezzilli R,Pedata M,Pasquali C,Gazouli M,Mambrini A,Sou

更新日期：2016-10-01 00:00:00

abstract：:The influence of the enzymatic inducer beta-naphthoflavone (BNF) and of the inhibitors alpha-naphthoflavone (ANF) and 2-diethylaminoethyl-2,2-diphenylvalerate HCl (SKF 525-A) on the frequency of sister chromatid exchanges (SCE) induced by cyclophosphamide (CPA) was studied in vivo in C57BL/6J male mice. Neither induce...

journal_title：Carcinogenesis

authors： Dragani TA,Sozzi G,Della Porta G

更新日期：1983-01-01 00:00:00

abstract：:Cyproterone acetate (CPA), a synthetic steroid hormone widely used as a human pharmaceutical, has recently been shown to induce unscheduled DNA synthesis (UDS) in vitro in primary cultures of rat and human hepatocytes. In the present study CPA was evaluated for its ability to initiate UDS in the liver of female rats i...

journal_title：Carcinogenesis

authors： Kasper P,Mueller L

更新日期：1996-10-01 00:00:00

abstract：:p90 Ribosomal S6 kinase (RSK) 4 is a serine-threonine kinase that belongs to the p90RSK family. RSK4 has been proposed as a tumor suppressor gene, related with anti-invasive activity, inhibition of the RAS-mitogen-activated protein kinase (MAPK) pathway and induction of senescence. Despite the related findings, little...

journal_title：Carcinogenesis

authors： López-Vicente L,Pons B,Coch L,Teixidó C,Hernández-Losa J,Armengol G,Ramon Y Cajal S

更新日期：2011-04-01 00:00:00

abstract：:Co-exposure to cadmium, cobalt, lead and other heavy metals occurs in many occupational settings, such as pigment and batteries production, galvanization and recycling of electric tools. However, little is known about interactions between several heavy metals. In the present study we determined DNA single strand break...

journal_title：Carcinogenesis

authors： Hengstler JG,Bolm-Audorff U,Faldum A,Janssen K,Reifenrath M,Götte W,Jung D,Mayer-Popken O,Fuchs J,Gebhard S,Bienfait HG,Schlink K,Dietrich C,Faust D,Epe B,Oesch F

更新日期：2003-01-01 00:00:00

abstract：:The caspase proteins are essential for the regulation of normal B cell development and regulation of apoptosis. We investigated five single nucleotide polymorphisms in four key caspase genes, CASP3 [Ex8-280C>A (rs6948) and Ex8+567T>C (rs1049216)], CASP8 Ex14-271A>T (rs13113), CASP9 Ex5+32G>A (rs1052576) and CASP10 Ex3...

journal_title：Carcinogenesis

authors： Lan Q,Zheng T,Chanock S,Zhang Y,Shen M,Wang SS,Berndt SI,Zahm SH,Holford TR,Leaderer B,Yeager M,Welch R,Hosgood D,Boyle P,Rothman N

更新日期：2007-04-01 00:00:00

abstract：:The extent to which N-acetylbenzidine and N,N'-diacetylbenzidine are formed may influence benzidine-induced carcinogenesis. This study compared the formation of these metabolites by rat and human liver slices. The relationship between the NAT2 genotype and the formation of these acetylated products was also evaluated ...

journal_title：Carcinogenesis

authors： Lakshmi VM,Bell DA,Watson MA,Zenser TV,Davis BB

更新日期：1995-07-01 00:00:00

abstract：:Phenobarbital and clofibrate, two non-genotoxic carcinogens, have been investigated regarding the relationship between reactive oxygen species, antioxidant enzyme expression and apoptosis in primary cultures of rat hepatocytes. Low toxicity concentrations, 200 and 100 microg/ml for phenobarbital and clofibrate respect...

