SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor-suppressive function in the development of hepatocellular carcinoma.

abstract：:Androgens and estrogens may play a role in gastric cancer etiology. To investigate the association of gastric cancer with single-nucleotide polymorphisms (SNPs) in six genes (COMT, CYP1B1, CYP17A1, CYP19A1, HSD17B1 and SHBG) involved in estrogen and androgen synthesis and metabolism, 58 haplotype-tagging SNPs were gen...

journal_title：Carcinogenesis

authors： Freedman ND,Ahn J,Hou L,Lissowska J,Zatonski W,Yeager M,Chanock SJ,Chow WH,Abnet CC

更新日期：2009-01-01 00:00:00

abstract：:The expression of CYP1B1 in human mammary fibroblasts (HMFs) was characterized as a potential modulator of their individual function as well as effects on adjacent mammary epithelia. We have used these characteristics to explore the diversity of fibroblast cells isolated from reduction mammoplasty patients and from di...

journal_title：Carcinogenesis

authors： Eltom SE,Larsen MC,Jefcoate CR

更新日期：1998-08-01 00:00:00

abstract：:Previous studies have shown that platinum-DNA adduct level in leukocyte DNA (measured by antibody methodology) is directly related to disease response in ovarian cancer and testicular cancer. To determine if this principle could be more broadly applied, platinum-DNA damage was studied in a blinded fashion in leukocyte...

journal_title：Carcinogenesis

authors： Parker RJ,Gill I,Tarone R,Vionnet JA,Grunberg S,Muggia FM,Reed E

更新日期：1991-07-01 00:00:00

abstract：:I-compounds are endogenous bulky DNA modifications which are detected by nuclease P1-enhanced 32P-post-labeling in tissue DNA of animals not knowingly exposed to carcinogens. Their profiles and levels depend inter alia on animal age, species, strain, tissue, gender, diet and exposure to chemicals such as cytochrome P4...

journal_title：Carcinogenesis

authors： Zhou GD,Vulimiri SV,Randerath E,Randerath K

更新日期：1998-10-01 00:00:00

abstract：:A method was devised to quantitate N-acetoxy-N-acetyl-2-aminofluorene (N-AcO-AAF) induced crosslinking of the ionic complex between [methyl-3H]thymidine labeled pBR322 DNA and lysozyme. This involved chromatography of the modified complex on Sephadex CM 25 with a high salt buffer that dissociated the non-covalently bo...

journal_title：Carcinogenesis

authors： Rayshell M,Ross J,Werbin H

更新日期：1983-01-01 00:00:00

abstract：:The purpose of this study was to determine if decreasing dietary protein from 24% (high protein) to 5% casein (low protein), substituting sucrose and cornstarch isocalorifically for casein, would modify the activity of protein kinase C (PKC) alpha and beta isoenzymes, as well as the expression of PKC alpha, beta, delt...

journal_title：Carcinogenesis

authors： La Porta CA,Comolli R

更新日期：1995-05-01 00:00:00

abstract：:We have measured the levels of thymine glycol (TG) and thymidine glycol (dTG) in human urine, using an HPLC method. The results show that all 30 specimens examined (including 10 non-neoplastic and 20 neoplastic human urines) contained significant amounts of TG and dTG, average levels (mean +/- SEM) were 0.376 +/- 0.02...

journal_title：Carcinogenesis

authors： Cao EH,Wang JJ

更新日期：1993-07-01 00:00:00

abstract：:The fidelity of DNA synthesis is critically dependent on the correct balance and availability of the deoxynucleoside triphosphate (dNTP) precursors for the polymerases involved in replication and repair. Since folate-derived one-carbon groups are essential for the de novo synthesis of both purines and pyrimidines, the...

journal_title：Carcinogenesis

authors： James SJ,Cross DR,Miller BJ

更新日期：1992-12-01 00:00:00

abstract：:Inducers of Phase II enzymes, already consumed by humans as food additives, medicines or as constituents of vegetables, can prevent experimental carcinogenesis. Since protection is neither carcinogen- nor organ-specific, clinical trials are already underway to establish the efficacy of 'anticarcinogenic enzyme inducer...

journal_title：Carcinogenesis

authors： Prochaska HJ,Fernandes CL

更新日期：1993-12-01 00:00:00

abstract：:Our previous report demonstrated that RSK2 plays an important role in cell proliferation and transformation induced by tumor promoters such as epidermal growth factor mediated through the N-terminal kinase domain of RSK2 in JB6 Cl41 mouse skin epidermal cells in vitro. However, no direct evidence has been reported reg...

