Abstract:
:Dehydroepiandrosterone (DHEA), a major adrenal secretory product in men and women, is a potent inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). Long-term treatment with this steroid has previously been found to suppress spontaneous breast cancer development in C3H mice. DHEA is now shown to inhibit Epstein-Barr virus (EBV)-induced morphologic transformation and stimulation of DNA synthesis in human lymphocytes. 16 alpha-Br-epiandrosterone, a DHEA analog that is about 60 times as potent as DHEA as an inhibitor of G6PDH, is much more effective as an inhibitor of EBV-induced transformation.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Henderson E,Schwartz A,Pashko L,Abou-Gharbia M,Swern Ddoi
10.1093/carcin/2.7.683subject
Has Abstractpub_date
1981-01-01 00:00:00pages
683-6issue
7eissn
0143-3334issn
1460-2180journal_volume
2pub_type
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