Polymorphisms in the MTHFR and VDR genes and skin cancer risk.

abstract：:In the previous 500 2-year chemical bioassays within the National Toxicology Program, large intestinal tumors (cecal carcinomas) related to chemical exposure have not been observed in B6C3F1 mice. The recently completed o-nitrotoluene study provided the first cecal tumor response and an opportunity to evaluate the mor...

journal_title：Carcinogenesis

authors： Sills RC,Hong HL,Flake G,Moomaw C,Clayton N,Boorman GA,Dunnick J,Devereux TR

更新日期：2004-04-01 00:00:00

abstract：:Despite recent additions to the armory of chemotherapeutic agents for colorectal cancer (CRC) treatment, the results of chemotherapy remain unsatisfactory. 5-Fluorouracil (5-FU) still represents the cornerstone of treatment and resistance to its actions is a major obstacle to successful chemotherapy. Therefore, new ac...

journal_title：Carcinogenesis

authors： Kodach LL,Bos CL,Durán N,Peppelenbosch MP,Ferreira CV,Hardwick JC

更新日期：2006-03-01 00:00:00

abstract：:We have tested the hypothesis that the inhibition by hydroxyurea of repair patch ligation and chromatin rearrangement during u.v.-induced DNA excision repair results from a reduction in cellular deoxyribonucleotide concentrations and not from a direct effect of hydroxyurea on the repair process. Using permeable human ...

journal_title：Carcinogenesis

authors： Hunting DJ,Dresler SL

更新日期：1985-10-01 00:00:00

abstract：:We have previously demonstrated that the active dihydrofolate reductase (DHFR) gene is efficiently repaired in Chinese hamster ovary (CHO) cells which remove only a small fraction of u.v.-induced pyrimidine dimers from the overall genome. Preferential DNA repair of essential genes may explain why the u.v. resistance o...

journal_title：Carcinogenesis

authors： Bohr VA,Hanawalt PC

更新日期：1987-09-01 00:00:00

abstract：:Low vitamin E and selenium (Ve/Se) nutritional status is known to be associated with increased risk of esophageal squamous cell carcinoma (ESCC). A previous human intervention trial demonstrated that Ve/Se supplementation decreased the occurrence of esophageal cancer death among younger participants but not among olde...

journal_title：Carcinogenesis

authors： Yang H,Fang J,Jia X,Han C,Chen X,Yang CS,Li N

更新日期：2011-03-01 00:00:00

abstract：:Both dehydroepiandrosterone (DHEA) and the synthetic steroid 16 alpha-Br-epiandrosterone (Br-Epi), a more potent inhibitor of glucose-6-phosphate dehydrogenase (G6PDH) than DHEA, inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of superoxide anion (O2-) formation by human neutrophils. DHEA has previo...

journal_title：Carcinogenesis

authors： Whitcomb JM,Schwartz AG

更新日期：1985-03-01 00:00:00

abstract：:A line of C3H mouse fibroblasts designated CVP3SC6 (CVP) was found to be nonresponsive to the induction of morphological transformation by the polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP) and its BaP-7,8-diol and BaP-diol-epoxide derivates. This cell line was, however, susceptible to BaP-induced mutation to ou...

journal_title：Carcinogenesis

authors： Gehly EB,Heidelberger C

更新日期：1982-01-01 00:00:00

abstract：:Cisplatin alone or in combination with 5FU (5-fluorouracil) and docetaxel (TPF) are common regimen chemotherapeutics for treatment of advanced oral squamous cell carcinoma (OSCC). Despite the initial positive response, several patients experience relapse due to chemoresistance. The potential role of Bcl-2 antiapoptoti...

journal_title：Carcinogenesis

authors： Maji S,Shriwas O,Samal SK,Priyadarshini M,Rath R,Panda S,Das Majumdar SK,Muduly DK,Dash R

更新日期：2019-03-12 00:00:00

abstract：:Dietary-related indoles, isothiocyanates, and the allyl isothiocyanate glucosinolate, sinigrin, were administered to F344 rats in the diet for 2 weeks (chronic protocol) or by gavage 2 h before sacrifice (acute protocol) and the effects of these pretreatments on the alpha-hydroxylation of two carcinogenic nitrosamines...

journal_title：Carcinogenesis

authors： Chung FL,Wang MY,Hecht SS

更新日期：1985-04-01 00:00:00

abstract：:Mammalian DNA contains bulky endogenous DNA modifications (I-compounds), which increase with age in unexposed animals, as shown by 32P-postlabeling. We have examined the perinatal formation of a subclass (type II) of I-compounds in rat liver, kidney, skin and lung. These I-compounds represent bulky oxidative DNA lesio...

journal_title：Carcinogenesis

authors： Randerath E,Zhou GD,Randerath K

更新日期：1996-12-01 00:00:00

abstract：:Adult rat hepatocytes in primary culture were used to study the effect of tryptophan pyrolysis products on the transcriptional process. Hepatocytes were treated with 1, 5 and 10 micrograms/ml of 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]-indole (Trp-P-1) or 3-amino-1-methyl-5H-pyrido-[4,3-b]-indole (Trp-P-2) for 2 and 4 h...

