Abstract:
:We investigated whether curcumin, a chemopreventive agent, inhibited chenodeoxycholate (CD)- or phorbol ester (PMA)-mediated induction of cyclooxygenase-2 (COX-2) in several gastrointestinal cell lines (SK-GT-4, SCC450, IEC-18 and HCA-7). Treatment with curcumin suppressed CD- and PMA-mediated induction of COX-2 protein and synthesis of prostaglandin E2. Curcumin also suppressed the induction of COX-2 mRNA by CD and PMA. Nuclear run-offs revealed increased rates of COX-2 transcription after treatment with CD or PMA and these effects were inhibited by curcumin. Treatment with CD or PMA increased binding of AP-1 to DNA. This effect was also blocked by curcumin. In addition to the above effects on gene expression, we found that curcumin directly inhibited the activity of COX-2. These data provide new insights into the anticancer properties of curcumin.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Zhang F,Altorki NK,Mestre JR,Subbaramaiah K,Dannenberg AJdoi
10.1093/carcin/20.3.445keywords:
subject
Has Abstractpub_date
1999-03-01 00:00:00pages
445-51issue
3eissn
0143-3334issn
1460-2180journal_volume
20pub_type
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