Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells.

abstract：:Consumption of fruits and vegetables has been associated with a decrease in cancer incidence and cardiovascular disease, presumably caused by antioxidants. We designed a human intervention study to assess antioxidative and possible anti-genotoxic properties of fruit-borne antioxidants. We hypothesized that individuals...

journal_title：Carcinogenesis

authors： Wilms LC,Boots AW,de Boer VC,Maas LM,Pachen DM,Gottschalk RW,Ketelslegers HB,Godschalk RW,Haenen GR,van Schooten FJ,Kleinjans JC

更新日期：2007-08-01 00:00:00

abstract：:Although microRNAs (miRNA) have extensively been investigated in cancer research, less attention has been paid to their regulation by carcinogens and/or protective factors in early stages of the carcinogenesis process. The present study was designed to evaluate the modulation of mRNA expression as related to exposure ...

journal_title：Carcinogenesis

authors： Izzotti A,Larghero P,Cartiglia C,Longobardi M,Pfeffer U,Steele VE,De Flora S

更新日期：2010-05-01 00:00:00

abstract：:3-Amino-1,2,4-triazole, a thyroid carcinogen and goitrogen, is negative in a wide variety of short-term mutagenicity assays. However, amitrole induces gene mutations and morphological transformation in Syrian hamster embryo fibroblasts, cells known to carry out the prostaglandin H synthase (PHS)-mediated peroxidative ...

journal_title：Carcinogenesis

authors： Krauss RS,Eling TE

更新日期：1987-05-01 00:00:00

abstract：:When hepatocytes isolated from mouse liver are cultivated in vitro, a small fraction of cells can survive, forming colonies, while most cells die within a few weeks. We compared the colony forming capacity of hepatocytes in three mouse strains; two strains susceptible for hepatocarcinogenesis, C3H/HeJ (C3) and DBA/2J ...

journal_title：Carcinogenesis

authors： Yoshie M,Nishimori H,Lee GH,Ogawa K

更新日期：1998-06-01 00:00:00

abstract：:The purpose of this study was to examine the activity and associated kinetic parameters of epidermal protein kinase C (PKC) following stimulation by sn-1,2-dioctanoylglycerol (DIC8) or 12-O-tetradecanoylphorbol-13-acetate (TPA) and to examine the relationship between levels of epidermal PKC activity and the induction ...

journal_title：Carcinogenesis

authors： Mills KJ,Smart RC

更新日期：1989-05-01 00:00:00

abstract：:Aberrant crypt foci (ACF), putative preneoplastic lesions, are early morphological changes induced by the colon carcinogen azoxymethane (AOM). Although inbred mice differ markedly in their susceptibility to AOM carcinogenesis, we have previously shown that ACF develop in both resistant and sensitive mouse strains afte...

journal_title：Carcinogenesis

authors： Papanikolaou A,Wang QS,Papanikolaou D,Whiteley HE,Rosenberg DW

更新日期：2000-08-01 00:00:00

abstract：:Alterations of epigenetic modifications are promising targets for cancer therapy, and several epigenetic drugs are now being clinically utilized. At the same time, individual epigenetic modifications have physiological functions in normal cells, and cancer cell specificity is considered difficult to achieve using a dr...

journal_title：Carcinogenesis

authors： Takeshima H,Wakabayashi M,Hattori N,Yamashita S,Ushijima T

更新日期：2015-02-01 00:00:00

abstract：:Semi-permeable magnetic microcapsules previously shown able to trap gastrointestinal carcinogens and containing polyethyleneimine (PEI) were covalently labelled with [14CH3], and administered for the first time to humans (six healthy volunteers, 1.3 microCi/dose) in gelatin capsules together with radio-opaque gut tran...

journal_title：Carcinogenesis

authors： Bingham SA,Ellul A,Cummings JH,O'Neill I

更新日期：1992-04-01 00:00:00

abstract：:Crude plasma membranes were prepared from the liver of control rats or of rats submitted to an initiation by diethyl-nitrosamine and selection with 2-acetylaminofluorene and carbon tetrachloride (group IS) or of rats submitted to an initiation-selection protocol followed by a promotion with phenobarbital (group IS PB)...

journal_title：Carcinogenesis

authors： Marino A,Ravelingien N,De Cannière D,Préat V,Dehaye JP,Pector JC

更新日期：1991-04-01 00:00:00

abstract：:Several converging lines of evidence suggest that keratinocyte stem cells including those clonogenic in vitro, are the target cells in skin carcinogenesis. However, the mechanism of their involvement in carcinogenesis continues to be unknown. Recently, we have demonstrated that the number of keratinocyte clonogenic st...

