Genome-wide association study in discordant sibships identifies multiple inherited susceptibility alleles linked to lung cancer.

abstract：:Excess consumption of trans-fatty acid (TFA), an unsaturated fatty acid containing trans double bonds, is a major risk factor for cardiovascular disease and metabolic syndrome. However, little is known about the link between TFA and hepatocellular carcinoma (HCC) despite it being a frequent form of cancer in humans. I...

journal_title：Carcinogenesis

authors： Hu X,Wang X,Jia F,Tanaka N,Kimura T,Nakajima T,Sato Y,Moriya K,Koike K,Gonzalez FJ,Nakayama J,Aoyama T

更新日期：2020-04-22 00:00:00

abstract：:Botryodiplodin induces DNA-protein cross-links (DPC) in mammalian cells in culture. Removal of the mycotoxin followed by incubation of cells in fresh medium leads to the gradual disappearance of DPC. The present experiments attempted to determine to what extent the repair mechanism acts through a system involving tran...

journal_title：Carcinogenesis

authors： Moulé Y,Darracq N

更新日期：1984-10-01 00:00:00

abstract：:A series of cells representing normal, non-tumorigenic cell lines, as well as differentiating neoplastic and undifferentiated neoplastic rat tracheal epithelial cell populations were evaluated for their ability to establish homologous and/or heterologous cell-cell gap junction communication in culture. Gap junction co...

journal_title：Carcinogenesis

authors： Terzaghi-Howe M,Chang GW,Popp D

更新日期：1997-11-01 00:00:00

abstract：:The metabolic activation of the heterocyclic food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) by two human cytochrome P450 monoxygenases (P4501A1 and P4501A2) and two human N-acetyltransferases (NAT1 and NAT2) was investigated. Various combinations of these enzymes were functionally expressed in COS-1 cell...

journal_title：Carcinogenesis

authors： Probst MR,Blum M,Fasshauer I,D'Orazio D,Meyer UA,Wild D

更新日期：1992-10-01 00:00:00

abstract：:There is increasing concern that compounds formed during the chemical or biological transformation of pollutants in the environment may be more detrimental to human and environmental health than the original pollutant. In this study, two bacterial transformation products of polycyclic aromatic hydrocarbons (PAHs), pyr...

journal_title：Carcinogenesis

authors： Zielinska-Park J,Nakamura J,Swenberg JA,Aitken MD

更新日期：2004-09-01 00:00:00

abstract：:Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in mice, resulting from a downregulation of p21, p27(kip1) and E-cadherin and an upregulation of β-caten...

journal_title：Carcinogenesis

authors： Bi X,Pohl NM,Qian Z,Yang GR,Gou Y,Guzman G,Kajdacsy-Balla A,Iozzo RV,Yang W

更新日期：2012-02-01 00:00:00

abstract：:Malondialdehyde (MDA), a product of lipid peroxidation, causes mutations in bacterial and mammalian cells and cancer in rats. MDA reacts with deoxynucleosides in vitro and the monomeric adduct of MDA with deoxyguanosine (M1G-dR) is the major adduct. M1G-dR has been detected in rat and human liver. Random mutagenesis s...

journal_title：Carcinogenesis

authors： Chaudhary AK,Reddy GR,Blair IA,Marnett LJ

更新日期：1996-05-01 00:00:00

abstract：:Mouse ovarian surface epithelial cells (MOSEC) were obtained from virgin, mature mice by mild trypsinization and were repeatedly passaged in vitro. Early passage cells (<20 passages) exhibited a cobblestone morphology and contact inhibition of growth. After approximately 20 passages in vitro, cobblestone morphology an...

journal_title：Carcinogenesis

authors： Roby KF,Taylor CC,Sweetwood JP,Cheng Y,Pace JL,Tawfik O,Persons DL,Smith PG,Terranova PF

更新日期：2000-04-01 00:00:00

abstract：:The carcinogenicities of 1-nitropyrene (1-NP), 4-nitropyrene (4-NP), 1,3-dinitropyrene (1,3-DNP), 1,6-dinitropyrene (1,6-DNP), 1,8-dinitropyrene (1,8-DNP), 3-hydroxy-1-nitropyrene (3-OH-1-NP) and a mixture of 6- and 8-hydroxy-1-nitropyrene (6/8-OH-1-NP) were investigated in newborn female rats. Newborn female CD rats ...

journal_title：Carcinogenesis

authors： Imaida K,Lee MS,Land SJ,Wang CY,King CM

更新日期：1995-12-01 00:00:00

abstract：:This study is focused on chemical induction of lung tumors in xeroderma pigmentosum group A gene (XPA)-deficient mice to clarify the role of nucleotide excision repair (NER) in internal organs. Six-week-old female XPA-/-, XPA(+/-) and XPA(+/+) mice were instilled intratracheally with benzo[a] pyrene (B[a]P). A total o...