journal_title：Carcinogenesis

authors： Díez-Fernández C,Sanz N,Alvarez AM,Wolf A,Cascales M

更新日期：1998-10-01 00:00:00

abstract：:Previous studies demonstrate that the heavy metal cadmium and the metalloid arsenite activate estrogen receptor-alpha in breast cancer cells by forming a high-affinity complex with the ligand-binding domain of the receptor and that environmentally relevant doses of cadmium have estrogen-like activity in vivo. The pres...

journal_title：Carcinogenesis

authors： Divekar SD,Li HH,Parodi DA,Ghafouri TB,Chen R,Cyrus K,Foxworth AE,Fornace AJ,Byrne C,Martin MB

更新日期：2020-07-14 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) have been described to play critical roles in initiation, progression and metastasis of various cancers. However, the involvement of CAFs in oral cancer (OC) has not been well addressed. In this study, we demonstrate that CAFs, when cocultured with OC cells (OCCs), produce high lev...

journal_title：Carcinogenesis

authors： Li X,Xu Q,Wu Y,Li J,Tang D,Han L,Fan Q

更新日期：2014-06-01 00:00:00

abstract：:Staurosporine (stsp) is a kinase inhibitor which induces cornified envelope assembly and terminal differentiation in normal and neoplastic mouse keratinocytes. In the tumorigenic cell lines 308 and SP-1 experiments were performed to determine if this effect was due only to activation of transglutaminases (TGases) alre...

journal_title：Carcinogenesis

authors： Stanwell C,Dlugosz AA,Yuspa SH

更新日期：1996-06-01 00:00:00

abstract：:A diet that is deficient in methionine, choline, folic acid and vitamin B12 has been found to induce alterations rapidly in liver tRNA methylation in male Fischer rats. In vitro assays indicated that activity of N2-guanine tRNA methyltransferase II (NMG2) was increased to 150% of controls levels in 1 week and 300% of ...

journal_title：Carcinogenesis

authors： Wainfan E,Dizik M,Hluboky M,Balis ME

更新日期：1986-03-01 00:00:00

abstract：:The DNA damaging and mutagenic activities of procarbazine, a methylating drug employed in cancer chemotherapy and suspected of causing therapy-related leukaemia, were investigated in the liver and bone marrow of lambda lacZ transgenic mice (MutaMouse). The drug was administered using two different protocols, a 'high-d...

journal_title：Carcinogenesis

authors： Pletsa V,Valavanis C,van Delft JH,Steenwinkel MJ,Kyrtopoulos SA

更新日期：1997-11-01 00:00:00

abstract：:Resistance to chemically-induced mammary tumors in the Copenhagen rat is well defined, but the mechanism of resistance has yet to be determined. We have tested whether or not Copenhagen rat resistance is dependent on T-cells, since several lines of evidence supported an involvement of the immune system. We crossed Cop...

journal_title：Carcinogenesis

authors： Korkola JE,Wood GA,Archer MC

更新日期：1997-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Genomic copy number deletion at chromosome 14q31.1-32.13 was frequently observed in HCC; however, the relevant functional target(s) at that locus is not well determined. Here, we performed integrative genomic analyses and ...

journal_title：Carcinogenesis

authors： Zhang C,Cao P,Yang A,Xia X,Li Y,Shi M,Yang Y,Wei X,Yang C,Zhou G

更新日期：2019-05-14 00:00:00

abstract：:Bone metastasis in patient with advanced-stage prostate cancer, the most commonly diagnosed malignancy in Western countries, increases the risk of intractable bone pain. The nephroblastoma overexpressed (NOV/CCN3) gene, a member of the CCN gene family, is responsible for the secretion of CCN3, a matrix-associated prot...

journal_title：Carcinogenesis

authors： Chen PC,Cheng HC,Tang CH

更新日期：2013-07-01 00:00:00

abstract：:One of the peaks present in HPLC profiles of [3H]benzo[a]-pyrene (BaP)-deoxyribonucleosides prepared by enzymatic degradation of [3H]BaP-DNA isolated from Wistar rat embryo cell cultures exposed to [G-3H]BaP was found to be r-7,c-9,c-10,t-8-tetrahydroxy-7,8,9,10-tetrahydroBaP, a BaP-DNA adduct decomposition product (P...

