5-Sulfooxymethylfurfural as a possible ultimate mutagenic and carcinogenic metabolite of the Maillard reaction product, 5-hydroxymethylfurfural.

abstract：:Observational studies and animal evidence suggest an association between coffee consumption and the risk of prostate cancer. However, the results are inconsistent. We evaluated the association by conducting a meta-analysis of prospective cohort studies. PubMed and Embase were searched through June 2013 to identify stu...

journal_title：Carcinogenesis

authors： Cao S,Liu L,Yin X,Wang Y,Liu J,Lu Z

更新日期：2014-02-01 00:00:00

abstract：:Preparations of dietary fibre have an ability to bind potentially toxic compounds in vitro, but it is unclear how the measured binding properties are a reflection of either the relative affinity of such compounds for fibre or the saturation binding capacity of the fibre. Cooking and processing of foods and fermentatio...

journal_title：Carcinogenesis

authors： Ryden P,Robertson JA

更新日期：1995-02-01 00:00:00

abstract：:The ability of dietary retinyl palmitate, canthaxanthin or the combination of both, to prevent induction of immunosuppression by UVB irradiation was tested by passive transfer of splenocytes. The basal diet was the American Institute of Nutrition diet 76A, containing 4 IU retinyl palmitate/g diet. Groups of 55 mice we...

journal_title：Carcinogenesis

authors： Gensler HL

更新日期：1989-01-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI 3-kinase) signaling pathway has been shown to play a pivotal role in intracellular signal transduction pathways involved in cell growth, cellular transformation and tumorigenesis. Analysis of several colon adenocarcinoma cell lines indicates that the PI 3-kinase signaling pathway is u...

journal_title：Carcinogenesis

authors： Khaleghpour K,Li Y,Banville D,Yu Z,Shen SH

更新日期：2004-02-01 00:00:00

abstract：:Male Ah-responsive C57BL/10ScSn mice received a single dose of iron-dextran (600 mg Fe/kg) and were fed a diet containing 0.01% of the PCBs mixture Aroclor 1254 for up to 12 months. Iron caused a marked synergistic increase in liver size from 2 months with greatly elevated mitotic rates, numbers of basophilic foci and...

journal_title：Carcinogenesis

authors： Smith AG,Francis JE,Carthew P

更新日期：1990-03-01 00:00:00

abstract：:Flow cytometric analysis of fibroblasts, normal breast epithelial cells and breast or other cancer cell lines identified variation in the abilities of cell lines to undergo cell cycle arrest as a response to hypoxia. Human mammary epithelial cells (HMEC), normal fibroblasts (Hs68 and WI38), HeLa cervical carcinoma and...

journal_title：Carcinogenesis

authors： Box AH,Demetrick DJ

更新日期：2004-12-01 00:00:00

abstract：:We previously demonstrated that fasting/refeeding enhances the initiation phase of liver and colorectal carcinogenesis in rats. The present study was undertaken to establish whether cycles of fasting/refeeding carried out during the promotion phase of carcinogenesis may also affect the formation of aberrant crypt foci...

journal_title：Carcinogenesis

authors： Caderni G,Perrelli MG,Cecchini F,Tessitore L

更新日期：2002-02-01 00:00:00

abstract：:We have compared liver, kidney and colon DNA damage, as single strand breaks, in mice with different strain-dependent susceptibility to the colon-specific carcinogen 1,2-dimethylhydrazine (DMH). The mouse strains studied were: AKR/J, DBA2 totally resistant; CD1, C57BL/6N moderately susceptible; SWR/J very susceptible ...

journal_title：Carcinogenesis

authors： Bolognesi C,Mariani MR,Boffa LC

更新日期：1988-08-01 00:00:00

abstract：:Although epidemiological evidence in humans and bile acid feeding studies in rodents implicate bile acids as tumor promoters, the role of endogenous bile acids in colon carcinogenesis remains unclear. In this study, we exploited mice deficient in the ileal apical sodium-dependent bile acid transporter (ASBT, encoded b...

journal_title：Carcinogenesis

authors： Raufman JP,Dawson PA,Rao A,Drachenberg CB,Heath J,Shang AC,Hu S,Zhan M,Polli JE,Cheng K

更新日期：2015-10-01 00:00:00

abstract：:The oxidative stress induced in vivo by benzoyl peroxide (BzPo) or 12-O-tetradecanoylphorbol-13-acetate (TPA) was evaluated in terms of chemiluminescence (CL) emitted by SENCAR mouse skin, a non-invasive method that allows an estimation of overall oxidative stress. The ability of a biomimetic superoxide dismutase, cop...

