Abstract:
:Treatment of pregnant mice with 3-methylcholanthrene (MC) causes lung and liver tumors in the offspring, the incidences of which are greatly influenced by the Ah locus regulated induction phenotype for aryl hydrocarbon hydroxylase activity (AHH) in both the mother and fetuses. In order to examine the biochemical and molecular mechanisms responsible for the modulating effect of maternal environment on tumor susceptibility, reciprocal crosses between responsive C57BL/6 and non-responsive DBA/2 mice were made and the pregnant mothers were treated i.p. on the 17th day of gestation with either olive oil alone, 30 mg/kg of MC, or 30 mg/kg of beta-naphthoflavone (beta NF). At various times after injection, the mothers were killed and the fetuses removed for enzymatic and molecular blot analysis. In fetal lung tissues, the absolute levels and relative induction ratios of AHH activity from D2B6F1 fetuses were very similar to those obtained in B6D2F1 fetuses during the first 24 h following a transplacental exposure to either inducing agent. This was also the case 48 h after an injection of beta NF. However, 48 h after exposure to MC, the AHH activity in fetal lungs from B6 mothers had declined to practically control values, whereas fetal lungs from D2 mothers still exhibited a high level of AHH activity. Similar induction kinetics for the CYPIA1 gene were obtained in fetal livers. These results were confirmed at the RNA level by quantitative slot-blot analysis of fetal RNA preparations. In both organs, treatment with inducing agents for the P450IA1 gene resulted in a rapid and early induction of CYPIA1 RNA by 4 h. Fetuses from D2 mothers, however, showed a more sustained induction of CYPIA1 RNA following exposure to MC than did fetuses from B6 mothers. These results suggest that the observed increase in tumor susceptibility observed in the offspring of D2 mothers compared to the offspring of B6 mothers was due, at least in part, to the differences in the persistence of induction of the CYPIA1 gene locus, and may be the result of differences in the clearance rates of MC from the fetal and maternal compartments or its pharmacokinetic distribution in the two types of maternal environments.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Miller MS,Jones AB,Chauhan DP,Anderson LMdoi
10.1093/carcin/11.11.1979subject
Has Abstractpub_date
1990-11-01 00:00:00pages
1979-84issue
11eissn
0143-3334issn
1460-2180journal_volume
11pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::Isoflavone genistein is a specific inhibitor of protein tyrosine kinase (PTK) and has been shown to have a variety of anticancer activities in cultured cells and animal models. We report here that genistein significantly inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoyl phorbol-13-acetate...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.8.1509
更新日期:1998-08-01 00:00:00
abstract::Administration of 2-acetylaminofluorene (2-AAF) to rats increased mdr1b expression in Fischer, Wistar and Sprague-Dawley rat livers; however, the response was much smaller in Sprague-Dawley livers. To investigate the basis of this difference we further examined the regulation of the mdr1b gene in hepatocytes isolated ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.3.451
更新日期:1996-03-01 00:00:00
abstract::Low vitamin E and selenium (Ve/Se) nutritional status is known to be associated with increased risk of esophageal squamous cell carcinoma (ESCC). A previous human intervention trial demonstrated that Ve/Se supplementation decreased the occurrence of esophageal cancer death among younger participants but not among olde...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq279
更新日期:2011-03-01 00:00:00
abstract::Methylation of the non-carcinogen 15,16-dihydrocyclopenta[a]phenanthren-17-one (CPP-17-one) at the bay region to form 11-CH3-CPP-17-one confers carcinogenic potential. In the present study we have investigated the in vitro metabolism and mutagenicity of the methylated compound by hepatic microsomal preparations from r...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.9.1783
更新日期:1993-09-01 00:00:00
abstract::Arsenic is an established human carcinogen. Deficiencies in available animal models have inhibited a detailed analysis of the mechanism of arsenic induced cancer. This study sought to determine the role of a methyl-deficient diet in combination with sodium arsenite on the genomic methylation status and Ha-ras methylat...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/23.5.777
