Abstract:
:The development of a variety of odontogenic lesions was elicited by a single i.p. injection of N-nitroso-N-methylurea (NMU) at a dose of 150 mg/kg body weight. A total of 190 male Wistar/Furth rats were used in this study. The odontogenic lesions appeared macroscopically, mainly as supernumerary lower incisors, 88 +/- 3.48 (SE) days after administration of the carcinogen. Tumors were classified as compound and complex odontomas, odontoameloblastomas and ameloblastomas. 72% of rats (31 out of 43) 6 weeks old at the time of inoculation developed microscopic alterations in the odontogenic organs of the incisors; only 4% (2 of 49) of rats injected at 8 weeks of age developed similar alterations. These findings suggest the presence of an ontogenic mechanism susceptible to damage by chemical carcinogens.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Smulow JB,Konstantinidis A,Sonnenschein Cdoi
10.1093/carcin/4.9.1085subject
Has Abstractpub_date
1983-09-01 00:00:00pages
1085-8issue
9eissn
0143-3334issn
1460-2180journal_volume
4pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::In order to develop more efficient in vitro systems for the study of pro-mutagenic or pro-carcinogenic chemicals, we have produced transgenic C3H/10T1/2 cell lines expressing human cytochrome P450 (CYP) 2A6. A retroviral vector containing the cDNA was packaged in psi-2 cells, and used to infect C3H/10T1/2 cells. From ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.7.1421
更新日期:1993-07-01 00:00:00
abstract::The spectrum of mutations induced by N-acetoxy-N-acetyl-2-aminofluorene (N-AcO-AAF) was examined by the pZipHprtNeo shuttle vector in mammalian cells. The vector carries a cDNA of the human hypoxanthine phosphoribosyl transferase (hprt) gene, which is stably integrated into chromosomal DNA of a mouse cell line, VH12. ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.11.2245
更新日期:1993-11-01 00:00:00
abstract::Ulcerative colitis is a dynamic, chronic inflammatory condition of the colon associated with an increased colon cancer risk. Ginkgo biloba is a putative antioxidant and has been used for thousands of years to treat a variety of ailments. The aim of this study was to test whether the standardized G.biloba extract, EGb ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn143
更新日期:2008-09-01 00:00:00
abstract::The heterocyclic aromatic amines, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx) are formed during frying of meat. PhIP and 4,8-DiMeIQx have, after metabolic activation, been shown to form adducts with DNA at the C8 of guanine both in vitro and...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.8.1555
更新日期:1997-08-01 00:00:00
abstract::The modifying effects of 4,4'-diaminodiphenylmethane (DDPM) (0.1% in diet) administration on liver carcinogenesis induced by 2-acetylaminofluorene (2-AAF) (0.02% in diet), 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) ( 0.06% in diet), diethylnitrosamine (DEN) (0.001% in drinking water) and N-ethyl-N-hydroxyethylnit...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.5.719
更新日期:1987-05-01 00:00:00
abstract::Hairless mice were given 5 topical applications of 470 nmol 20-methylcholanthrene (MCA) at one week intervals. In one experimental group the MCA was dissolved in reagent grade acetone alone, in another group it was dissolved in a mixture consisting of 50% acetone and 50% dimethyl sulfoxide (DMSO). A control group rece...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.11.1129
更新日期:1981-01-01 00:00:00
abstract::DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within Lynch syndrome. MSI-H is characterized by length alterations within simple repeated sequences, microsatellites. Lynch syndrome is primarily ...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgm228
更新日期:2008-04-01 00:00:00
abstract::Previous studies have indicated that the Nb rat has a higher predisposition to the spontaneous development of nephroblastoma than most other strains of laboratory rat. In order to determine whether this inherent susceptibility could be exploited as a model for Wilms' tumor, Nb rats were treated with various chemicals ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.11.1551
更新日期:1985-11-01 00:00:00
abstract::Reactive intermediates (ultimate mutagens/carcinogens) generated by alkylating agents are unstable and difficult to characterize by chemical means. We have used a genetic system to distinguish the in vivo interactions of eight carcinogenic methylating agents and five ethylating agents by the patterns of induced mutati...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.7.1161
更新日期:1991-07-01 00:00:00
abstract::We have previously demonstrated that the active dihydrofolate reductase (DHFR) gene is efficiently repaired in Chinese hamster ovary (CHO) cells which remove only a small fraction of u.v.-induced pyrimidine dimers from the overall genome. Preferential DNA repair of essential genes may explain why the u.v. resistance o...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.9.1333
更新日期:1987-09-01 00:00:00
abstract::Endocrine therapies, which inhibit estrogen receptor (ER)alpha signaling, are the most common and effective treatment for ERalpha-positive breast cancer. However, the use of these agents is limited by the frequent development of resistance. The cyclin-dependent kinase family member CRK7 (aka CRKRS) was identified from...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp187
更新日期:2009-10-01 00:00:00
abstract::Fifty-five types of commercial cigarettes on the West German market were analyzed for tobacco-specific nitrosamines (TSNA) in mainstream smoke. The cigarettes included filter and nonfilter cigarettes with very high, high, medium, low and ultra-low tar and nicotine yields. The observed range for N'-nitrosonornicotine w...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.1.169
更新日期:1989-01-01 00:00:00
abstract::The E3 ubiquitin ligase EDD is overexpressed in recurrent, platinum-resistant ovarian cancers, suggesting a role in tumor survival and/or platinum resistance. EDD knockdown by small interfering RNA (siRNA) induced apoptosis in A2780ip2, OVCAR5 and ES-2 ovarian cancer cells, correlating with loss of the prosurvival pro...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt489
更新日期:2014-05-01 00:00:00
abstract::IARC Monographs are globally-recognized assessments of carcinogenicity published by International Agency for Research on Cancer and directed to national authorities as a contribution to public health. Currently, though not constraining the scope of studies examined, Monographs are declared to involve only hazard ident...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa129