journal_title：Carcinogenesis

authors： Cho YY,Lee MH,Lee CJ,Yao K,Lee HS,Bode AM,Dong Z

更新日期：2012-12-01 00:00:00

abstract：:Transforming growth factor-beta 1 (TGF-beta1) plays a significant role in regulating the proliferation and apoptosis of prostate epithelial and stromal cells. We explored the association between the T (Leu) to C (Pro) polymorphism at codon10 of the TGF-beta1 gene (TGFB1) and the risk of prostate cancer (PCa) or benign...

journal_title：Carcinogenesis

authors： Li Z,Habuchi T,Tsuchiya N,Mitsumori K,Wang L,Ohyama C,Sato K,Kamoto T,Ogawa O,Kato T

更新日期：2004-02-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3-K)/Akt signaling pathway is important in the regulation of cell proliferation through its production of phosphatidylinositol 3,4,5-triphosphate (PIP3). Activation of this pathway is frequently observed in human cancers, including non-small cell lung carcinoma. The PI3-K/Akt pathway i...

journal_title：Carcinogenesis

authors： Yeung YT,Fan S,Lu B,Yin S,Yang S,Nie W,Wang M,Zhou L,Li T,Li X,Bode AM,Dong Z

更新日期：2020-05-14 00:00:00

abstract：:Genotoxic carcinogens, including 2-acetylaminofluorene (2-AAF), in addition to exerting their genotoxic effects, often cause a variety of non-genotoxic alterations in cells. It is believed that these non-genotoxic effects may be indispensable events in tumorigenesis; however, there is insufficient knowledge to clarify...

journal_title：Carcinogenesis

authors： Bagnyukova TV,Tryndyak VP,Montgomery B,Churchwell MI,Karpf AR,James SR,Muskhelishvili L,Beland FA,Pogribny IP

更新日期：2008-03-01 00:00:00

abstract：:The P53 tumor suppressor pathway plays an important role in cancer development. The auto-regulatory feedback mechanism of the P53 and MDM2 expression is critical in keeping proper tumor suppressor function of this pathway. This study examined the effect of P53 Arg72Pro variants on transactivation of polymorphic MDM2 p...

journal_title：Carcinogenesis

authors： Yang M,Guo Y,Zhang X,Miao X,Tan W,Sun T,Zhao D,Yu D,Liu J,Lin D

更新日期：2007-09-01 00:00:00

abstract：:There is indirect evidence to suggest that the excision-repair mechanism responsible for the removal of UV-induced thymine dimers may also play a role in the repair of cis-diamminedichloroplatinum(II) (cis-DDP)-induced DNA adducts in both bacteria and mammalian cells. It was hypothesized that UV dimers and cis-DDP add...

journal_title：Carcinogenesis

authors： Swinnen LJ,Fisher SG,Erickson LC

更新日期：1989-08-01 00:00:00

abstract：:Evidence from live cell bioassays shows that the flat mucosa from patients with colon cancer exhibits resistance to bile salt-induced apoptosis. Three independent cell lines derived from the colonic epithelial cell line HCT-116 were selected for resistance to bile salt-induced apoptosis. These cell lines were develope...

journal_title：Carcinogenesis

authors： Crowley-Weber CL,Payne CM,Gleason-Guzman M,Watts GS,Futscher B,Waltmire CN,Crowley C,Dvorakova K,Bernstein C,Craven M,Garewal H,Bernstein H

更新日期：2002-12-01 00:00:00

abstract：:Carcinogenesis develops in stages that have been operationally defined as initiation, promotion and progression. Although morphological end points have been described for detection and quantitation of these stages, to date initiation has been assessed only in the context of clonal growth in response to certain promoti...

journal_title：Carcinogenesis

authors： Dragan YP,Campbell HA,Baker K,Vaughan J,Mass M,Pitot HC

更新日期：1994-11-01 00:00:00

abstract：:A large series of assays of the hepatocarcinogenic potential of 112 different compounds were carried out using a rapid bioassay system developed in this laboratory based on the two-step concept of hepatocarcinogenesis. Rats were initially given a single dose (200 mg/kg) of diethylnitrosamine (DEN) i.p. and starting 2 ...

journal_title：Carcinogenesis

authors： Ito N,Tsuda H,Tatematsu M,Inoue T,Tagawa Y,Aoki T,Uwagawa S,Kagawa M,Ogiso T,Masui T

更新日期：1988-03-01 00:00:00

abstract：:Use of supercritical carbon dioxide extraction in the analysis of smokeless tobacco for tobacco-specific N-nitrosamines revealed the presence of higher levels of 4-(methylnitros-amino)-1-(3-pyridyl)-1-butanone (NNK) than had been determined with conventional methods. Whether human saliva may be similarly capable of re...

journal_title：Carcinogenesis

authors： Prokopczyk B,Wu M,Cox JE,Hoffmann D

更新日期：1992-05-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase, which catalyzes the formation of poly(ADP-ribose) polymers, is an enzyme involved in cell proliferation, differentiation and transformation as well as in recovery from DNA damage. Poly(ADP-ribose) polymers are rapidly synthesized from the ADP-ribose moieties from intracellular NAD+, which,...