journal_title：Carcinogenesis

authors： Popova NV,Teti KA,Wu KQ,Morris RJ

更新日期：2003-03-01 00:00:00

abstract：:Results of previous serologic studies on the association of human papillomavirus (HPV) with esophageal squamous cell carcinoma (ESCC) have been inconsistent. From 2007 to 2010, the authors collected blood samples and relevant demographic data from 1435 patients with ESCC and 2071 age- and sex-matched normal controls f...

journal_title：Carcinogenesis

authors： He Z,Xu Z,Hang D,Guo F,Abliz A,Weiss NS,Xi L,Liu F,Ning T,Pan Y,Guo C,Liang Y,Lu C,Zhang L,Cai H,Ke Y

更新日期：2014-04-01 00:00:00

abstract：:Transcripts originating from the transcriptional read through of two adjacent, similarly oriented genes have been identified in normal and neoplastic tissues, but their functional role and the mechanisms that regulate their expression are mostly unknown. Here, we investigated whether the expression of read-through tra...

journal_title：Carcinogenesis

authors： Maspero D,Dassano A,Pintarelli G,Noci S,De Cecco L,Incarbone M,Tosi D,Santambrogio L,Dragani TA,Colombo F

更新日期：2020-07-14 00:00:00

abstract：:It has previously been proposed that redox cycling between catechol estrogens and their quinones, mediated by cytochrome P450, could lead to the generation of free radicals that would subsequently cause oxidative damage to DNA and proteins that might have a role in hormonal carcinogenesis. Alternative, non-enzymatic m...

journal_title：Carcinogenesis

authors： Li Y,Trush MA,Yager JD

更新日期：1994-07-01 00:00:00

abstract：:Liposarcoma (LS) is the most common soft-tissue sarcoma. Dedifferentiated liposarcoma (DDLS) shows more aggressive biological behavior than that of well-differentiated liposarcoma (WDLS), so advanced therapeutic agents based on molecular mechanism are urgently needed. Here we show that tissue inhibitors of metalloprot...

journal_title：Carcinogenesis

authors： Shrestha M,Ando T,Chea C,Sakamoto S,Nishisaka T,Ogawa I,Miyauchi M,Takata T

更新日期：2019-10-16 00:00:00

abstract：:CXCR4 is a chemokine receptor probably involved in the homing of metastatic breast cancer, and its expression is modulated by tumor environmental stimuli such as hepatocyte growth factor (HGF) and hypoxia. Here, we demonstrate that, depending on the stimulus, different transcription factors can cooperate in enhancing ...

journal_title：Carcinogenesis

authors： Maroni P,Bendinelli P,Matteucci E,Desiderio MA

更新日期：2007-02-01 00:00:00

abstract：:The ability of dietary retinyl palmitate, canthaxanthin or the combination of both, to prevent induction of immunosuppression by UVB irradiation was tested by passive transfer of splenocytes. The basal diet was the American Institute of Nutrition diet 76A, containing 4 IU retinyl palmitate/g diet. Groups of 55 mice we...

journal_title：Carcinogenesis

authors： Gensler HL

更新日期：1989-01-01 00:00:00

abstract：:I-compounds are endogenous bulky DNA modifications which are detected by nuclease P1-enhanced 32P-post-labeling in tissue DNA of animals not knowingly exposed to carcinogens. Their profiles and levels depend inter alia on animal age, species, strain, tissue, gender, diet and exposure to chemicals such as cytochrome P4...

journal_title：Carcinogenesis

authors： Zhou GD,Vulimiri SV,Randerath E,Randerath K

更新日期：1998-10-01 00:00:00

abstract：:The effects of hyperoxia on lung tumor development were examined in mice and rats. In mice, exposure to 70% O2 prevented the development of urethan- or 3-methylcholanthrene-induced lung tumors. Dietary antioxidants [butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA)] were unable to prevent the inhibitio...

journal_title：Carcinogenesis

authors： Lindenschmidt RC,Margaretten N,Griesemer RA,Witschi HP

更新日期：1986-09-01 00:00:00

abstract：:Benzo[a]pyrene diol epoxide (BPDE)-DNA adducts are involved in the induction of p53 mutations and probably in the causation of human lung cancer associated with cigarette smoking. The ratio between CYP1A1 and GST enzyme activities is a critical determinant of the target dose of carcinogenic BPDE and other DNA-reactive...

journal_title：Carcinogenesis

authors： Alexandrov K,Cascorbi I,Rojas M,Bouvier G,Kriek E,Bartsch H

更新日期：2002-12-01 00:00:00

abstract：:Cancer of the stomach is one of the most commonly diagnosed malignancies and remains an important cause of mortality world wide. This type of cancer is not uniformly distributed among populations but shows a marked variation in both incidence and mortality. Although gastric cancer is declining in many parts of the wor...

journal_title：Carcinogenesis

authors： Stadtländer CT,Waterbor JW

更新日期：1999-12-01 00:00:00

abstract：:The nucleotide excision repair (NER) pathway is central in response to damage induced by environmental carcinogens. Efficiency of this pathway, probably genetically determined, may modulate individual risk of developing squamous cell carcinoma of the head and neck (SCCHN) as well as second primary malignancy (SPM) aft...

