Effect of a long-acting analogue of somatostatin, SMS 201-995, on the development of intestinal tumours in azoxymethane-treated rats.

abstract：:Functional activation of beta-catenin/Tcf signaling plays an important role in the early events in colorectal carcinogenesis. We examined the effect of ionomycin against beta-catenin/Tcf signaling in colon cancer cells. Reporter gene assay showed that ionomycin inhibited beta-catenin/Tcf signaling efficiently. In addi...

journal_title：Carcinogenesis

authors： Park CH,Hahm ER,Lee JH,Jung KC,Rhee HS,Yang CH

更新日期：2005-11-01 00:00:00

abstract：:Inactivation of the adenomatous polyposis coli (Apc) gene by loss of the wild-type Apc allele (LOH) is a prerequisite for the development of intestinal adenomas in Msh2 proficient Min (Apc+/-Msh2+/+) mice. In contrast, adenomas from Msh2 deficient Min (Apc+/-Msh2-/-) mice are not usually associated with LOH. Given the...

journal_title：Carcinogenesis

authors： Sohn KJ,Choi M,Song J,Chan S,Medline A,Gallinger S,Kim YI

更新日期：2003-02-01 00:00:00

abstract：:Folate and vitamin D have been shown to be influenced by ultraviolet (UV) radiation. UVA radiation can break down plasma folate, whereas vitamin D can be synthesized in UVB-exposed skin. Folate metabolism is involved in DNA synthesis and repair, and vitamin D processes anti-proliferative effects. The functions of both...

journal_title：Carcinogenesis

authors： Han J,Colditz GA,Hunter DJ

更新日期：2007-02-01 00:00:00

abstract：:Remodeling or deregulation of the calcium signaling pathway is a relevant hallmark of cancer including cutaneous melanoma (CM). In this study, using data from a published genome-wide association study (GWAS) from The University of Texas M.D. Anderson Cancer Center, we assessed the role of 41,377 common single-nucleoti...

journal_title：Carcinogenesis

authors： Wang X,Liu H,Xu Y,Xie J,Zhu D,Amos CI,Fang S,Lee JE,Li X,Nan H,Song Y,Wei Q

更新日期：2019-04-29 00:00:00

abstract：:To investigate the sensitivity of heterozygous p53-deficient CBA mice to carcinogens, 20 female mice [p53(+/-)] and 20 wild-type littermates [p53(+/+)] were given an intraperitoneal injection of 120 mg/kg body wt of N-ethyl-N-nitrosourea (ENU) and were maintained without any other treatment for a further 26 weeks. His...

journal_title：Carcinogenesis

authors： Mitsumori K,Onodera H,Shimo T,Yasuhara K,Takagi H,Koujitani T,Hirose M,Maruyama C,Wakana S

更新日期：2000-05-01 00:00:00

abstract：:To test the hypothesis that aberrations of DNA repair contribute to susceptibility for the progression of gastroesophageal reflux disease (GERD) into Barrett esophagus (BE) and esophageal adenocarcinoma (EADC), we studied the frequency of polymorphisms of selected DNA repair genes in patients with GERD (n = 126), BE (...

journal_title：Carcinogenesis

authors： Casson AG,Zheng Z,Evans SC,Veugelers PJ,Porter GA,Guernsey DL

更新日期：2005-09-01 00:00:00

abstract：:2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) is a heterocyclic amine mutagen found in cooked meats and is carcinogenic in mice and rats at high doses (mg/kg body wt). Humans, however, are exposed to low amounts (p.p.b.) in the diet, and the effects caused by exposure to human equivalent doses of MeIQx have be...

journal_title：Carcinogenesis

authors： Frantz CE,Bangerter C,Fultz E,Mayer KM,Vogel JS,Turteltaub KW

更新日期：1995-02-01 00:00:00

abstract：:Cyclin D1 is believed to play an important role in the genesis and/or progression of transitional cell cancer (TCC) of the urinary bladder. Cyclin D1 gene (CCND1) mRNA is alternatively spliced to produce two transcripts, and the splicing pattern may be modulated by a G to A single nucleotide polymorphism within the sp...

journal_title：Carcinogenesis

authors： Wang L,Habuchi T,Takahashi T,Mitsumori K,Kamoto T,Kakehi Y,Kakinuma H,Sato K,Nakamura A,Ogawa O,Kato T

更新日期：2002-02-01 00:00:00

abstract：:Normal human fibroblasts do not synthesize platelet-derived growth factor (PDGF), but they respond to its mitogenic action. In contrast, cells from several human fibrosarcomas have been shown to synthesize PDGF at significant levels. To investigate the possible role of PDGF expression in the development of tumors of m...

journal_title：Carcinogenesis

authors： Yang D,Kohler SK,Maher VM,McCormick JJ

更新日期：1994-10-01 00:00:00

abstract：:The JB6 mouse epidermal cell system has been extensively used as an in vitro model for the study of tumor promotion. The present study aimed to assess the relevance of monolayer measurements to the process of transformation, which is induced more efficiently under anchorage-independent (AI) conditions. Although it wou...

