Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women.

abstract：:Mammalian DNA contains bulky endogenous DNA modifications (I-compounds), which increase with age in unexposed animals, as shown by 32P-postlabeling. We have examined the perinatal formation of a subclass (type II) of I-compounds in rat liver, kidney, skin and lung. These I-compounds represent bulky oxidative DNA lesio...

journal_title：Carcinogenesis

authors： Randerath E,Zhou GD,Randerath K

更新日期：1996-12-01 00:00:00

abstract：:Specific repair endonucleases were used to quantify oxidative modifications in mitochondrial DNA (mtDNA) from rat liver and from porcine liver and kidney by means of a relaxation assay. In rat liver mitochondria the number of modifications sensitive to formamidopyrimidine--DNA glycosylase (FPG protein), which include ...

journal_title：Carcinogenesis

authors： Hegler J,Bittner D,Boiteux S,Epe B

更新日期：1993-11-01 00:00:00

abstract：:Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolite can be rapidly hydrolyzed in acidic urine to undergo further metabolic activation and form DNA adducts in the urothelium. We conducted a large multicenter case-control study in Spain to explore the etiology of bladder cancer and evaluated the assoc...

journal_title：Carcinogenesis

authors： Alguacil J,Kogevinas M,Silverman DT,Malats N,Real FX,García-Closas M,Tardón A,Rivas M,Torà M,García-Closas R,Serra C,Carrato A,Pfeiffer RM,Fortuny J,Samanic C,Rothman N

更新日期：2011-06-01 00:00:00

abstract：:A diet that is deficient in methionine, choline, folic acid and vitamin B12 has been found to induce alterations rapidly in liver tRNA methylation in male Fischer rats. In vitro assays indicated that activity of N2-guanine tRNA methyltransferase II (NMG2) was increased to 150% of controls levels in 1 week and 300% of ...

journal_title：Carcinogenesis

authors： Wainfan E,Dizik M,Hluboky M,Balis ME

更新日期：1986-03-01 00:00:00

abstract：:A line of C3H mouse fibroblasts designated CVP3SC6 (CVP) was found to be nonresponsive to the induction of morphological transformation by the polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP) and its BaP-7,8-diol and BaP-diol-epoxide derivates. This cell line was, however, susceptible to BaP-induced mutation to ou...

journal_title：Carcinogenesis

authors： Gehly EB,Heidelberger C

更新日期：1982-01-01 00:00:00

abstract：:A mismatch between metabolic demand and oxygen delivery leads to microenvironmental changes in solid tumors. The resulting tumor hypoxia is associated with malignant progression, therapy resistance and poor prognosis. However, the molecular mechanisms underlying therapy resistance in hypoxic tumors are not fully under...

journal_title：Carcinogenesis

authors： Wirthner R,Wrann S,Balamurugan K,Wenger RH,Stiehl DP

更新日期：2008-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Genomic copy number deletion at chromosome 14q31.1-32.13 was frequently observed in HCC; however, the relevant functional target(s) at that locus is not well determined. Here, we performed integrative genomic analyses and ...

journal_title：Carcinogenesis

authors： Zhang C,Cao P,Yang A,Xia X,Li Y,Shi M,Yang Y,Wei X,Yang C,Zhou G

更新日期：2019-05-14 00:00:00

abstract：:Pretreatment of Fischer 344 rats with the antioxidant ethoxyquin (EQ), followed by administration of aflatoxin B1 (AFB1) in the continuing presence of EQ was used to examine the effect of the antioxidant on liver and kidney. EQ (0.5% in diet) completely prevented the formation of AFB1-induced preneoplastic liver lesio...

journal_title：Carcinogenesis

authors： Manson MM,Green JA,Driver HE

更新日期：1987-05-01 00:00:00

abstract：:Nitrosododecamethyleneimine (NDMI) was given to NZR/Gd rats by gavage in olive oil solution, confirming its hepatocarcinogenic activity. Twenty male and 20 female rats received 2.5 mg NDMI twice a week for 52 weeks; a further 10 male rats received 25.0 mg twice a week for 12 weeks. Two-thirds of the animals survived m...

journal_title：Carcinogenesis

authors： Goodall CM,Lijinsky W

更新日期：1984-04-01 00:00:00

abstract：:The catalytic activity of the nuclear enzyme poly(ADP-ribose) polymerase (NAD+ ADP-ribosyl transferase, EC 2,4,2,30) is totally dependent upon the presence of DNA strand breaks. Having isolated a full-length cDNA for the polymerase, we have now evaluated the effect of endogenously and exogenously induced DNA strand br...

journal_title：Carcinogenesis

authors： Bhatia K,Pommier Y,Giri C,Fornace AJ,Imaizumi M,Breitman TR,Cherney BW,Smulson ME