journal_title：Carcinogenesis

authors： Zafereo ME,Sturgis EM,Liu Z,Wang LE,Wei Q,Li G

更新日期：2009-06-01 00:00:00

abstract：:N-Hydroxy-2-acetylaminofluorene (N-OH-AAF), N-hydroxy-4'-fluoro-4-acetylaminobiphenyl (N-OH-FAABP) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) were compared for their initiation and promotion activity in the rat liver using a modified Solt-Farber system. N-OH-AAF, N-OH-FAABP and N-OH-AABP showed comparable initiat...

journal_title：Carcinogenesis

authors： van de Poll ML,van der Hulst DA,Tates AD,Meerman JH

更新日期：1990-02-01 00:00:00

abstract：:A two-stage carcinogenesis experiment was performed in Syrian golden hamsters using a single intragastric initiation with 10 mg/kg body weight of 7,12-dimethylbenz[a]anthracene (DMBA) and repetitive topical promotion on the back skin with two different doses (80 and 160 mg, respectively) of benzoyl peroxide in 1 ml ac...

journal_title：Carcinogenesis

authors： Schweizer J,Loehrke H,Edler L,Goerttler K

更新日期：1987-03-01 00:00:00

abstract：:The lymphocyte response to u.v. radiation (254 nm) was investigated by two different methods in 29 unselected patients with multiple epidermal cancer. The u.v.-induced DNA synthesis was determined as the increase in incorporation of [3H]thymidine in irradiated cells compared with nonirradiated cells after incubation f...

journal_title：Carcinogenesis

authors： Munch-Petersen B,Frentz G,Squire B,Wallevik K,Horn CC,Reymann F,Faber M

更新日期：1985-06-01 00:00:00

abstract：:Bacterial formation of carcinogenic N-nitroso compounds may play a role in the etiology of human cancer. Biochemical and immunological studies in denitrifying bacteria (Pseudomonas aeruginosa) strongly support the identification of cytochrome cd(1)-nitrite reductase as the enzyme responsible for the catalysis of nitro...

journal_title：Carcinogenesis

authors： Calmels S,Ohshima H,Henry Y,Bartsch H

更新日期：1996-03-01 00:00:00

abstract：:This commentary celebrates the 40th year of Carcinogenesis, spanning 1980-2020 with a focus on lung cancer. For lung cancer, these 40 years come toward the end of a century of scientific inquiry that began with descriptions of this highly fatal malignancy and that closes with emphasis on molecular processes and genomi...

journal_title：Carcinogenesis

authors： Samet JM

更新日期：2020-10-15 00:00:00

abstract：:Co-exposure to cadmium, cobalt, lead and other heavy metals occurs in many occupational settings, such as pigment and batteries production, galvanization and recycling of electric tools. However, little is known about interactions between several heavy metals. In the present study we determined DNA single strand break...

journal_title：Carcinogenesis

authors： Hengstler JG,Bolm-Audorff U,Faldum A,Janssen K,Reifenrath M,Götte W,Jung D,Mayer-Popken O,Fuchs J,Gebhard S,Bienfait HG,Schlink K,Dietrich C,Faust D,Epe B,Oesch F

更新日期：2003-01-01 00:00:00

abstract：:The JB6 mouse epidermal cell system has been extensively used as an in vitro model for the study of tumor promotion. The present study aimed to assess the relevance of monolayer measurements to the process of transformation, which is induced more efficiently under anchorage-independent (AI) conditions. Although it wou...

journal_title：Carcinogenesis

authors： Dong Z,Cmarik JL,Wendel EJ,Colburn NH

更新日期：1994-05-01 00:00:00

abstract：:Oxidative DNA modifications such as 7,8-dihydro-8-oxoguanine (8-oxoG) are generated endogenously in apparently all living cells. The defect of the repair of 8-oxoG in Csb(m/m)Ogg1⁻(/)⁻ mice results in elevated basal levels of these lesions and increased frequencies of spontaneous mutations, which initiate tumorigenesi...

journal_title：Carcinogenesis

authors： Fusser M,Nesse GJ,Khobta A,Xia N,Li H,Klungland A,Epe B

更新日期：2011-01-01 00:00:00

abstract：:Catechol (1,2-dihydroxybenzene) is a major phenolic compound present in the co-carcinogenic fraction of cigarette tar. It has been shown to be a potent co-carcinogen with benzo[a]pyrene (BaP) in mouse skin. In this study we have examined the co-carcinogenic and co-initiating activities of catechol with racemic and ena...

journal_title：Carcinogenesis

authors： Melikian AA,Jordan KG,Braley J,Rigotty J,Meschter CL,Hecht SS,Hoffmann D

更新日期：1989-10-01 00:00:00