更新日期:2020-12-01 00:00:00
abstract::Azido-IQ (2-azido-3-methylimidazo[4,5-f]quinoline), a novel analog of the food mutagen and carcinogen IQ (2-amino-3-methylimidazo[4,5-f]quinoline) was synthesized and characterized. Both thermolysis and photolysis of this azide yield a short-lived nitrene which can react as an electrophile either directly or via proto...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.5.869
更新日期:1988-05-01 00:00:00
abstract::3-Methyladenine DNA glycosylases initiate base excision repair by flipping the nucleotide bearing the target base out of double-stranded DNA into an active site pocket for glycosylic bond cleavage and base release. Substrate bases for the murine 3-methyladenine DNA glycosylase (other than 3-methyladenine) include hypo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/21.5.901
更新日期:2000-05-01 00:00:00
abstract::Administration of methylglyoxal at doses of 300-600 mg/kg body weight by gastric tube to male F344 rats induced 100-fold increase in ornithine decarboxylase activity (formation of 682 pmol CO2/30 min/mg protein) within 7 h, 26-fold increase in DNA synthesis (incorporation of 17 800 d.p.m. of [3H]thymidine/microgram DN...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.1.91
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected becaus...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq001
更新日期:2010-04-01 00:00:00
abstract::Male and female strain A/J mice were exposed to a mixture of cigarette sidestream and mainstream smoke at a chamber concentration of total suspended particulates of 82.5 mg/m3. Exposure time was 6 h/day, 5 days/week for 5 months. The animals were allowed to recover for another 4 months in filtered air before sacrifice...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.10.1789
更新日期:1998-10-01 00:00:00
abstract::The cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) (p27) is a marker of prognosis in many cancers, including breast cancer. Low p27 expression correlates with poor prognosis, especially in hormone receptor positive breast tumors. This association suggests a role for p27 in hormone-dependent cancer. We used the Wnt-...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp089
更新日期:2009-06-01 00:00:00
abstract::The influence of various dietary constituents--phenethylisothiocyanate (PEITC), oleic acid (OA), triolein (TO), and vitamin A (ROL)--on the genotoxic activity of nitrosamines (NDMA, NDELA, NPYR) was investigated. For this purpose differential DNA repair assays with Escherichia coli K-12 strains were performed in vitro...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.9.1643
更新日期:1992-09-01 00:00:00
abstract::The purpose of this study was to compare the metabolism and DNA binding of aflatoxicol (AFL) with that of aflatoxin B1 (AFB1) in vivo and in isolated hepatocytes from Mt Shasta strain rainbow trout (Salmo gairdneri). Maximum total binding of [3H]AFL to liver DNA from trout exposed by intraperitoneal injection was 38-4...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.8.1065
更新日期:1987-08-01 00:00:00
abstract::Carcinogen treatment of cultured mammalian cells prior to infection with u.v.-irradiated virus results in enhanced virus survival and mutagenesis suggesting the induction of SOS-type processes. In this paper, we report the development of a primary rat hepatocyte culture system to investigate cellular responses to DNA ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.4.495
更新日期:1984-04-01 00:00:00
abstract::The sensitivity of various mouse strains to skin carcinogenesis has been investigated in two ways; (i) by comparing carcinogenesis induced by treatments involving both the application of tumour promoters and the application of single or multiple doses of a carcinogen, and (ii) by comparing the binding characteristics ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.7.805
更新日期:1982-01-01 00:00:00
abstract::Chondrosarcoma is a form of malignant skeletal tumor of cartilaginous origin. The non-malignant form of the disease is termed chondroma. Correctly distinguishing between the two forms is essential for making therapeutic decisions. However, due to their similar histological appearances and the lack of a reliable diagno...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs254
更新日期:2012-11-01 00:00:00
abstract::The relationship between striatal dopamine-stimulated adenylate cyclase (DAC) and 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors was studied. An inverse correlation between activity of this enzyme and the number and growth of tumors was observed in several strains and substrains of rats. Chronic, but not...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.7.971
更新日期:1984-07-01 00:00:00
abstract::Despite decades of research in defining the health effects of low-dose (<100 mGy) ionizing photon radiation (LDR), the relationship between LDR and human cancer risk remains elusive. Because chemical carcinogens modify the tumor microenvironment, which is critical for cancer development, we investigated the role and ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs159
更新日期:2012-07-01 00:00:00
abstract::Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers, and most patients develop chemoresistance after first-line treatments. Despite recent advances, the 5-year relative survival is ~45% for all OC subtypes, and invasive epithelial OC has only a 17% survival rate when diagnosed at a late sta...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgx054
更新日期:2017-10-01 00:00:00
abstract::The phosphoinositide 3-kinase (PI 3-kinase) signaling pathway has been shown to play a pivotal role in intracellular signal transduction pathways involved in cell growth, cellular transformation and tumorigenesis. Analysis of several colon adenocarcinoma cell lines indicates that the PI 3-kinase signaling pathway is u...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgg195
更新日期:2004-02-01 00:00:00
abstract::Maternal nutrition during pregnancy influences the development and metabolism of the fetus. Recent studies suggest that the cancer risk of offspring later in life is associated with maternal diet, but little is known about the effect of a maternal diet high in methyl nutrients on breast cancer risk. Lipotropes are met...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs125
更新日期:2012-05-01 00:00:00