journal_title：Carcinogenesis

authors： Stierum RH,van Herwijnen MH,Hageman GJ,Kleinjans JC

更新日期：1994-04-01 00:00:00

abstract：:Cyclic 1,N2-propanodeoxyguanosine adducts are formed in vitro in DNA treated with alpha-acetoxy-N-nitrosopyrrolidine or its metabolite, crotonaldehyde. However, the in vivo formation of these cyclic adducts in DNA has not been demonstrated due to the lack of a sensitive detection method. In this study, a 32P-postlabel...

journal_title：Carcinogenesis

authors： Chung FL,Young R,Hecht SS

更新日期：1989-07-01 00:00:00

abstract：:The activity levels of L-ornithine carboxy-lyase (ODC) (E.C. 4.1.1.17) and S-adenosyl-L-methionine carboxy-lyase (SAM-D) (E.C.4.1.1.50) were determined in individual papillomas induced in mouse skin by a two-stage technique, and in normal mouse epidermis. Cycloheximide treatment abolished both enzyme activities. In no...

journal_title：Carcinogenesis

authors： Astrup EG,Boutwell RK

更新日期：1982-01-01 00:00:00

abstract：:To study the roles of DNA polymerases alpha and beta during replication and repair of damaged DNA, use was made of the fact that during chronic treatment with carcinogens, replication and repair do not necessarily follow the same time sequence. Early cell damage and restorative hyperplasia cause a transient wave of DN...

journal_title：Carcinogenesis

authors： Craddock VM

更新日期：1981-01-01 00:00:00

abstract：:Breakdown of basement membrane (BM) is believed to be an essential step for tumor invasion and metastases. We have previously demonstrated that matrix metalloproteinase-9 (MMP-9), the 92 kDa collagenase expression correlates with metastases in human colorectal cancer (CRC). This study explores the relationship between...

journal_title：Carcinogenesis

authors： Zeng ZS,Cohen AM,Guillem JG

更新日期：1999-05-01 00:00:00

abstract：:Studies with experimental animals indicate that acetaldehyde, the first metabolite of ethanol that is microbially formed in the colonic lumen, may play a role in ethanol-associated colorectal co-carcinogenesis. Although intracoIonic acetaldehyde concentrations are highest during the metabolism of exogenous ethanol, so...

journal_title：Carcinogenesis

authors： Koivisto T,Salaspuro M

更新日期：1998-11-01 00:00:00

abstract：:Genetic variants in multiple cellular pathways have been associated with an altered risk of oesophageal cancer. In this study, eight genes previously associated with an altered risk of oesophageal squamous cell carcinoma (OSCC) in European or Asian populations were investigated in two South African populations. We gen...

journal_title：Carcinogenesis

authors： Bye H,Prescott NJ,Matejcic M,Rose E,Lewis CM,Parker MI,Mathew CG

更新日期：2011-12-01 00:00:00

abstract：:4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a major metabolite of the tobacco-specific pulmonary carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), has a chiral center but the tumorigenicity of the NNAL enantiomers has not been previously examined. In this study, we assessed the relative tumori...

journal_title：Carcinogenesis

authors： Upadhyaya P,Kenney PM,Hochalter JB,Wang M,Hecht SS

更新日期：1999-08-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are regarded as important functional regulators of various biological processes and are also known to be involved in the occurrence and development of human cancers, including breast cancer (BC). In our present study, the RNA expression profiling data for a large cohort of human BC sampl...

journal_title：Carcinogenesis

authors： Fang K,Hu C,Zhang X,Hou Y,Gao D,Guo Z,Li L

更新日期：2020-09-24 00:00:00

abstract：:Mutations of the tumor suppressor gene p53 have been found in hepatocellular carcinomas (HCCs) from many countries where HCC is common, but p53 mutations detected by direct sequencing in HCCs from the United States (where HCC is uncommon) have been reported only rarely. p53 Exons 1 to 11 were analyzed by polymerase ch...

journal_title：Carcinogenesis

authors： Kazachkov Y,Khaoustov V,Yoffe B,Solomon H,Klintmalm GB,Tabor E

更新日期：1996-10-01 00:00:00

abstract：:In Saccharomyces cerevisiae a number of chemical agents induce synthesis of cytochrome P450. A cytochrome P450 gene has been well characterized in this yeast: CYP51, which codes for a constitutive enzyme involved in the 14 alpha-demethylation of lanosterol, a key step in the biosynthesis of ergosterol. In this work, w...

journal_title：Carcinogenesis

authors： Del Carratore R,Morichetti E,Cecchini E,Bronzetti G,Gallo E,Galeotti CL

更新日期：1992-11-01 00:00:00