Abstract:
:A line of C3H mouse fibroblasts designated CVP3SC6 (CVP) was found to be nonresponsive to the induction of morphological transformation by the polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP) and its BaP-7,8-diol and BaP-diol-epoxide derivates. This cell line was, however, susceptible to BaP-induced mutation to ouabain resistance (Ouar). Concentrations of BaP between 0.63 and 5 microM caused an 11- to 370-fold increase in the frequency of Ouar cells relative to that found in untreated cultures. Isolates of Ouar cells were at least 10,000-fold more resistant to the cytotoxic effects of Oua and exhibited a stable resistant phenotype after 120 days of growth in the absence of the selective agent.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Gehly EB,Heidelberger Cdoi
10.1093/carcin/3.9.963subject
Has Abstractpub_date
1982-01-01 00:00:00pages
963-7issue
9eissn
0143-3334issn
1460-2180journal_volume
3pub_type
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