更新日期:2002-05-01 00:00:00
abstract::Multicellular tumor spheroids (MCTSs) constitute a three-dimensional culture system that recapitulates the in vivo tumor microenvironment. Tumor cells cultured as MCTSs present antineoplastic resistance due to the effect of microenvironmental signals acting upon them. In this work, we evaluated the biological function...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa078
更新日期:2020-11-13 00:00:00
abstract::Telomere dynamics are a critical component of both aging and cancer. Telomeres progressively shorten in almost all dividing cells and most human cells do not express or maintain sufficient telomerase activity to fully maintain telomeres. There is accumulating evidence that when only a few telomeres are short, they for...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgh296
更新日期:2005-05-01 00:00:00
abstract::Integrins control the cell attachment to the extracellular matrix and play an important role in mediating cell proliferation, migration and survival. A number of important cancer-associated integrin genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3' untranslated regions. We examined...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn126
更新日期:2008-07-01 00:00:00
abstract::Benzo(a]pyrene was metabolized in liver cell lines derived from BC-IV and BD-IV rats which included several chemically-transformed lines (IAR-6-1; IAR-19; IAR-28), one spontaneous transformant (IAR-27) as well as one non-malignant line (IAR-20). Cultures were treated with tritiated benzo[a]pyrene over a 5-day period. ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.6.635
更新日期:1982-01-01 00:00:00
abstract::Tumor induction with chronic feeding of methyl-donor-deficient diets has been well established; however, the biochemical and molecular mechanisms which predipose to tumorigenesis in this model are still not well understood. The purpose of the present investigation was to assess DNA damage and altered nucleotide metabo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.7.1209
更新日期:1989-07-01 00:00:00
abstract::Sixty-three male cigarette smokers were entered into a cross-sectional study to determine whether inverse associations existed between polycyclic aromatic hydrocarbon (PAH)-DNA adduct levels and intake/serum levels of vitamin A, vitamin C and vitamin E. Associations between PAH-DNA adducts and intakes of carotene, as ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.11.2449
更新日期:1994-11-01 00:00:00
abstract::It has been proposed that extremely low frequency magnetic fields may enhance tumorigenesis through a co-promotional mechanism. This hypothesis has been further tested using the two-stage model of mouse skin carcinogenesis, i.e. 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced promotion of skin carcinogenesis in mic...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.4.685
更新日期:1999-04-01 00:00:00
abstract::Human papillomavirus (HPV) type 16 infection is an etiologic factor in a subset of head and neck squamous cell carcinomas (HNSCC). It is unknown if host genetic susceptibility modifies the HPV16-HNSCC association. DNA samples collected as part of a Boston area case-control study of HNSCC were genotyped for single-nucl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp076
更新日期:2009-06-01 00:00:00
abstract::We conducted a cross-sectional molecular epidemiological study of coke oven workers exposed to the established carcinogen polycyclic aromatic hydrocarbons (PAHs) to evaluate the relationships between both traditional 'exposure markers' and a series of biomarkers, including urinary 1-hydroxypyrene as a marker of intern...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.11.1963
更新日期:1998-11-01 00:00:00
abstract::The individual genotoxic response of cultured human lymphocytes to diepoxybutane (DEB), an epoxide metabolite of 1,3-butadiene, shows a bimodal distribution. Blood donors can be classified as either DEB-sensitive or DEB-resistant on the basis of the frequency of sister chromatid exchanges (SCEs) induced by DEB in whol...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.6.1261
更新日期:1995-06-01 00:00:00
abstract::Epidemiological evidence has suggested that consumption of a diet rich in cruciferous vegetables reduces the risk of several types of cancers and chronic degenerative diseases. In particular, broccoli sprouts are a convenient and rich source of the glucosinolate, glucoraphanin, which can release the chemopreventive ag...
