O6-ethylguanine and O6-benzylguanine incorporated site-specifically in codon 12 of the rat H-ras gene induce semi-targeted as well as targeted mutations in Rat4 cells.

abstract：:Isoflavone genistein is a specific inhibitor of protein tyrosine kinase (PTK) and has been shown to have a variety of anticancer activities in cultured cells and animal models. We report here that genistein significantly inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoyl phorbol-13-acetate...

journal_title：Carcinogenesis

authors： Wei H,Bowen R,Zhang X,Lebwohl M

更新日期：1998-08-01 00:00:00

abstract：:The role of O-GlcNAc transferase (OGT) in gene regulation and tumor invasion is poorly understood. Here, we have identified several previously undiscovered OGT-interacting proteins, including the PRMT5/WDR77 complex, the PRC2 complex, the ten-eleven translocation (TET) family, the CRL4B complex and the nucleosome remo...

journal_title：Carcinogenesis

authors： Gao J,Yang Y,Qiu R,Zhang K,Teng X,Liu R,Wang Y

更新日期：2018-10-08 00:00:00

abstract：:Gemcitabine has limited clinical benefits in pancreatic ductal adenocarcinoma. The solvent-based traditional taxanes docetaxel and paclitaxel have not shown clinical results superior to gemcitabine. Nab-paclitaxel, a water-soluble albumin-bound paclitaxel, may carry superior distribution properties into the tumor micr...

journal_title：Carcinogenesis

authors： Awasthi N,Zhang C,Schwarz AM,Hinz S,Wang C,Williams NS,Schwarz MA,Schwarz RE

更新日期：2013-10-01 00:00:00

abstract：:Lipid peroxidation aldehydes of the 4-hydroxy-alpha, beta-unsaturated type, as well as the tobacco-smoke related alpha, beta-unsaturated aldehyde, acrolein, were highly cytotoxic and decreased the intracellular thiol content in cultured human bronchial fibroblasts after treatment with micromolar concentrations. In com...

journal_title：Carcinogenesis

authors： Krokan H,Grafstrom RC,Sundqvist K,Esterbauer H,Harris CC

更新日期：1985-12-01 00:00:00

abstract：:In this study we have investigated the relationship between the dose of 1,2-dimethylhydrazine (DMH) and the yield (and location) of tumours in a mouse strain susceptible to colon tumour induction. Female SWR mice were injected with 6.8 mg/kg DMH i.p. once a week for 1, 5, 10 and 20 weeks and the animals were followed ...

journal_title：Carcinogenesis

authors： Jackson PE,Cooper DP,O'Connor PJ,Povey AC

更新日期：1999-03-01 00:00:00

abstract：:Cancer of the stomach is one of the most commonly diagnosed malignancies and remains an important cause of mortality world wide. This type of cancer is not uniformly distributed among populations but shows a marked variation in both incidence and mortality. Although gastric cancer is declining in many parts of the wor...

journal_title：Carcinogenesis

authors： Stadtländer CT,Waterbor JW

更新日期：1999-12-01 00:00:00

abstract：:A mismatch between metabolic demand and oxygen delivery leads to microenvironmental changes in solid tumors. The resulting tumor hypoxia is associated with malignant progression, therapy resistance and poor prognosis. However, the molecular mechanisms underlying therapy resistance in hypoxic tumors are not fully under...

journal_title：Carcinogenesis

authors： Wirthner R,Wrann S,Balamurugan K,Wenger RH,Stiehl DP

更新日期：2008-12-01 00:00:00

abstract：:Two samples of 4-amino-2-nitrophenol were tested for mutagenicity in Salmonella typhimurium strains TA1535, TA1537, TA1538, TA98, and TA100. Significant mutagenic activity was detected with a sample of this compound obtained from Aldrich (technical grade (Aldrich), TGA) both in the presence and in the absence of a rat...

journal_title：Carcinogenesis

authors： Shahin MM,Bugaut A,Junino A,Kalopissis G

更新日期：1982-01-01 00:00:00

abstract：:We investigated whether the addition of d-limonene to the diets of rats would modify the process of mammary tumor induction by 7,12-dimethylbenz[a]anthracene (DMBA). When diets containing 1000 or 10 000 p.p.m. d-limonene were fed to rats from one week before DMBA administration to the end of the experiment (27 weeks p...

journal_title：Carcinogenesis

authors： Elegbede JA,Elson CE,Qureshi A,Tanner MA,Gould MN

更新日期：1984-05-01 00:00:00

abstract：:N2-ethylidene-2'-deoxyguanosine (N2-ethylidene-dG) is a major DNA adduct induced by acetaldehyde. Although it is unstable in the nucleoside form, it is relatively stable when present in DNA. In this study, we analyzed three acetaldehyde-derived DNA adducts, N2-ethylidene-dG, N2-ethyl-2'-deoxyguanosine (N2-Et-dG) and a...

journal_title：Carcinogenesis

authors： Matsuda T,Matsumoto A,Uchida M,Kanaly RA,Misaki K,Shibutani S,Kawamoto T,Kitagawa K,Nakayama KI,Tomokuni K,Ichiba M