journal_title：Carcinogenesis

authors： Durán HA,de Rey BM

更新日期：1991-11-01 00:00:00

abstract：:Benzoquinones (BQ) are genotoxic species that stem from metabolism of phenolic compounds. We have developed a method for measuring adducts of 1,2- and 1,4-benzoquinone (1,2-BQ and 1,4-BQ) with cysteine residues of hemoglobin (Hb) and albumin (Alb). The method employs a reductive catalyst (Raney nickel) to selectively ...

journal_title：Carcinogenesis

authors： McDonald TA,Waidyanatha S,Rappaport SM

更新日期：1993-09-01 00:00:00

abstract：:The metabolism in mouse epidermis of benzo[b]fluoranthene (BbF) was studied. [3H]BbF was applied topically, mice were killed at various intervals, and metabolites were extracted from the epidermis and analyzed by h.p.l.c. The major metabolites were identified by comparisons to standards as 4-, 5-, and 6-hydroxyBbF. Su...

journal_title：Carcinogenesis

authors： Geddie JE,Amin S,Huie K,Hecht SS

更新日期：1987-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Genomic copy number deletion at chromosome 14q31.1-32.13 was frequently observed in HCC; however, the relevant functional target(s) at that locus is not well determined. Here, we performed integrative genomic analyses and ...

journal_title：Carcinogenesis

authors： Zhang C,Cao P,Yang A,Xia X,Li Y,Shi M,Yang Y,Wei X,Yang C,Zhou G

更新日期：2019-05-14 00:00:00

abstract：:Semi-permeable magnetic microcapsules previously shown able to trap gastrointestinal carcinogens and containing polyethyleneimine (PEI) were covalently labelled with [14CH3], and administered for the first time to humans (six healthy volunteers, 1.3 microCi/dose) in gelatin capsules together with radio-opaque gut tran...

journal_title：Carcinogenesis

authors： Bingham SA,Ellul A,Cummings JH,O'Neill I

更新日期：1992-04-01 00:00:00

abstract：:Debrisoquine hydroxylase activity has been attributed to CYP2D6 and poor metabolizers of debrisoquine have a reduced relative risk of developing aggressive bladder cancer. Production of a proximate carcinogen could occur in liver or bladder mucosa. However, it is not known if CYP2D6 is expressed in human bladder mucos...

journal_title：Carcinogenesis

authors： Romkes-Sparks M,Mnuskin A,Chern HD,Persad R,Fleming C,Sibley GN,Smith P,Wilkinson GR,Branch RA

更新日期：1994-09-01 00:00:00

abstract：:Medulloblastoma (MB) cells arise from granule neuron precursors (GNPs) that have lost growth control. During normal development, GNPs divide in response to Sonic hedgehog (SHH), a ligand that binds to the patched (PTCH) receptor on GNPs. If one copy of the Ptch gene is lost, as in human Gorlin's syndrome and in Ptch(+...

journal_title：Carcinogenesis

authors： Barakat MT,Humke EW,Scott MP

更新日期：2013-06-01 00:00:00

abstract：:Liposarcoma (LS) is the most common soft-tissue sarcoma. Dedifferentiated liposarcoma (DDLS) shows more aggressive biological behavior than that of well-differentiated liposarcoma (WDLS), so advanced therapeutic agents based on molecular mechanism are urgently needed. Here we show that tissue inhibitors of metalloprot...

journal_title：Carcinogenesis

authors： Shrestha M,Ando T,Chea C,Sakamoto S,Nishisaka T,Ogawa I,Miyauchi M,Takata T

更新日期：2019-10-16 00:00:00

abstract：:4,4'-Methylene-bis(2-chloroaniline) (MOCA) can produce tumors in rodents and dogs and an increased incidence of bladder tumors has been reported in exposed workers. It is therefore of interest to identify the human cytochrome P450 (P450) enzymes involved in MOCA N-oxidation, the primary reaction involved in the format...

journal_title：Carcinogenesis

authors： Yun CH,Shimada T,Guengerich FP

更新日期：1992-02-01 00:00:00

abstract：:Apigenin is a plant flavonoid which has been shown to significantly inhibit UV-induced mouse skin tumorigenesis when applied topically, and may represent an alternative sunscreen agent in humans. We have investigated the molecular mechanism(s) by which apigenin inhibits skin tumorigenesis. Initial studies examined the...

journal_title：Carcinogenesis

authors： Lepley DM,Li B,Birt DF,Pelling JC

更新日期：1996-11-01 00:00:00

abstract：:Well-differentiated squamous cell carcinomas were induced in hamster buccal pouch epithelium by twice weekly topical applications of N-methyl-N-benzylnitrosamine (MBN) or 7,12-dimethylbenz[a]anthracene (DMBA) over a period of 15 weeks. Each of the 22 tumors induced (14 MBN and eight DMBA) were evaluated by single-stra...