journal_title：Carcinogenesis

authors： Thybaud-Lambay V,Decloitre F,Moulé Y,Florentin Y

更新日期：1983-01-01 00:00:00

abstract：:In this study we have investigated the relationship between the dose of 1,2-dimethylhydrazine (DMH) and the yield (and location) of tumours in a mouse strain susceptible to colon tumour induction. Female SWR mice were injected with 6.8 mg/kg DMH i.p. once a week for 1, 5, 10 and 20 weeks and the animals were followed ...

journal_title：Carcinogenesis

authors： Jackson PE,Cooper DP,O'Connor PJ,Povey AC

更新日期：1999-03-01 00:00:00

abstract：:Gemcitabine has limited clinical benefits in pancreatic ductal adenocarcinoma. The solvent-based traditional taxanes docetaxel and paclitaxel have not shown clinical results superior to gemcitabine. Nab-paclitaxel, a water-soluble albumin-bound paclitaxel, may carry superior distribution properties into the tumor micr...

journal_title：Carcinogenesis

authors： Awasthi N,Zhang C,Schwarz AM,Hinz S,Wang C,Williams NS,Schwarz MA,Schwarz RE

更新日期：2013-10-01 00:00:00

abstract：:Occupational exposure to styrene was studied in nine workers of a hand lamination plant in Bohemia. Personal dosimeters were used to monitor the styrene workplace exposure, and the levels of styrene in blood and mandelic acid in urine were measured. Blood samples were taken at four occasions during a 7 month period to...

journal_title：Carcinogenesis

authors： Vodicka P,Bastlová T,Vodicková L,Peterková K,Lambert B,Hemminki K

更新日期：1995-07-01 00:00:00

abstract：:To better understand the mechanisms of mutagenesis by the carcinogen, methylene chloride (DCM), we have determined the nature and distribution of forward mutations induced by DCM in the N-terminal region of the lacI gene of Escherichia coli. A total of 116 lacI-d mutations (50 from Uvr+, 66 from UvrB- strain) were cha...

journal_title：Carcinogenesis

authors： Zielenska M,Ahmed A,Pienkowska M,Anderson M,Glickman BW

更新日期：1993-05-01 00:00:00

abstract：:Inhalation of diesel exhaust (DE), which contains soot particles with adsorbed mutagenic organic compounds, and its virtually mutagen-free soot particle analog, carbon black (CB), produce similar types and prevalences of pulmonary neoplasms in chronically exposed F344 rats. This result suggests that DE-induced neoplas...

journal_title：Carcinogenesis

authors： Swafford DS,Nikula KJ,Mitchell CE,Belinsky SA

更新日期：1995-05-01 00:00:00

abstract：:Environmental contributions to cancer development are widely accepted, but only a fraction of all pertinent exposures have probably been identified. Traditional toxicological approaches to the problem have largely focused on the effects of individual agents at singular endpoints. As such, they have incompletely addres...

journal_title：Carcinogenesis

authors： Robey RB,Weisz J,Kuemmerle NB,Salzberg AC,Berg A,Brown DG,Kubik L,Palorini R,Al-Mulla F,Al-Temaimi R,Colacci A,Mondello C,Raju J,Woodrick J,Scovassi AI,Singh N,Vaccari M,Roy R,Forte S,Memeo L,Salem HK,Amedei A,

更新日期：2015-06-01 00:00:00

abstract：:We employed cDNA microarray analysis to identify, in mammary adenocarcinomas induced by 7,12-dimethylbenz[a] anthracene (DMBA) in the rat, target genes as potential biomarkers for cancer chemoprevention by 1,4-phenylenebis(methylene)selenocyanate (p-XSC). Confirmation of selected genes was conducted by reverse transcr...

journal_title：Carcinogenesis

authors： El-Bayoumy K,Narayanan BA,Desai DH,Narayanan NK,Pittman B,Amin SG,Schwartz J,Nixon DW

更新日期：2003-09-01 00:00:00

abstract：:Human fibroblasts were embedded in microscopic-sized agarose beads and lysed in situ to produce chromosome-sized DNA trapped inside the beads. Conventional alkaline agarose gel electrophoresis of trapped DNA from cells damaged by X-rays before embedding gave mol. wts similar to those obtained with alkaline sucrose gra...

journal_title：Carcinogenesis

authors： Cleaver JE

更新日期：1989-09-01 00:00:00

abstract：:Studies have shown that fisetin, a small phytochemical molecule, has antitumor activity; however, its antiangiogenic activity has not yet been examined. Accordingly, herein, we investigated the antiangiogenic efficacy and associated mechanisms of fisetin in human umbilical vein endothelial cells (HUVECs). Fisetin (10-...

