Benzo[a]pyrene metabolites: formation in rat liver cell-culture lines, binding to macromolecules, and mutagenesis in V79 hamster cells.

abstract：:To test the hypothesis that polymorphic variants of antioxidant genes modify the risk of pancreatic cancer, we examined seven single-nucleotide polymorphisms (SNPs) of genes coding for superoxide dismutase (SOD) 2, glutathione S-transferase alpha 4 (GSTA4), catalase and glutathione peroxidase in 575 patients with panc...

journal_title：Carcinogenesis

authors： Tang H,Dong X,Day RS,Hassan MM,Li D

更新日期：2010-04-01 00:00:00

abstract：:1,3-Dimethyl-3-phenyl-1-nitrosourea (DMPNU) shows no spontaneous decomposition in aqueous buffered solution (pH 7.0) at 37 degrees C over a measuring period of 10 days, but it is directly genotoxic in all assays applied. This compound induces base substitutions in Salmonella typhimurium (especially in the plasmid harb...

journal_title：Carcinogenesis

authors： Thust R,Mendel J,Kaina B,Braun R

更新日期：1983-01-01 00:00:00

abstract：:Genetically modified mice with overexpressed and/or deleted genes have been used extensively to model human cancer. However, it is uncertain as to what extent the mouse models reproduce the corresponding cancers in humans. We have compared the global gene expression patterns in human and mouse hepatocellular carcinoma...

journal_title：Carcinogenesis

authors： Lee JS,Grisham JW,Thorgeirsson SS

更新日期：2005-06-01 00:00:00

abstract：:Mutations in genes important for the preservation of genome stability can increase the frequency of gene amplification, a process relevant to tumor development. To investigate whether telomerase, the enzyme deputed to telomere maintenance, also plays a role in gene amplification, we studied the amplification of the ca...

journal_title：Carcinogenesis

authors： Rebuzzini P,Martinelli P,Blasco M,Giulotto E,Mondello C

更新日期：2007-03-01 00:00:00

abstract：:Genome-wide DNA hypomethylation was one of the first epigenetic alterations described in cancer cells. However, the cause of this hypomethylation is still poorly understood. We have previously developed a line of primary mesenchymal stem cells (MSC, the putative origin of various types of sarcoma) in which five oncoge...

journal_title：Carcinogenesis

authors： Wild L,Funes JM,Boshoff C,Flanagan JM

更新日期：2010-10-01 00:00:00

abstract：:The LEC rat spontaneously develops liver cancer after suffering chronic liver injury caused by abnormal copper accumulation in the liver, but the role of copper accumulation in the induction of liver cancer remains obscure. We histochemically and biochemically examined the content of copper and metallothionein (MT), a...

journal_title：Carcinogenesis

authors： Sawaki M,Enomoto K,Hattori A,Tsuzuki N,Sugawara N,Mori M

更新日期：1994-09-01 00:00:00

abstract：:Apigenin is a plant flavonoid which has been shown to significantly inhibit UV-induced mouse skin tumorigenesis when applied topically, and may represent an alternative sunscreen agent in humans. We have investigated the molecular mechanism(s) by which apigenin inhibits skin tumorigenesis. Initial studies examined the...

journal_title：Carcinogenesis

authors： Lepley DM,Li B,Birt DF,Pelling JC

更新日期：1996-11-01 00:00:00

abstract：:Nutritional deficiencies or imbalances are suspected contributory factors to several types of human cancers, and perhaps other human diseases related to long-term metabolic derangements. In order to study these more effectively in laboratory animals, it is suggested that the laboratory diets more closely mimic the nut...

journal_title：Carcinogenesis

authors： Newmark HL

更新日期：1987-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fifth most common malignancy caused by environmental and genetic factors. MicroRNAs (miRNAs) are a class of short non-coding RNAs with posttranscriptional regulatory functions. They participate in diverse biological pathways and function as gene regulators. Genetic polymorphisms i...

journal_title：Carcinogenesis

authors： Gao Y,He Y,Ding J,Wu K,Hu B,Liu Y,Wu Y,Guo B,Shen Y,Landi D,Landi S,Zhou Y,Liu H

更新日期：2009-12-01 00:00:00

abstract：:2-methoxyestradiol (2-MeOE(2)) is an endogenous metabolite of 17beta-estradiol and a proposed inhibitor of tumor growth and angiogenesis. However, 2-MeOE(2) is also an inhibitor of microtubule assembly and other microtubule inhibitors, e.g. colcemid and diethylstilbestrol, induce aneuploidy and cell transformation in ...

