Abstract:
:The rat liver microsomal metabolism of 3-deutero-6-nitrobenzo(a)pyrene ([3-2H]6-NO2-BaP) was studied. The metabolites were separated by h.p.l.c. The 500 MHz 1H n.m.r. spectral analysis of the metabolites indicated that the 3-hydroxy-6-NO2-BaP and 6-NO2-BaP-3,9-hydroquinone each retained 33% of the deuterium label at the C-2 position. It is proposed that the migration of deuterium occurs via an NIH shift mechanism. These results indicate that a 2,3-epoxide is a common intermediate.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Chou MW,Evans FE,Yang SK,Fu PPdoi
10.1093/carcin/4.6.699subject
Has Abstractpub_date
1983-01-01 00:00:00pages
699-702issue
6eissn
0143-3334issn
1460-2180journal_volume
4pub_type
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