journal_title：Carcinogenesis

authors： Ide F,Iida N,Nakatsuru Y,Oda H,Tanaka K,Ishikawa T

更新日期：2000-06-01 00:00:00

abstract：:We describe studies to determine if susceptibility to pituitary tumours is associated with the putatively high risk GSTM1 null and CYP2D6 EM genotypes. Frequency distributions of these genotypes were similar in cases and controls though the frequency of CYP2D6 PM and GSTM1 B tended to be lower (P = 0.072 and P = 0.095...

journal_title：Carcinogenesis

authors： Perrett CW,Clayton RN,Pistorello M,Boscaro M,Scanarini M,Bates AS,Buckley N,Jones P,Fryer AA,Gilford J

更新日期：1995-07-01 00:00:00

abstract：:Expression of blood group-related antigens (BGRAs) A, B, H, Le(b), Le(x) and Le(y) was examined immunohistochemically in neoplastic and hyperplastic lesions induced by N-nitrosobis(2-oxopropyl)amine in Syrian hamsters to determine a relationship between histological and biological patterns of the lesion and expression...

journal_title：Carcinogenesis

authors： Tomioka T,Fujii H,Egami H,Takiyama Y,Pour PM

更新日期：1991-03-01 00:00:00

abstract：:It has been proposed that extremely low frequency magnetic fields may enhance tumorigenesis through a co-promotional mechanism. This hypothesis has been further tested using the two-stage model of mouse skin carcinogenesis, i.e. 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced promotion of skin carcinogenesis in mic...

journal_title：Carcinogenesis

authors： DiGiovanni J,Johnston DA,Rupp T,Sasser LB,Anderson LE,Morris JE,Miller DL,Kavet R,Walborg EF Jr

更新日期：1999-04-01 00:00:00

abstract：:Desmosomes are intercellular junctions that confer strong cell-cell adhesion. Altered expression of desmocollin 3 (DSC3), a member of the desmosomal cadherin family, was found in various cancers; however, its functional involvement in carcinogenesis has not yet been elucidated. Expression/localization of DSC3 was anal...

journal_title：Carcinogenesis

authors： Cui T,Chen Y,Yang L,Knösel T,Huber O,Pacyna-Gengelbach M,Petersen I

更新日期：2012-12-01 00:00:00

abstract：:The role of BRCA1 in sporadic breast and ovarian cancers remains elusive. Direct involvement of BRCA1 in the development of breast and ovarian cancer is suggested by the finding that the BRCA1 promoter region CpG island is methylated in a proportion of breast and ovarian cancers. The aim of this study was to compare t...

journal_title：Carcinogenesis

authors： Bianco T,Chenevix-Trench G,Walsh DC,Cooper JE,Dobrovic A

更新日期：2000-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that are often located in genomic breakpoint regions and can act as oncogenes or tumor suppressor genes in human cancer. Our previous study showed that microRNA-423 (miR-423), which localized to the frequently amplified region of chromosome 17q11, was upregulated i...

journal_title：Carcinogenesis

authors： Lin J,Huang S,Wu S,Ding J,Zhao Y,Liang L,Tian Q,Zha R,Zhan R,He X

更新日期：2011-11-01 00:00:00

abstract：:Previous studies have shown that TIPE1 inhibits tumor proliferation and metastasis in certain cancers; however, increased expression of TIPE1 is observed in cervical cancer cell lines and tissues, indicating it might exert a distinctive role in cervical cancer. Cell and xenograft tumorigenicity assays showed that TIPE...

journal_title：Carcinogenesis

authors： Zhao P,Pang X,Jiang J,Wang L,Zhu X,Yin Y,Zhai Q,Xiang X,Feng F,Xu W

更新日期：2019-06-10 00:00:00

abstract：:The induction of aberrant crypt foci (ACF) by irradiation of gamma-rays (60Co), and the effect of dietary sugar beet fiber (SBF) on irradiation-induced ACF were examined. We found that abdominal irradiation of gamma-rays could induce ACF in the rat colon. The irradiation was performed once a week at a dose rate of 2 o...

journal_title：Carcinogenesis

authors： Ishizuka S,Ito S,Onuma M,Kasai T,Aoyama Y,Hara H

更新日期：1999-06-01 00:00:00

abstract：:The anti-neoplastic agent procarbazine is genetically active in a variety of short term mutagenicity tests, and it also possesses carcinogenic and teratogenic potential. This compound has consistently yielded false negative results in in vitro microbial mutagenicity tests in the presence and absence of mammalian metab...

journal_title：Carcinogenesis

authors： Gatehouse DG,Paes DJ

更新日期：1983-01-01 00:00:00

abstract：:Cyclin D1 is one of the major enhancers of cell cycle progression and its expression is regulated in several growth stimulatory signaling pathways. ARA54 is an androgen receptor (AR) co-activator that enhances AR-dependent transcriptional activation. Although expression of ARA54 mRNA is observed in a variety of human ...

journal_title：Carcinogenesis

authors： Kikuchi H,Uchida C,Hattori T,Isobe T,Hiramatsu Y,Kitagawa K,Oda T,Konno H,Kitagawa M