journal_title：Carcinogenesis

authors： Tsutsui T,Tamura Y,Hagiwara M,Miyachi T,Hikiba H,Kubo C,Barrett JC

更新日期：2000-04-01 00:00:00

abstract：:A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospi...

journal_title：Carcinogenesis

authors： Brenner AV,Butler MA,Wang SS,Ruder AM,Rothman N,Schulte PA,Chanock SJ,Fine HA,Linet MS,Inskip PD

更新日期：2007-12-01 00:00:00

abstract：:The formation of thioether conjugates is an important pathway for inactivation of certain carcinogens. This study assessed the mechanism by which the bladder carcinogen 2-amino-4-(5-nitro-2-furyl)-thiazole (ANFT) forms a glutathione conjugate (ANFT-SG). Peroxidatic metabolism of ANFT, in the presence of glutathione, r...

journal_title：Carcinogenesis

authors： Lakshmi VM,Zenser TV,Sohani S,Davis BB

更新日期：1992-11-01 00:00:00

abstract：:Macrophages and their immortalized cell lines can be activated to form nitrite and nitrate via oxidation of arginine and this is accompanied by the formation of N-nitroso compounds. The mechanism of nitrosamine formation has been investigated through the use of compounds which are known either to inhibit or enhance ac...

journal_title：Carcinogenesis

authors： Kosaka H,Wishnok JS,Miwa M,Leaf CD,Tannenbaum SR

更新日期：1989-03-01 00:00:00

abstract：:The sensitivity of various mouse strains to skin carcinogenesis has been investigated in two ways; (i) by comparing carcinogenesis induced by treatments involving both the application of tumour promoters and the application of single or multiple doses of a carcinogen, and (ii) by comparing the binding characteristics ...

journal_title：Carcinogenesis

authors： Wheldrake JF,Marshall J,Ramli J,Murray AW

更新日期：1982-01-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants with high carcinogenic potencies that have been linked to the etiology of human cancers through their presence in cigarette smoke and environmental mixtures. They are metabolically activated in cells by cytochrome P450 enzymes and/or perox...

journal_title：Carcinogenesis

authors： Melendez-Colon VJ,Luch A,Seidel A,Baird WM

更新日期：1999-10-01 00:00:00

abstract：:Syrian hamster embryo cells were treated with crocidolite asbestos at a dose (1 microgram/cm2) which was shown in previous studies to induce cell transformation and aneuploidy in these cells. Treatment of cells with asbestos induced a greater than 20-fold increase in the incidence of cells in anaphase with abnormaliti...

journal_title：Carcinogenesis

authors： Hesterberg TW,Barrett JC

更新日期：1985-03-01 00:00:00

abstract：:Ovarian cancer is developed from a single layer of thin epithelial cells covering the surface of ovary, named human ovarian surface epithelial cells. Like all primary human cells, human ovarian surface epithelial cells have a finite life span and will go into senescence and eventually die when cultured in vitro. Immor...

journal_title：Carcinogenesis

authors： Yang G,Rosen DG,Mercado-Uribe I,Colacino JA,Mills GB,Bast RC Jr,Zhou C,Liu J

更新日期：2007-01-01 00:00:00

abstract：:This commentary celebrates the 40th year of Carcinogenesis, spanning 1980-2020 with a focus on lung cancer. For lung cancer, these 40 years come toward the end of a century of scientific inquiry that began with descriptions of this highly fatal malignancy and that closes with emphasis on molecular processes and genomi...

journal_title：Carcinogenesis

authors： Samet JM

更新日期：2020-10-15 00:00:00

abstract：:Mammalian DNA contains bulky endogenous DNA modifications (I-compounds), which increase with age in unexposed animals, as shown by 32P-postlabeling. We have examined the perinatal formation of a subclass (type II) of I-compounds in rat liver, kidney, skin and lung. These I-compounds represent bulky oxidative DNA lesio...

journal_title：Carcinogenesis

authors： Randerath E,Zhou GD,Randerath K

更新日期：1996-12-01 00:00:00

abstract：:The purpose of this study was to determine if decreasing dietary protein from 24% (high protein) to 5% casein (low protein), substituting sucrose and cornstarch isocalorifically for casein, would modify the activity of protein kinase C (PKC) alpha and beta isoenzymes, as well as the expression of PKC alpha, beta, delt...

journal_title：Carcinogenesis

authors： La Porta CA,Comolli R

更新日期：1995-05-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is an important process implicated in tumor invasion and metastasis. Twist1 is a transcription factor that induces EMT, including E-cadherin suppression and cancer cell migration and invasion; hence it promotes cancer metastasis. Twist1 directly or indirectly regulates the expre...