更新日期：1990-01-01 00:00:00

abstract：:Prostate stromal and epithelial cell communication is important in prostate functioning and cancer development. Primary human stromal cells from normal prostate stromal cells (PRSC) maintain a smooth muscle phenotype, whereas those from prostate cancer (6S) display reactive and fibroblastic characteristics. Dihydrotes...

journal_title：Carcinogenesis

authors： Liu X,Allen JD,Arnold JT,Blackman MR

更新日期：2008-04-01 00:00:00

abstract：:The effect of whole body ionising radiation from a linear accelerator on rat tissue O6-methylguanine (O6-meG) methyltransferase (MT) activity has been assessed using an assay which measures the transfer of 3H-radioactivity from 3H-methylated substrate DNA to protein. The maximal effect occurred 2 days after a 1 krad d...

journal_title：Carcinogenesis

authors： Margison GP,Butler J,Hoey B

更新日期：1985-12-01 00:00:00

abstract：:It has been proposed that extremely low frequency magnetic fields may enhance tumorigenesis through a co-promotional mechanism. This hypothesis has been further tested using the two-stage model of mouse skin carcinogenesis, i.e. 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced promotion of skin carcinogenesis in mic...

journal_title：Carcinogenesis

authors： DiGiovanni J,Johnston DA,Rupp T,Sasser LB,Anderson LE,Morris JE,Miller DL,Kavet R,Walborg EF Jr

更新日期：1999-04-01 00:00:00

abstract：:We have investigated the role of the signaling intermediate, EPS8, in tumor progression using a model system and in vivo. HN4 primary tumor cells express low levels of EPS8, similar to normal keratinocytes, and show minimal invasion in vitro in response to epidermal growth factor, whereas HN12 cells express high level...

journal_title：Carcinogenesis

authors： Wang H,Patel V,Miyazaki H,Gutkind JS,Yeudall WA

更新日期：2009-01-01 00:00:00

abstract：:Cigarette smoking is a major cause of human cancer at a variety of sites, although its carcinogenic mechanisms remains unestablished. Cigarette smoke can be divided into two phases, gas phase and particulate matter (tar). Both phases contain high concentrations of oxidants and free radicals, especially nitric oxide (N...

journal_title：Carcinogenesis

authors： Yoshie Y,Ohshima H

更新日期：1997-07-01 00:00:00

abstract：:A method was devised to quantitate N-acetoxy-N-acetyl-2-aminofluorene (N-AcO-AAF) induced crosslinking of the ionic complex between [methyl-3H]thymidine labeled pBR322 DNA and lysozyme. This involved chromatography of the modified complex on Sephadex CM 25 with a high salt buffer that dissociated the non-covalently bo...

journal_title：Carcinogenesis

authors： Rayshell M,Ross J,Werbin H

更新日期：1983-01-01 00:00:00

abstract：:Propylene oxide, a widely used monofunctional alkylating agent, has been shown to be genotoxic in in vitro test systems and induces tumors in the nasal tissues of experimental animals. Propylene oxide, like related alkylating agents, forms several different adducts with DNA bases, but predominantly at the 7-position o...

journal_title：Carcinogenesis

authors： Plna K,Nilsson R,Koskinen M,Segerbäck D

更新日期：1999-10-01 00:00:00

abstract：:Eukaryotic 3'-end formation is a critical step for mRNA maturation and involves a requisite cleavage and polyadenylation event downstream of a polyadenylation signal. Recent discoveries suggest that in nearly 70% of human genes, cleavage and polyadenylation can occur at multiple locations through a process known as al...

journal_title：Carcinogenesis

authors： Masamha CP,Wagner EJ

更新日期：2018-01-12 00:00:00

abstract：:Carcinogenicity of catechol, a naturally occurring and industrial chemical which has been shown to have strong cell proliferating potential on rat glandular stomach epithelium, was investigated in male and female F344 rats and B6C3F1 mice. Groups of 30 male and female F344 rats and B6C3F1 mice were treated with 0.8% c...

journal_title：Carcinogenesis

authors： Hirose M,Fukushima S,Tanaka H,Asakawa E,Takahashi S,Ito N

更新日期：1993-03-01 00:00:00

abstract：:The in vivo formation of specific 7,12-dimethylbenz[a]-anthracene (DMBA)-DNA adducts in the mammary gland of the female Sprague-Dawley rat was studied in response to dietary butylated hydroxytoluene (BHT). Dietary BHT concentrations of 0.4 and 0.8% significantly inhibited total DMBA-DNA binding by 41.5 and 35.6% respe...

journal_title：Carcinogenesis

authors： Singletary KW,Nelshoppen JM

更新日期：1991-10-01 00:00:00

abstract：:Carcinomas of the ethmoidal region of the nose are observed relatively frequently in cattle in several countries in tropical and subtropical latitudes. Viruses have been implicated as causative agents, but it has been observed that affected animals sometimes suffer from aflatoxicosis, and a role of aflatoxin B1 (AFB1)...