更新日期：2007-08-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) have been described to play critical roles in initiation, progression and metastasis of various cancers. However, the involvement of CAFs in oral cancer (OC) has not been well addressed. In this study, we demonstrate that CAFs, when cocultured with OC cells (OCCs), produce high lev...

journal_title：Carcinogenesis

authors： Li X,Xu Q,Wu Y,Li J,Tang D,Han L,Fan Q

更新日期：2014-06-01 00:00:00

abstract：:Sulforaphane (SFN), an isothiocyanate first isolated from broccoli, exhibits chemopreventive properties in prostate cancer cells through mechanisms that are poorly understood. We recently reported on a novel mechanism of chemoprotection by SFN in human colon cancer cells, namely the inhibition of histone deacetylase (...

journal_title：Carcinogenesis

authors： Myzak MC,Hardin K,Wang R,Dashwood RH,Ho E

更新日期：2006-04-01 00:00:00

abstract：:Carcinomas of the ethmoidal region of the nose are observed relatively frequently in cattle in several countries in tropical and subtropical latitudes. Viruses have been implicated as causative agents, but it has been observed that affected animals sometimes suffer from aflatoxicosis, and a role of aflatoxin B1 (AFB1)...

journal_title：Carcinogenesis

authors： Larsson P,Pettersson H,Tjälve H

更新日期：1989-06-01 00:00:00

abstract：:The ability of dietary retinyl palmitate, canthaxanthin or the combination of both, to prevent induction of immunosuppression by UVB irradiation was tested by passive transfer of splenocytes. The basal diet was the American Institute of Nutrition diet 76A, containing 4 IU retinyl palmitate/g diet. Groups of 55 mice we...

journal_title：Carcinogenesis

authors： Gensler HL

更新日期：1989-01-01 00:00:00

abstract：:The purpose of this study was to compare the metabolism and DNA binding of aflatoxicol (AFL) with that of aflatoxin B1 (AFB1) in vivo and in isolated hepatocytes from Mt Shasta strain rainbow trout (Salmo gairdneri). Maximum total binding of [3H]AFL to liver DNA from trout exposed by intraperitoneal injection was 38-4...

journal_title：Carcinogenesis

authors： Loveland PM,Wilcox JS,Pawlowski NE,Bailey GS

更新日期：1987-08-01 00:00:00

abstract：:Inactivation of the adenomatous polyposis coli (Apc) gene by loss of the wild-type Apc allele (LOH) is a prerequisite for the development of intestinal adenomas in Msh2 proficient Min (Apc+/-Msh2+/+) mice. In contrast, adenomas from Msh2 deficient Min (Apc+/-Msh2-/-) mice are not usually associated with LOH. Given the...

journal_title：Carcinogenesis

authors： Sohn KJ,Choi M,Song J,Chan S,Medline A,Gallinger S,Kim YI

更新日期：2003-02-01 00:00:00

abstract：:Remodeling or deregulation of the calcium signaling pathway is a relevant hallmark of cancer including cutaneous melanoma (CM). In this study, using data from a published genome-wide association study (GWAS) from The University of Texas M.D. Anderson Cancer Center, we assessed the role of 41,377 common single-nucleoti...

journal_title：Carcinogenesis

authors： Wang X,Liu H,Xu Y,Xie J,Zhu D,Amos CI,Fang S,Lee JE,Li X,Nan H,Song Y,Wei Q

更新日期：2019-04-29 00:00:00

abstract：:Tobacco smoking and occupational exposure are major risk factors of bladder cancer via exposure to polycyclic aromatic hydrocarbons (PAHs) and aromatic amines, which lead to oxidative stress and DNA damage. Several enzymes, which play key roles in oxidative stress are polymorphic in humans. Myeloperoxidase (MPO) produ...

journal_title：Carcinogenesis

authors： Hung RJ,Boffetta P,Brennan P,Malaveille C,Gelatti U,Placidi D,Carta A,Hautefeuille A,Porru S

更新日期：2004-06-01 00:00:00

abstract：:Induction of glutathione S-transferase (GST) enzymes can increase detoxification of carcinogens and reduce carcinogen-induced mutagenesis and tumorigenesis. To determine if the anticarcinogen ellagic acid induces cellular enzymes which detoxify carcinogens, we examined the effect of ellagic acid on the expression of g...

journal_title：Carcinogenesis

authors： Barch DH,Rundhaugen LM,Pillay NS

更新日期：1995-03-01 00:00:00

abstract：:The objective was to study the relationship between cyclin D1 gene (CCND1) polymorphism and lung cancer in the Chinese population. Blood samples of 182 cases and 185 controls were collected from a hospital based case-control study. PCR-SSCP was used to examine the G/A polymorphism in exon 4 of CCND1. The results showe...

journal_title：Carcinogenesis

authors： Qiuling S,Yuxin Z,Suhua Z,Cheng X,Shuguang L,Fengsheng H

更新日期：2003-09-01 00:00:00