journal_title：Carcinogenesis

authors： Nam EH,Lee Y,Moon B,Lee JW,Kim S

更新日期：2015-03-01 00:00:00

abstract：:Pancreatic cancer has remained refractory to treatment. In large part, this results from the lack of an animal model that mimics pancreatic cancer in man. We describe a novel experimental model of pancreatic cancer that shares the genetic background, histologic features and natural history of human mixed acinar-ductal...

journal_title：Carcinogenesis

authors： Doiron B,DeFronzo RA

更新日期：2018-02-09 00:00:00

abstract：:Germline genetic variability might contribute, at least partially, to the survival of pancreatic ductal adenocarcinoma (PDAC) patients. Two recently performed genome-wide association studies (GWAS) on PDAC overall survival (OS) suggested (P < 10(-5)) the association between 30 genomic regions and PDAC OS. With the aim...

journal_title：Carcinogenesis

authors： Rizzato C,Campa D,Talar-Wojnarowska R,Halloran C,Kupcinskas J,Butturini G,Mohelníková-Duchoňová B,Sperti C,Tjaden C,Ghaneh P,Hackert T,Funel N,Giese N,Tavano F,Pezzilli R,Pedata M,Pasquali C,Gazouli M,Mambrini A,Sou

更新日期：2016-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the leading causes for cancer related mortality worldwide. Poor prognosis of HCC patients is mainly due to frequent metastasis and recurrence. Deregulation of metastasis suppressors in malignant cells plays critical roles during cancer metastasis. Thus, novel metastasis suppres...

journal_title：Carcinogenesis

authors： Luo Q,Wang C,Jin G,Gu D,Wang N,Song J,Jin H,Hu F,Zhang Y,Ge T,Huo X,Chu W,Shu H,Fang J,Yao M,Gu J,Cong W,Qin W

更新日期：2015-10-01 00:00:00

abstract：:The purpose of this study was to compare the metabolism and DNA binding of aflatoxicol (AFL) with that of aflatoxin B1 (AFB1) in vivo and in isolated hepatocytes from Mt Shasta strain rainbow trout (Salmo gairdneri). Maximum total binding of [3H]AFL to liver DNA from trout exposed by intraperitoneal injection was 38-4...

journal_title：Carcinogenesis

authors： Loveland PM,Wilcox JS,Pawlowski NE,Bailey GS

更新日期：1987-08-01 00:00:00

abstract：:Teflon tubing used in the isolated, ventilated and perfused lung apparatus (IVPL) was found to yield artifactually high values for nitrosamine formation after it had been exposed to nitrite. In contrast to an earlier report, we found that submilligram levels of nitrite do not react to form significant quantities of ni...

journal_title：Carcinogenesis

authors： Cooney RV,Ross PD,Bartolini GL

更新日期：1986-05-01 00:00:00

abstract：:3-Amino-1,2,4-triazole, a thyroid carcinogen and goitrogen, is negative in a wide variety of short-term mutagenicity assays. However, amitrole induces gene mutations and morphological transformation in Syrian hamster embryo fibroblasts, cells known to carry out the prostaglandin H synthase (PHS)-mediated peroxidative ...

journal_title：Carcinogenesis

authors： Krauss RS,Eling TE

更新日期：1987-05-01 00:00:00

abstract：:Occupational nitrosamine exposures from a rubber vehicle seal (VS) curing operation were compared with the peripheral blood lymphocyte concentrations of two nitrosamine-related DNA adducts, N(7)-methylguanine (N(7)mdG) and O(6)-methylguanine (O(6)mdG), and with the activity of the enzyme that repairs O(6)mdG adducts, ...

journal_title：Carcinogenesis

authors： Reh BD,DeBord DG,Butler MA,Reid TM,Mueller C,Fajen JM

更新日期：2000-01-01 00:00:00

abstract：:Aphidicolin is a specific inhibitor of DNA polymerase alpha. Its influence of DNA repair has been studied in both normal and excision deficient xeroderma pigmentosum cells exposed to u.v. irradiation at 254 nm. Single strand DNA breaks accumulated in u.v. irradiated normal cells when the inhibitor was present. Such br...

journal_title：Carcinogenesis

authors： Waters R

更新日期：1981-01-01 00:00:00

abstract：:Rats received a choline-deficient diet containing 0.1% (w/w) DL-ethionine (CDE) for 4, 10, 14 or 22 weeks. A separate group was treated for 4 weeks with CDE and then received a normal diet for 4 weeks. The L and M2 isoenzymes of pyruvate kinase were immunocytochemically demonstrated in liver sections. L-PK expression ...

journal_title：Carcinogenesis

authors： Hacker HJ,Steinberg P,Bannasch P

更新日期：1998-01-01 00:00:00