journal_title：Carcinogenesis

authors： Dong Z,Cmarik JL,Wendel EJ,Colburn NH

更新日期：1994-05-01 00:00:00

abstract：:Analysis of 24 h urine samples of rats administered N-nitrosodipropylamine (NDPA), N-nitroso-2-hydroxypropylpropylamine (NHPPA) or N-nitroso-2-oxopropylpropylamine (NOPPA) showed that the major excretion product in each case was the beta-glucuronide of NHPPA. This conjugate was shown to be present at levels of about 5...

journal_title：Carcinogenesis

authors： Leung KH,Archer MC

更新日期：1981-01-01 00:00:00

abstract：:Mutations in codon 61 of the Ha-ras proto-oncogene have been shown to occur with a high frequency in both spontaneous and carcinogen-induced liver tumours of the B6C3F1 mouse. In the present study we analysed the frequency and pattern of Ha-ras mutations in liver tumours in a different strain of mice, namely the CF1 m...

journal_title：Carcinogenesis

authors： Bauer-Hofmann R,Buchmann A,Wright AS,Schwarz M

更新日期：1990-10-01 00:00:00

abstract：:BALB/c 3T3 A31-1-13 cells are highly susceptible to chemical-induced cell transformation and their gap-junctional intercellular communication (GJIC) is decreased when these cells become confluent. On the other hand, A31-1-1 cells do not show such a change in GJIC and are more resistant to chemical induction of transfo...

journal_title：Carcinogenesis

authors： Katoh F,Yamasaki H

更新日期：1991-10-01 00:00:00

abstract：:The reaction of chloroacetaldehyde, a reactive metabolic of the carcinogen vinyl chloride, with DNA produces in addition to the hitherto known adducts, 1,N6-ethenoadenine and 3,N4-ethenocytosine, an ethenoguanine adduct, namely N2,3-ethenoguanine. This adduct is formed in the reaction of chloroacetaldehyde with the fr...

journal_title：Carcinogenesis

authors： Oesch F,Doerjer G

更新日期：1982-01-01 00:00:00

abstract：:In order to test the controversially discussed hypothesis that oval cells are part of a liver stem cell compartment and can give rise to cholangiocellular as well as hepatocellular carcinomas in the course of liver carcinogenesis, we transfected an oval cell line established in our laboratory with an oncogenically act...

journal_title：Carcinogenesis

authors： Becker R,Lüthgens B,Oesch F,Dienes HP,Steinberg P

更新日期：1996-12-01 00:00:00

abstract：:We have shown previously that the difference between C57BL/6J and C3H/HeJ male mice in their susceptibilities to chemically-induced liver tumors results predominantly from an allelic difference at the Hepatocarcinogen sensitivity (Hcs) locus. This locus modulates the rate of growth of preneoplastic liver lesions and m...

journal_title：Carcinogenesis

authors： Hanigan MH,Winkler ML,Drinkwater NR

更新日期：1990-04-01 00:00:00

abstract：:Male rats were treated with [ring-3H]N-acetyl-2-aminofluorene and sacrificed at different periods of time after a single i.p. dose. Chromatin was isolated from liver homogenates and treated with RNAse and proteinase K. The resulting crude DNA was purified as the N-hexadecyl-N-trimethylammonium salt. The amounts of 2-a...

journal_title：Carcinogenesis

authors： Visser A,Westra JG

更新日期：1981-01-01 00:00:00

abstract：:5-Aminolevulinic acid (ALA), a heme precursor accumulated in chemical and inborn porphyrias, may behave as an endogenous pro-oxidant. In chronically treated rats (40 mg ALA/kg body wt every 2 days for 15 days) the steady-state level of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in liver DNA (94.5 +/- 23.3 residues/10(6) dG)...

journal_title：Carcinogenesis

authors： Fraga CG,Onuki J,Lucesoli F,Bechara EJ,Di Mascio P

更新日期：1994-10-01 00:00:00

abstract：:Metastasis is the primary cause of treatment failures and mortality in most cancers. Triple-negative breast cancer (TNBC) is refractory to treatment and rapidly progresses to disseminated disease. We utilized an orthotopic mouse model that molecularly and phenotypically resembles human TNBC to study the effects of exo...

journal_title：Carcinogenesis

authors： Peeney D,Jensen SM,Castro NP,Kumar S,Noonan S,Handler C,Kuznetsov A,Shih J,Tran AD,Salomon DS,Stetler-Stevenson WG

更新日期：2020-05-14 00:00:00

abstract：:In this study, our goal was to identify genes whose expression in liver is altered in female F-344 rats during mitosuppression induced by 42 days of ethinyl estradiol (EE) treatment (Yager et al., Carcinogenesis, 15, 2117-2123, 1994). Northern analysis demonstrated that the mRNA levels for transforming growth factor-b...