journal_title：Carcinogenesis

authors： Bhat TA,Nambiar D,Pal A,Agarwal R,Singh RP

更新日期：2012-02-01 00:00:00

abstract：:Several studies have shown that hexavalent chromium [Cr(VI)] induces apoptosis in a variety of in vitro test systems. We instilled intra-tracheally either saline or sodium dichromate (0.25 mg/kg body weight), for three consecutive days, to Sprague-Dawley rats. TUNEL analyses showed a marked increase of the apoptotic i...

journal_title：Carcinogenesis

authors： D'Agostini F,Izzotti A,Bennicelli C,Camoirano A,Tampa E,De Flora S

更新日期：2002-04-01 00:00:00

abstract：:Pirh2 is a Ring-H2 domain containing E3 ubiquitin ligase that targets several important tumor suppressor genes for proteasomal degradation. Overexpression of Pirh2 is frequently detected in many clinical tumor tissues including hepatocellular carcinoma (HCC). However, the molecular mechanism of Pirh2 activation in tum...

journal_title：Carcinogenesis

authors： Hu L,Liu M,Chen L,Chan TH,Wang J,Huo KK,Zheng BJ,Xie D,Guan XY

更新日期：2012-08-01 00:00:00

abstract：:Arsenic is a human carcinogen whose mechanism of action is unknown. Previously, this laboratory demonstrated that arsenite acts as a comutagen by interfering with DNA repair, although a specific DNA repair enzyme sensitive to arsenite has not been identified. A number of stable arsenite-sensitive and arsenite-resistan...

journal_title：Carcinogenesis

authors： Rossman TG,Wang Z

更新日期：1999-02-01 00:00:00

abstract：:Epigenetic silencing of tumor suppressor genes commonly occurs in human cancers via increasing DNA methylation and repressive histone modifications at gene promoters. However, little is known about how pathogenic environmental factors contribute to cancer development by affecting epigenetic regulatory mechanisms. Prev...

journal_title：Carcinogenesis

authors： Chen H,Kluz T,Zhang R,Costa M

更新日期：2010-12-01 00:00:00

abstract：:When hepatocytes isolated from mouse liver are cultivated in vitro, a small fraction of cells can survive, forming colonies, while most cells die within a few weeks. We compared the colony forming capacity of hepatocytes in three mouse strains; two strains susceptible for hepatocarcinogenesis, C3H/HeJ (C3) and DBA/2J ...

journal_title：Carcinogenesis

authors： Yoshie M,Nishimori H,Lee GH,Ogawa K

更新日期：1998-06-01 00:00:00

abstract：:The complete tumour promoter phorbol, 12-myristate, 13-acetate (PMA) induces terminal differentiation in the majority of normal cultured human and mouse keratinocytes but a subpopulation exists which is resistant to this effect (PMAR). We have compared with PMA the effects of mezerein (Mez) and phorbol, 12-retinoate, ...

journal_title：Carcinogenesis

authors： Parkinson EK,Pera MF,Emmerson A,Gorman PA

更新日期：1984-08-01 00:00:00

abstract：:Gestational trophoblastic diseases (GTD) are group of pregnancy-related tumors characterized by abnormal levels of 'β-hCG' with higher incidence in South-East Asia, especially India. Our laboratory has reported that wild-type BRCA1 transcriptionally regulates β-hCG in triple negative breast cancers (TNBCs). These fact...

journal_title：Carcinogenesis

authors： Nadhan R,Vaman JV,Sengodan SK,Hemalatha SK,Chellappan N,Sadasivan S,Pasuthottiyil Varkey A,Yesodharan S,Raji Sathyanpillai K,Bhuvaneswari Venugopal AK,Prameelakumari Sreenivasan S,Rajan A,Latha NR,Varghese GR,Thankappan R,A

更新日期：2020-07-10 00:00:00

abstract：:Previous studies had indicated that complete skin tumor promoters of the phorbol ester class induce epidermal transglutaminase and cornification in a subpopulation of cultured mouse epidermal basal cells in proportion to their promoting properties. This report describes the effect of promoting agents other than phorbo...

journal_title：Carcinogenesis

authors： Yuspa SH,Ben T,Hennings H

更新日期：1983-11-01 00:00:00

abstract：:Using an 18 week two-stage protocol we have compared the tumour-promoting properties of a range of phorbol and daphnane esters on female CD-1 mice. The induction of epidermal hyperplasia in this mouse strain by these compounds has also been assessed by comparison with the standard phorbol ester, 12-O-tetradecanoylphor...

journal_title：Carcinogenesis

authors： Brooks G,Evans AT,Aitken A,Evans FJ

更新日期：1989-02-01 00:00:00

abstract：:Multiple myeloma (MM) is characterized by a wide spectrum of genetic changes. Global hypomethylation of repetitive genomic sequences such as long interspersed nuclear element 1 (LINE-1), Alu and satellite alpha (SAT-alpha) sequences has been associated with chromosomal instability in cancer. Methylation status of repe...

journal_title：Carcinogenesis

authors： Bollati V,Fabris S,Pegoraro V,Ronchetti D,Mosca L,Deliliers GL,Motta V,Bertazzi PA,Baccarelli A,Neri A

更新日期：2009-08-01 00:00:00