更新日期：2007-11-01 00:00:00

abstract：:The syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-6-methylchrysene (6-MeC-1,2-diol-3,4-epoxide) were synthesized and their mutagenic activities in Salmonella typhimurium were compared with those of the syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (5-MeC-1,2...

journal_title：Carcinogenesis

authors： Amin S,Huie K,Hecht SS,Harvey RG

更新日期：1986-12-01 00:00:00

abstract：:Mutagenicity and carcinogenicity of the ubiquitous environmental pollutant benzo[a]pyrene is mediated via its reactive diol epoxide metabolite, anti-BPDE, with the predominant formation of N(2)-deoxyguanine adducts in genomic DNA. Polyclonal and monoclonal antibodies specific for (+/-)-anti-BPDE DNA adducts were used ...

journal_title：Carcinogenesis

authors： Venkatachalam S,Denissenko M,Wani AA

更新日期：1995-09-01 00:00:00

abstract：:Previous studies have shown that platinum-DNA adduct level in leukocyte DNA (measured by antibody methodology) is directly related to disease response in ovarian cancer and testicular cancer. To determine if this principle could be more broadly applied, platinum-DNA damage was studied in a blinded fashion in leukocyte...

journal_title：Carcinogenesis

authors： Parker RJ,Gill I,Tarone R,Vionnet JA,Grunberg S,Muggia FM,Reed E

更新日期：1991-07-01 00:00:00

abstract：:Inhalation of diesel exhaust (DE), which contains soot particles with adsorbed mutagenic organic compounds, and its virtually mutagen-free soot particle analog, carbon black (CB), produce similar types and prevalences of pulmonary neoplasms in chronically exposed F344 rats. This result suggests that DE-induced neoplas...

journal_title：Carcinogenesis

authors： Swafford DS,Nikula KJ,Mitchell CE,Belinsky SA

更新日期：1995-05-01 00:00:00

abstract：:Low selenium (Se) status correlates with increased risk of colorectal cancer (CRC). Since Se exerts its biological roles through the selenoproteins, genetic variations in selenoprotein genes may influence susceptibility to CRC. This study analysed 12 single-nucleotide polymorphisms (SNPs) in selenoprotein genes [gluta...

journal_title：Carcinogenesis

authors： Méplan C,Hughes DJ,Pardini B,Naccarati A,Soucek P,Vodickova L,Hlavatá I,Vrána D,Vodicka P,Hesketh JE

更新日期：2010-06-01 00:00:00

abstract：:The naturally occurring anticarcinogens flavone and alpha-angelicalactone incorporated separately and simultaneously in the diet at 0.5, 0.1, 0.05 and 0.01% w/w, were studied with respect to their effects on oesophageal, gastric, intestinal, colonic and hepatic (i) glutathione S-transferase (GST) enzyme activity, (ii)...

journal_title：Carcinogenesis

authors： Nijhoff WA,Bosboom MA,Smidt MH,Peters WH

更新日期：1995-03-01 00:00:00

abstract：:Despite decades of research in defining the health effects of low-dose (<100 mGy) ionizing photon radiation (LDR), the relationship between LDR and human cancer risk remains elusive. Because chemical carcinogens modify the tumor microenvironment, which is critical for cancer development, we investigated the role and ...

journal_title：Carcinogenesis

authors： Chen W,Xu X,Bai L,Padilla MT,Gott KM,Leng S,Tellez CS,Wilder JA,Belinsky SA,Scott BR,Lin Y

更新日期：2012-07-01 00:00:00

abstract：:Antibodies specific for u.v.-induced DNA damage were raised in rabbits, and used to study damage and repair of nuclear DNA in nude mouse and human skin in vivo by immuno-fluorescence and immunoperoxidase techniques. Purification of the antibodies by affinity chromatography strongly reduced unspecific background staini...

journal_title：Carcinogenesis

authors： Eggset G,Volden G,Krokan H

更新日期：1983-01-01 00:00:00

abstract：:Prostate cancer (CaP) is the second leading cause of cancer death in American men. Chronic inflammation has been one of several factors associated with the development of CaP. Single-nucleotide polymorphisms (SNPs) in cytokine genes have been associated with increased inflammation, increased cytokine production and po...

journal_title：Carcinogenesis

authors： Zabaleta J,Lin HY,Sierra RA,Hall MC,Clark PE,Sartor OA,Hu JJ,Ochoa AC

更新日期：2008-03-01 00:00:00

abstract：:Observational studies and animal evidence suggest an association between coffee consumption and the risk of prostate cancer. However, the results are inconsistent. We evaluated the association by conducting a meta-analysis of prospective cohort studies. PubMed and Embase were searched through June 2013 to identify stu...

journal_title：Carcinogenesis

authors： Cao S,Liu L,Yin X,Wang Y,Liu J,Lu Z

更新日期：2014-02-01 00:00:00

abstract：:Cancer is a genetic disease in which the interplay between alterations in protein-coding genes and non-coding RNAs (ncRNAs) plays a fundamental role. In recent years, the full coding component of the human genome was sequenced in various cancers, whereas such attempts related to ncRNAs are still fragmentary. We screen...