journal_title：Carcinogenesis

authors： Larsson P,Pettersson H,Tjälve H

更新日期：1989-06-01 00:00:00

abstract：:The transforming potential of acrylonitrile epoxide (ANO) was tested in a modified NIH3T3 transfection-transformation assay. This involves a new ras construct obtained by ligating a human c-Ha-ras-1 proto-oncogene to the pSV2neo mammalian vector. The new plasmid was allowed to react with ANO or an established carcinog...

journal_title：Carcinogenesis

authors： Yuan B,Wong JL

更新日期：1991-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the leading causes for cancer related mortality worldwide. Poor prognosis of HCC patients is mainly due to frequent metastasis and recurrence. Deregulation of metastasis suppressors in malignant cells plays critical roles during cancer metastasis. Thus, novel metastasis suppres...

journal_title：Carcinogenesis

authors： Luo Q,Wang C,Jin G,Gu D,Wang N,Song J,Jin H,Hu F,Zhang Y,Ge T,Huo X,Chu W,Shu H,Fang J,Yao M,Gu J,Cong W,Qin W

更新日期：2015-10-01 00:00:00

abstract：:Yeasts were isolated from 12 cases of oral precancerous lesions (leukoplakia and erythroleukoplakia) by sampling the lesion as well as normal mucosa of each patient, yielding 21 strains of Candida albicans belonging to 15 biotypes, two strains of C. tropicalis, one strain of C. parapsilosis and two strains of Torulops...

journal_title：Carcinogenesis

authors： Krogh P,Hald B,Holmstrup P

更新日期：1987-10-01 00:00:00

abstract：:Exposure to diesel exhaust (DE) is known to cause lung tumors in rats. To clarify the mutagenicity of DE, we estimated mutant frequency (MF) and determined the mutation spectra in rat lung after exposure to DE using lambda/lacI transgenic rats (Big Blue system). Male Big Blue rats (6 weeks old) were exposed for 4 week...

journal_title：Carcinogenesis

authors： Sato H,Sone H,Sagai M,Suzuki KT,Aoki Y

更新日期：2000-04-01 00:00:00

abstract：:The aim of this study was to investigate selected proteomic markers of the metabolic phenotype of breast carcinomas as prognostic markers of cancer progression. For this purpose, a series of 101 breast carcinomas and 13 uninvolved breast samples were examined for quantitative differences in protein expression of mitoc...

journal_title：Carcinogenesis

authors： Isidoro A,Casado E,Redondo A,Acebo P,Espinosa E,Alonso AM,Cejas P,Hardisson D,Fresno Vara JA,Belda-Iniesta C,González-Barón M,Cuezva JM

更新日期：2005-12-01 00:00:00

abstract：:1,3-Butadiene (BD), a widely used monomer in the production of synthetic rubber and other resins, is one of the 189 hazardous air pollutants identified in the 1990 Clean Air Act Amendments. BD induces tumors at multiple organ sites in B6C3F1 mice and Sprague-Dawley rats; mice are much more susceptible to the carcinoge...

journal_title：Carcinogenesis

authors： Csanády GA,Guengerich FP,Bond JA

更新日期：1992-07-01 00:00:00

abstract：:The repair kinetics and sensitivity to inhibitors of DNA strand breaks caused by superoxide anion, hydrogen peroxide, benzoyl peroxide and anthralin have been studied and compared with strand breaks caused by well-studied agents such as ionizing radiation and bleomycin. The latter two agents are generally believed to ...

journal_title：Carcinogenesis

authors： Birnboim HC

更新日期：1986-09-01 00:00:00

abstract：:To determine the contribution of susceptibility loci in explaining the genetic basis of acute lymphoblastic leukemia (ALL), we genotyped 29 high-potential candidate genes with 672 tagged single-nucleotide polymorphisms (SNPs) in a sample (163 cases and 251 healthy controls) of Caucasian children. Fifty SNPs in 15 gene...

journal_title：Carcinogenesis

authors： Beuten J,Gelfond JA,Piwkham D,Pollock BH,Winick NJ,Collier AB 3rd,Tomlinson GE

更新日期：2011-09-01 00:00:00

abstract：:Hepatic microsomes of female F344 rats were capable of N,O-acyltransfer of N-hydroxy-N-acetyl-2-aminofluorene (N-OH-AAF) and N-hydroxy-N-formyl-2-aminofluorene (N-OH-FAF), N-deacetylation of N-OH-AAF and N-acetyl-2-aminofluorene (2-AAF), and O-deacetylation of 4-nitrophenyl acetate (NPA). The activity for N,O-acyltran...

journal_title：Carcinogenesis

authors： Wang CY,Zukowski K,Lee MS,Sone T

更新日期：1992-11-01 00:00:00