journal_title：Carcinogenesis

authors： Pruess-Schwartz D,Mauthe RJ,Baird WM

更新日期：1988-10-01 00:00:00

abstract：:Prostate cancer (PCa) is the second cause of cancer deaths in men in the USA. When the cancer recurs, early stages can be controlled with hormone ablation therapy to delay the rate of cancer progression but, over time, the cancer overcomes its hormone dependence, becomes highly aggressive and metastasizes. Clinical tr...

journal_title：Carcinogenesis

authors： Wang L,Li W,Lin M,Garcia M,Mulholland D,Lilly M,Martins-Green M

更新日期：2014-10-01 00:00:00

abstract：:Zinc has been shown to be accumulated in N-methyl-N-nitrosourea (MNU)-induced rat mammary tumors. Zinc is required for cell proliferation and tumorigenesis is characterized by dysregulation of cell proliferation. An accumulation of zinc in mammary tumors perhaps indicates a reliance on zinc to sustain tumor growth. Li...

journal_title：Carcinogenesis

authors： Lee S,Simpson M,Nimmo M,Xu Z

更新日期：2004-10-01 00:00:00

abstract：:Incubation of 3-[3H]fluoranthene with a rat liver microsomal activation system in the presence of calf thymus DNA resulted in radioactivity bound to the DNA. The fluoranthene-modified DNA was enzymatically digested and a DNA adduct elution profile developed using h.p.l.c. The fraction containing the major fluoranthene...

journal_title：Carcinogenesis

authors： Babson JR,Russo-Rodriguez SE,Rastetter WH,Wogan GN

更新日期：1986-06-01 00:00:00

abstract：:We hypothesized that superoxide from Kupffer cells (KC) contributes to hepatocarcinogenesis. p47phox(-/-) mice, deficient in phagocyte NADPH oxidase and superoxide generation, received a single dose of the hepatocarcinogen diethylnitrosamine (DEN). The following hepatic effects were observed at time points between 30 ...

journal_title：Carcinogenesis

authors： Teufelhofer O,Parzefall W,Kainzbauer E,Ferk F,Freiler C,Knasmüller S,Elbling L,Thurman R,Schulte-Hermann R

更新日期：2005-02-01 00:00:00

abstract：:An iron chelate, ferric ethylenediamine-N,N'-diacetate [Fe(III)-EDDA], was found to produce hydroxyl radicals with hydrogen peroxide, as determined by both a deoxyribose degradation test and electron spin resonance. Hydroxyl radical production was inhibited not only by adding hydroxyl radical scavengers and catalase, ...

journal_title：Carcinogenesis

authors： Liu M,Okada S

更新日期：1994-12-01 00:00:00

abstract：:Cigarette smoke (CS) contains hundreds of carcinogens and is a potent inducer of oxidative and bulky DNA damage, which when insufficiently repaired leads to activation of DNA damage response and possibly mutations. The DNA repair protein xeroderma pigmentosum group C (XPC) is primed to play an important role in CS-ind...

journal_title：Carcinogenesis

authors： Zhou H,Saliba J,Sandusky GE,Sears CR

更新日期：2019-05-14 00:00:00

abstract：:Inactivation of the adenomatous polyposis coli (Apc) gene by loss of the wild-type Apc allele (LOH) is a prerequisite for the development of intestinal adenomas in Msh2 proficient Min (Apc+/-Msh2+/+) mice. In contrast, adenomas from Msh2 deficient Min (Apc+/-Msh2-/-) mice are not usually associated with LOH. Given the...

journal_title：Carcinogenesis

authors： Sohn KJ,Choi M,Song J,Chan S,Medline A,Gallinger S,Kim YI

更新日期：2003-02-01 00:00:00