journal_title：Carcinogenesis

authors： Wojcik SE,Rossi S,Shimizu M,Nicoloso MS,Cimmino A,Alder H,Herlea V,Rassenti LZ,Rai KR,Kipps TJ,Keating MJ,Croce CM,Calin GA

更新日期：2010-02-01 00:00:00

abstract：:EphB2, a receptor tyrosine kinase regulated by the beta-catenin/Tcf4 complex, is expressed in the proliferative compartment of mouse intestine and regulates bidirectional migration of intestinal precursor cells in the crypt-villus axis through repulsive interaction with Ephrin-B ligands. Recently, it has been shown th...

journal_title：Carcinogenesis

authors： Guo DL,Zhang J,Yuen ST,Tsui WY,Chan AS,Ho C,Ji J,Leung SY,Chen X

更新日期：2006-03-01 00:00:00

abstract：:Transforming growth factor-alpha (TGF-alpha) is a potent mitogenic factor which acts by binding to the epidermal growth factor (EGF). c-erbB-2 is a member of the EGF receptor family and is known to be associated with cellular growth and differentiation. The roles played by these factors in benign prostatic hyperplasia...

journal_title：Carcinogenesis

authors： Giri DK,Pal R,Wadhwa SN,Talwar GP

更新日期：1995-04-01 00:00:00

abstract：:The mechanism of inactivation of the O6-methylguanine-DNA methyltransferase (MGMT), responsible for repair of mutagenic and cytotoxic O6-alkylguanine, in Mex- tumor cells, is not completely understood. We have examined the role of CpG methylation in the human MGMT promoter in a luciferase (luc) reporter plasmid and as...

journal_title：Carcinogenesis

authors： Bhakat KK,Mitra S

更新日期：2003-08-01 00:00:00

abstract：:Teflon tubing used in the isolated, ventilated and perfused lung apparatus (IVPL) was found to yield artifactually high values for nitrosamine formation after it had been exposed to nitrite. In contrast to an earlier report, we found that submilligram levels of nitrite do not react to form significant quantities of ni...

journal_title：Carcinogenesis

authors： Cooney RV,Ross PD,Bartolini GL

更新日期：1986-05-01 00:00:00

abstract：:4-Aminobiphenyl (4-ABP), a potent carcinogen in rodents (liver cancer) and human (bladder cancer), is found as an environmental contaminant and in tobacco smoke. Hemoglobin adducts and lung DNA adducts of 4-ABP are found in tobacco smokers. In vitro metabolism studies with human and rat liver microsomes have shown tha...

journal_title：Carcinogenesis

authors： Kimura S,Kawabe M,Ward JM,Morishima H,Kadlubar FF,Hammons GJ,Fernandez-Salguero P,Gonzalez FJ

更新日期：1999-09-01 00:00:00

abstract：:Modulation of cellular thiols has been used to ameliorate the toxic side effects associated with cancer chemotherapy and is currently being investigated as a novel therapeutic strategy in cancer treatment. One of the most extensively studied modulators of thiol levels is N-acetylcysteine (NAC), a cytoprotective drug w...

journal_title：Carcinogenesis

authors： McLellan LI,Lewis AD,Hall DJ,Ansell JD,Wolf CR

更新日期：1995-09-01 00:00:00

abstract：:Certain hexavalent chromium [Cr(VI)] compounds are implicated as occupational respiratory carcinogens. Cr(VI) induces a broad spectrum of DNA damage, but Cr(VI)-induced DNA double-strand breaks (DSBs) have not been reported. Previously we found that Cr(VI) activates the ataxia telangiectasia mutated (ATM) kinase. ATM ...

journal_title：Carcinogenesis

authors： Ha L,Ceryak S,Patierno SR

更新日期：2004-11-01 00:00:00

abstract：:The genetic factors that mediate the pathogenesis of multiple primary cutaneous basal cell carcinomas (BCC) are largely unclear. Thus, some patients suffer many BCC (>30) and/or rapid accrual (number of tumours/year from first presentation) of further lesions. We have studied, in 827 English Caucasians, the influence ...

journal_title：Carcinogenesis

authors： Lear JT,Heagerty AH,Smith A,Bowers B,Payne CR,Smith CA,Jones PW,Gilford J,Yengi L,Alldersea J,Fryer AA,Strange RC

更新日期：1996-09-01 00:00:00

abstract：:To compare mutagenesis by O6-methylguanine (m6G), O4-methylthymine (m4T) and O6-ethylguanine (e6G), and assess their genotoxicity in Escherichia coli, double-stranded and gapped plasmids were constructed containing a single m6G, e6G or m4T in the initiation codon (ATG) of a lacZ' gene. Modified base induced mutations ...

journal_title：Carcinogenesis

authors： Pauly GT,Hughes SH,Moschel RC

更新日期：1998-03-01 00:00:00