Abstract:
:A single i.p. injection of diethylnitrosamine (DEN) or benzo[a]pyrene (BAP) in 1-day-old female rats produced a high incidence of gamma-glutamyltranspeptidase-(GGT)-positive hepatocyte foci within 4 weeks after the rats were weaned onto a 0.05% phenobarbital diet; the injection of benzo[e]pyrene did not produce foci under these conditions. Liver tumors appeared in rats treated with DEN within 8 weeks after weaning and in BAP-treated rats within 16 weeks after weaning. The results suggest that the treatment protocol used in this study may increase the utility of the liver tumorigenesis model as a broadly applicable in vitro system for the rapid detection of tumorigenic potential in environmental contaminants.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Peraino C,Staffeldt EF,Ludeman VAdoi
10.1093/carcin/2.5.463subject
Has Abstractpub_date
1981-01-01 00:00:00pages
463-5issue
5eissn
0143-3334issn
1460-2180journal_volume
2pub_type
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