journal_title：Carcinogenesis

authors： Chen J,Schwartz DA,Young TA,Norris JS,Yager JD

更新日期：1996-12-01 00:00:00

abstract：:The objectives of this study were to isolate several rat liver epithelial cell clones containing the human bcl-2 and myc/bcl-2 genes in order to study their potential cooperative effect on neoplastic transformation and gap junction-mediated intercellular communication (GJIC) and to test the hypothesis that the loss of...

journal_title：Carcinogenesis

authors： DeoCampo ND,Wilson MR,Trosko JE

更新日期：2000-08-01 00:00:00

abstract：:The effect of phenobarbital (PB), p,p'-dichlorodiphenyltrichloroethane (DDT) or carbon tetrachloride (CCl4) on dimethylnitrosamine (DMN)-induced hepatocarcinogenesis in Syrian golden hamsters was examined. Hamsters were given a single injection of DMN (6 mg/kg body wt) followed by either PB or DDT in the diet or repea...

journal_title：Carcinogenesis

authors： Tanaka T,Mori H,Williams GM

更新日期：1987-09-01 00:00:00

abstract：:Retinoids have been shown to exert an anticarcinogenic effect through suppression of the cell cycle, induction of apoptosis and/or differentiation. In rat liver, in particular, retinoic acid has been shown to inhibit regeneration after partial hepatectomy, most probably through repression of the expression of c-fos an...

journal_title：Carcinogenesis

authors： Ledda-Columbano GM,Pibiri M,Molotzu F,Cossu C,Sanna L,Simbula G,Perra A,Columbano A

更新日期：2004-11-01 00:00:00

abstract：:Glucosinolates are common components of cruciferous vegetables that can be hydrolyzed during food processing to yield isothiocyanates, some of which have been shown to inhibit the induction of mammary tumors in rats by 7,12-dimethyl-benz[a]anthracene. To determine how intact glucosinolates affect the metabolism of ben...

journal_title：Carcinogenesis

authors： Baird WM,Zennie TM,Ferin M,Chae YH,Hatchell J,Cassady JM

更新日期：1988-04-01 00:00:00

abstract：:Previously we have reported the development of a model in vitro system for the study of osteosarcoma. In this system, when chick periosteal explants are infected with Fujinami sarcoma virus (FSV), osteosarcoma-like tissue is formed. In the present study, a series of histopathologic parameters of neoplastic transformat...

journal_title：Carcinogenesis

authors： Birek C,Pawson T,McCulloch CA,Tenenbaum HC

更新日期：1988-10-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) are important regulators of angiogenesis. HIF-1 is composed of HIF-1alpha and HIF-1beta subunits, and regulates VEGF expression at transcriptional level. In this study, we demonstrated that insulin induced H2O2 production and p70S6K1 acti...

journal_title：Carcinogenesis

authors： Zhou Q,Liu LZ,Fu B,Hu X,Shi X,Fang J,Jiang BH

更新日期：2007-01-01 00:00:00

abstract：:Inducers of Phase II enzymes, already consumed by humans as food additives, medicines or as constituents of vegetables, can prevent experimental carcinogenesis. Since protection is neither carcinogen- nor organ-specific, clinical trials are already underway to establish the efficacy of 'anticarcinogenic enzyme inducer...

journal_title：Carcinogenesis

authors： Prochaska HJ,Fernandes CL

更新日期：1993-12-01 00:00:00

abstract：:The magnitude of benefit is variable for advanced non-small cell lung cancer (NSCLC) patients receiving platinum-based chemotherapy. The purpose of this study is to determine whether genetic variations in the transforming growth factor-beta (TGF-β) pathway are associated with clinical outcomes in NSCLC patients receiv...

journal_title：Carcinogenesis

authors： Lin M,Stewart DJ,Spitz MR,Hildebrandt MA,Lu C,Lin J,Gu J,Huang M,Lippman SM,Wu X

更新日期：2011-07-01 00:00:00

abstract：:Constituents in food and fluids, tobacco chemicals and many drugs are candidates for oral absorption and oxidative metabolism. On this basis, the expression of cytochrome P450 isozymes (CYPs) and the conversion of CYP substrates were analysed in reference to buccal mucosa. A RT-PCR based analysis of human buccal tissu...

journal_title：Carcinogenesis

authors： Vondracek M,Xi Z,Larsson P,Baker V,Mace K,Pfeifer A,Tjälve H,Donato MT,Gomez-Lechon MJ,Grafström RC

更新日期：2001-03-01 00:00:00

abstract：:Inbred male Leeds rats were administered either the liver carcinogen N-nitrosopiperidine or the non-carcinogen 2,2',6,6'-tetramethyl-N-nitrosopiperidine in their drinking water at a concentration of 0.02%. Treatment was continued until the animals were killed, at 12 or 28 days, when their hepatic tissues were removed ...

journal_title：Carcinogenesis

authors： Flaks B,Challis BC

更新日期：1981-01-01 00:00:00