journal_title:Carcinogenesis
pub_type: 杂志文章,随机对照试验
doi:10.1093/carcin/bgr229
更新日期:2012-01-01 00:00:00
abstract::Chemical carcinogens are generally activated enzymatically to electrophiles that form covalently bound carcinogen-DNA adducts. Detoxifying enzymes are competing with the activating enzymes for these procarcinogenic chemical substrates. Wide person-to-person variations in these two types of enzymatic activities are fou...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/10.9.1563
更新日期:1989-09-01 00:00:00
abstract::Polymorphisms in 3' untranslated region (UTR) of cancer-related genes might affect regulation by microRNA (miRNA) and contribute to carcinogenesis. In this study, we screened several single nucleotide polymorphisms (SNPs) in 3'UTR of cancer-related genes and investigated their effects on the risk of esophageal squamou...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs259
更新日期:2012-11-01 00:00:00
abstract::Bioassays and DNA-binding studies of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its analogs with deuterium substitution at the positions alpha to the nitrosamino group ([4,4-D2]NNK and [CD3]NNK) were carried out in A/J mice in order to assess the potential importance of DNA methylation or pyridyloxobutyl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.6.1017
更新日期:1990-06-01 00:00:00
abstract::2-methoxyestradiol (2-MeOE(2)) is an endogenous metabolite of 17beta-estradiol and a proposed inhibitor of tumor growth and angiogenesis. However, 2-MeOE(2) is also an inhibitor of microtubule assembly and other microtubule inhibitors, e.g. colcemid and diethylstilbestrol, induce aneuploidy and cell transformation in ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/21.4.735
更新日期:2000-04-01 00:00:00
abstract::Tuberin (protein encodes by tuberous sclerosis complex 2, Tsc2) deficiency is associated with the decrease in the DNA repair enzyme 8-oxoG-DNA glycosylase (OGG1) in tumour kidney of tuberous sclerosis complex (TSC) patients. The purpose of this study was to elucidate the mechanisms by which tuberin regulates OGG1. The...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq189
更新日期:2010-11-01 00:00:00
abstract::The metabolism of benzo[a]pyrene (BP) in cultured human epidermal keratinocytes was investigated using thin layer chromatography, high pressure liquid chromatography and cell-mediated mutagenesis assay. Epidermal keratinocytes were obtained from skin of normal subjects and all experiments were performed on primary cul...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.7.559
更新日期:1980-07-01 00:00:00
abstract::Possible relationships between structure and metabolism of nitrosamines have been investigated in the rat small intestine. Isolated segments of jejunum and ileum were perfused from the luminal side for 2 h with a Tyrode solution containing one of four symmetrical dialkylnitrosamines with 2-5 carbon atoms per side chai...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.7.1207
更新日期:1986-07-01 00:00:00
abstract::Resveratrol has elicited many provocative anticancer effects in laboratory animals and cultured cells, including reduced levels of oxidative DNA damage, inhibition of tumor initiation and progression and induction of apoptosis in tumor cells. Use of resveratrol as a cancer-preventive agent in humans will require that ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr236
更新日期:2012-01-01 00:00:00
abstract::Transforming growth factor-beta 1 (TGF-beta1) plays a significant role in regulating the proliferation and apoptosis of prostate epithelial and stromal cells. We explored the association between the T (Leu) to C (Pro) polymorphism at codon10 of the TGF-beta1 gene (TGFB1) and the risk of prostate cancer (PCa) or benign...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgg197
更新日期:2004-02-01 00:00:00
abstract::The natural flavonoid quercetin has been suggested by epidemiological studies to have preventive activity against lung cancer; however, the mechanism of which has not been well elucidated. In this report, we demonstrate that quercetin significantly enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAI...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm133
更新日期:2007-10-01 00:00:00
abstract::7-Hydroxymethylbenz[a]anthracene (7-HBA) showed potent mutagenicity towards Salmonella typhimurium TA 98 in the presence of untreated rat liver cytosol fortified with the PAPS-generating system, sodium sulphate and ATP. No mutagenic activity was observed either when the cytosol was boiled or when sodium sulphate or AT...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.2.207
更新日期:1986-02-01 00:00:00
abstract::Prostate cancer (CaP) is the second leading cause of cancer death in American men. Chronic inflammation has been one of several factors associated with the development of CaP. Single-nucleotide polymorphisms (SNPs) in cytokine genes have been associated with increased inflammation, increased cytokine production and po...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm277
更新日期:2008-03-01 00:00:00
abstract::U.v. damage to the DNA of HeLa cells induces the polymerisation of ADP-ribose, but only if repair synthesis is inhibited so that incomplete repair sites (i.e., DNA breaks) accumulate to abnormally high levels. 3-Aminobenzamide greatly reduces the ADP-ribose polymerisation response. However, 3-aminobenzamide does not r...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.7.1033
更新日期:1985-07-01 00:00:00
abstract::Primary hepatocyte cultures from six human donors were established and their abilities to metabolize the polycyclic aromatic hydrocarbon carcinogen benzo[a]pyrene (B[a]P) were examined. Cells from each donor were plated at similar densities (1 X 10(7) cells/100 mm dish). All cultures metabolized B[a]P to a significant...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.12.1577
更新日期:1984-12-01 00:00:00