journal_title：Carcinogenesis

authors： Chang KW,Lin SC,Koos S,Pather K,Solt D

更新日期：1996-03-01 00:00:00

abstract：:DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within Lynch syndrome. MSI-H is characterized by length alterations within simple repeated sequences, microsatellites. Lynch syndrome is primarily ...

journal_title：Carcinogenesis

authors： Imai K,Yamamoto H

更新日期：2008-04-01 00:00:00

abstract：:The effect of phenobarbital (PB), p,p'-dichlorodiphenyltrichloroethane (DDT) or carbon tetrachloride (CCl4) on dimethylnitrosamine (DMN)-induced hepatocarcinogenesis in Syrian golden hamsters was examined. Hamsters were given a single injection of DMN (6 mg/kg body wt) followed by either PB or DDT in the diet or repea...

journal_title：Carcinogenesis

authors： Tanaka T,Mori H,Williams GM

更新日期：1987-09-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) have been described to play critical roles in initiation, progression and metastasis of various cancers. However, the involvement of CAFs in oral cancer (OC) has not been well addressed. In this study, we demonstrate that CAFs, when cocultured with OC cells (OCCs), produce high lev...

journal_title：Carcinogenesis

authors： Li X,Xu Q,Wu Y,Li J,Tang D,Han L,Fan Q

更新日期：2014-06-01 00:00:00

abstract：:Treatment of human skin fibroblasts in early S-phase with (+-)7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene (BPDE-I) results in more extensive modification of early replicating DNA than parental DNA. We have investigated the effects of benzamide (BZ) and 3-aminobenzamide (3-ABZ), i...

journal_title：Carcinogenesis

authors： Kurian P,Kumari HL,Milo GE

更新日期：1992-03-01 00:00:00

abstract：:Treatment of murine Swiss 3T3 fibroblasts and XB/2 keratinocytes with UV-B light (302 nm) resulted in a dose-dependent inhibition of [125I]epidermal growth factor (EGF) binding. The light dose required to achieve 50% inhibition of binding in both cell types was 80-85 J/m2. Decreased [125I]platelet-derived growth facto...

journal_title：Carcinogenesis

authors： Brooks G,Goss MW,Hart IR

更新日期：1990-07-01 00:00:00

abstract：:Breast cancer is a leading cause of cancer-related mortality in women. Triple-negative breast cancer (TNBC; HER2-, ER-/PR-) is an aggressive subtype prone to drug resistance and metastasis, which is characterized by high intratumor microvascular density (iMVD) resulting from angiogenesis. However, the mechanisms contr...

journal_title：Carcinogenesis

authors： Kumar N,Prasad P,Jash E,Jayasundar S,Singh I,Alam N,Murmu N,Somashekhar SP,Goldman A,Sehrawat S

更新日期：2018-10-08 00:00:00

abstract：:Epigenetic silencing of tumor suppressor genes commonly occurs in human cancers via increasing DNA methylation and repressive histone modifications at gene promoters. However, little is known about how pathogenic environmental factors contribute to cancer development by affecting epigenetic regulatory mechanisms. Prev...

journal_title：Carcinogenesis

authors： Chen H,Kluz T,Zhang R,Costa M

更新日期：2010-12-01 00:00:00

abstract：:Low-carbohydrate diets have become a popular approach for weight loss in recent years. However, whether low-carbohydrate diets are associated with the risk of pancreatic cancer remains to be elucidated. Hence, we examined the association of low-carbohydrate diets with the risk of pancreatic cancer in a US population. ...

journal_title：Carcinogenesis

authors： Zhong GC,Li QJ,Yang PF,Wang YB,Hao FB,Wang K,Hu JJ,Wu JJ

更新日期：2021-01-22 00:00:00

abstract：:Adduct formation has been considered to be a major causal factor of DNA damage by carcinogenic heterocyclic amines. By means of experiments with an electrochemical detector coupled to a high-performance liquid chromatograph, we revealed that N-hydroxy metabolite of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (Ph...

journal_title：Carcinogenesis

authors： Murata M,Kawanishi S

更新日期：2002-05-01 00:00:00

abstract：:TP63, a member of the TP53 gene family, encodes two groups of three isoforms (alpha, beta and gamma). The TAp63 isoforms act as transcription factors. The DeltaNp63 isoforms lack the main transcription activation domain and act as dominant-negative inhibitors of transactivation (TA) isoforms. To clarify the role of th...

journal_title：Carcinogenesis

authors： Petitjean A,Ruptier C,Tribollet V,Hautefeuille A,Chardon F,Cavard C,Puisieux A,Hainaut P,Caron de Fromentel C

更新日期：2008-02-01 00:00:00